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Effects of Temperature on Breathing

K. E. Cooper, W. L. Veale

10.1002/cphy.cp030220

Source: Supplement 11: Handbook of Physiology, The Respiratory System, Control of Breathing

Originally published: 1986

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Effects of Raising Body Temperature in Humans
2 Use of Respiratory Tract as Thermoregulatory Mechanism
2.1 Panting
2.2 Carotid Rete Mechanism
3 Stimulation of Skin by Cold Water and Breathing Pattern
4 Breathing Changes in Fever and Hypothermia
4.1 Fever
4.2 Hypothermia
5 General Considerations of Interaction of Body Temperature and Acid‐Base Homeostasis
References
 1. Albers, C., K. H. Götz, and P. Welbers. Oxygen transport and acid‐base balance in the blood of the sheatfish, Silurus glanis. Respir. Physiol. 46: 223–236, 1981.
 2. Ask‐Upmark, E. The Carotid Sinus and the Cerebral Circulation. An Anatomical, Experimental, and Clinical Investigation Including Some Observations on Rete Mirabile Caroticum. Lund, Sweden: Berlingska Boktryckeriet, 1935, p. 126–181.
 3. Baker, M. A., and J. N. Hayward. Carotid rete and brain temperature of cat. Nature London 216: 139–141, 1967.
 4. Baker, M. A., and J. N. Hayward. The influence of the nasal mucosa and the carotid rete upon hypothalamic temperature in sheep. J. Physiol. London 198: 561–579, 1968.
 5. Bannister, R. G., D. J. C. Cunningham, and G. G. Douglas. The carbon dioxide stimulus to breathing in severe exercise. J. Physiol. London 125: 90–117, 1954.
 6. Barltrop, D. The relation between body temperature and respiration (Abstract). J. Physiol. London 125: 19P–20P, 1954.
 7. Bazett, H. C. Studies on the effects of baths on man. I. Relationship between the effects produced and the temperature of the bath. Am. J. Physiol. 70: 412–429, 1924.
 8. Bazett, H. C., and J. B. S. Haldane. Some effects of hot baths on man (Abstract). J. Physiol. London 55: 4P, 1921.
 9. Bech, C., W. Rautenberg, B. May, and K. Johansen. Effect of spinal cord temperature on carotid blood flow in the Pekin duck. Pfluegers Arch. 385: 269–271, 1980.
 10. Bickler, P. E. Effect of temperature on acid‐base balance and ventilation in desert iguanas. J. Appl. Physiol: Respirat. Environ. Exercise Physiol. 51: 452–460, 1981.
 11. Bligh, J. The receptors concerned in the thermal stimulus to panting in sheep. J. Physiol. London 146: 142–151, 1959.
 12. Bligh, J. Temperature Regulation in Mammals and Other Vertebrates. New York: Elsevier, 1973, p. 66–67. (Frontiers Biol. Ser. 30.).
 13. Bligh, J., and T. E. Allen. A comparative consideration of the modes of evaporative heat loss from animals. In: Physiological and Behavorial Temperature Regulation, edited by J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk Springfield, IL: Thomas, 1970, p. 97–107.
 14. Bogert, C. M. How reptiles regulate their body temperature. Sci. Am. 200: 105–120, 1959.
 15. Bouverot, P., G. Hildwein, and D. Le Goff. Evaporative water loss, respiratory pattern, gas exchange and acid‐base balance during thermal panting in Pekin ducks exposed to moderate heat. Respir. Physiol. 21: 255–269, 1974.
 16. Bradley, G. W., C. von Euler, I. Marttila, and B. Roos. Steady state effects of CO2 and temperature on the relationship between lung volume and inspiratory duration (Hering‐Breuer threshold curve). Acta Physiol. Scand. 92: 351–363, 1974.
 17. Brewin, E. G., R. P. Gould, F. S. Nashat, and E. Neil. An investigation of problems of acid‐base equilibrium in hypothermia. Guy's Hosp. Rep. 104: 177–214, 1955.
 18. Cameron, I. R., and S. J. G. Semple. The central respiratory stimulant action of salicylates. Clin. Sci. 35: 391–401, 1968.
