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Newly Discovered Gut Peptides

Chung Owyang, Dexter Louie

10.1002/cphy.cp060228

Source: Supplement 17: Handbook of Physiology, The Gastrointestinal System, Neural and Endocrine Biology

Originally published: 1989

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Galanin
1.1 Structure
1.2 Distribution
1.3 Biological Actions
2 Calcitonin Gene‐Related Peptide
2.1 Synthesis and Structure
2.2 Distribution
2.3 Biological Actions
3 Pancreastatin
3.1 Structure
3.2 Biological Actions
4 Valosin
4.1 Structure
4.2 Biological Actions
5 Pancreatic Monitor Peptide
6 Cholecystokinin‐Releasing Peptide
References
 1. Ahrén, B., P., Arkhammar, P. O. Berggren, and T. Nilsson, Galanin inhibits glucose‐stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration. Biochem. Biophys. Res. Commun. 140: 1059–1063, 1986.
 2. Ahrén, B., H., Martensson, and A. Nobin, Effects of calcitonin gene‐related peptide (CGRP) on islet hormone secretion in the pig. Diabetologia 30: 354–359, 1987.
 3. Amara, S. G., V., Jones, M. G. Rosenfeld, E. S. Ong, and R. M. Evans, Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature Lond. 29: 240–249, 1982.
 4. Asimakis, G. K., D. J., Dipette, V. R. Conti, O. B. Holland, and J. B. Zwischenberger, Hemodynamic action of calcitonin gene‐related peptide in the isolated rat heart. Life Sci. 41: 597–603, 1987.
 5. Bartho, L., F., Lembeck, and P. Holzer, Calcitonin gene‐related peptide is a potent relaxant of intestinal muscle. Eur. J. Pharmacol. 135: 449–451, 1987.
 6. Bauer, F. E., T. E., Adrian, N. D. Christofides, G. L. Ferri, N. Yanaihara, J. M. Polak, and S. R. Bloom, Distribution and molecular heterogeneity of galanin in human, pig, guinea pig, and rat gastrointestinal tracts. Gastroenterology 91: 877–883, 1986.
 7. Bauer, F. E., T. E., Adrian, N. Yanaihara, J. M. Polak, and S. R. Bloom, Chromatographic evidence for high‐molecularmass galanin immunoreactivity in pig and cat adrenal glands. FEBS Lett. 201: 327–331, 1986.
 8. Bauer, F. E., N. D., Christofides, G. W. Hacker, M. A. Blank, J. M. Polak, and S. R. Bloom, Distribution of galanin immunoreactivity in the genitourinary tract of man and rat. Peptides Fayetteville 7: 5–10, 1986.
 9. Bauer, F. E., L., Ginsberg, M. Venetikou, D. J. Mackay, J. M. Burrin, and S. R. Bloom, Growth hormone release in man induced by galanin, a new hypothalamic peptide. Lancet 2: 192–195, 1986.
 10. Bauer, F. E., G. W., Hacker, G. Terenghi, T. E. Adrian, J. M. Polak, and S. R. Bloom, Localization and molecular forms of galanin in human adrenals: elevated levels in pheo‐chromocytomas. J. Clin. Endocrinol. Metab. 63: 1372–1378, 1986.
 11. Bishop, A. E., J. M., Polak, F. E. Bauer, N. D. Christofides, F. Carlei, and S. R. Bloom, Occurrence and distribution of a newly discovered peptide, galanin, in the mammalian enteric nervous system. Gut 27: 849–857, 1986.
 12. Buéno, L., and P. Riviére, Control of ingestive behavior and rumination by neuropeptides. Reprod. Nutr. Dev. 27: 157–169, 1987.
 13. Chernick, S. S., S., Lepkovsky, and I. L. Chaikoff, A dietary factor regulating the enzyme content of the pancreas: changes induced in size and proteolytic activity of the chick pancreas by ingestion of raw soy‐bean meal. Am. J. Physiol. 155: 33–41, 1948.
 14. Cheung, A., J. M., Polak, F. E. Bauer, A. Cadieux, N. D. Christofides, D. R. Springall, and S. R. Bloom, Distribution of galanin immunoreactivity in the respiratory tract of pig, guinea pig, rat and dog. Thorax 40: 889–896, 1985.
