Comprehensive Physiology Wiley Online Library

5‐Hydroxytryptamine and Other Amines in the Lungs

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 5‐Hydroxytryptamine Uptake
1.1 Characterization of Uptake Process
1.2 Localization of Uptake Process
1.3 Monoamine Oxidases of Pulmonary Endothelial Cells
1.4 Pharmacological Inhibition of Uptake Process
1.5 Efflux of Accumulated 5‐Hydroxytryptamine
1.6 Uptake in Isolated and Cultured Endothelial Cells
1.7 Uptake and Platelet‐Lung Relationships
1.8 Uptake by the Lung and Pharmacological Action of 5‐Hydroxytryptamine on Pulmonary Circulation
2 Norepinephrine Uptake
2.1 Characterization of Uptake Process
2.2 Localization of Uptake Process
2.3 l‐Norepinephrine Uptake by Isolated Endothelial Cells
2.4 l‐Norepinephrine Uptake by the Lung: Uptake 1 (Neuronal) or Uptake 2 (Extraneuronal)
3 Effects of Experimental and Clinical Conditions on 5‐Hydroxytryptamine and Norepinephrine Uptake
3.1 Experimental Conditions
3.2 Application to Human Clinical Problems
4 Other Naturally Occurring Catecholamines
4.1 β‐Phenylethylamine
4.2 Dopamine
4.3 Epinephrine
4.4 Octopamine
5 Sympathomimetic Drugs
5.1 Metaraminol
5.2 Isoprenaline
5.3 Mescaline
6 Histamine
7 Uptake of Basic Amines by the Lung
8 Conclusion
Figure 1. Figure 1.

Schematic illustration of 3 main processes involved in handling of amines by pulmonary circulation. C in process 1 (carrier‐mediated process) represents carrier.

Figure 2. Figure 2.

Degradation of 5‐hydroxytryptamine.

Figure 3. Figure 3.

Degradation of norepinephrine.

Figure 4. Figure 4.

Chemical structure of major endogenous catecholamines and certain sympathomimetic drugs.

Figure 5. Figure 5.

Chemical structure of histamine.

Figure 6. Figure 6.

Chemical structure of some basic amines taken up by the lung.



Figure 1.

Schematic illustration of 3 main processes involved in handling of amines by pulmonary circulation. C in process 1 (carrier‐mediated process) represents carrier.



Figure 2.

Degradation of 5‐hydroxytryptamine.



Figure 3.

Degradation of norepinephrine.



Figure 4.

Chemical structure of major endogenous catecholamines and certain sympathomimetic drugs.



Figure 5.

Chemical structure of histamine.



Figure 6.

Chemical structure of some basic amines taken up by the lung.

