| References |
| 1. |
Aggarwal, R. and
P. A. Boyden.
Diminished Ca2+ and Ba2+ currents in myocytes surviving in the epicardial border zone of the 5‐day infarcted canine heart.
Circ. Res.
77:
1180–1191,
1995.
|
| 2. |
Aguilar‐Bryan, L.,
J. P. Clement,
G. Gonzalez,
K. Kunjilwar,
A. Babenko, and
J. Bryan.
Toward understanding the assembly and structure of KATP channels.
Physiol. Rev.
78:
227–245,
1998.
|
| 3. |
Ahmmed, G. U.,
P. H. Dong,
G. Song,
N. A. Ball,
Y. Xu,
R. A. Walsh, and
N. Chiamvimonvat.
Changes in Ca(2+) cycling proteins underlie cardiac action potential prolongation in a pressure‐overloaded guinea pig model with cardiac hypertrophy and failure.
Circ. Res.
86:
558–570,
2000.
|
| 4. |
Aimond, F.,
J. L. Alvarez,
J. M. Rauzier,
P. Lorente, and
G. Vassort.
Ionic basis of ventricular arrhythmias in remodeled rat heart during long‐term myocardial infarction.
Cardiovasc. Res.
42:
402–415,
1999.
|
| 5. |
An, R. H.,
R. Bangalore,
S. Z. Rosero and
R. S. Kass.
Lidocaine block of LQT‐3 mutant human Na+ channels.
Circ. Res.
79:
103–108,
1996.
|
| 6. |
An, R. H.,
X. L. Wang,
B. Kerem,
J. Benhorin,
A. Medina,
M. Goldmit, and
R. S. Kass.
Novel LQT‐3 mutation affects Na+ channel activity through interactions between alpha‐ and beta1‐subunits.
Circ. Res.
83:
141–146,
1998.
|
| 7. |
Antzelevitch, C. and
S. Sicouri.
Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes
J. Am. Coll. Cardiol.
23:
259–277,
1994.
|
| 8. |
Antzelevitch, C.,
S. Sicouri,
S. H. Litovsky,
A. Lukas,
S. C. Krishnan,
J. M. Diego,
G. A. Gintant, and
D. W. Liu.
Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.
Circ. Res.
69:
1427–1449,
1991.
|
| 9. |
Attali, B.,
E. Guillemare,
F. Lesage,
E. Honore,
G. Romey,
M. Lazdunski and
J. Barhanin.
The protein IsK is a dual activator of K+ and Cl− channels.
Nature
365:
850–852,
1993.
|
| 10. |
Backx, P. H. and
E. Marban.
Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes.
Circ. Res.
72:
890–900,
1993.
|
| 11. |
Bailly, P.,
J. P. Benitah,
M. Mouchoniere,
G. Vassort, and
P. Lorente.
Regional alteration of the transient outward current in human left ventricular septum during compensated hypertrophy.
Circulation
96:
1266–1274,
1997.
|
| 12. |
Baker, L. C.,
B. London,
B. R. Choi,
G. Koren, and
G. Salama.
Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia
Circ. Res.
86:
396–407,
2000.
|
| 13. |
Balke, C. W. and
S. R. Shorofsky.
Alterations in calcium handling in cardiac hypertrophy and heart failure.
Cardiovasc. Res.
37:
290–299,
1998.
|
| 14. |
Barbey, O.,
A. Gerbi,
F. Paganelli,
K. Robert,
S. Levy, and
J. M. Maixent.
Canine cardiac digitalis receptors are preserved in congestive heart failure induced by rapid ventricular pacing.
J. Recept. Signal Transduc. Res.
17:
447–458,
1997.
|
| 15. |
Barhanin, J.,
F. Lesage,
E. Guillemare,
M. Fink,
M. Lazdunski, and
G. Romey.
K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current.
Nature
384:
78–80,
1996.
|
| 16. |
Barry, D. M. and
J. M. Nerbonne.
Myocardial potassium channels: electrophysiological and molecular diversity.
Annu. Rev. Physiol.
58:
363–394,
1996.
|
| 17. |
Barry, D. M.,
H. Xu,
R. B. Schuessler, and
J. M. Nerbonne.
Functional knockout of the transient outward current, long‐QT syndrome, and cardiac remodeling in mice expressing a dominant‐negative Kv4 alpha subunit.
Circ. Res.
83:
560–567,
1998.
|
| 18. |
Baukrowitz, T.,
U. Schulte,
D. Oliver,
S. Herlitze,
T. Krauter,
S. J. Tucker,
J. P. Ruppersberg, and
B. Fakler.
PIP2 and PIP as determinants for ATP inhibition of K‐ATP channels.
Science
282:
1141–1144,
1998.
|
| 19. |
Baumgarten, C. M. and
H. A. Fozzard.
Intracellular chloride activity in mammalian ventricular muscle.
Amer. J. Physiol.
241
Cell Physiol. 10:
C121–9,
1981.
|
| 20. |
Becker, K. D.,
K. R. Gottshall,
R. Hickey,
J. C. Perriard, and
K. R. Chien.
Point mutations in human beta cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly.
J. Cell Biol.
137:
131–140,
1997.
|
| 21. |
Benitah, J. P.,
A. M. Gomez,
P. Bailly,
J. P. Da Ponte,
G. Berson,
C. Delgado, and
P. Lorente.
Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts.
J. Physiol.
469:
111–138,
1993.
|
| 22. |
Benitah, J. P.,
A. M. Gomez,
C. Delgado,
P. Lorente, and
W. J. Lederer.
A chloride current component induced by hypertrophy in rat ventricular myocytes.
Am. J. Physiol.
272
Heart Circ. Physiol. 41:
H2500–2506,
1997.
|
| 23. |
Bennett, P. B.,
K. Yazawa,
N. Makita and
A. L. George, Jr.
Molecular mechanism for an inherited cardiac arrhythmia.
Nature
376:
683–685,
1995.
|
| 24. |
Berenfeld, O. and
J. Jalife.
Purkinje‐muscle reentry as a mechanism of polymorphic ventricular arrhythmias in a 3‐dimensional model of the ventricles.
Circ. Res.
82:
1063–1077,
1998.
|
| 25. |
Berul, C. I.,
M. E. Christe,
M. J. Aronovitz,
C. E. Seidman,
Seidman, J. G., and
M. E. Mendelsohn.
Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice.
J. Clin. Invest.
99:
570–576,
1997.
|
| 26. |
Beuckelmann, D. J.,
M. Nabauer, and
E. Erdmann.
Characteristics of calcium‐current in isolated human ventricular myocytes from patients with terminal heart failure.
J. Mol. Cell. Cardiol.
23:
929–937,
1991.
|
| 27. |
Beuckelmann, D. J.,
M. Nabauer, and
E. Erdmann.
Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure.
Circ. Res.
73:
379–385,
1993.
|
| 28. |
Bonne, G.,
L. Carrier,
P. Richard,
B. Hainque, and
K. Schwartz.
Familial hypertrophic cardiomyopathy: from mutations to functional defects.
Circ. Res.
83:
580–593,
1998.
|
| 29. |
Bosch, R. F.,
X. Zeng,
J. B. Grammer,
K. Popovic,
C. Mewis, and
V. Kuhlkamp.
Ionic mechanisms of electrical remodeling in human atrial fibrillation.
Cardiovasc. Res
44:
121–131,
1999.
|
| 30. |
Bottinelli, R.,
D. A. Coviello,
C. S. Redwood,
M. A. Pellegrino,
B. J. Maron,
P. Spirito,
H. Watkins, and
C. Reggiani.
A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity.
Circ. Res.
82:
106–115,
1998.
|
| 31. |
Boyden, P. A. and
C. D. Jeck.
Ion channel function in disease.
Cardiovasc. Res.
29:
312–318,
1995.
|
| 32. |
Boyden, P. A. and
J. M. Pinto.
Reduced calcium currents in subendocardial Purkinje myocytes that survive in the 24‐ and 48‐hour infarcted heart.
Circulation
89:
2747–2759,
1994.
|
| 33. |
Boyle, W. A. and
J. M. Nerbonne.
A novel type of depolarization‐activated K+ current in isolated adult rat atrial myocytes.
Am. J. Physiol.
260
Heart Circ. Physiol. 29:
H1236–47,
1991.
|
| 34. |
Brooksby, P.,
A. J. Levi, and
J. V. Jones.
The electrophysiological characteristics of hypertrophied ventricular myocytes from the spontaneously hypertensive rat.
J. Hypertens.
11:
611–622,
1993.
|
| 35. |
Brugada, J. and
P. Brugada.
Further characterization of the syndrome of right bundle branch block, ST segment elevation, and sudden cardiac death.
J. Cardiovasc. Electrophysiol.
8:
325–331,
1997.
|
| 36. |
Brugada, P. and
J. Brugada.
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
J. Am. Coll. Cardiol.
20:
1391–1396,
1992.
|
| 37. |
Bryant, S. M.,
S. J. Shipsey, and
G. Hart.
Regional differences in electrical and mechanical properties of myocytes from guinea‐pig hearts with mild left ventricular hypertrophy.
Cardiovasc. Res.
35:
315–323,
1997.
|
| 38. |
Bryant, S. M.,
S. J. Shipsey, and
G. Hart.
Normal regional distribution of membrane current density in rat left ventricle is altered in catecholamine‐induced hypertrophy.
Cardiovasc. Res.
42:
391–401,
1999.
|
| 39. |
Bundgaard, H. and
K. Kjeldsen.
Human myocardial Na,K‐ATPase concentration in heart failure.
Mol. Cell. Biochem.
163–164:
277–283,
1996.
|
| 40. |
Cannon, S. C.
Sodium channel defects in myotonia and periodic paralysis.
Annu. Rev. Neurosci.
19:
141–164,
1996.
|
| 41. |
Casis, O.,
M. Gallego,
M. Iriarte, and
J. A. Sanchez‐Chapula.
Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle.
Diabetologia
43:
101–109,
2000.
|
| 42. |
Catterall, W. A.
Cellular and molecular biology of voltage‐gated sodium channels.
Physiol. Rev.
72:
S15–S48,
1992.
|
| 43. |
Catterall, W. A.
Molecular properties of sodium and calcium channels.
J. Bioenerg. Biomembr.
28:
219–230,
1996.
|
| 44. |
Cerbai, E.,
M. Barbieri,
Q. Li, and
A. Mugelli.
Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages.
Cardiovasc. Res.