 15. Ch'Ng, J. L., N. D., Christofides, P. Anand, S. J. Gibson, Y. S. Allen, H. C. Su, K. Tatemoto, J. F. Morrison, J. M. Polak, and S. R. Bloom, Distribution of galanin immunoreactivity in the central nervous system and the responses of galanin‐containing neuronal pathways to injury. Neuroscience 16: 343–354, 1985.
 16. Clague, J. R., C., Sternini, and N. C. Brecha, Localization of calcitonin gene‐related peptide‐like immunoreactivity in neurons of the rat gastrointestinal tract. Neurosci. Lett. 56: 63–68, 1985.
 17. Corring, T., Mechanisme de la sécrétion pancreatique exocrine chez le porc: régulation par rétro inhibition. Ann. Biol. Anim. Biochim. Biophys. 13: 755–756, 1973.
 18. Crenshaw, E. B., A. F. Russo, L. W. Swanson, and M. G. Rosenfeld, Neuron‐specific alternative RNA processing in transgenic mice expressing a metallothionein‐calcitonin fusion gene. Cell 49: 389–398, 1987.
 19. Debas, H. T., G. F., Slaff, and M. I. Grossman, Intestinal phase of gastric acid secretion: augmentation of maximal response of Heidenhain pouch to gastrin and histamine. Gastroenterology 68: 691–698, 1975.
 20. Delvalle, J., H., Debas, K. Tatemoto, and T. Yamada, Pancreastatin directly inhibits gastric parietal cell activity (Abstract). Gastroenterology 92: 1368, 1987.
 21. Deutch, A. Y., and R. H. Roth, Calcitonin gene‐related peptide in the ventral tegmental area: selective modulation of prefrontal cortical dopamine metabolism. Neurosci. Lett. 74: 169–174, 1987.
 22. Dunning, B. E., B., Ahrén, R. C. Veith, G. Böttcher, F. Sundler, and G. J. Taborsky, JR, Galanin: a novel pancreatic neuropeptide. Am. J. Physiol. 251 (Endocrinol. Metab. 14): E127–E133, 1986.
 23. Dunning, B. E., and G. J. Taborsky, JR, Calcitonin gene‐related peptide: a potent and selective stimulator of gastrointestinal somatostatin secretion. Endocrinology 120: 1774–1781, 1987.
 24. Edvinsson, L., R., Ekman, I. Jansen, A. Ottosson, and R. Uddman, Peptide‐containing nerve fibers in human cerebral arteries: immunocytochemistry, radioimmunoassay, and in vitro pharmacology. Ann. Neurol. 21: 431–437, 1987.
 25. Eiden, L. E., Is chromogranin a prohormone? Nature Lond. 325: 301, 1987.
 26. Ekblad, E., R., Håkanson, F. Sundler, and C. Wahlestedt, Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations. Br. J. Pharmacol. 86: 241–246, 1985.
 27. Ekblad, E., A., Rökaeus, R. Håkanson, and F. Sundler, Galanin nerve fibers in the rat gut: distribution, origin and projections. Neuroscience 16: 355–363, 1985.
 28. Ekblad, E., C., Winther, R. Ekman, R. Håkanson, and F. Sundler, Projections of peptide‐containing neurons in rat small intestine. Neuroscience 20: 169–188, 1987.
 29. Ezra, D., F. R., Laurindo, D. S. Goldstein, R. E. Goldstein, and G. Feuerstein, Calcitonin gene‐related peptide: a potent modulator of coronary flow. Eur. J. Pharmacol. 137: 101–105, 1987.
 30. Fiscone, G., C. F., Wu, S. Consolo, O. Nordström, N. Brynne, T. Bartfai, T. Melander, and T. Hökfelt, Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo and in vitro studies. Proc. Natl. Acad. Sci. USA 84: 7339–7343, 1987.
 31. Fox, J. E., T. J., Mcdonald, F. Kostolanska, and K. Tatemoto, Galanin: an inhibitory neural peptide of the canine small intestine. Life Sci. 39: 103–110, 1986.
 32. Franco‐Cereceda, A., L., Bengtsson, and J. M. Lundberg, Inotropic effects of calcitonin gene‐related peptide, vasoactive intestinal polypeptide and somatostatin on the human right atrium in vitro. Eur. J. Pharmacol. 134: 69–76, 1987.