References
 1. Alabaster, V. A. Inactivation of endogenous amines in the lungs. In: Lung Biology in Health and Disease. Metabolic Functions of the Lung, edited by Y. S. Bakhle and J. R. Vane. New York: Dekker, 1977, vol. 4, chapt. 1, p. 3–31.
 2. Alabaster, V. A., and Y. S. Bakhle. Removal of 5‐hydroxy‐tryptamine in the pulmonary circulation of rat isolated lungs. Br. J. Pharmacol. 40: 468–482, 1970.
 3. Alabaster, V. A., and Y. S. Bakhle. The removal of nor‐adrenaline in the pulmonary circulation of rat isolated lungs. Br. J. Pharmacol. 47: 325–331, 1973.
 4. Al‐Ubaidi, F., and Y. S. Bakhle. Metabolism of vasoactive hormones in human isolated lung. Clin. Sci. 58: 45–51, 1980.
 5. Anderson, M. W., T. C. Orton, R. D. Pickett, and T. E. Eling. Accumulation of amines in the isolated perfused rabbit lung. J. Pharmacol. Exp. Ther. 189: 456–466, 1974.
 6. Axelrod, J., and J. K. Inscoe. The uptake and binding of circulating serotonin and the effect of drugs. J. Pharmacol. Exp. Ther. 141: 161–165, 1963.
 7. Bakhle, Y. S., and R. R. Ben‐Harari. Effects of oestrous cycle and exogenous ovarian steroids on 5‐hydroxytryptamine metabolism in rat lung. J. Physiol. London 291: 11–18, 1979.
 8. Bakhle, Y. S., and R. R. Ben‐Harari. Effects of the oestrous cycle and exogenous ovarian steroids on metabolism of ã‐phenylethylamine in rat lung. Br. J. Pharmacol. 67: 109–114, 1979.
 9. Bakhle, Y. S., and A. J. Block. Effects of halothane on pulmonary inactivation of noradrenaline and prostaglandin E2 in anaesthetized dogs. Clin. Sci. Mol. Med. 50: 87–90, 1976.
 10. Bakhle, Y. S., J. Hartiala, H. Toivonen, and P. Uotila. Effects of cigarette smoke on the metabolism of vasoactive hormones in rat isolated lungs. Br. J. Pharmacol. 65: 495–499, 1979.
 11. Bakhle, Y. S., and J. R. Vane. Pharmacokinetic function of the pulmonary circulation. Physiol. Rev. 54: 1007–1045, 1974.
 12. Bakhle, Y. S., and M. B. H. Youdim. The metabolism of 5‐hydroxytryptamine and ã‐phenylethylamine in perfused rat lung and in vitro. Br. J. Pharmacol. 65: 147–154, 1979.
 13. Ben‐Harari, R. R., and Y. S. Bakhle. Uptake of ã‐phenylethylamine in rat isolated lung. Biochem. Pharmacol. 29: 489–494, 1980.
 14. Bennett, A. The metabolism of histamine by guinea‐pig and rat lung in vitro. Br. J. Pharmacol. 24: 147–155, 1965.
 15. Block, E. R. Recovery from hyperoxic depression of pulmonary 5‐hydroxytryptamine clearance: effect of inspired O2 tension. Lung 155: 131–140, 1978.
 16. Block, E. R., and J. K. Cannon. Effect of oxygen exposure on lung clearance of amines. Lung 155: 287–295, 1978.
 17. Block, E. R., and A. B. Fisher. Depression of serotonin clearance by rat lungs during oxygen exposure. J. Appl. Physiol: Respirat. Environ. Exercise Physiol. 42: 33–38, 1977.
 18. Block, E. R., and A. B. Fisher. Effect of hyperbaric oxygen exposure on pulmonary clearance of 5‐hydroxytryptamine. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 43: 254–257, 1977.
 19. Block, E. R., and A. B. Fisher. Prevention of hyperoxic‐induced depression of pulmonary serotonin clearance by pretreatment with superoxide dismutase. Am. Rev. Respir. Dis. 116: 441–447, 1977.
 20. Block, E. R., and F. J. Schoen. Effect of alpha naphthylthiourea on uptake of 5‐hydroxytryptamine from the pulmonary circulation. Am. Rev. Respir. Dis. 123: 69–73, 1981.
 21. Boileau, J. C., L. Campeau, and P. Biron. Pulmonary fate of histamine, isoproterenol, physalaemin, and substance P. Can. J. Physiol. Pharmacol. 48: 681–684, 1970.
 22. Boileau, J. C., L. Campeau, and P. Biron. Comparative pulmonary fate of intravenous epinephrine. Rev. Can. Biol. 30: 281–286, 1971.