28:
1180–1187,
1994.
|
| 45. |
Cerbai, E.,
M. Barbieri and
A. Mugelli.
Characterization of the hyperpolarization‐activated current, I(f), in ventricular myocytes isolated from hypertensive rats.
J. Physiol. (Lond.)
481:
585–591,
1994.
|
| 46. |
Cerbai, E.,
M. Barbieri, and
A. Mugelli.
Occurrence and properties of the hyperpolarization‐activated current If in ventricular myocytes from normotensive and hypertensive rats during aging.
Circulation
94:
1674–1681,
1996.
|
| 47. |
Cerbai, E.,
R. Pino,
F. Porciatti,
G. Sani,
M. Toscano,
M. Maccherini,
G. Giunti, and
A. Mugelli.
Characterization of the hyperpolarization‐activated current, I(f), in ventricular myocytes from human failing heart.
Circulation
95:
568–571,
1997.
|
| 48. |
Chandra, R.,
C. F. Starmer, and
A. O. Grant.
Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells.
Am. J. Physiol.
274
Heart Circ. Physiol. 43:
H1643–H1654,
1998.
|
| 49. |
Charlemagne, D. and
B. Swynghedauw.
Myocardial phenotypic changes in Na+, K+ ATPase in left ventricular hypertrophy: pharmacological consequences.
Eur. Heart J.
16
(Suppl C):
20–23,
1995.
|
| 50. |
Chatelain, P.,
D. Demol, and
J. Roba.
Comparison of [3H]nitrendipine binding to heart membranes of normotensive and spontaneously hypertensive rats.
J. Cardiovasc. Pharmacol.
6:
220–223,
1984.
|
| 51. |
Chattou, S.,
J. Diacono, and
D. Feuvray.
Decrease in sodium‐calcium exchange and calcium currents in diabetic rat ventricular myocytes.
Acta Physiol. Scand.
166:
137–144,
1999.
|
| 52. |
Chauhan, V. S.,
S. Tuvia,
M. Buhusi,
V. Bennett, and
A. O. Grant.
Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal Ankyrin(B) knockout mice.
Circ. Res.
86:
441–447,
2000.
|
| 53. |
Chen, Q.,
G. E. Kirsch,
D. Zhang,
R. Brugada,
J. Brugada,
P. Brugada,
D. Potenza,
A. Moya,
M. Borggrefe,
G. Breithardt,
R. Ortiz‐Lopez,
Z. Wang,
C. Antzelevitch,
R. E. O'Brien,
E. Schulze‐Bahr,
M. T. Keating,
J. A. Towbin, and
Q. Wang.
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation.
Nature
392:
293–296,
1998.
|
| 54. |
Chinushi, M.,
E. M. Restivo,
E. B. Caref, and
N. el‐Sherif.
Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long‐QT syndrome.
Circ. Res.
83:
614–628,
1998.
|
| 55. |
Chouabe, C.,
L. Espinosa,
P. Megas,
A. Chakir,
O. Rougier,
A. Freminet, and
R. Bonvallet.
Reduction of I(Ca,L) and I(to1) density in hypertrophied right ventricular cells by simulated high altitude in adult rats.
J. Mol. Cell. Cardiol.
29:
193–206,
1997.
|
| 56. |
Clemo, H. F.,
B. S. Stambler, and
C. M. Baumgarten.
Persistent activation of a swelling‐activated cation current in ventricular myocytes from dogs with tachycardia‐induced congestive heart failure.
Circ. Res.
83:
147–157,
1998.
|
| 57. |
Coleman, H. N.,
R. R. Taylor,
P. E. Pool,
G. H. Whipple,
J. W. Covell,
J. Ross, Jr., and
E. Braunwald.
Congestive heart failure following chronic tachycardia.
Am. Heart J.
81:
790–798,
1971.
|
| 58. |
Compton, S. J.,
R. L. Lux,
M. R. Ramsey,
K. R. Strelich,
M. C. Sanguinetti,
L. S. Green,
M. T. Keating, and
J. W. Mason.
Genetically defined therapy of inherited long‐QT syndrome. Correction of abnormal repolarization by potassium.
Circulation
94:
1018–1022,
1996.
|
| 59. |
Cooklin, M.,
W. R. Wallis,
D. J. Sheridan, and
C. H. Fry.
Changes in cell‐to‐cell electrical coupling associated with left ventricular hypertrophy.
Circ. Res.
80:
765–771,
1997.
|
| 60. |
Coulombe, A.,
A. Momtaz,
P. Richer,
B. Swynghedauw, and
E. Coraboeuf.
Reduction of calcium‐independent transient outward potassium current density in DOCA salt hypertrophied rat ventricular myocytes.
Pflugers Arch.
427:
47–55,
1994.
|
| 61. |
Cribbs, L. L.,
J. H. Lee,
J. Yang,
J. Satin,
Y. Zhang,
A. Dav,
J. Barclay,
M. P. Williamson,
M. Fox,
M. Rees, and
E. Perez‐Reyes.
Cloning and characterization of alpha1H from human heart, a member of the T‐type Ca2+ channel gene family.
Circ. Res.
83:
103–109,
1998.
|
| 62. |
Curran, M. E.,
I. Splawski,
K. W. Timothy,
G. M. Vincent,
E. D. Green, and
M. T. Keating.
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.
Cell
80:
795–803,
1995.
|
| 63. |
De Bakker, J. M.,
F. J. van Capelle,
N. M. van Hemel,
R. N. Hauer,
J. J. Defauw,
F. E. Vermeulen, and
P. F. Bakker de Wekker.
Macroreentry in the infarcted human heart: the mechanism of ventricular tachycardias with a “focal” activation pattern.
J. Am. Coll. Cardiol.
18:
1005–1014,
1991.
|
| 64. |
De Mello, W. C.
Impaired regulation of cell communication by beta‐adrenergic receptor activation in the failing heart.
Hypertension
27:
265–268,
1996.
|
| 65. |
De Mello, W. C.
Renin‐angiotensin system and cell communication in the failing heart.
Hypertension
27:
1267–1272,
1996.
|
| 66. |
Deal, K. K.,
S. K. England, and
M. M. Tamkun.
Molecular physiology of cardiac potassium channels.
Physiol. Rev.
76:
49–67,
1996.
|
| 67. |
Demirovic, J. and
R. J. Myerburg.
Epidemiology of sudden coronary death: an overview.
Prog. Cardiovasc. Dis.
37:
39–48,
1994.
|
| 68. |
Deroubaix, E.,
D. Thuringer,
A. Coulombe,
J. J. Mercadier, and
E. Coraboeuf.
Dilation and action potential lengthening in cardiomyopathic Syrian hamster heart.
Basic Res. Cardiol.
94:
274–283,
1999.
|
| 69. |
Dhein, S.
Gap junction channels in the cardiovascular system: pharmacological and physiological modulation.
Trends Pharmacol. Sci.
19:
229–241,
1998.
|
| 70. |
DiFrancesco, D.
The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current.
Cardiovasc. Res.
29:
449–456,
1995.
|
| 71. |
Dixon, I. M.,
T. Hata, and
N. S. Dhalla.
Sarcolemmal Na(+)‐K(+)‐ATPase activity in congestive heart failure due to myocardial infarction.
Am. J. Physiol.
262
Cell Physiol. 31:
C664–671,
1992.
|
| 72. |
Dixon, I. M.,
S. L. Lee, and
N. S. Dhalla.
Nitrendipine binding in congestive heart failure due to myocardial infarction.
Circ. Res.
66:
782–788,
1990.
|
| 73. |
Duggal, P.,
M. R. Vesely,
D. Wattanasirichaigoon,
J. Villafane,
V. Kaushik and
A. H. Beggs.
Mutation of the gene for IsK associated with both Jervell and Lange‐Nielsen and Romano‐Ward forms of Long‐QT syndrome.
Circulation
97:
142–146,
1998.
|
| 74. |
Dumaine, R. and
G. E. Kirsch.
Mechanism of lidocaine block of late current in long Q‐T mutant Na+ channels.
Am. J. Physiol.
274
Heart Circ. Physiol. 43:
H477–H487,
1998.
|
| 75. |
Dumaine, R.,
Q. Wang,
M. T. Keating,
H. A. Hartmann,
P. J. Schwartz,
A. M. Brown, and
G. E. Kirsch.
Multiple mechanisms of Na+ channel—linked long‐QT syndrome.
Circ. Res.
78:
916–924,
1996.
|
| 76. |
El‐Sherif, N.,
E. B. Caref,
H. Yin, and
M. Restivo.
The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns.
Circ. Res.
79:
474–492,
1996.
|
| 77. |
England, S. K.,
V. N. Uebele,
H. Shear,
J. Kodali,
P. B. Bennett, and
M. M. Tamkun.
Characterization of a voltage‐gated K+ channel beta subunit expressed in human heart.
Proc. Nat. Acad. Sci. U.S.A.
92:
6309–6313,
1995.
|
| 78. |
Espinosa, L.,
C. Chouabe,
A. Morales,
J. Lachuer,
B. Georges,
M. Fatemi,
C. Terrenoire,
Y. Tourneur, and
R. Bonvallet.
Increased sodium‐calcium exchange current in right ventricular cell hypertrophy induced by simulated high altitude in adult rats.
J. Mol. Cell. Cardiol.
32:
639–653,
2000.
|
| 79. |
Fan, Z. and
J. C. Makielski.
Intracellular H+ and Ca2+ modulation of trypsin‐modified ATP‐sensitive K+ channels in rabbit ventricular myocytes.
Circ. Res.
72:
715–722,
1993.
|
| 80. |
Fan, Z. and
J. C. Makielski.
Anionic phospholipids activate ATP‐sensitive potassium channels.
J. Biol. Chem.
272:
5388–5395,
1997.
|
| 81. |
Fan, Z.,
X.‐W. Niu,
R. A. Haworth,
M. R. Wolff, and
J. C. Makielski.
ATP sensitive potassium channel activity is altered in a canine pacing congestive heart failure model.
Biophys. J.
76:
A417,
1999.
(Abstract).
|
| 82. |
Fananapazir, L.,
D. McAreavey, and
N. D. Epstein.
Cardiac Electrophysiology, edited by
D. P. Zipes and
J. Jalife.
Philadelphia:
W. B. Saunders,
1995:
769–779.
|
| 83. |
Feng, J.,
B. Wible,
G. R. Li,
Z. Wang, and
S. Nattel.
Antisense oligodeoxynucleotides directed against Kv1.5 mRNA specifically inhibit ultrarapid delayed rectifier K+ current in cultured adult human atrial myocytes.