 33. Franco‐Cereceda, A., C., Gennari, R. Nami, D. Agnusdei, J. Pernow, J. M. Lundberg, and J. A. Fischer, Cardiovascular effects of calcitonin gene‐related peptides I and II in man. Circ. Res. 60: 393–397, 1987.
 34. Franco‐Cereceda, A., H., Henke, J. M. Lundberg, J. B. Petermann, T. Hökfelt, and J. A. Fischer, Calcitonin gene‐related peptide (CGRP) in capsaicin‐sensitive substance P immunoreactive sensory neurons in animals and man: distribution and release by capsaicin. Peptides Fayetteville 8: 399–410, 1987.
 35. Fukuoka, S., T., Fushiki, Y. Kitagawa, E. Sugimoto, and K. Iwai, Growth stimulating activity on 3T3 fibroblasts of the molecular weight 6,500‐peptide purified from rat pancreatic juice. Biochem. Biophys. Res. Commun. 139: 545–550, 1986.
 36. Fukuoka, S., T., Fushiki, Y. Kitagawa, E. Sugimoto, and K. Iwai, Competition of a growth stimulating/cholecystokinin (CCK) releasing‐peptide (monitor peptide) with epidermal growth factor for binding to 3T3 fibroblasts. Biochem. Biophys. Res. Commun. 145: 646–650, 1987.
 37. Fukuoka, S., H., Kawajiri, T. Fushiki, K. Takahashi, and K. Iwai, Localization of pancreatic enzyme secretion‐stimulating activity and trypsin inhibitory activity in zymogen granule of the rat pancreas. Biochim. Biophys. Acta 884: 18–24, 1986.
 38. Fukuoka, S., M., Tsujikawa, T. Fushiki, and K. Iwai, Stimulation of pancreatic enzyme secretion by a peptide purified from rat bile‐pancreatic juice. J. Nutr. 116: 1540–1546, 1986.
 39. Fushiki, T., S., Fukuoka, and K. Iwai, Stimulatory effect of an endogenous peptide in rat pancreatic juice on pancreatic enzyme secretion in the presence of atropine: evidence for different mode of action of stimulation from exogenous trypsin inhibitors. Biochem. Biophys. Res. Commun. 118: 532–537, 1984.
 40. Fushiki, T., S., Fukuoka, H. Kajiura, and K. Iwai, Atropine‐nonsensitive feedback regulatory mechanism of rat pancreatic enzyme secretion in response to food protein intake. J. Nutr. 117: 948–954, 1987.
 41. Gazelius, B., B., Edwall, L. Olgart, J. M. Lundberg, T. Hökfelt, and J. A. Fischer, Vasodilatory effects and coexistence of calcitonin gene‐related peptide (CGRP) and substance P in sensory nerves of cat dental pulp. Acta Physiol. Scand. 130: 33–40, 1987.
 42. Gibbins, I. L., J. B., Furness, and M. Costa, Pathway‐specific patterns of the coexistence of substance P, calcitonin gene‐related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea pig. Cell Tissue Res. 248: 417–437, 1987.
 43. Gibson, S. J., J. M., Polak, S. R. Bloom, I. M. Sabate, P. M. Mulderry, M. A. Ghatei, G. P. Mcgregor, J. F. B. Morrison, J. S. Kelly, R. M. Evans, and M. G. Rosenfeld, Calcitonin gene‐related peptide immunoreactivity in the spinal cord of man and eight other species. J. Neurosci. 4: 310–311, 1984.
 44. Goto, K., S., Kimura, and A. Saito, Inhibitory effect of calcitonin gene‐related peptide on excitation and contraction of smooth muscles of the rat vas deferens. J. Pharmacol. Exp. Ther. 241: 635–641, 1987.
 45. Green, G. M., and R. L. Lyman, Feedback regulation of pancreatic enzyme secretion as a mechanism for trypsin inhibitor‐induced hypersecretion in rats. Proc. Soc. Exp. Biol. Med. 140: 6–12, 1972.
 46. Green, G. M., B. A., Olds, G. Matthews, and R. L. Lyman, Protein, as a regulator of pancreatic enzyme secretion in the rat. Proc. Soc. Exp. Biol. Med. 142: 1162–1167, 1973.