 19. Cameron, J. N., and C. V. Batterton. Temperature and blood acid‐base status in the blue crab, Callinectes sapidus. Respir. Physiol. 35: 101–110, 1978.
 20. Carter, N. W., F. C. Rector, Jr., D. S. Campion, and D. W. Seldin. Measurement of intracellular pH of skeletal muscle with pH‐sensitive glass microelectrodes. J. Clin. Invest. 46: 920–933, 1967.
 21. Chatonnet, J., M. Cabanac, and M. Mottaz. Les conditions de températures cérébrale et cutanée moyenne pour l'apparition de la polypnée thermique chez le chien. C. R. Seances Soc. Biol. Paris 158: 1354–1356, 1964.
 22. Comroe, J. H., Jr. The hyperpnea of muscular exercise. Physiol. Rev. 24: 319–339, 1944.
 23. Cooper, K. E. Temperature regulation and its disorders. In: Recent Advances in Medicine (15th ed.), edited by D. N. Baron, N. Compston, and A. M. Dawson London: Churchill, 1968, p. 343–350.
 24. Cooper, K. E., and C. A. Guenter. The effect of pulmonary ventilation of drugs which influence body temperature. In: Respiratory Pharmacology, edited by J. G. Widdicombe Oxford, UK: Pergamon, 1981, p. 259–267. (Int. Encyclopedia Pharmacol. Ther., sect. 104.).
 25. Cooper, K. E., E. Preston, and W. L. Veale. Effects of atropine, injected into a lateral cerebral ventricle of the rabbit, on fevers due to intravenous leucocyte pyrogen and hypothalamic and intraventricular injections of prostaglandin E1. J. Physiol. London 254: 729–741, 1976.
 26. Cotes, J. E. The role of body temperature in controlling ventilation during exercise in one normal subject breathing oxygen. J. Physiol. London 129: 554–563, 1955.
 27. Cranston, W. I., M. C. Pepper, and D. N. Ross. Carbon dioxide and control of respiration during hypothermia. J. Physiol. London 127: 380–389, 1955.
 28. Crawshaw, L. I. Effect of rapid temperature change on mean body temperature and gill ventilation in carp. Am. J. Physiol. 231: 837–841, 1976.
 29. Cullen, G. E., H. R. Kegler, and H. W. Robinson. The pK' of the Henderson‐Hasselbalch equation for hydrion concentration of serum. J. Biol. Chem. 66: 301–322, 1925.
 30. Cunningham, D. J. C. Integrative aspects of the regulation of breathing: a personal view. In: Respiratory Physiology I, edited by J. G. Widdicombe Baltimore, MD: University Park, 1974, vol. 2, p. 311. (Int. Rev. Physiol. Ser.).
 31. Cunningham, D. J. C., and J. L. H. O'Riordan. The effect of a rise in the temperature of the body on the respiratory response to carbon dioxide at rest. Q. J. Exp. Physiol. 42: 329–345, 1957.
 32. Currie, J. Medical Reports on the Effects of Water Cold and Warm as a Remedy in Fever and Other Diseases. Appendix II. An Account of the Remarkable Effects of a Shipwreck on the Mariners; With Experiments and Observations on the Influence of Immersion in Fresh and Salt Waters, Hot and Cold, on the Process of the Living Body (2nd. ed.). Liverpool, England: McCreery, 1798, p. 20–45.
 33. Davies, D. G. Temperature‐induced changes in blood acidbase status in the alligator, Alligator mississipiensis. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45: 922–926, 1978.
 34. Dawson, T. J. Primitive mammals and patterns in the evolution of thermoregulation. In: Essays on Temperature Regulation, edited by J. Bligh and R. Moore Amsterdam: North‐Holland, 1972, p. 1–18.
 35. Dawson, W. R., and G. A. Bartholomew. Metabolic and cardiac responses to temperature in the lizard (Dipsosaurus dorsales). Physiol. Zool. 31: 100–111, 1958.