Circ. Res.
80:
572–579,
1997.
|
| 84. |
Fisher, D. J.
Recent insights into the regulation of cardiac Ca2+ flux during perinatal development and in cardiac failure.
Current Opini. Cardiol.
10:
44–51,
1995.
|
| 85. |
Fozzard, H. A. and
D. A. Hanck.
Structure and function of voltage‐dependent sodium channels: comparison of brain II and cardiac isoforms.
Physiol. Rev.
76:
887–926,
1996.
|
| 86. |
Franz, M. R.,
P. L. Karasik,
C. Li,
J. Moubarak, and
M. Chavez.
Electrical remodeling of the human atrium: similar effects in patients with chronic atrial fibrillation and atrial flutter.
J. Am. Coll. Cardiol.
30:
1785–1792,
1997.
|
| 87. |
Freeman, L. C.,
L. M. Pacioretty,
N. S. Moise,
R. S. Kass, and
R. F. Gilmour, Jr.
Decreased density of Ito in left ventricular myocytes from German Shepherd dogs with inherited arrhythmias.
J. Cardiovasc. Electrophysiol.
8:
872–883,
1997.
|
| 88. |
Furukawa, T.,
H. Ito,
J. Nitta,
M. Tsujino,
S. Adachi,
M. Hiroe,
F. Marumo,
T. Sawanobori, and
M. Hiraoka.
Endothelin‐1 enhances calcium entry through T‐type calcium channels in cultured neonatal rat ventricular myocytes.
Circ. Res.
71:
1242–1253,
1992.
|
| 89. |
Furukawa, T.,
R. J. Myerburg,
N. Furukawa,
S. Kimura, and
A. L. Bassett.
Metabolic inhibition of ICa,L and IK differs in feline left ventricular hypertrophy.
Am. J. Physiol.
266
Heart Circ. Physiol. 35:
H1121–H1131,
1994.
|
| 90. |
Galletti, F.,
A. Rutledge,
V. Krogh and
D. J. Triggle.
Age related changes in Ca2+ channels in spontaneously hypertensive rats.
Gen. Pharmacol.
22:
173–176,
1991.
|
| 91. |
Gao, J.,
R. T. Mathias,
I. S. Cohen, and
G. J. Baldo.
Two functionally different Na/K pumps in cardiac ventricular myocytes.
J. Gen. Physiol.
106:
995–1030,
1995.
|
| 92. |
Garratt, C. J.,
M. Duytschaever,
M. Killian,
R. Dorland,
F. Mast, and
M. A. Allessie.
Repetitive electrical remodeling by paroxysms of atrial fibrillation in the goat: no cumulative effect on inducibility or stability of atrial fibrillation.
J. Cardiovasc. Electrophysiol.
10:
1101–1108,
1999.
|
| 93. |
Gaspo, R.,
R. F. Bosch,
E. Bou‐Abboud, and
S. Nattel.
Tachycardia‐induced changes in Na+ current in a chronic dog model of atrial fibrillation.
Circ. Res.
81:
1045–1052,
1997.
|
| 94. |
Gaspo, R.,
H. Sun,
S. Fareh,
M. Levi,
L. Yue,
B. G. Allen,
T. E. Hebert, and
S. Nattel.
Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia‐induced atrial fibrillation.
Cardiovasc. Res.
42:
434–442,
1999.
|
| 95. |
Gaughan, J. P.,
C. A. Hefner, and
S. R. Houser.
Electrophysiological properties of neonatal rat ventricular myocytes with alpha 1‐adrenergic‐induced hypertrophy.
Am. J. Physiol.
275
Heart Circ. Physiol. 44:
H577–H5790,
1998.
|
| 96. |
Geisterfer‐Lowrance, A. A.,
M. Christe,
D. A. Conner,
J. S. Ingwall,
F. J. Schoen,
C. E. Seidman and
J. G. Seidman.
A mouse model of familial hypertrophic cardiomyopathy.
Science
272:
731–734,
1996.
|
| 97. |
George, A. L., Jr.,
T. A. Varkony,
H. A. Drabkin,
J. Han,
J. F. Knops,
W. H. Finley,
G. B. Brown,
D.C. Ward, and
M. Haas.
Assignment of the human heart tetrodotoxin‐resistant voltage‐gated Na+ channel alpha‐subunit gene (SCN5A) to band 3p21.
Cytogenet. Cell Genet.
68:
67–70,
1995.
|
| 98. |
Gidh‐Jain, M.,
B. Huang,
P. Jain,
V. Battula, and
N. el‐Sherif.
Reemergence of the fetal pattern of L‐type calcium channel gene expression in non infarcted myocardium during left ventricular remodeling.
Biochem. Biophys. Res. Commun.
216:
892–897,
1995.
|
| 99. |
Gidh‐Jain, M.,
B. Huang,
P. Jain,
G. Gick, and
N. el‐Sherif.
Alterations in cardiac gene expression during ventricular remodeling following experimental myocardial infarction.
J. Mol. Cell. Cardiol.
30:
627–637,
1998.
|
| 100. |
Gilmour, R. F.Jr.,
J. J. Heger,
E. N. Prystowsky, and
D. P. Zipes.
Cellular electrophysiologic abnormalities of diseased human ventricular myocardium.
Am. J. Cardiol.
51:
137–144,
1983.
|
| 101. |
Gross, G.J. and
J. A. Auchampach.
Role of ATP dependent potassium channels in myocardial ischaemia.
Cardiovasc. Res.
26:
1011–1016,
1992.
|
| 102. |
Gruver, E. J.,
M. G. Glass,
J. D. Marsh, and
J. K. Gwathmey.
An animal model of dilated cardiomyopathy: characterization of dihydropyridine receptors and contractile performance.
Am. J. Physiol.
265
Heart Circ. Physiol. 34:
H1704–H1711,
1993.
|
| 103. |
Gruver, E. J.,
J. P. Morgan,
B. S. Stambler, and
J. K. Gwathmey.
Uniformity of calcium channel number and isometric contraction in human right and left ventricular myocardium.
Basic Res. Cardiol.
89:
139–148,
1994.
|
| 104. |
Gulch, R. W.,
R. Baumann, and
R. Jacob.
Analysis of myocardial action potential in left ventricular hypertrophy of Goldblatt rats.
Basic Res. Cardiol.
74:
69–82,
1979.
|
| 105. |
Hagiwara, N.,
H. Irisawa, and
M. Kameyama.
Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino‐atrial node cells.
J. Physiol. (Lond)
395:
233–253,
1988.
|
| 106. |
Hancox, J. C. and
C. Howarth.
The actions of nickel on membrane currents activated by hyperpolarisation in single cells from the rabbit atrioventricular node.
Gen. Pharmacol.
26:
1727–1734,
1995.
|
| 107. |
Hart, G.
Cellular electrophysiology in cardiac hypertrophy and failure.
Cardiovasc. Res.
28:
933–946,
1994.
|
| 108. |
Hiraoka, M.,
S. Kawano,
Y. Hirano, and
T. Furukawa.
Role of cardiac chloride currents in changes in action potential characteristics and arrhythmias.
Cardiovasc. Res.
40:
23–33,
1998.
|
| 109. |
Hoppe, U. C.,
E. Jansen,
M. Sudkamp, and
D. J. Beuckelmann.
Hyperpolarization‐activated inward current in ventricular myocytes from normal and failing human hearts.
Circulation
97:
55–65,
1998.
|
| 110. |
Hurwitz, J. L. and
M. E. Josephson.
Sudden cardiac death in patients with chronic coronary heart disease.
Circulation
85:
143–149,
1992.
|
| 111. |
Isom, L. L.,
D. S. Ragsdale,
K. S. De Jongh,
R. E. Westenbroek,
B. F. Reber,
T. Scheuer, and
W. A. Catterall.
Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif.
Cell
83:
433–442,
1995.
|
| 112. |
Isomoto, S. and
Y. Kurachi.
Function, regulation, pharmacology, and molecular structure of ATP‐sensitive K+ channels in the cardiovascular system.
J. Cardiovasc. Electrophysiol.
8:
1431–1446,
1997.
|
| 113. |
Jacques, D.,
G. Bkaily,
G. Jasmin,
D. Menard, and
L. Proschek.
Early fetal like slow Na+ current in heart cells of cardiomyopathic hamster.
Mole. Cell. Biochem.
176:
249–256,
1997.
|
| 114. |
January, C. T.,
V. Chau, and
J. C. Makielski.
Triggered activity in the heart: cellular mechanisms of early after‐depolarizations.
Eur. Heart J.
12
(Suppl F):
4–9,
1991.
|
| 115. |
January, C. T. and
H. A. Fozzard.
Delayed afterdepolarizations in heart muscle: mechanisms and relevance.
Pharmacol. Rev.
40:
219–227,
1988.
|
| 116. |
January, C. T. and
J. M. Riddle.
Early afterdepolarizations: mechanism of induction and block. A role for L‐type Ca2+ current.
Circ. Res.
64:
977–990,
1989.
|
| 117. |
Janvier, N. C. and
M. R. Boyett.
The role of Na‐Ca exchange current in the cardiac action potential.
Cardiovasc. Res.
32:
69–84,
1996.
|
| 118. |
Jeck, C.,
J. Pinto, and
P. Boyden.
Transient outward currents in subendocardial Purkinje myocytes surviving in the infarcted heart.
Circulation
92:
465–473,
1995.
|
| 119. |
Jiang, C.,
D. Atkinson,
J. A. Towbin,
I. Splawski,
M. H. Lehmann,
H. Li,
K. Timothy,
R. T. Taggart,
P. J. Schwartz,
G. M. Vincent, et al.
Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity.
Nat. Genet.
8:
141–147,
1994.
|
| 120. |
Johns, D.C.,
H. B. Nuss, and
E. Marban.
Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant‐negative Kv4.2 constructs.
J. Biol. Chem.
272:
31598–31603,
1997.
|
| 121. |
Kaab, S.,
J. Dixon,
J. Duc,
D. Ashen,
M. Nabauer,
D. J. Beuckelmann,
G. Steinbeck,
D. McKinnon, and
G. F. Tomaselli.
Molecular basis of transient outward potassium current down‐regulation in human heart failure—a decrease in KV4.3 mRNA correlates with a reduction in current density.
Circulation
98:
1383–1393,
1998.
|
| 122. |
Kaab, S.,
H. B. Nuss,
N. Chiamvimonvat,
B. O'Rourke,
P. H. Pak,
D. A. Kass,
E. Marban, and
G. F. Tomaselli.
Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing‐induced heart failure.