 47. Green, T., and G. J. Dockray, Calcitonin gene‐related peptide and substance P in afferents to the upper gastrointestinal tract in the rat. Neurosci. Lett. 76: 151–156, 1987.
 48. Grossman, M. I., Candidate hormones of the gut. Gastroenterology 67: 730–755, 1974.
 49. Hamill, G. S., G., Skofitsch, and D. M. Jacobowitz, Immunocytochemical localization of atrial natriuretic factor, galanin and calcitonin gene‐related peptide within the rat interpeduncular nucleus. Brain Res. Bull. 17: 83–93, 1986.
 50. Iwai, K., S., Fukuoka, T. Fushiki, T. Kodaira, and N. Ikei, Elevation of plasma CCK concentration after intestinal administration of a pancreatic enzyme secretion‐stimulating peptide purified from rat‐bile pancreatic juice: analysis with N‐terminal region specific radioimmunoassay. Biochem. Biophys. Res. Commun. 136: 701–706, 1986.
 51. Iwai, K., S., Fukuoka, T. Fushiki, M. Tsujikawa, M. Hirose, S. Tsunasawa, and F. Sakiyama, Purification and sequencing of a trypsin‐sensitive cholecystokinin‐releasing peptide from rat pancreatic juice. Its homology with pancreatic secretory trypsin inhibitor. J. Biol. Chem. 262: 8956–8959, 1987.
 52. Ju, G., T., Hökfelt, E. Brodin, J. Fahrenkrug, J. A. Fischer, P. Frey, R. P. Elde, and J. C. Brown, Primary sensory neurons of the rat showing calcitonin gene‐related peptide immunoreactivity and their relation to substance P‐, somatostatin‐, galanin‐, vasoactive intestinal polypeptide‐ and cholecystokinin‐immunoreactive ganglion cells. Cell Tissue Res. 247: 417–431, 1987.
 53. Ju, G., T., Melander, S. Ceccatelli, T. Hökfelt, and P. Frey, Immunohistochemical evidence for a spinothalamic pathway co‐containing cholecystokinin‐ and galanin‐like immunoreactivities in the rat. Neuroscience 20: 439–456, 1987.
 54. Kimura, S., Y., Sugita, I. Kanazawa, A. Saito, and K. Goto, Isolation and amino acid sequence of calcitonin gene‐related peptide from porcine spinal cord. Neuropeptides 9: 75–82, 1987.
 55. Kobayashi, H., K., Hashimoto, S. Uchida, J. Sakuma, K. Takami, M. Tohyama, F. Izumi, and H. Yoshida, Calcitonin gene‐related peptide stimulates adenylate cyclase activity in rat striated muscle. Experientia Basel 43: 314–316, 1987.
 56. Kohler, C., H., Ericson, T. Watanabe, J. Polak, S. L. Palay, V. Palay, and V. Chan‐Palay, Galanin immunoreactivity in hypothalamic neurons: further evidence for multiple chemical messengers in the tuberomammillary nucleus. J. Comp. Neurol. 250: 58–64, 1986.
 57. Koller, K. J., and M. J. Brownstein, Use of a cDNA clone to identify a supposed precursor protein containing valosin. Nature Lond. 325: 542–545, 1987.
 58. Konecki, D. S., U. M., Benedum, H.‐H. Gerdes, and W. B. Huttner, The primary structure of human chromogranin A and pancreastatin. J. Biol. Chem. 262: 17026–17030, 1987.
 59. Konturek, S. J., W. E., Schmidt, V. Mutt, J. W. Konturek, and W. Creutzfeldt, Valosin stimulates gastric and exocrine pancreatic secretion and inhibits fasting small intestine myoelectric activity in the dog. Gastroenterology 92: 1181–1186, 1987.
 60. Koop, H., R., Eissele, V. Kuhlkamp, E. Bothe, J. Dionysius, and R. Arnold, Calcitonin gene‐related peptide stimulates rat gastric somatostatin release in vitro. Life Sci. 40: 541–546, 1987.
 61. Koshiyama, H., Y., Kato, T. Inoue, Y. Murakami, Y. Ishi‐Kawa, N. Yanaihara, and H. Imura, Central galanin stimulates pituitary prolactin secretion in rats: possible involvement of hypothalamic vasoactive intestinal polypeptide. Neurosci. Lett. 75: 49–54, 1987.