 23. Boileau, J. C., C. Crexells, and P. Biron. Free pulmonary passage of dopamine. Rev. Can. Biol. 31: 69–72, 1972.
 24. Briant, R. H., E. W. Blackwell, F. M. Williams, D. S. Da Vies, and C. T. Dollery. The metabolism of sympathomimetic bronchodilator drugs by the isolated perfused dog lung. Xenobiotica 3: 787–799, 1973.
 25. Catravas, J. D., and C. N. Gillis. Pulmonary clearance of [14C]5‐hydroxytryptamine and [3H]norepinephrine in vivo: effects of pretreatment with imipramine or cocaine. J. Pharmacol. Exp. Ther. 213: 120–127, 1980.
 26. Coquil, J. F., C. Goridis, G. Mack, and N. H. Neff. Monoamine oxidase in rat arteries: evidence for different forms and selective localization. Br. J. Pharmacol. 48: 590–599, 1973.
 27. Crawford, N. The lungs and serotonin metabolism: a study of the pulmonary arterio‐venous levels of plasma free and platelet‐bound serotonin in man. Clin. Chim. Acta 12: 264–273, 1965.
 28. Cronau, L. H., M. D. Kerstein, S. Mandel, and C. N. Gillis. 5‐Hydroxytryptamine extraction by the lung. Surg. Gynecol. Obstet. 143: 51–55, 1976.
 29. Cross, S. A. M., V. A. Alabaster, Y. S. Bakhle, and J. R. Vane. Sites of uptake of 3H‐5‐hydroxytryptamine in rat isolated lung. Histochemistry 39: 83–91, 1974.
 30. Davila, D., and T. Davila. Uptake and release of 3H‐metaraminol by rat lung. Basic aspects, ionic and energy requirements. Arch. Int. Pharmacodyn. Ther. 214: 53–61, 1975.
 31. Davila, T., and D. Davila. Uptake and release of 3H‐metar‐aminol by rat lung. The influence of various drugs. Arch. Int. Pharmacodyn. Ther. 215: 336–344, 1975.
 32. Davis, R. B., and Y. Wang. Rapid pulmonary removal of 5‐hydroxytryptamine in the intact dog. Proc. Soc. Exp. Biol. Med. 118: 797–800, 1965.
 33. Dollery, C. T., and A. F. Junod. Concentration of (+/‐)‐propranolol in isolated perfused lungs of rat. Br. J. Pharmacol. 57: 67–71, 1976.
 34. Eichholtz, F., and E. B. Verney. On some conditions affecting the perfusion of isolated mammalian organs. J. Physiol. London 59: 340–344, 1924‐1925.
 35. Eiseman, B., L. Bryant, and T. Waltuch. Metabolism of vasomotor agents by the isolated perfused lung. J. Thorac. Cardiovasc. Surg. 48: 798–806, 1964.
 36. Eling, T. E., R. D. Pickett, T. C. Orton, and M. W. Anderson. A study of the dynamics of imipramine accumulation in the isolated perfused rabbit lung. Drug Metab. Dispos. 3: 389–399, 1975.
 37. Ferreira, S. H., K. K. Ng, and J. R. Vane. The continuous bioassay of the release and disappearance of histamine in the circulation. Br. J. Pharmacol. 49: 543–553, 1973.
 38. Fisher, A. B., and G. G. Pietra. Comparison of serotonin uptake from the alveolar and capillary spaces of isolated rat lung. Am. Rev. Respir. Dis. 123: 74–78, 1981.
 39. Fisher, A. B., H. Steinberg, and C. Dodia. Reversal of 2‐deoxyglucose inhibition of serotonin uptake in isolated guinea pig lung. J. Appl. Physiol: Respirat. Environ. Exercise Physiol. 46: 447–450, 1979.
 40. Fishman, A. P., and G. G. Pietra. Handling of bioactive materials by the lung. Pt. 1. N. Engl. J. Med. 291: 884–890, 1974.
 41. Fishman, A. P., and G. G. Pietra. Handling of bioactive materials by the lung. Pt. 2. N. Engl. J. Med. 291: 953–959, 1974.
 42. Fowler, C. J., B. A. Callingham, T. J. Mantle, and K. F. Tipton. Monoamine oxidase A and B: a useful concept? Biochem. Pharmacol. 27: 97–101, 1978.
 43. Gaddum, J. H., C. O. Hebb, A. Silver, and A. A. B. Swan. 5‐Hydroxytryptamine. Pharmacological action and destruction in perfused lungs. Q. J. Exp. Physiol. 38: 255–262, 1953.
 44. Gallagher, B., D. Christman, J. Fowler, R. McGregor, A. P. Wolf, P. Som, A. N. Ansari, and H. Atkins. Radioisotope scintigraphy for the study of dynamics of amine regulation by the human lung. Chest 71, Suppl.: 282–284, 1977.