Circ. Res.
78:
262–273,
1996.
|
| 123. |
Kambouris, N. G.,
H. B. Nuss,
D.C. Johns,
G. F. Tomaselli,
E. Marban, and
J. R. Balser.
Phenotypic characterization of a novel long‐QT syndrome mutation (R1623Q) in the cardiac sodium channel.
Circulation
97:
640–644,
1998.
|
| 124. |
Kameyama, M.,
M. Kakei,
R. Sato,
T. Shibasaki,
H. Matsuda, and
H. Irisawa.
Intracellular Na+ activates a K+ channel in mammalian cardiac cells.
Nature
309:
354–356,
1984.
|
| 125. |
Kaplan, N. M.
Beta blockade in the primary prevention of hypertensive cardiovascular events with focus on sudden cardiac death.
Am. J. Cardiol.
80:
20J–22J,
1997.
|
| 126. |
Kaprielian, R.,
A. D. Wickenden,
Z. Kassiri,
T. G. Parker,
P. P. Liu, and
P. H. Backx.
Relationship between K+ channel down‐regulation and[Ca2+i in rat ventricular myocytes following myocardial infarction.
J. Physiol. (Lond.)
517
Pt 1:
229–245,
1999.
|
| 127. |
Katz, A. M.
Molecular biology of calcium channels in the cardiovascular system.
Am. J. Cardiol.
80:
171–221,
1997.
|
| 128. |
Kazen‐Gillespie, K. A.,
D. S. Ragsdale,
M. R. D'Andrea,
L. N. Mattei,
K. E. Rogers, and
L. L. Isom.
Cloning, localization, and functional expression of sodium channel beta1A subunits.
J. Biol. Chem.
275:
1079–1088,
2000.
|
| 129. |
Keung, E. C.
Calcium current is increased in isolated adult myocytes from hypertrophied rat myocardium.
Circ. Res.
64:
753–763,
1989.
|
| 130. |
Keung, E. C.,
L. Toll,
M. Ellis, and
R. A. Jensen.
L‐type cardiac calcium channels in doxorubicin cardiomyopathy in rats morphological, biochemical, and functional correlations.
J. Clin. Invest.
87:
2108–2113,
1991.
|
| 131. |
Kim, D.
A mechanosensitive K+ channel in heart cells. Activation by arachidonic acid.
J. Gen. Physiol.
100:
1021–1040,
1992.
|
| 132. |
Kleiman, R. B. and
S. R. Houser.
Calcium currents in normal and hypertrophied isolated feline ventricular myocytes.
Am. J. Physiol.
255
Heart Circ. Physiol. 24:
H1434–H1442,
1988.
|
| 133. |
Kleiman, R. B. and
S. R. Houser.
Outward currents in normal and hypertrophied feline ventricular myocytes.
Am. J. Physiol.
256:
H1450–H1461,
1989.
|
| 134. |
Koumi, S. I.,
R. L. Martin, and
R. Sato.
Alterations in ATP‐sensitive potassium channel sensitivity to ATP in failing human hearts.
Am. J. Physiol.
272
Heart Circ. Physiol. 41:
H1656–H1665,
1997.
|
| 135. |
Krapivinsky, G.,
E. A. Gordon,
K. Wickman,
B. Velimirovic,
L. Krapivinsky, and
D. E. Clapham.
The G‐protein‐gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)‐channel proteins.
Nature
374:
135–141,
1995.
|
| 136. |
Kuo, T. H.,
D. F. Johnson,
W. Tsang, and
J. Wiener.
Photoaffinity labeling of the calcium channel antagonist receptor in the heart of the cardiomyopathic hamster.
Biochem. Biophys. Res. Commun.
148:
926–933,
1987.
|
| 137. |
Kupershmidt, S.,
T. Yang, and
D. M. Roden.
Modulation of cardiac Na+ current phenotype by betal‐subunit expression.
Circ. Res.
83:
441–447,
1998.
|
| 138. |
Le Grand, B.,
S. Hatem,
E. Deroubaix,
J. P. Couetil, and
E. Coraboeuf.
Calcium current depression in isolated human atrial myocytes after cessation of chronic treatment with calcium antagonists.
Circ. Res.
69:
292–300,
1991.
|
| 139. |
Le Grand, B. L.,
S. Hatem,
E. Deroubaix,
J. P. Couetil, and
E. Coraboeuf.
Depressed transient outward and calcium currents in dilated human atria.
Cardiovasc. Res.
28:
548–556,
1994.
|
| 140. |
Lee, J. K.,
I. Kodama,
H. Honjo,
T. Anno,
K. Kamiya, and
J. Toyama.
Stage‐dependent changes in membrane currents in rats with monocrotaline‐induced right ventricular hypertrophy.
Am. J. Physiol.
272
Heart Circ. Physiol. 41:
H2833–H2842,
1997.
|
| 141. |
Lee, S. L.,
I. Ostadalova,
F. Kolar, and
N. S. Dhalla.
Alterations in Ca(2+)‐channels during the development of diabetic cardiomyopathy.
Mol. Cell. Biochem.
109:
173–179,
1992.
|
| 142. |
Lesage, F.,
E. Guillemare,
M. Fink,
F. Duprat,
M. Lazdunski,
G. Romey, and
J. Barhanin.
TWIK‐1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
EMBO J.
15:
1004–1011,
1996.
|
| 143. |
Li, G. R.,
J. Feng,
L. Yue, and
M. Carrier.
Transmural heterogeneity of action potentials and Ito 1 in myocytes isolated from the human right ventricle.
Am. J. Physiol.
275
Heart Circ. Physiol. 44:
H369–H377,
1998.
|
| 144. |
Li, Q. and
E. C. Keung.
Effects of myocardial hypertrophy on transient outward current.
Am. J. Physiol.
266
Heart Circ. Physiol. 35:
H1738–H1745,
1994.
|
| 145. |
Liu, D. W.,
G. A. Gintant, and
C. Antzelevitch.
Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle.
Circ. Res.
72:
671–687,
1993.
|
| 146. |
Liu, X. and
E. Songu‐Mize.
Alterations in alpha subunit expression of cardiac Na+,K+‐ATPase in spontaneously hypertensive rats: effect of antihypertensive therapy.
Eur. J. Pharmacol.
327:
151–156,
1997.
|
| 147. |
Locati, E. H.,
W. Zareba,
A. J. Moss,
P. J. Schwartz,
G. M. Vincent,
M. H. Lehmann,
J. A. Towbin,
S. G. Priori,
C. Napolitano,
J. L. Robinson,
M. Andrews,
K. Timothy, and
W. J. Hall.
Age‐ and sex‐related differences in clinical manifestations in patients with congenital long‐QT syndrome: findings from the International LQTS Registry.
Circulation
97:
2237–2244,
1998.
|
| 148. |
London, B.,
A. Jeron,
J. Zhou,
P. Buckett,
X. Han,
G. F. Mitchell, and
G. Koren.
Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage‐gated potassium channel.
Proc. Nat. Acad. Sci. U.S.A.
95:
2926–2931,
1998.
|
| 149. |
London, B.,
D. W. Wang,
J. A. Hill, and
P. B. Bennett.
The transient outward current in mice lacking the potassium channel gene Kv1.4.
J. Physiol. (Lond.)
509:
171–182,
1998.
|
| 150. |
Ludwig, A.,
X. Zong,
M. Jeglitsch,
F. Hofmann, and
M. Biel.
A family of hyperpolarization‐activated mammalian cation channels.
Nature
393:
587–591,
1998.
|
| 151. |
Lue, W. M. and
P. A. Boyden.
Abnormal electrical properties of myocytes from chronically infarcted canine heart. Alterations in Vmax and the transient outward current.
Circulation
85:
1175–1188,
1992.
|
| 152. |
Luk, H. N. and
E. Carmeliet.
Na(+)‐activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicity.
Pflugers Arch.
416:
766–768,
1990.
|
| 153. |
Luke, R. A. and
J. E. Saffitz.
Remodeling of ventricular conduction pathways in healed canine infarct border zones.
J. Clin. Invest.
87:
1594–1602,
1991.
|
| 154. |
Makielski, J. C.,
J. T. Limberis,
S. Y. Chang,
Z. Fan, and
J. W. Kyle.
Coexpression of beta 1 with cardiac sodium channel alpha subunits in oocytes decreases lidocaine block.
Mol. Pharmacol.
49:
30–39,
1996.
|
| 155. |
Maltsev, V. A.,
H. N. Sabbah,
R. S. D. Higgins,
N. Silverman,
M. Lesch, and
A. I. Undrovinas.
Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes.
Circulation
98:
2545–2552,
1998.
|
| 156. |
Marban, E.,
T. Yamagishi, and
G. F. Tomaselli.
Structure and function of voltage‐gated sodium channels.
J. Physiol. (Lond.)
508:
647–657,
1998.
|
| 157. |
Marian, A. J. and
R. Roberts.
Molecular genetic basis of hypertrophic cardiomyopathy: genetic markers for sudden cardiac death.
J. Cardiovasc. Electrophysiol.
9:
88–99,
1998.
|
| 158. |
Martinez, M. L.,
M. P. Heredia and
C. Delgado.
Expression of T‐type Ca(2+) channels in ventricular cells from hypertrophied rat hearts.
J. Mol. Cell. Cardiol.
31:
1617–1625,
1999.
|
| 159. |
Martins, J. B.,
W. Kim, and
M. L. Marcus.
Chronic hypertension and left ventricular hypertrophy facilitate induction of sustained ventricular tachycardia in dogs 3 hours after left circumflex coronary artery occlusion [see comments].
J. Am. Coll. Cardiol.
14:
1365–1373,
1989.
|
| 160. |
Matsuda, N.,
N. Hagiwara,
M. Shoda,
H. Kasanuki, and
S. Hosoda.
Enhancement of the L‐type Ca2+ current by mechanical stimulation in single rabbit cardiac myocytes.
Circ. Res.
78:
650–659,
1996.
|
| 161. |
McDonald, T. V.,
Z. Yu,
Z. Ming,
E. Palma,
M. B. Meyers,
K. W. Wang,
S. A. Goldstein, and
G. I. Fishman.
A minK‐HERG complex regulates the cardiac potassium current I(Kr).
Nature
388:
289–292,
1997.
|
| 162. |
McIntosh, M. A.,
S. M. Cobbe,
K. A. Kane, and
A. C. Rankin.
Action potential prolongation and potassium currents in leftventricular myocytes isolated from hypertrophied rabbit hearts.