 62. Kyrkouli, S. E., B. G., Stanley, and S. F. Leibowitz, Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide. Eur. J. Pharmacol. 122: 159–160, 1986.
 63. Laufer, R., and J. P. Changeux, Calcitonin gene‐related peptide elevates cyclic AMP levels in chick skeletal muscle: possible neurotrophic role for a coexisting neuronal messenger. EMBO J. 6: 901–906, 1987.
 64. Lauweryns, J. M., and L. Vanranst, Calcitonin gene‐related peptide immunoreactivity in rat lung: light and electron microscopic study. Thorax 42: 183–189, 1987.
 65. Lee, Y., N., Hayashi, C. J. Hillyard, S. I. Girgis, I. Macintyre, P. C. Emson, and M. Tohyama, Calcitonin gene‐related peptide‐like immunoreactive sensory fibers form synaptic contact with sympathetic neurons in the rat celiac ganglion. Brain Res. 407: 149–151, 1987.
 66. Lee, Y., Y., Shiotani, N. Hayashi, T. Kamada, C. J. Hillyard, S. I. Girgis, I. Macintyre, and M. Tohyama, Distribution and origin of calcitonin gene‐related peptide in the rat stomach and duodenum: an immunocytochemical analysis. J. Neural Transm. 68: 1–14, 1987.
 67. Lee, Y., K., Takami, Y. Kawai, S. Girgis, C. J. Hillyard, I. Macintyre, P. C. Emson, and H. Tohyama, Distribution of calcitonin gene‐related peptide in the rat peripheral nervous system with reference to its coexistence with substance P. Neuroscience 15: 1227–1237, 1985.
 68. Lenz, H. J., and M. R. Brown, Intracerebroventricular administration of human calcitonin and human calcitonin gene‐related peptide inhibits meal‐stimulated gastric acid secretion in the dog. Dig. Dis. Sci. 32: 409–416, 1987.
 69. Leung, F. W., E. G., Tallos, Y. F. Tache, and P. H. Guth, Calcitonin gene‐related peptide inhibits acid secretion without modifying blood flow. Am. J. Physiol. 252 (Gastrointest. Liver Physiol. 15): G215–G228, 1987.
 70. Lindskog, S., and B. Ahrén, Galanin: effects on basal and stimulated insulin and glucagon secretion in the mouse. Acta Physiol. Scand. 129: 305–309, 1987.
 71. Louie, D. S., D., May, P. Miller, and C. Owyang, Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am. J. Physiol. 250 (Gastrointest. Liver Physiol. 13): G252–G259, 1986.
 72. Lu, L., D. S., Louie, D. May, and C. Owyang, Regulation of pancreatic enzyme secretion by a trypsin‐sensitive, intestinal peptide that stimulates cholecystokinin release (Abstract). Dig. Dis. Sci. 32: 1175, 1987.
 73. Maggi, C. A., S., Manzini, S. Giuliani, P. Santicioli, and A. Meli, Calcitonin gene‐related peptide activates non‐adrenergic, non‐cholinergic relaxations of the rat isolated duodenum. J. Pharm. Pharmacol. 39: 327–328, 1987.
 74. Manabe, T., T., Yoshimura, E. Kii, Y. Tanaka, G. Ohshio, T. Tobe, K. Akaji, and H. Yajima, Galanin‐induced hyperglycemia: effect on insulin and glucagon. Endocr. Res. Commun. 12: 93–98, 1986.
 75. Mason, R. T., R. A., Peterfreund, P. E. Sawchenko, A. Z. Corrigan, J. E. Rivier, and W. W. Vale, Release of the predicted calcitonin gene‐related peptide from cultured rat trigeminal ganglion cells. Nature Lond. 308: 653–655, 1984.
 76. Maton, P. N., V. E., Sutliff, Z.‐C Zhou, J. D. Gardner, and R. T. Jensen, Characterization of receptors for calcitoningene‐related peptide (CGRP) on gastric smooth muscle cells (Abstract). Gastroenterology 90: 1537, 1986.
 77. Mcdonald, T. J., J., Dupre, G. R. Greenberg, F. Tepperman, B. Brooks, K. Tatemoto, and V. Mutt, The effect of galanin on canine plasma glucose and gastroenteropancreatic hormone responses to oral nutrients and intravenous arginine. Endocrinology 119: 2340–2345, 1986.