 45. Geddes, D. M., K. Nesbitt, T. Traill, and J. P. Blackburn. First pass uptake of 14C‐propranolol by the lung. Thorax 34: 810–813, 1979.
 46. Gewitz, M. H., and C. N. Gillis. Uptake and metabolism of biogenic amines in the developing rabbit lung. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50: 118–122, 1981.
 47. Gillis, C. N. Metabolism of vasoactive hormones by lung. Anesthesiology 39: 626–632, 1973.
 48. Gillis, C. N., L. H. Cronau, N. M. Greene, and G. L. Hammond. Removal of 5‐hydroxytryptamine and norepinephrine from the pulmonary vascular space of man: influence of cardiopulmonary bypass and pulmonary arterial pressure on these processes. Surgery 76: 608–616, 1974.
 49. Gillis, C. N., L. H. Cronau, S. Mandel, and G. L. Hammond. Indicator dilution measurement of 5‐hydroxytryptamine clearance by human lung. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 1178–1183, 1979.
 50. Gillis, C. N., and N. M. Greene. Possible clinical implications of metabolism of bloodborne substrates by the human lung. In: Lung Biology in Health and Disease. Metabolic Functions of the Lung, edited by Y. S. Bakhle and J. R. Vane. New York: Dekker, 1977, vol. 4, chapt. 6, p. 173–193.
 51. Gillis, C. N., N. M. Greene, L. H. Cronau, and G. L. Hammond. Pulmonary extraction of 5‐hydroxytryptamine and norepinephrine before and after cardiopulmonary bypass in man. Circ. Res. 30: 666–674, 1972.
 52. Gillis, C. N., R. J. Huxtable, and R. A. Roth. Effects of monocrotaline pretreatment of rats on removal of 5‐hydroxytryptamine and noradrenaline by perfused lung. Br. J. Pharmacol. 63: 435–443, 1978.
 53. Gillis, C. N., and Y. Iwasawa. Technique for measurement of norepinephrine and 5‐hydroxytryptamine uptake by rabbit lung. J. Appl. Physiol. 33: 404–408, 1972.
 54. Gillis, C. N., and J. A. Roth. Pulmonary disposition of circulating vasoactive hormones. Biochem. Pharmacol. 25: 2547–2553, 1976.
 55. Gillis, C. N., and J. A. Roth. The fate of biogenic monoamines in perfused rabbit lung. Br. J. Pharmacol. 59: 585–590, 1977.
 56. Ginn, R., and J. R. Vane. Disappearance of catecholamines from the circulation. Nature London 219: 740–742, 1968.
 57. Gruby, L. A., C. Rowlands, B. Q. Varley, and J. H. Wyllie. The fate of 5‐hydroxytryptamine in the lungs. Br. J. Surg. 58: 525–532, 1971.
 58. Heinemann, H. O., and A. P. Fishman. Nonrespiratory functions of mammalian lung. Physiol. Rev. 49: 1–47, 1969.
 59. Hughes, J., C. N. Gillis, and F. E. Bloom. The uptake and disposition of dl‐norepinephrine in perfused rat lung. J. Pharmacol. Exp. Ther. 169: 237–248, 1969.
 60. Huxtable, R., D. Ciaramitaro, and D. Eisenstein. The effect of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium. Mol. Pharmacol. 14: 1189–1203, 1978.
 61. Iversen, L. L. Uptake mechanisms for neurotransmitter amines. Biochem. Pharmacol. 23: 1927–1935, 1974.
 62. Iwasawa, Y., and C. N. Gillis. Effect of steroid and other hormones on lung removal of noradrenaline. Eur. J. Pharmacol. 22: 367–370, 1973.
 63. Iwasawa, Y., and C. N. Gillis. Pharmacological analysis of norepinephrine and 5‐hydroxytryptamine removal from the pulmonary circulation: differentiation of uptake sites for each amine. J. Pharmacol. Exp. Ther. 188: 386–393, 1974.
 64. Iwasawa, Y., C. N. Gillis, and G. Aghajanian. Hypothermic inhibition of 5‐hydroxytryptamine and norepinephrine uptake by lung: cellular location of amines after uptake. J. Pharmacol. Exp. Ther. 186: 498–507, 1973.
 65. Junod, A. F. Accumulation of 14C‐imipramine in isolated perfused rat lungs. J. Pharmacol. Exp. Ther. 183: 182–187, 1972.
 66. Junod, A. F. Uptake, metabolism and efflux of 14C‐5‐hydroxytryptamine in isolated, perfused rat lungs. J. Pharmacol. Exp. Ther. 183: 341–355, 1972.