J. Mol. Cell. Cardiol.
30:
43–53,
1998.
|
| 163. |
McIntosh, M. A.,
S. M. Cobbe, and
G. L. Smith.
Heterogeneous changes in action potential and intracellular Ca2+ in left ventricular myocyte sub‐types from rabbits with heart failure
Cardiovasc. Res.
45:
397–409,
2000.
|
| 164. |
Meszaros, J.,
J. J. Coutinho,
S. M. Bryant,
K. O. Ryder, and
G. Hart.
L‐type calcium current in catecholamine‐induced cardiac hypertrophy in the rat.
Exp. Physiol.
82:
71–83,
1997.
|
| 165. |
Meszaros, J.,
K. O. Ryder, and
G. Hart.
Transient outward current in catecholamine‐induced cardiac hypertrophy in the rat.
Am. J. Physiol.
271
Heart Circ. Physiol. 40:
H2360–H2367,
1996.
|
| 166. |
Michels, V. V.,
P. P. Moll,
F. A. Miller,
A. J. Tajik,
J. S. Chu,
D. J. Driscoll,
J. C. Burnett,
R. J. Rodeheffer,
J. H. Chesebro and
H. D. Tazelaar.
The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy.
N. Engl. J. Med.
326:
77–82,
1992.
|
| 167. |
Momtaz, A.,
A. Coulombe,
P. Richer,
J. J. Mercadier, and
E. Coraboeuf.
Action potential and plateau ionic currents in moderately and severely DOCA‐salt hypertrophied rat hearts.
J. Mol. Cell. Cardiol.
28:
2511–2522,
1996.
|
| 168. |
Morgan, K.,
E. B. Stevens,
B. Shah,
P. J. Cox,
A. K. Dixon,
K. Lee,
R. D. Pinnock,
J. Hughes,
P. J. Richardson,
K. Mizuguchi, and
A. P. Jackson.
beta 3: An additional auxiliary subunit of the voltage‐sensitive sodium channel that modulates channel gating with distinct kinetics.
Proc. Natl. Acad. Sci. U.S.A.
97:
2308–2313,
2000.
|
| 169. |
Morley, G. E.,
J. F. Ek‐Vitorin,
S. M. Taffet, and
M. Delmar.
Structure of connexin43 and its regulation by pHi.
J. Cardiovasc. Electrophysiol.
8:
939–951,
1997.
|
| 170. |
Moss, A. J.,
P. J. Schwartz,
R. S. Crampton,
D. Tzivoni,
E. H. Locati,
J. MacCluer,
W. J. Hall,
L. Weitkamp,
G. M. Vincent, and
A. Garson, Jr.
The long QT syndrome. Prospective longitudinal study of 328 families.
Circulation
84:
1136–1144,
1991.
|
| 171. |
Mukherjee, R.,
K. W. Hewett, and
F. G. Spinale.
Myocyte electrophysiological properties following the development of supraventricular tachycardia‐induced cardiomyopathy.
J. Mol. Cell. Cardiol.
27:
1333–1348,
1995.
|
| 172. |
Myerburg, R. J.,
A. Interian, Jr.,
R. M. Mitrani,
K. M. Kessler, and
A. Castellanos.
Frequency of sudden cardiac death and profiles of risk [see comments].
Am. J. Cardiol.
80:
10F–19F,
1997.
|
| 173. |
Nabauer, M.,
D. J. Beuckelmann, and
E. Erdmann.
Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure.
Circ. Res.
73:
386–394,
1993.
|
| 174. |
Nabauer, M.,
D. J. Beuckelmann,
P. Uberfuhr, and
G. Steinbeck.
Regional differences in current density and ratedependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle.
Circulation
93:
168–177,
1996.
|
| 175. |
Nabauer, M. and
S. Kaab.
Potassium channel down‐regulation in heart failure.
Cardiovasc. Res.
37:
324–334,
1998.
|
| 176. |
Nagatomo, T.,
C. T. January, and
J. C. Makielski.
Preferential Block of Late INa in the LQT3 ΔKPQ Mutant by the Class IC Antiarrhythmic Flecainide.
Molecular Pharmacology
57:
101–107
2000.
|
| 177. |
Nagatomo, T.,
Z. Fan,
B. Ye,
G. S. Tonkovich,
C. T. January,
J. W. Kyle, and
J. C. Makielski.
Temperature dependence of early and late currents in human cardiac wild‐type and long QT delta KPQ Na+ channels.
Am. J. Physiol.
275
Heart Circ. Physiol. 44:
H2016–H2024,
1998.
|
| 178. |
Nakamura, T. Y.,
M. Artman,
B. Rudy, and
W. A. Coetzee.
Inhibition of rat ventricular IK1 with antisense oligonucleotides targeted to Kir2.1 mRNA.
Am. J. Physiol.
274
Heart Circ. Physiol. 43:
H892–900,
1998.
|
| 179. |
Nattel, S.
Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation.
Cardiovasc. Res
42:
298–308,
1999.
|
| 180. |
Neyroud, N.,
F. Tesson,
I. Denjoy,
M. Leibovici,
C. Donger,
J. Barhanin,
S. Faure,
F. Gary,
P. Coumel,
C. Petit,
K. Schwartz and
P. Guicheney.
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange‐Nielsen cardioauditory syndrome.
Nat. Genet.
15:
186–189,
1997.
|
| 181. |
Nichols, C. G.,
E. N. Makhina,
W. L. Pearson,
Q. Sha, and
A. N. Lopatin.
Inward rectification and implications for cardiac excitability.
Circ. Res.
78:
1–7,
1996.
|
| 182. |
Noma, A.
Ionic mechanisms of the cardiac pacemaker potential.
Jpn. Heart J.
37:
673–682,
1996.
|
| 183. |
Nuss, H. B. and
S. R. Houser.
Voltage dependence of contraction and calcium current in severely hypertrophied feline ventricular myocytes.
J. Mol. Cell. Cardiol.
23:
717–726,
1991.
|
| 184. |
Nuss, H. B. and
S. R. Houser.
T‐type Ca2+ current is expressed in hypertrophied adult feline left ventricular myocytes.
Circ. Res.
73:
777–782,
1993.
|
| 185. |
Oberst, L.,
G. L. Zhao,
J. T. Park,
R. Brugada,
L. H. Michael,
M. L. Entman,
R. Roberts, and
A. J. Marian.
Dominantnegative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice.
J. Clin. Invest.
102:
1498–1505,
1998.
|
| 186. |
Olson, T. M.,
V. V. Michels,
S. N. Thibodeau,
Y. S. Tai, and
M. T. Keating.
Actin mutations in dilated cardiomyopathy, a heritable form of heart failure.
Science
280:
750–752,
1998.
|
| 187. |
Ouadid, H.,
B. Albat, and
J. Nargeot.
Calcium currents in diseased human cardiac cells.
J. Cardiovasc. Pharmacol.
25:
282–291,
1995.
|
| 188. |
Pacioretty, L. M.,
S. C. Barr,
W. P. Han, and
R. F. Gilmour, Jr.
Reduction of the transient outward potassium current in a canine model of Chagas' disease.
Am. J. Physiol.
268
Heart Circ. Physiol. 37:
H1258–H1264,
1995.
|
| 189. |
Pak, P. H.,
H. B. Nuss,
R. S. Tunin,
S. Kaab,
G. F. Tomaselli,
E. Marban, and
D. A. Kass.
Repolarization abnormalities, arrhythmia and sudden death in canine tachycardia‐induced cardiomyopathy.
J. Am. Coll. Cardiol.
30:
576–584,
1997.
|
| 190. |
Peters, N. S.,
J. Coromilas,
N. J. Severs, and
A. L. Wit.
Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia.
Circulation
95:
988–996,
1997.
|
| 191. |
Pinto, J. M. and
P. A. Boyden.
Reduced inward rectifying and increased E‐4031‐sensitive K+ current density in arrhythmogenic subendocardial purkinje myocytes from the infarcted heart.
J. Cardiovasc. Electrophysiol.
9:
299–311,
1998.
|
| 192. |
Pinto, J. M. and
P. A. Boyden.
Electrical remodeling in ischemia and infarction.
Cardiovasc. Res.
42:
284–297,
1999.
|
| 193. |
Pinto, J. M.,
F. Yuan,
B. J. Wasserlauf,
A. L. Bassett, and
R. J. Myerburg.
Regional gradation of L‐type calcium currents in the feline heart with a healed myocardial infarct.
J. Cardiovasc. Electrophysiol.
8:
548–560,
1997.
|
| 194. |
Pogwizd, S. M.
Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits.
Circulation
92:
1034–1048,
1995.
|
| 195. |
Pogwizd, S. M. and
P. B. Corr.
Biochemical and electrophysiological alterations underlying ventricular arrhythmias in the failing heart.
Eur. Heart J.
15
Suppl D:
145–154,
1994.
|
| 196. |
Pogwizd, S. M.,
R. H. Hoyt,
J. E. Saffitz,
P. B. Corr,
J. L. Cox, and
M. E. Cain.
Reentrant and focal mechanisms underlying ventricular tachycardia in the human heart.
Circulation
86:
1872–1887,
1992.
|
| 197. |
Pogwizd, S. M.,
M. Qi,
W. Yuan,
A. M. Samarel, and
D. M. Bers.
Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure.
Circ. Res.
85:
1009–1019,
1999.
|
| 198. |
Potreau, D.,
J. P. Gomez, and
N. Fares.
Depressed transient outward current in single hypertrophied cardiomyocytes isolated from the right ventricle of ferret heart.
Cardiovasc. Res.
30:
440–448,
1995.
|
| 199. |
Priori, S. G.,
C. Napolitano,
F. Cantu,
A. M. Brown, and
P. J. Schwartz.
Differential response to Na+ channel blockade, beta‐adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long‐QT syndrome.
Circ. Res.
78:
1009–1015,
1996.
|
| 200. |
Pye, M. P. and
S. M. Cobbe.
Arrhythmogenesis in experimental models of heart failure: the role of increased load.
Cardiovasc. Res.
32:
248–257,
1996.
|
| 201. |
Rasmussen, R. P.,
W. Minobe, and
M. R. Bristow.
Calcium antagonist binding sites in failing and nonfailing human ventricular myocardium.
Biochem. Pharmacol.
39:
691–696,
1990.
|
| 202. |
Rayment, I.,
H. M. Holden,
J. R. Sellers,
L. Fananapazir, and
N. D. Epstein.
Structural interpretation of the mutations in the beta‐cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy.