 78. Mcdonald, T. J., J., Dupre, K. Tatemoto, G. R. Greenberg, J. Radziuk, and V. Mutt, Galanin inhibits insulin secretion and induces hyperglycemia in dogs. Diabetes 34: 192–196, 1985.
 79. Melander, T., T., Hökfelt, A. Rökaeus, A. C. Cuello, W. H. Oertel, A. Verhofstad, and M. Goldstein, Coexistence of galanin‐like immunoreactivity with catecholamines, 5‐hydroxytryptamine, GABA and neuropeptides in the rat CNS. J. Neurosci. 6: 3640–3654, 1986.
 80. Melander, T., and W. A. Staines, A galanin‐like peptide coexists in putative cholinergic somata of the septum‐basal forebrain complex and in acetylcholinesterase‐containing fibers and varicosities within the hippocampus in the owl monkey (Aotus trivirgatus). Neurosci. Lett. 68: 17–22, 1986.
 81. Melander, T., W. A., Staines, and A. Rökaeus, Galanin‐like immunoreactivity in hippocampal afferents in the rat, with special reference to cholinergic and noradrenergic inputs. Neuroscience 19: 223–240, 1986.
 82. Molander, C., J., Ygge, and C. J. Dalsgaard, Substance P‐, somatostatin‐ and calcitonin gene‐related peptide‐like immunoreactivity and fluoride resistant acid phosphatase‐activity in relation to retrogradely labeled cutaneous, muscular and visceral primary sensory neurons in the rat. Neurosci. Lett. 74: 37–42, 1987.
 83. Morris, H. R., M., Punico, T. Etienne, J. Tippins, S. I. Girgis, and I. Macintyre, Isolation and characterization of human calcitonin gene‐related peptide. Nature Land. 308: 746–748, 1984.
 84. Mulderry, P. K., M. A., Ghatei, and S. R. Bloom, In vitro production and characterization of low molecular weight forms of calcitonin gene‐related peptide immunoreactivity from rat thyroid. Biochem. Biophys. Res. Commun. 144: 883–890, 1987.
 85. Murakami, Y., Y., Kato, H. Koshiyama, T. Inoue, N. Yanaihara, and H. Imura, Galanin stimulates growth hormone (GH) secretion via GH‐releasing factor (GRF) in conscious rats. Eur. J. Pharmacol. 136: 415–418, 1987.
 86. Nakagawa, T., M., Mabry, A. Debustros, J. N. Ihle, B. D. Nelkin, and S. B. Baylin, Introduction of v‐Ha‐ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells. Proc. Natl. Acad. Sci. USA 84: 5923–5927, 1987.
 87. Nordström, O., T., Melander, T. Hökfelt, T. Bartfai, and M. Goldstein, Evidence for an inhibitory effect of the peptide galanin on dopamine release from the rat median eminence. Neurosci. Lett. 73: 21–26, 1987.
 88. Okimura, Y., K., Chihara, H. Abe, T. Kita, Y. Kashio, M. Sato, and T. Fujita, Calcitonin gene‐related peptide‐like immunoreactivity in the central nervous system and peripheral organs of rats. Regul. Pept. 17: 327–337, 1987.
 89. Oku, R., M., Satoh, N. Fujii, A. Otaka, H. Yajima, and H. Takagi, Calcitonin gene‐related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats. Brain Res. 403: 350–354, 1987.
 90. Ottlecz, A., W. K., Samson, and S. M. Mccann, Galanin: evidence for a hypothalamic site of action to release growth hormone. Peptides Fayetteville 7: 51–53, 1986.
 91. Owyang, C., D. S., Louie, and D. Tatum, Feedback regulation of pancreatic enzyme secretion: suppression of cholecystokinin release by trypsin. J. Clin. Invest. 77: 2042–2047, 1986.
 92. Owyang, C., D., May, and D. S. Louie, Trypsin suppression of pancreatic enzyme secretion. Differential effect on cholecystokinin release and the enteropancreatic reflex. Gastroenterology 91: 637–643, 1986.