 36. Euler, C. von, F. Herrero, and I. Wexler. Control mechanisms determining rate and depth of respiratory movements. Respir. Physiol. 10: 93–108, 1970.
 37. Euler, C. von, and T. Trippenbach. Temperature effects on the inflation reflex during expiratory time in the cat. Acta Physiol. Scand. 96: 338–350, 1976.
 38. Findlay, J. D., and J. R. S. Hales. Hypothalamic temperature and the regulation of respiration of the ox exposed to severe heat. J. Physiol. London 203: 651–663, 1969.
 39. Findlay, J. D., and D. L. Ingram. Brain temperature as a factor in the control of thermal polypnoea in the ox (Bos taurus). J. Physiol. London 155: 72–85, 1961.
 40. Fleming, R. Acid‐base balance of the blood in dogs at reduced body temperature. Arch. Surg. Chicago 68: 145–152, 1954.
 41. Frankel, H. M., J. Seitz, and W. Nolan. Arterial PaCO2 during chronic hyperthermia in sheep. Pfluegers Arch. 384: 143–147, 1980.
 42. Furuya, T., and T. Kubota. Physiological reaction of men under exercise to radiant heat. Bull. Tokyo Med. Dent. Univ. 22: 79–92, 1975.
 43. Goode, R. C. Acute responses to cold water. In: Proc. Cold Water Symp. Toronto: Royal Life Saving Soc. Canada, 1976, p. 19–22.
 44. Grunstein, M. M., W. M. Fisk, L. A. Leiter, and J. Milic‐Emili. Effect of body temperature on respiratory frequency in anesthetized cats. J. Appl. Physiol. 34: 154–159, 1973.
 45. Haldane, J. S. The influence of high air temperatures. J. Hyg. 5: 494–513, 1905.
 46. Hales, J. R. S. Effects of heat stress on blood flow in respiratory and non‐respiratory muscles in the sheep: an explanation of the apparent high efficiency of panting. Pfluegers Arch. 345: 119–132, 1973.
 47. Hales, J. R. S. Physiological responses to heat. In: Environmental Physiology I, edited by D. Robertshaw Baltimore, MD: University Park, 1974, vol. 7, p. 134–137. (Int. Rev. Physiol. Ser.).
 48. Hales, J. R. S., J. W. Bennett, and R. A. Dampney. Influence of chronic denervation of the carotid bifurcation regions on panting in the sheep. Pfluegers Arch. 360: 243–253, 1975.
 49. Hales, J. R. S., and J. D. Findlay. Respiration of the ox: normal values and the effects of exposure to hot environments. Respir. Physiol. 4: 33–352, 1968.
 50. Hales, J. R. S., and J. D. Findlay. The oxygen cost of thermally‐induced and CO2‐induced hyperventilation in the ox. Respir. Physiol. 4: 353–362, 1968.
 51. Hales, J. R. S., and M. Iriki. Integrated changes in regional circulatory activity evoked by spinal cord and peripheral thermoreceptor stimulation. Brain Res. 87: 267–279, 1975.
 52. Hazel, J. R., and C. L. Prosser. Molecular mechanisms of temperature compensation in poikilotherms. Physiol. Rev. 54: 620–677, 1974.
 53. Hensel, H., K. Brück, and P. Raths. Nervous and hormonal factors in temperature regulation. In: Temperature and Life, edited by H. Precht, J. Christopherson, H. Hensel, and W. Larcher New York: Springer‐Verlag, 1973, p. 565–592.
 54. Hervey, G. R. Physiological changes encountered in hypothermia. Proc. R. Soc. Med. 66: 1053–1058, 1973.
 55. Holmes, R. L., P. P. Newman, and J. H. Wolstencroft. A heat sensitive region in the medulla. J. Physiol. London 152: 93–98, 1960.
 56. Howell, B. J., F. W. Baumgardner, K. Bondi, and H. Rahn. Acid‐base balance in cold‐blooded vertebrates as a function of body temperature. Am. J. Physiol. 218: 600–606, 1970.
 57. Hull, W. E., and E. C. Long. Respiratory impedance and volume flow at high frequency in dogs. J. Appl. Physiol. 16: 439–443, 1961.