 67. Junod, A. F. Mechanism of uptake of biogenic amines in the pulmonary circulation. In: Lung Metabolism, edited by A. F. Junod and R. de Haller. London: Academic, 1975, p. 387–398.
 68. Junod, A. F. Metabolism, production, and release of hormones and mediators in the lung. Am. Rev. Respir. Dis. 112: 93–108, 1975.
 69. Junod, A. F. Uptake, release and metabolism of drugs in the lungs. In: International Encyclopedia of Pharmacology and Therapeutics. Respiratory Pharmacology, edited by J. G. Widdicombe. Oxford, UK: Pergamon, 1981, p. 733–745.
 70. Junod, A. F., and C. Ody. Amine uptake and metabolism by endothelium of pig pulmonary artery and aorta. Am. J. Physiol. 232 (Cell Physiol.1): C88–C94, 1977.
 71. Krell, R. D., J. McCoy, and P. Christian. Accumulation and metabolism of [14C] histamine by rat lung in vivo. Biochem. Pharmacol. 27: 820–821, 1978.
 72. Larmi, T. K. I., and E. Heikkinen. Pulmonary degradation and cardiovascular effects of intracavally infused 5‐hydroxytryptamine in man. Scand. J. Thorac. Cardiovasc. Surg. 1: 123–126, 1967.
 73. Lilja, B., and S. E. Lindell. Metabolism of [14C]histamine in heart‐lung‐liver preparations of cats. Br. J. Pharmacol. 16: 203–208, 1961.
 74. McEwen, C. M., Jr., K. T. Cullen, and A. J. Sober. Rabbit serum monoamine oxidase. Purification and characterization. J. Biol. Chem. 241: 4544–4556, 1966.
 75. Minchin, R. F., B. W. Madsen, and K. F. Ilett. Effect of desmethylimipramine on the kinetics of chlorphentermine accumulation in isolated perfused rat lung. J. Pharmacol. Exp. Ther. 211: 514–518, 1979.
 76. Naito, H., and C. N. Gillis. Effects of halothane and nitrous oxide on removal of norepinephrine from the pulmonary circulation. Anesthesiology 39: 575–580, 1973.
 77. Nicholas, T. E., J. M. Strum, L. S. Angelo, and A. F. Junod. Site and mechanism of uptake of 3H‐l‐norepinephrine by isolated perfused rat lungs. Circ. Res. 35: 670–680, 1974.
 78. Orton, T. C., M. W. Anderson, R. D. Pickett, T. E. Eling, and J. R. Fouts. Xenobiotic accumulation and metabolism by isolated perfused rabbit lungs. J. Pharmacol. Exp. Ther. 186: 482–497, 1973.
 79. Pearson, J. D., H. J. Olverman, and J. L. Gordon. Transport of 5‐hydroxytryptamine by endothelial cells. Biochem. Soc. Trans. 5: 1181–1183, 1977.
 80. Philpot, R. M., M. W. Anderson, and T. E. Eling. Uptake, accumulation and metabolism of chemicals by the lung. In: Lung Biology in Health and Disease. Metabolic Functions of the Lung, edited by Y. S. Bakhle and J. R. Vane. New York: Dekker, 1977, vol. 4, chapt. 5, p. 123–171.
 81. Pickett, R. D., M. W. Anderson, T. C. Orton, and T. E. Eling. The pharmacodynamics of 5‐hydroxytryptamine uptake and metabolism by the isolated perfused rabbit lung. J. Pharmacol. Exp. Ther. 194: 545–553, 1975.
 82. Rickaby, D. A., C. A. Dawson, and M. B. Maron. Pulmonary inactivation of serotonin and site of serotonin pulmonary vasoconstriction. J. Appl. Physiol: Respirat. Environ. Exercise Physiol. 48: 606–612, 1980.
 83. Rosenbloom, P. M., and A. D. Bass. A lung perfusion preparation for the study of drug metabolism. J. Appl. Physiol. 29: 138–144, 1970.
 84. Roth, J. A., and C. N. Gillis. Deamination of ã‐phenylethylamine by monoamine oxidase‐inhibition by imipramine. Biochem. Pharmacol. 23: 2537–2545, 1974.
 85. Roth, J. A., and C. N. Gillis. Multiple forms of amine oxidase in perfused rabbit lung. J. Pharmacol. Exp. Ther. 194: 537–544, 1975.
 86. Roth, R. A., and C. N. Gillis. Effect of ventilation and pH on removal of mescaline and biogenic amines by rabbit lung. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 44: 553–558, 1978.