 93. Palmer, J. B., F. M., Cuss, P. K. Mulderry, M. A. Ghatei, D. R. Springall, A. Cadieux, S. R. Bloom, J. M. Polak, and P. J. Barnes, Calcitonin gene‐related peptide is localised to human airway nerves and potently constricts human airway smooth muscle. Br. J. Pharmacol. 91: 95–101, 1987.
 94. Palmer, J. M., M., Schemann, K. Tamura, and J. D. Woods, Galanin mimics slow synaptic inhibition in myenteric neurons. Eur. J. Pharmacol. 124: 379–380, 1986.
 95. Pettersson, M., B., Ahrén, G. Böttcher, and F. Sundler, Calcitonin gene‐related peptide: occurrence in pancreatic islets in the mouse and the rat and inhibition of insulin secretion in the mouse. Endocrinology 119: 865–869, 1986.
 96. Polak, J. M., and S. R. Bloom, Regulatory peptides of the gastrointestinal and respiratory tracts. Arch. Int. Pharmacodyn. Ther. 280: 16–49, 1986.
 97. Rökaeus, A., and M. J. Brownstein, Construction of a porcine adrenal medullary cDNA library and nucleotide sequence analysis of two clones encoding a galanin precursor. Proc. Natl. Acad. Sci. USA 83: 6287–6291, 1986.
 98. Rökaeus, A., T., Melander, T. Hökfelt, J. M. Lundberg, K. Tatemoto, M. Carlquist, and V. Mutt, A galanin‐like peptide in the central nervous system and intestine of rat. Neurosci. Lett. 47: 161–166, 1984.
 99. Rosenfeld, M. G., J. J., Mermod, S. G. Amara, L. W. Swanson, P. E. Sawchenko, J. Rivier, and W. W. Vale, Production of a novel neuropeptide encoded by the calcitonin gene via tissue‐specific RNA processing. Nature Lond. 304: 129–135, 1983.
 100. Saito, A., Y., Tomobe, and K. Goto, Effect of capsaicin on smooth muscles of rat vas deferens: involvement of calcitonin gene‐related peptide? J. Pharmacol. Exp. Ther. 242: 666–672, 1987.
 101. Schmidt, W. E., V., Mutt, M. Carlquist, H. Kratzin, J. M. Conlon, and W. Creuzfeldt, Valosin: isolation and characterization of a novel peptide from porcine intestine. FEBS Lett. 191: 264–268, 1985.
 102. Seifert, H., P., Sawchenko, J. Chesnut, J. Rivier, W. Vale, and S. J. Pandol, Receptor for calcitonin gene‐related peptide: binding to exocrine pancreas mediates biological actions. Am. J. Physiol. 249 (Gastrointest. Liver Physiol. 12): G147–G151, 1985.
 103. Silvestre, R. A., P., Miralles, L. Monge, P. Moreno, M. L. Villanueva, and J. Marco, Effects of galanin on hormone secretion from the in situ perfused rat pancreas and on glucose production in rat hepatocytes in vitro. Endocrinology 121: 378–383, 1987.
 104. Silvestre, R. A., P., Miralles, L. Monge, M. L. Villanueva, and J. Marco, Inhibitory effect of galanin on pancreatic polypeptide release by the perfused rat pancreas. Life Sci. 40: 1829–1833, 1987.
 105. Skofitsch, G., and D. M. Jacobowitz, Quantitative distribution of galanin‐like immunoreactivity in the rat central nervous system. Peptides Fayetteville 7: 609–613, 1986.
 106. Slaff, J., D., Jacobson, C. R. Tillman, C. Curington, and P. Toskes, Protease‐specific suppression of pancreatic exocrine secretion. Gastroenterolgy 87: 44–52, 1984.
 107. Steenbergh, P. H., J. W. M., Hoppener, J. Zandberg, C. J. M. Lips, and H. S. Jansz, A second human calcitonin/CGRP gene. FEBS Lett. 183: 403–407, 1985.
 108. Tache, Y., M., Gunion, M. Lauffenberger, and Y. Goto, Inhibition of gastric acid secretion by intracerebral injection of calcitonin gene related peptide in rats. Life Sci. 35: 871–878, 1984.
 109. Tache, Y., T., Pappas, M. Lauffenburger, Y. Goto, J. H. Walsh, and H. Debas, Calcitonin gene‐related peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs. Gastroenterology 87: 344–349, 1987.