 58. Ingram, D. L., and G. C. Whittow. The effect of heating the hypothalamus on respiration in the ox (Bos taurus). J. Physiol. London 163: 200–210, 1962.
 59. Ingram, D. L., and G. C. Whittow. The effects of variations in respiratory activity and in the skin temperatures of the ears on the temperature of the blood in the external jugular vein of the ox (Bos taurus). J. Physiol. London 163: 211–220, 1962.
 60. Jackson, D. C., and K. Schmidt‐Nielsen. Countercurrent heat exchange in the respiratory passages. Proc. Natl. Acad. Sci. USA 51: 1192–1197, 1964.
 61. Jessen, C. Auslösung von Hecheln durch isolierte Wärmung des Rückenmarks am wachen Hund. Pfluegers Arch. Gesamte Physiol. Menschen Tiere 297: 53–70, 1967.
 62. Keatinge, W. R., M. B. McIlroy, and A. Goldfien. Cardiovascular responses to ice‐cold showers. J. Appl. Physiol. 19: 1145–1150, 1964.
 63. Keatinge, W. R., and J. A. Nadel. Immediate respiratory response to sudden cooling of the skin. J. Appl. Physiol. 20: 65–69, 1965.
 64. Kraus, D. R., and D. C. Jackson. Temperature effects on ventilation and acid‐base balance of the green turtle. Am. J. Physiol. 239 (Regulatory Integrative Comp. Physiol. 8): R254–R258, 1980.
 65. Krausz, S., and J. Marder. Physiological responses of dogs on exposure to hot, arid conditions. Acid‐base status. Pfluegers Arch. 370: 283–286, 1977.
 66. Krönert, H., and K. Pleschka. Lingual blood flow and its hypothalmic control in the dog during panting. Pfluegers Arch. 367: 25–31, 1976.
 67. Landis, E. M., W. L. Long, J. W. Dunn, C. L. Jackson, and U. Meyer. Studies on the effects of baths on man. III. Effects of hot baths on respiration, blood and urine. Am. J. Physiol. 76: 35–48, 1926.
 68. Langman, V. A., G. M. Maloiy, K. Schmidt‐Nielsen, and R. C. Schroter. Nasal heat exchange in the giraffe and other large mammals. Respir. Physiol. 37: 325–333, 1979.
 69. Loeschcke, H. H. Central nervous chemoreceptors. In: Respiratory Physiology I, edited by J. G. Widdecombe Baltimore, MD: University Park, 1974, vol. 2, p. 188. (Int. Rev. Physiol. Ser.).
 70. MacLean, D., and D. Emslie‐Smith. Accidental Hypothermia. Oxford, UK: Blackwell, 1977, p. 97‐100, 116‐122.
 71. Magazanik, A., Y. Shapiro, and S. Shibolet. Dynamic changes in acid‐base balance during heatstroke in dogs. Pfluegers Arch. 388: 129–135, 1980.
 72. Magilton, J. H., and C. S. Swift. Thermoregulation of the canine brain by alfar‐fold and intervening arteriovenous heat exchange systems (Abstract). Physiologist 10: 241, 1967.
 73. Malan, A. Intracellular acid‐base state at a variable temperature in air‐breathing vertebrates and its representation. Respir. Physiol. 33: 115–119, 1978.
 74. Malan, A., T. L. Wilson, and R. B. Reeves. Intracellular pH in cold‐blooded vertebrates as a function of body temperature. Respir. Physiol. 28: 29–47, 1976.
 75. Malkinson, T. J., K. E. Cooper, S. Martin, and P. Simper. Expired air volumes of males and females during cold water immersion. Can. J. Physiol. Pharmacol. 59: 843–846, 1981.
 76. Martin, B. J., E. J. Morgan, C. W. Zwillich, and J. V. Weil. Influence of exercise hyperthermia on exercise breathing pattern. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 1039–1042, 1979.
 77. Martin, S., and K. E. Cooper. The relationship of deep and surface skin temperatures to the ventilatory responses elicited during cold water immersion. Can. J. Physiol. Pharmacol. 56: 999–1004, 1978.
