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Brain Blood Flow and Control of Breathing

Teodoro V. Santiago, Norman H. Edelman

10.1002/cphy.cp030206

Source: Supplement 11: Handbook of Physiology, The Respiratory System, Control of Breathing

Originally published: 1986

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Control of Brain Blood Flow
1.1 Brain Blood Flow and Metabolism
1.2 Brain Blood Flow Responses to Hypoxia
1.3 Brain Blood Flow Responses to Alterations of CO2 Tension
1.4 Neural Control of Brain Blood Flow
1.5 Pressure‐Flow Autoregulation
2 Ventilatory Effects of Brain Hypoxia
2.1 Ventilatory Depression
2.2 Ventilatory Stimulation
2.3 Effects of Brain Hypoxia on Respiratory Reflexes
3 Role of Brain Blood Flow in Ventilatory Response to Hypercapnia
4 Brain Ischemia
5 Brain Blood Flow and Sleep
6 Brain Blood Flow and Anesthesia
Figure 1. Figure 1.

Brain blood flow (BBF) of goats is shown for awake state, slow‐wave sleep (SWS), and rapid‐eye‐movement sleep (REM). Bar, 2 SEM. Flow was significantly greater during SWS than during awake state and significantly greater during REM sleep than during other two states.
Figure 2. Figure 2.

Increase in brain blood flow (ΔBBF) of goats from awake state to slow‐wave sleep (SWS, ◯) and to rapid‐eye‐movement sleep (REM, •) is plotted against increase in CO2 tension () in arterial blood. In both states there was a linear relation between increase in BBF and increase in . Slope of response for SWS was approximately equal to that observed during inhalation of CO2 by awake goats (indicated by shaded bar).

From Santiago et al. 138, by copyright permission of The American Society for Clinical Investigation
Figure 3. Figure 3.

Tidal volume (VT), brain blood flow (BBF), and systemic blood pressure (BP) are shown as functions of time for continuous sequence of slow‐wave sleep (SWS), rapid‐eye‐movement sleep (REM), and wakefulness (AWA). There was a general temporal correlation between reduction in VT and increase in BBF during REM sleep.


Figure 1.

Brain blood flow (BBF) of goats is shown for awake state, slow‐wave sleep (SWS), and rapid‐eye‐movement sleep (REM). Bar, 2 SEM. Flow was significantly greater during SWS than during awake state and significantly greater during REM sleep than during other two states.



Figure 2.

Increase in brain blood flow (ΔBBF) of goats from awake state to slow‐wave sleep (SWS, ◯) and to rapid‐eye‐movement sleep (REM, •) is plotted against increase in CO2 tension () in arterial blood. In both states there was a linear relation between increase in BBF and increase in . Slope of response for SWS was approximately equal to that observed during inhalation of CO2 by awake goats (indicated by shaded bar).

From Santiago et al. 138, by copyright permission of The American Society for Clinical Investigation


Figure 3.

Tidal volume (VT), brain blood flow (BBF), and systemic blood pressure (BP) are shown as functions of time for continuous sequence of slow‐wave sleep (SWS), rapid‐eye‐movement sleep (REM), and wakefulness (AWA). There was a general temporal correlation between reduction in VT and increase in BBF during REM sleep.

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Article Title: Brain Blood Flow and Control of Breathing
 

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Teodoro V. Santiago, Norman H. Edelman. Brain Blood Flow and Control of Breathing. Compr Physiol 2011, Supplement 11: Handbook of Physiology, The Respiratory System, Control of Breathing: 163-179. First published in print 1986. doi: 10.1002/cphy.cp030206