Proc. Natl. Acad. Sci. U. S. A.
92:
3864–3868,
1995.
|
| 203. |
Rees, S. A.,
J. I. Vandenberg,
A. R. Wright,
A. Yoshida, and
T. Powell.
Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes.
J. Gen. Physiol.
106:
1151–1170,
1995.
|
| 204. |
Reinecke, H.,
R. Studer,
R. Vetter,
J. Holtz, and
H. Drexler.
Cardiac Na+/Ca2+ exchange activity in patients with end‐stage heart failure.
Cardiovasc. Res.
31:
48–54,
1996.
|
| 205. |
Rials, S. J.,
Y. Wu,
X. Xu,
R. A. Filart,
R. A. Marinchak, and
P. R. Kowey.
Regression of left ventricular hypertrophy with captopril restores normal ventricular action potential duration, dispersion of refractoriness, and vulnerability to inducible ventricular fibrillation.
Circulation
96:
1330–1336,
1997.
|
| 206. |
Rials, S. J.,
X. Xu,
Y. Wu,
R. A. Marinchak, and
P. R. Kowey.
Regression of LV hypertrophy with captopril normalizes membrane currents in rabbits.
Am. J. Physiol.
275
Heart Circ. Physiol. 44:
H1216–H1224,
1998.
|
| 207. |
Richard, S.,
F. Leclercq,
S. Lemaire,
C. Piot, and
J. Nargeot.
Ca2+ currents in compensated hypertrophy and heart failure.
Cardiovasc. Res.
37:
300–311,
1998.
|
| 208. |
Roden, D. M. and
A. L. George, Jr.
Structure and function of cardiac sodium and potassium channels.
Am. J. Physiol.
273
Heart Circ. Physiol. 42:
H511–H525,
1997.
|
| 209. |
Rozanski, G. J.,
Z. Xu,
R. T. Whitney,
H. Murakami, and
I. H. Zucker.
Electrophysiology of rabbit ventricular myocytes following sustained rapid ventricular pacing.
J. Mol. Cell. Cardiol.
29:
721–732,
1997.
|
| 210. |
Rozanski, G. J.,
Z. Xu,
K. Zhang, and
K. P. Patel.
Altered K+ current of ventricular myocytes in rats with chronic myocardial infarction.
Am. J. Physiol.
274
Heart Circ. Physiol. 43:
H259–H265,
1998.
|
| 211. |
Ruiz‐Opazo, N.,
X. H. Xiang, and
V. L. Herrera.
Pressureoverload deinduction of human alpha 2 Na,K‐ATPase gene expression in transgenic rats.
Hypertension
29:
606–612,
1997.
|
| 212. |
Russell, M. W.,
M. Dick,
F. S. Collins, and
L. C. Brody.
KVLQT1 mutations in three families with familial or sporadic long QT syndrome.
Hum. Mol. Genet.
5:
1319–1324,
1996.
|
| 213. |
Ryder, K. O.,
S. M. Bryant, and
G. Hart.
Membrane current changes in left ventricular myocytes isolated from guinea pigs after abdominal aortic coarctation.
Cardiovasc. Res.
27:
1278–1287,
1993.
|
| 214. |
Saffitz, J. E.,
R. B. Schuessler, and
K. A. Yamada.
Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias.
Cardiovasc. Res.
42:
309–317,
1999.
|
| 215. |
Sahin‐Erdemli, I.,
R. M. Medford, and
E. Songu‐Mize.
Regulation of Na+,K(+)‐ATPase alpha‐subunit isoforms in rat tissues during hypertension.
Eur. J. Pharmacol.
292:
163–171,
1995.
|
| 216. |
Sakakibara, Y.,
J. A. Wasserstrom,
T. Furukawa,
H. Jia,
C. E. Arentzen,
R. S. Hartz, and
D. H. Singer.
Characterization of the sodium current in single human atrial myocytes.
Circ. Res.
71:
535–546,
1992.
|
| 217. |
Sanguinetti, M. C.,
M. E. Curran,
A. Zou,
J. Shen,
P. S. Spector,
D. L. Atkinson, and
M. T. Keating.
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
Nature
384:
80–83,
1996.
|
| 218. |
Sanguinetti, M. C.,
C. Jiang,
M. E. Curran, and
M. T. Keating.
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.
Cell
81:
299–307,
1995.
|
| 219. |
Sanguinetti, M. C. and
N. K. Jurkiewicz.
Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.
J. Gen. Physiol.
96:
195–215,
1990.
|
| 220. |
Sasaki, N.,
T. Mitsuiye,
Z. Wang, and
A. Noma.
Increase of the delayed rectifier K+ and Na(+)‐K+ pump currents by hypotonic solutions in guinea pig cardiac myocytes.
Circ. Res.
75:
887–895,
1994.
|
| 221. |
Sawicki, P. T.,
S. Kiwitt,
R. Bender, and
M. Berger.
The value of QT interval dispersion for identification of total mortality risk in non‐insulin‐dependent diabetes mellitus.
J. Intern. Med.
243:
49–56,
1998.
|
| 222. |
Saxena, N. C.,
J. S. Fan, and
G. N. Tseng.
Effects of elevating [Na]i on membrane currents of canine ventricular myocytes: role of intracellular Ca ions.
Cardiovasc. Res.
33:
548–560,
1997.
|
| 223. |
Scamps, F. and
E. Carmeliet.
Delayed K+ current and external K+ in single cardiac Purkinje cells.
Am. J. Physiol.
257
Cell Physiol. 26:
C1086–C1092,
1989.
|
| 224. |
Scamps, F.,
E. Mayoux,
D. Charlemagne, and
G. Vassort.
Calcium current in single cells isolated from normal and hypertrophied rat heart. Effects of beta‐adrenergic stimulation.
Circ. Res.
67:
199–208,
1990.
|
| 225. |
Schaffer, S. W.,
C. Ballard‐Croft,
S. Boerth, and
S. N. Allo.
Mechanisms underlying depressed Na+/Ca2+ exchanger activity in the diabetic heart.
Cardiovasc. Res.
34:
129–136,
1997.
|
| 226. |
Schott, J. J.,
F. Charpentier,
S. Peltier,
P. Foley,
E. Drouin,
J. B. Bouhour,
P. Donnelly,
G. Vergnaud,
L. Bachner,
J. P. Moisan, et al.
Mapping of a gene for long QT syndrome to chromosome 4q25–27.
Am. J. Hum. Genet.
57:
1114–1122,
1995.
|
| 227. |
Schroder, F.,
R. Handrock,
D. J. Beuckelmann,
S. Hirt,
R. Hullin,
L. Priebe,
R. H. Schwinger,
J. Weil, and
S. Herzig.
Increased availability and open probability of single L‐type calcium channels from failing compared with nonfailing human ventricle.
Circulation
98:
969–976,
1998.
|
| 228. |
Schulze‐Bahr, E.,
W. Haverkamp,
H. Wedekind,
C. Rubie,
M. Hordt,
M. Borggrefe,
G. Assmann,
G. Breithardt, and
H. Funke.
Autosomal recessive long‐QT syndrome (Jervell Lange‐Nielsen syndrome) is genetically heterogeneous.
Hum. Genet.
100:
573–576,
1997.
|
| 229. |
Schwartz, P. J.,
E. H. Locati,
C. Napolitano, and
S. G. Priori.
The long QT syndrome. In:
Cardiac Electrophysiology, edited by
D. P. Zipes and
J. Jalife.
Philadelphia:
W. B. Saunders,
1995:
788–811.
|
| 230. |
Schwartz, P. J.,
S. G. Priori,
E. H. Locati,
C. Napolitano,
F. Cantu,
J. A. Towbin,
M. T. Keating,
H. Hammoude,
A. M. Brown, and
L. S. Chen.
Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene‐specific therapy.
Circulation
92:
3381–3386,
1995.
|
| 231. |
Schwartz, P. J.,
M. Stramba‐Badiale,
A. Segantini,
P. Austoni,
G. Bosi,
R. Giorgetti,
F. Grancini,
E. D. Marni,
F. Perticone,
D. Rosti, and
P. Salice.
Prolongation of the QT interval and the sudden infant death syndrome [see comments].
N. Engl. J. Med.
338:
1709–1714,
1998.
|
| 232. |
Selzer, A. and
H. W. Wray.
Paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhythmias.
Circulation
30:
17–26,
1964.
|
| 233. |
Sen, L. and
T. W. Smith.
T‐type Ca2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts.
Circ. Res.
75:
149–155,
1994.
|
| 234. |
Sepp, R.,
N. J. Severs, and
R. G. Gourdie.
Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy.
Heart
76:
412–417,
1996.
|
| 235. |
Shibata, E. F.,
T. Drury,
H. Refsum,
V. Aldrete, and
W. Giles.
Contributions of a transient outward current to repolarization in human atrium.
Am. J. Physiol.
257
Heart Circ. Physiol. 26:
H1773–H1781,
1989.
|
| 236. |
Shimoni, Y.,
R. B. Clark, and
W. R. Giles.
Role of an inwardly rectifying potassium current in rabbit ventricular action potential.
J. Physiol.
448:
709–727,
1992.
|
| 237. |
Shimoni, Y.,
H. S. Ewart, and
D. Severson.
Type I and II models of diabetes produce different modifications of K+ currents in rat heart: role of insulin.
J. Physiol. (Lond.)
507:
485–496,
1998.
|
| 238. |
Shipsey, S. J.,
S. M. Bryant, and
G. Hart.
Effects of hypertrophy on regional action potential characteristics in the rat left ventricle: a cellular basis for T‐wave inversion?
Circulation
96:
2061–2068,
1997.
|
| 239. |
Shyng, S. L. and
C. G. Nichols.
Membrane phospholipid control of nucleotide sensitivity of K‐ATP channels.
Science
282:
1138–1141,
1998.
|
| 240. |
Silver, L. H. and
S. R. Houser.
Decreased sodium‐potassium pump activity in isolated hypertrophied feline ventricular myocytes.
Life Sci.
37:
607–615,
1985.
|
| 241. |
Sipido, K. R.,
E. Carmeliet, and
F. Van de Werf.
T‐type Ca2+ current as a trigger for Ca2+ release from the sarcoplasmic reticulum in guinea‐pig ventricular myocytes.
J. Physiol.
508:
439–451,
1998.
|
| 242. |
Smith, J. M. and
G. M. Wahler.
ATP‐sensitive potassium channels are altered in ventricular myocytes from diabetic rats.