 78. Martin, S., R. J. Diewold, and K. E. Cooper. Alcohol, respiration, skin and body temperature during cold water immersion. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 43: 211–215, 1977.
 79. Maskrey, M. Delay in the onset of thermal tachypnoea in shorn sheep exposed to 42°C in winter and summer. Aust. J. Biol. Sci. 27: 259–266, 1974.
 80. Maskrey, M., and S. C. Nicol. Responses of conscious rabbits to CO2 at ambient temperatures of 5, 20, and 35°C. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 522–526, 1979.
 81. Masoro, E. J., and P. D. Siegel. Acid‐Base Regulation. Its Physiology and Pathophysiology. Philadelphia, PA: Saunders, 1971, p. 35–37.
 82. McNicol, M. W. Respiratory failure and acid‐base status in hypothermia. Postgrad. Med. J. 43: 674–676, 1967.
 83. Murrish, D. E., and K. Schmidt‐Nielsen. Exhaled air temperature and water conservation in lizards. Respir. Physiol. 10: 151–158, 1970.
 84. Nangia, O. P., N. Singh, and S. S. Sukhija. Effect of exercise on thermal and acid‐base balance in buffaloes. Trop. Anim. Health Prod. 12: 185–188, 1980.
 85. Newman, P. P., and J. H. Wolstencroft. Cardiovascular and respiratory responses to heating the carotid blood. J. Physiol. London 152: 87–92, 1960.
 86. Parmenter, C. J., and H. Heatwole. Panting thresholds of lizards. IV. The effect of dehydration on the panting threshold of Amphibolurus barbatus and Amphibolurus muricatus. J. Exp. Zool. 191: 327–332, 1975.
 87. Petersen, E. S., and H. Vejby‐Christensen. Effects of a rise in body temperature on the pattern of breathing in man (Abstract). J. Physiol. London 250: 40P–41P, 1975.
 88. Phillips, G. D., and G. V. Raghavan. Responses of unshorn and shorn sheep to thermal stress. J. Physiol. London 208: 317–328, 1970.
 89. Phillips, G. D., and G. V. Raghavan. Role of naso‐buccal passages in thermoregulation in sheep. J. Physiol. London 208: 329–337, 1970.
 90. Randall, W. C. Factors influencing the temperature regulation of birds. Am. J. Physiol. 139: 56–63, 1943.
 91. Reeves, R. B., and A. Malan. Model studies of intracellular acid‐base temperature responses in ectotherms. Respir. Physiol. 28: 49–63, 1976.
 92. Richards, S. A. The role of hypothalamic temperature in the control of panting in the chicken exposed to heat. J. Physiol. London 211: 341–358, 1970.
 93. Roos, A., and W. F. Boron. Intracellular pH. Physiol. Rev. 61: 296–434, 1981.
 94. Rosenfeld, J. B. Acid‐base and electrolyte disturbances in hypothermia. Am. J. Cardiol. 12: 678–682, 1963.
 95. Saxton, C. Respiration during heat stress. Aviat. Space Environ. Med. 46: 41–46, 1975.
 96. Schläfke, M. E., and H. H. Loeschcke. Lokalisation eines an der regulation von Atmung und Kreislauf beteiligten Gebietes an der ventralen Oberfläche der Medulla oblongata durch Kälteblockade (Abstract). Pfluegers Arch. 297: 201, 1967.
 97. Schmidt‐Nielsen, K. Desert Animals. Oxford, UK: Clarendon, 1964, p. 210–211.
 98. Schmidt‐Nielsen, K. How Animals Work. New York: Cambridge Univ. Press, 1972, p. 26–30.
 99. Schmidt‐Nielsen, K., W. L. Bretz, and C. R. Taylor. Panting in dogs: unidirectional air flow over evaporative surfaces. Science 169: 1102–1104, 1970.
 100. Schmidt‐Nielsen, K., F. R. Harnsworth, and D. E. Murrish. Counter‐current heat exchange in the respiratory passages: effect on water and heat balance. Respir. Physiol. 9: 263–276, 1970.