 87. Roth, R. A., Jr., J. A. Roth, and C. N. Gillis. Disposition of 14C‐mescaline by rabbit lung. J. Pharmacol. Exp. Ther. 200: 394–401, 1977.
 88. Roth, R. A., and K. B. Wallace. Disposition of biogenic amines and angiotensin I by lungs of spontaneously hypertensive rats. Am. J. Physiol. 239 (Heart Circ. Physiol. 8): H736–H741, 1980.
 89. Roth, R. A., K. B. Wallace, R. H. Alper, and M. D. Bailie. Effect of paraquat treatment of rats on disposition of 5‐hydroxytryptamine and angiotensin I by perfused lung. Biochem. Pharmacol. 28: 2349–2355, 1979.
 90. Sabelli, H. C., R. L. Borison, B. I. Diamond, H. S. Havdala, and N. Narasimhachari. Phenylethylamine and brain function. Biochem. Pharmacol. 27: 1729–1730, 1978.
 91. Said, S. I. The lung as a metabolic organ. N. Engl. J. Med. 279: 1330–1334, 1969.
 92. Said, S. I. The lung in relation to vasoactive hormones. Federation Proc. 32: 1972–1975, 1973.
 93. Shepro, D., J. C. Batbouta, L. S. Robblee, M. P. Carson, and F. A. Belamarich. Serotonin transport by cultured bovine aortic endothelium. Circ. Res. 36: 799–805, 1975.
 94. Small, R., E. Macarak, and A. B. Fisher. Production of 5‐hydroxyindoleacetic acid from serotonin by cultured endothelial cells. J. Cell. Physiol. 90: 225–232, 1976.
 95. Sneddon, J. M. Sodium‐dependent accumulation of 5‐hydroxytryptamine by rat blood platelets. Br. J. Pharmacol. 37: 680–688, 1969.
 96. Sole, M. J., M. Drobac, L. Schwartz, M. N. Hussain, and E. F. Vaughan‐Neil. The extraction of circulating catecholamines by the lungs in normal man and in patients with pulmonary hypertension. Circulation 60: 160–163, 1979.
 97. Steinberg, H., D. J. P. Bassett, and A. B. Fisher. Depression of pulmonary 5‐hydroxytryptamine uptake by metabolic inhibitors. Am. J. Physiol. 228: 1298–1303, 1975.
 98. Steinberg, H., and D. K. Das. Competition between platelets and lung for 5‐hydroxytryptamine uptake. Exp. Lung Res. 1: 121–130, 1980.
 99. Strum, J. M., and A. F. Junod. Radioautographic demonstration of 5‐hydroxytryptamine‐3H uptake by pulmonary endothelial cells. J. Cell Biol. 54: 456–467, 1972.
 100. Thomas, D. P., and J. R. Vane. 5‐Hydroxytryptamine in the circulation of the dog. Nature London 216: 335–338, 1967.
 101. Tissari, A. H., and D. F. Bogdanski. Biogenic amine transport. IV. Comparison of effects of ouabain and K+ deficiency on the transport of 5‐hydroxytryptamine and norepinephrine by synaptosomes. Pharmacology 5: 225–234, 1977.
 102. Vane, J. R. The release and fate of vaso‐active hormones in the circulation. Br. J. Pharmacol. 35: 209–242, 1969.
 103. Whitby, L. G., J. Axelrod, and H. Weil‐Malherbe. The fate of H3‐norepinephrine in animals. J. Pharmacol. Exp. Ther. 132: 193–201, 1961.
 104. White, M. K., H. B. Hechtman, and D. Shepro. Canine lung uptake of plasma and platelet serotonin. Microvasc. Res. 9: 230–241, 1975.
 105. Wilson, A. G. E., F. C. P. Law, T. E. Eling, and M. W. Anderson. Uptake, metabolism and efflux of methadone in “single pass” isolated perfused rabbit lungs. J. Pharmacol. Exp. Ther. 199: 360–367, 1976.
 106. Yang, H.‐Y. T., and N. H. Neff. The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines. J. Pharmacol. Exp. Ther. 189: 733–740, 1974.
 107. Youdim, M. B. H., Y. S. Bakhle, and R. R. Ben‐Harari. Inactivation of monoamines by the lung. In: Metabolic Functions of the Lung. Amsterdam: Excerpta Med., 1980, p. 105–128. (Ciba Found. Symp. 78.)

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Alain F. Junod. 5‐Hydroxytryptamine and Other Amines in the Lungs. Compr Physiol 2011, Supplement 10: Handbook of Physiology, The Respiratory System, Circulation and Nonrespiratory Functions: 337-349. First published in print 1985. doi: 10.1002/cphy.cp030109