Mol. Cell. Biochem.
158:
43–51,
1996.
|
| 243. |
Smith, P. L.,
T. Baukrowitz, and
G. Yellen.
The inward rectification mechanism of the HERG cardiac potassium channel.
Nature
379:
833–836,
1996.
|
| 244. |
Snyders, D. J.,
M. M. Tamkun, and
P. B. Bennett.
A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression.
J. Gen. Physiol.
101:
513–543,
1993.
|
| 245. |
Sodder, V. H.,
L. D. Bowie, and
J. S. Cameron.
Trypsin alters ATP sensitivity of KATP channels in control and hypertrophied myocytes.
Eur. J. Pharmacol.
315:
115–118,
1996.
|
| 246. |
Spach, M. S. and
J. P. Boineau.
Microfibrosis produces electrical load variations due to loss of side‐to‐side cell connections: a major mechanism of structural heart disease arrhythmias.
Pacing Clin. Electrophysiol.
20:
397–413,
1997.
|
| 247. |
Spector, P. S.,
M. E. Curran,
M. T. Keating, and
M. C. Sanguinetti.
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open‐channel block by methanesulfonanilides.
Circ. Res.
78:
499–503,
1996.
|
| 248. |
Spindler, M.,
K. W. Saupe,
M. E. Christe,
H. L. Sweeney,
C. E. Seidman,
J. G. Seidman, and
J. S. Ingwall.
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
J. Clin. Invest.
101:
1775–1783,
1998.
|
| 249. |
Splawski, I.,
K. W. Timothy,
G. M. Vincent,
D. L. Atkinson, and
M. T. Keating.
Molecular basis of the long‐QT syndrome associated with deafness.
N. Engl. J. Med.
336:
1562–1567,
1997.
|
| 250. |
Stacy, G. P., Jr.,
R. L. Jobe,
L. K. Taylor, and
D. E. Hansen.
Stretch‐induced depolarizations as a trigger of arrhythmias in isolated canine left ventricles.
Am. J. Physiol.
263
Heart Circ. Physiol. 32:
H613–H621,
1992.
|
| 251. |
Studer, R.,
H. Reinecke,
R. Vetter,
J. Holtz, and
H. Drexler.
Expression and function of the cardiac Na+/Ca2+ exchanger in postnatal development of the rat, in experimental‐induced cardiac hypertrophy and in the failing human heart.
Basic Res. Cardiol.
92
(Suppl 1):
53–58,
1997.
|
| 252. |
Swynghedauw, B.
Molecular mechanisms of myocardial remodeling.
Physiol. Rev.
79:
215–262,
1999.
|
| 253. |
Sylven, C.,
E. Jansson,
P. Sotonyi,
F. Waagstein, and
M. Bronnegard.
Na,K‐ATPase receptor subunits alpha 1, alpha 2 and alpha 3 mRNA in dilated cardiomyopathy.
Biol. Pharm. Bull.
18:
907–909,
1995.
|
| 254. |
Takumi, T.,
H. Ohkubo, and
S. Nakanishi.
Cloning of a membrane protein that induces a slow voltage‐gated potassium current.
Science
242:
1042–1045,
1988.
|
| 255. |
Tanaka, T.,
R. Nagai,
H. Tomoike,
S. Takata,
K. Yano,
Yabuta, K,
N. Haneda,
O. Nakano,
A. Shibata,
T. Sawayama,
H. Kasai,
Y. Yazaki, and
Y. Nakamura.
Four novel KVLQT1 and four novel HERG mutations in familial long‐QT syndrome.
Circulation
95:
565–567,
1997.
|
| 256. |
Tardiff, J. C.,
S. M. Factor,
B. D. Tompkins,
T. E. Hewett,
B. M. Palmer,
R. L. Moore,
S. Schwartz,
J. Robbins, and
L. A. Leinwand.
A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.
J. Clin. Invest.
101:
2800–2811,
1998.
|
| 257. |
Ten Eick, R. E.,
K. Zhang,
R. D. Harvey, and
A. L. Bassett.
Enhanced functional expression of transient outward current in hypertrophied feline myocytes.
Cardiovasc. Drugs Ther.
7
(Suppl 3):
611–619,
1993.
|
| 258. |
Terzic, A.,
A. Jahangir, and
Y. Kurachi.
Cardiac ATP‐sensitive K+ channels: regulation by intracellular nucleotides and K+ channel‐opening drugs.
Am. J. Physiol.
269
Cell Physiol. 38:
C525–C545,
1995.
|
| 259. |
Thomas, S. A.,
R. B. Schuessler,
C. I. Berul,
M. A. Beardslee,
E. C. Beyer,
M. E. Mendelsohn, and
J. E. Saffitz.
Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber‐specific molecular determinants of conduction.
Circulation
97:
686–691,
1998.
|
| 260. |
Thuringer, D.,
E. Deroubaix,
A. Coulombe,
E. Coraboeuf, and
J. J. Mercadier.
Ionic basis of the action potential prolongation in ventricular myocytes from Syrian hamsters with dilated cardiomyopathy.
Cardiovasc. Res.
31:
747–757,
1996.
|
| 261. |
Tomaselli, G. F.,
D. J. Beuckelmann,
H. G. Calkins,
R. D. Berger,
P. D. Kessler,
J. H. Lawrence,
D. Kass,
A. M. Feldman, and
E. Marban.
Sudden cardiac death in heart failure. The role of abnormal repolarization.
Circulation
90:
2534–2539,
1994.
|
| 262. |
Tomaselli, G. F. and
E. Marban.
Electrophysiological remodeling in hypertrophy and heart failure.
Cardiovasc. Res
42:
270–283,
1999.
|
| 263. |
Tomita, F.,
A. L. Bassett,
R. J. Myerburg, and
S. Kimura.
Diminished transient outward currents in rat hypertrophied ventricular myocytes.
Circ. Res.
75:
296–303,
1994.
|
| 264. |
Tritthart, H.,
H. Luedcke,
R. Bayer,
H. Stierle, and
R. Kaufmann.
Right ventricular hypertrophy in the cat—an electrophysiological and anatomical study.
J. Mol. Cell. Cardiol.
7:
163–174,
1975.
|
| 265. |
Trudeau, M. C.,
J. W. Warmke,
B. Ganetzky, and
G. A. Robertson.
HERG, a human inward rectifier in the voltage‐gated potassium channel family.
Science
269:
92–95,
1995.
|
| 266. |
Tsuchida, K. and
H. Watajima.
Potassium currents in ventricular myocytes from genetically diabetic rats.
Am. J. Physiol.
273
Endocrinol. Metab. Gastrointest. Physiol. 36:
E695–E700,
1997.
|
| 267. |
Undrovinas, A. I.,
V. A. Maltsev, and
H. N. Sabbah.
Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current.
Cell Mol. Life Sci.
55:
494–505,
1999.
|
| 268. |
Undrovinas, A. I.,
G. S. Shander, and
J. C. Makielski.
Cytoskeleton modulates gating of voltage‐dependent sodium channel in heart.
Am. J. Physiol.
269:
H203–H214,
1995.
|
| 269. |
Valdivia, C. R.,
R. A. Haworth,
J. N. Wood, and
J. C. Makielski.
Increased late Na+ current from a canine heart failure model and from human heart failure.
Biophys. J.
78:
523,
2000.
(Abstract).
|
| 270. |
Van der Velden, H. M.,
M. J. van Kempen,
M. C. Wijffels,
M. van Zijverden,
W. A. Groenewegen,
M. A. Allessie, and
H. J. Jongsma.
Altered pattern of connexin40 distribution in persistent atrial fibrillation in the goat.
J. Cardiovasc. Electrophysiol.
9:
596–607,
1998.
|
| 271. |
Van Wagoner, D. R.
Mechanosensitive gating of atrial ATP‐sensitive potassium channels.
Circ. Res.
72:
973–983,
1993.
|
| 272. |
Van Wagoner, D. R.,
A. L. Pond,
P. M. McCarthy,
J. S. Trimmer, and
J. M. Nerbonne.
Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation.
Circ. Res.
80:
772–781,
1997.
|
| 273. |
Van, W. D.,
A. L. Pond,
M. Lamorgese,
S. S. Rossie,
P. M. McCarthy, and
J. M. Nerbonne.
Atrial L‐type Ca2+ currents and human atrial fibrillation.
Circ. Res.
85:
428–436,
1999.
|
| 274. |
Vandenberg, J. I.,
G. C. Bett, and
T. Powell.
Contribution of a swelling‐activated chloride current to changes in the cardiac action potential.
Am. J. Physiol.
273
Cell Physiol. 42:
C541–C547,
1997.
|
| 275. |
Vandenberg, J. I.,
S. A. Rees,
A. R. Wright, and
T. Powell.
Cell swelling and ion transport pathways in cardiac myocytes.
Cardiovasc. Res.
32:
85–97,
1996.
|
| 276. |
Vassalle, M.,
H. Yu, and
I. S. Cohen.
The pacemaker current in cardiac Purkinje myocytes.
J. Gen. Physiol.
106:
559–578,
1995.
|
| 277. |
Vassort, G. and
J. Alvarez.
Cardiac T‐type calcium current: pharmacology and roles in cardiac tissues.
J. Cardiovasc. Electrophysiol.
5:
376–393,
1994.
|
| 278. |
Ver, A.,
I. Szanto,
T. Banyasz,
P. Csermely,
E. Vegh, and
J. Somogyi.
Changes in the expression of Na+/K+‐ATPase isoenzymes in the left ventricle of diabetic rat hearts: effect of insulin treatment.
Diabetologia
40:
1255–1262,
1997.
|
| 279. |
Vermeulen, J. T.
Mechanisms of arrhythmias in heart failure.
J. Cardiovasc. Electrophysiol.
9:
208–221,
1998.
|
| 280. |
Vikstrom, K. L.,
S. M. Factor, and
L. A. Leinwand.
Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy.
Mol. Med.
2:
556–567,
1996.
|
| 281. |
Wallis, W. R.,
C. Wu,
D. J. Sheridan, and
C. H. Fry.
Intracellular pH and H+ buffering capacity in guinea‐pigs with left ventricular hypertrophy induced by constriction of the thoracic aorta.
Exp. Physiol.
82:
227–230,
1997.
|
| 282. |
Wang, D. W.,
T. Kiyosue,
S. Shigematsu, and
M. Arita.
Abnormalities of K+ and Ca2+ currents in ventricular myocytes from rats with chronic diabetes.
Am. J. Physiol.