 101. Schneider, U. Katter Hautriez und Atrung. Hippokrates 28: 433–435, 1957.
 102. Schoener, E. P., and H. M. Frankel. Effect of hyperthermia and PaCO2 on the slowly adapting pulmonary stretch receptor. Am. J. Physiol. 222: 68–72, 1972.
 103. Severinghaus, J. W. Respiration and hypothermia. Ann. NY Acad. Sci. 80: 384–394, 1959.
 104. Severinghaus, J. W., M. Stupfel, and A. F. Bradley. Variations of serum carbonic acid, pK7' with pH and temperature. J. Appl. Physiol. 9: 197–200, 1956.
 105. Sihler, C. On the so‐called heat‐dyspnoea. J. Physiol. London 2: 191–201, 1879.
 106. Sihler, C. Some further observations on heat‐dyspnoea. J. Physiol. London 3: 1–10, 1880.
 107. Steen, I., and J. B. Steen. The importance of the legs in the thermoregulation of birds. Acta Physiol. Scand. 63: 285–291, 1965.
 108. Stitt, J. T. The regulation of respiratory evaporative heat loss in the rabbit. J. Physiol. London 258: 157–171, 1976.
 109. Szelényi, Z., and M. Székely. Comparison of the effector mechanisms during endotoxin fever in the adult rabbit. Acta Physiol. Acad. Sci. Hung. 54: 33–41, 1979.
 110. Taylor, C: R. Exercise and environmental heat loads: different mechanisms for solving different problems? In: Environmental Physiology II, edited by D. Robertshaw Baltimore, MD: University Park, 1977, vol. 15, p. 119–146. (Int. Rev. Physiol. Ser.).
 111. Tenney, S. M., and R. M. Miller. The respiratory and circulatory actions of salicylate. Am. J. Med. 19: 498–505, 1955.
 112. Toulmond, A. Temperature‐induced variations of blood acid‐base status in the lugworm, Arenicola marina (L.). I. In vitro study. Respir. Physiol. 31: 139–149, 1977.
 113. Truchot, J. P. Mechanisms of extracellular acid‐base regulation as temperature changes in decapod crustaceans. Respir. Physiol. 33: 161–176, 1978.
 114. Ts'ao, C. H., F. R. Meyer, B. E. Epperson, and L. O. Holgersen. The influence of temperature on respiration in exercising men (Abstract). Physiologist 5: 222, 1962.
 115. White, F. N., and G. Somero. Acid‐base regulation and phospholipid adaptations to temperature: time courses and physiological significance of modifying the milieu for protein function. Physiol. Rev. 62: 40–90, 1982.
 116. Widdicombe, J. G. Reflex control of breathing. In: Respiratory Physiology I, edited by J. G. Widdicombe Baltimore, MD: University Park, 1974, vol. 2, p. 293. (Int. Rev. Physiol. Ser.).
 117. Widdicombe, J. G., and A. Winning. Effects of hypoxia, hypercapnia and changes in body temperature on the pattern of breathing in cats. Respir. Physiol. 21: 203–221, 1974.
 118. Willis, T. De cerebre anatome. London: 1664. [Transl. into English by Samuel Pordage 1684].
 119. Wood, S. C., K. Johansen, M. L. Glass, and R. W. Hoyt. Acid‐base regulation during heating and cooling in the lizard, Varanus exanthematicus. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50: 779–783, 1981.
 120. Wunderlich, C. A. On the Temperature in Diseases, a Manual of Medical Thermometry (2nd ed.), translated by W. B. Woodman. London: New Sydenham Soc., 1871, vol. XLIX, p. 214–215.
 121. Wynn, V. Metabolic problems. In: Hypothermia in Surgical Practice, edited by K. E. Cooper and D. N. Ross London: Casell, 1960, chapt. 3, p. 31–40.

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K. E. Cooper, W. L. Veale. Effects of Temperature on Breathing. Compr Physiol 2011, Supplement 11: Handbook of Physiology, The Respiratory System, Control of Breathing: 691-702. First published in print 1986. doi: 10.1002/cphy.cp030220