 110. Takeda, N., K., Doi, N. Mori, H. Yamazaki, M. Tohyama, and T. Matsunaga, Localization and fine structure of calcitonin gene‐related peptide (CGRP)‐like immunoreactive nerve fibres in the organ of Corti of guinea pigs by immunohistochemistry. Acta Oto‐Laryngol. Stockh. 103: 567–571, 1987.
 111. Tamura, K., J. M., Palmer, and J. D. Wood, Galanin suppresses nicotinic synaptic transmission in the myenteric plexus of guinea pig small intestine. Eur. J. Pharmacol. 136: 445–446, 1987.
 112. Tatemoto, K., Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci. USA 79: 2514–2518, 1982.
 113. Tatemoto, K., S., Efendic, V. Mutt, G. Mark, G. J. Feistner, and J. D. Barchas, Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature Lond. 324: 476–478, 1986.
 114. Tatemoto, K., and V. Mutt, Isolation and characterization of the intestinal peptide porcine PHI (PHI‐27), a new member of the glucagon‐secretin family. Proc. Natl. Acad. Sci. USA 78: 6603–6607, 1981.
 115. Tatemoto, K., A., Rökaeus, H. Jörnvall, T. J. Mcdonald, and V. Mutt, Galanin—a novel biologically active peptide from porcine intestine. FEBS Lett. 164: 124–128, 1983.
 116. Umeda, Y., and T. Okada, Inhibition of gastric acid secretion by human calcitonin gene‐related peptide with picomolar potency in guinea‐pig parietal cell preparations. Biochem. Biophys. Res. Commun. 146: 430–436, 1987.
 117. Wakisaka, S., H., Ichikawa, S. Nishikawa, S. Matsuo, Y. Takano, and M. Akai, The distribution and origin of calcitonin gene‐related peptide‐containing nerve fibres in feline dental pulp. Relationship with substance P‐containing nerve fibres. Histochemistry 86: 585–589, 1987.
 118. Wanaka, A., T., Matsuyama, S. Yoneda, T. Kamada, P. C. Emson, J. Hillard, S. J. Girgis, I. Macintyre, and M. Tohyama, Distribution patterns of calcitonin gene‐related peptide‐containing fibers in the wall of the three different arteries: an immunohistochemical study. Cell Mol. Biol. 33: 201–209, 1987.
 119. Wiesenfeld‐Hallin, Z., T., Hökfelt, J. M. Lundberg, W. G. Forssmann, M. Reinecke, F. A. Tschopp, and J. A. Fischer, Immunoreactive calcitonin gene‐related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioural responses of the rat. Neurosci. Lett. 52: 199–204, 1984.
 120. Yanagisawa, M., N., Yagi, M. Otsuka, C. Yanaihara, and N. Yanaihara, Inhibitory effects of galanin on the isolated spinal cord of the newborn rat. Neurosci. Lett. 70: 278–282, 1986.
 121. Yau, W. M., J. A., Dorsett, and M. L. Youther, Evidence for galanin as an inhibitory neuropeptide on myenteric cholinergic neurons in the guinea pig small intestine. Neurosci. Lett. 72: 305–308, 1986.
 122. Yoshizaki, H., M., Takamiya, and T. Okada, Characterization of picomolar affinity binding sites for human [125I]calcitonin gene‐related peptide in rat brain and heart. Biochem. Biophys. Res. Commun. 146: 443–451, 1987.
 123. Zaidi, M., K., Fuller, P. J. Bevis, R. E. Gainesdas, T. J. Chambers, and I. Macintyre, Calcitonin gene‐related peptide inhibits osteoclastic bone resorption: a comparative study. Calcif. Tissue Int. 40: 149–154, 1987.
 124. Zeytin, F. N., S., Rusk, and S. E. Leff, Calcium, dexamethasone, and the antiglucocorticoid RU‐486 differentially regulate neuropeptide synthesis in a rat C cell line. Endocrinology 121: 361–370, 1987.

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Article Title: Newly Discovered Gut Peptides
 

How to Cite

Chung Owyang, Dexter Louie. Newly Discovered Gut Peptides. Compr Physiol 2011, Supplement 17: Handbook of Physiology, The Gastrointestinal System, Neural and Endocrine Biology: 691-702. First published in print 1989. doi: 10.1002/cphy.cp060228