269
Heart Circ. Physiol. 38:
H1288–H1296,
1995.
|
| 283. |
Wang, D. W.,
K. Yazawa,
A. L. George, Jr., and
P. B. Bennett.
Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome.
Proc. Natl. Acad. Sci. U.S.A.
93:
13200–13205,
1996.
|
| 284. |
Wang, D. W.,
K. Yazawa,
N. Makita,
A. L. George, Jr., and
P. B. Bennett.
Pharmacological targeting of long QT mutant sodium channels.
J. Clin. Invest.
99:
1714–1720,
1997.
|
| 285. |
Wang, J.,
R. H. Schwinger,
K. Frank,
J. Muller‐Ehmsen,
P. Martin‐Vasallo,
T. A. Pressley,
A. Xiang,
E. Erdmann, and
A. A. McDonough.
Regional expression of sodium pump subunits isoforms and Na+‐Ca++ exchanger in the human heart.
J. Clin. Invest.
98:
1650–1658,
1996.
|
| 286. |
Wang, Q.,
M. E. Curran,
I. Splawski,
T. C. Burn,
J. M. Millholland,
T. J. VanRaay,
J. Shen,
K. W. Timothy,
G. M. Vincent,
T. de Jager,
P. J. Schwartz,
J. A. Toubin,
A. J. Moss,
D. L. Atkinson,
G. M. Landes,
T. D. Connors, and
M. T. Keating.
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.
Nat. Genet.
12:
17–23,
1996.
|
| 287. |
Wang, Q.,
J. Shen,
I. Splawski,
D. Atkinson,
Z. Li,
J. L. Robinson,
A. J. Moss,
J. A. Towbin, and
M. T. Keating.
SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome.
Cell
80:
805–811,
1995.
|
| 288. |
Wang, Y. G. and
S. L. Lipsius.
A cellular mechanism contributing to postvagal tachycardia studied in isolated pacemaker cells from cat right atrium.
Circ. Res.
79:
109–114,
1996.
|
| 289. |
Wang, Z.,
B. Fermini, and
S. Nattel.
Sustained depolarization‐induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.
Circ. Res.
73:
1061–1076,
1993.
|
| 290. |
Warmke, J. W. and
B. Ganetzky.
A family of potassium channel genes related to eag in Drosophila and mammals.
Proc. Natl. Acad. Sci. U.S.A.
91:
3438–3442,
1994.
|
| 291. |
Watkins, H.,
A. Rosenzweig,
D. S. Hwang,
T. Levi,
W. McKenna,
C. E. Seidman, and
J. G. Seidman.
Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy
N. Engl. J. Med.
326:
1108–1114,
1992.
|
| 292. |
Wei, J.,
I. C.‐H. Yang,
A. R. Tapper,
K. T. Murray,
P. Viswanathan,
Y. Rudy,
P. B. Bennet,
K. Norris,
J. R. Balser,
D. M. Roden, and
A. L. George.
KCNE1 polymorphism confers risk of drug‐induced Long QT syndrome by altering kinetic properties of IKS potassium channels.
Circulation
100:
1–495,
1999.
(Abstract).
|
| 293. |
Wetzel, G. T. and
T. S. Klitzner.
Developmental cardiac electrophysiology recent advances in cellular physiology.
Cardiovasc. Res.
31
Spec No:
E52–E60,
1996.
|
| 294. |
Wijffels, M. C.,
C. J. Kirchhof,
R. Dorland, and
M. A. Allessie.
Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats.
Circulation
92:
1954–1968,
1995.
|
| 295. |
Wilde, A. A. and
M. J. Janse.
Electrophysiological effects of ATP sensitive potassium channel modulation: implications for arrhythmogenesis.
Cardiovasc. Res.
28:
16–24,
1994.
|
| 296. |
Wright, A. R.,
S. A. Rees,
J. I. Vandenberg,
V. W. Twist, and
T. Powell.
Extracellular osmotic pressure modulates sodiumcalcium exchange in isolated guinea‐pig ventricular myocytes.
J. Physiol. (Lond.)
488:
293–301,
1995.
|
| 297. |
Xu, X. P. and
P. M. Best.
Increase in T‐type calcium current in atrial myocytes from adult rats with growth hormone‐secreting tumors.
Proc. Natl. Acad. Sci. U.S.A.
87:
4655–4659,
1990.
|
| 298. |
Xu, X. P. and
P. M. Best.
Decreased transient outward K+ current in ventricular myocytes from acromegalic rats.
Am. J. Physiol.
260
Heart Circ. Physiol. 29:
H935–H942,
1991.
|
| 299. |
Xu, Z.,
K. P. Patel, and
G. J. Rozanski.
Metabolic basis of decreased transient outward K+ current in ventricular myocytes from diabetic rats.
Am. J. Physiol.
271
Heart Circ. Physiol. 40:
H2190–H2196,
1996.
|
| 300. |
Yan, G. X. and
C. Antzelevitch.
Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST‐segment elevation.
Circulation
100:
1660–1666,
1999.
|
| 301. |
Yang, Q. L.,
A. Sanbe,
H. Osinska,
T. E. Hewett,
R. Klevitsky, and
J. Robbins.
A mouse model of myosin binding protein C in human familial hypertrophic cardiomyopathy.
J. Clin. Invest.
102:
1292–1300,
1998.
|
| 302. |
Yang, W. P.,
P. C. Levesque,
W. A. Little,
M. L. Conder,
P. Ramakrishnan,
M. G. Neubauer and
M. A. Blanar.
Functional expression of two KvLQT1‐related potassium channels responsible for an inherited idiopathic epilepsy.
J. Biol. Chem.
273:
19419–19423,
1998.
|
| 303. |
Yang, W. P.,
P. C. Levesque,
W. A. Little,
M. L. Conder,
F. Y. Shalaby, and
M. A. Blanar.
KvLQT1, a voltage‐gated potassium channel responsible for human cardiac arrhythmias.
Proc. Natl. Acad. Sci. U.S.A.
94:
4017–4021,
1997.
|
| 304. |
Yanowitz, F.,
J. B. Preston, and
J. A. Abildskov.
Functional distribution of right and left stellate innervation to the ventricles. Production of neurogenic electrocardiographic changes by unilateral alteration of sympathetic tone.
Circ. Res.
18:
416–428,
1966.
|
| 305. |
Yao, A.,
Z. Su,
A. Nonaka,
I. Zubair,
K. W. Spitzer,
J. H. Bridge,
G. Muelheims,
J. J. Ross, and
W. H. Barry.
Abnormal myocyte Ca2+ homeostasis in rabbits with pacing‐induced heart failure.
Am. J. Physiol.
275
(Heart Circ. Physiol. 44):
H1441–H1448
1998.
|
| 306. |
Yao, J. A.,
M. Jiang,
J. S. Fan,
Y. Y. Zhou, and
G. N. Tseng.
Heterogeneous changes in K currents in rat ventricles three days after myocardial infarction.
Cardiovasc. Res
44:
132–145,
1999.
|
| 307. |
Yokoshiki, H.,
T. Kohya,
F. Tomita,
N. Tohse,
H. Nakaya,
M. Kanno, and
A. Kitabatake.
Restoration of action potential duration and transient outward current by regression of left ventricular hypertrophy.
J. Mol. Cell. Cardiol.
29:
1331–1339,
1997.
|
| 308. |
Yu, H.,
F. Chang, and
I. S. Cohen.
Pacemaker current i(f) in adult canine cardiac ventricular myocytes.
J. Physiol.
485:
469–483,
1995.
|
| 309. |
Yuan, F.,
N. R. Brandt,
J. M. Pinto,
B. J. Wasserlauf,
R. J. Myerburg, and
A. L. Bassett.
Hypertrophy decreases cardiac KATP channel responsiveness to exogenous and locally generated (glycolytic) ATP.
J. Mol. Cell. Cardiol.
29:
2837–2848,
1997.
|
| 310. |
Yuan, F.,
J. M. Pinto,
Q. Li,
B. J. Wasserlauf,
X. Yang,
A. L. Bassett, and
R. J. Myerburg.
Characteristics of I(K) and its response to quinidine in experimental healed myocardial infarction.
J. Cardiovasc. Electrophysiol.
10:
844–854,
1999.
|
| 311. |
Yue, D. T. and
E. Marban.
A novel cardiac potassium channel that is active and conductive at depolarized potentials.
Pflugers Arch.
413:
127–133,
1988.
|
| 312. |
Yue, L.,
J. Feng,
R. Gaspo,
G. R. Li,
Z. Wang, and
S. Nattel.
Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation.
Circ. Res.
81:
512–525,
1997.
|
| 313. |
Yue, L.,
P. Melnyk,
R. Gaspo,
Z. Wang and
S. Nattel.
Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation.
Circ. Res.
84:
776–784,
1999.
|
| 314. |
Zahler, R.,
M. Gilmore‐Hebert,
W. Sun, and
E. J. Benz.
Na, K‐ATPase isoform gene expression in normal and hypertrophied dog heart.
Basic Res. Cardiol.
91:
256–266,
1996.
|
| 315. |
Zareba, W.,
A. J. Moss,
P. J. Schwartz,
G. M. Vincent,
J. L. Robinson,
S. G. Priori,
J. Benhorin,
E. H. Locati,
J. A. Towbin,
M. T. Keating,
M. H. Lehmann, and
W. J. Hall.
Influence of the genotype on the clinical course of the Long‐QT syndrome.
N. Engl. J. Med.
339:
960–965,
1998.
|
| 316. |
Zhou, Z.,
Q. Gong,
M. L. Epstein, and
C. T. January.
HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects.
J. Biol. Chem.
273:
21061–21066,
1998.
|
| 317. |
Zhou, Z.,
Q. Gong,
B. Ye,
Z. Fan,
J. C. Makielski,
G. A. Robertson, and
C. T. January.
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.
Biophys. J.
74:
230–241,
1998.
|
| 318. |
Zhou, Z. and
C. T. January.
Both T‐ and L‐type Ca2+ channels can contribute to excitation‐contraction coupling in cardiac Purkinje cells.
Biophys. J.
74:
1830–1839,
1998.
|
| 319. |
Zhou, Z. and
S. L. Lipsius.
T‐type calcium current in latent pacemaker cells isolated from cat right atrium.
J. Mol. Cell. Cardiol.
26:
1211–1219,
1994.
|
| 320. |
Zygmunt, A. C. and
W. R. Gibbons.
Properties of the calciumactivated chloride current in heart.
J. Gen. Physiol.
99:
391–414,
1992.
|
