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Tests of Mechanical Function

N. R. Anthonisen

10.1002/cphy.cp030344

Source: Supplement 12: Handbook of Physiology, The Respiratory System, Mechanics of Breathing

Originally published: 1986

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Lung Volumes
1.1 Vital Capacity
1.2 Functional Residual Capacity and Residual Volume
1.3 Determinants of Lung Volume
2 Static Recoil
2.1 Lung Recoil
2.2 Chest Wall Recoil
3 Resistance
3.1 Methods of Measurement
3.2 Determinants of Resistance
4 Forced Expiration
4.1 Measurement
4.2 Determinants of Forced Expiratory Flow
4.3 Other Tests
5 Distributional Tests
5.1 Frequency Dependence of Compliance and Resistance
5.2 Closing Volume
Figure 1. Figure 1.

Lung volumes as defined by spirometer tracing on right. TLC, total lung capacity; VC, vital capacity; RV, residual volume; IC, inspiratory capacity; FRC, functional residual capacity; IRV, inspiratory reserve volume; TV, tidal volume; ERV, expiratory reserve volume.

From Comroe et al. 60, The Lung: Clinical Physiology and Pulmonary Function Tests (2nd ed.). Copyright 1962 by Year Book Medical Publishers, Inc., Chicago, IL
Figure 2. Figure 2.

Elastic recoil of lung, chest wall, and lung plus chest wall (algebraic sum of pressure pertaining to lung and chest wall curves at equal volumes). Ordinate, volume in percent TLC; abscissa, pressure difference across each structure, pressure on outside being subtracted from pressure on inside.

Adapted from Rahn et al. 295
Figure 3. Figure 3.

Determinants of RV. Four spirometer tracings shown, 2 (A, B) from young subject and 2 (C, D) from old subject. Expired volume (ordinates) plotted against time (abscissas) as in each tracing the subject approaches RV. In A and C, maximum expirations are unaided; in B and D, positive external pressure is applied to chest wall (squeeze).

Adapted from Leith and Mead 199
Figure 4. Figure 4.

Effect of volume of esophageal balloon on measured esophageal pressure. Ordinate, esophageal pressure in cmH2O; abscissa, balloon volume in ml. Data collected at lung volumes ranging from 0% to 100% VC. Solid lines, esophageal pressure‐volume relationship at each lung volume; dashed line, pressure‐volume characteristic of isolated esophageal balloon; dotted line, esophageal pressure‐volume relationship for system with volume‐displacement coefficient of 0.05 ml/cmH2O and balloon volume of 2 ml at atmospheric pressure. Pes, esophageal pressure; Ves, esophageal balloon volume.

From Milic‐Emili et al. 250
Figure 5. Figure 5.

Effect of age on pressure‐volume curve of the lung. Ordinate, volume in percent TLC; abscissa, transpulmonary pressure. Each curve from a group of normal nonsmoking men averaging 29 yr, 49 yr, and 70 yr.

Adapted from Knudson et al. 184
Figure 6. Figure 6.

Pulmonary pressure‐flow curves. Ordinate, flow in liters/s; abscissa, transpulmonary pressure. Positive flow is inspiratory, negative flow is expiratory. Ovoid figure, flow and transpulmonary pressure during slight hyperventilation; heavy solid line, pressure‐flow relationship of several larger breaths after volume‐related pressure has been subtracted.

Adapted from Mead and Whittenberger 241
Figure 7. Figure 7.

Isovolume expiratory pressure‐flow curves. Ordinate, flow (); abscissa, transpulmonary pressure. Data gathered at 4 lung volumes are shown.

Adapted from Hyatt et al. 162
Figure 8. Figure 8.

Recordings of forced expiration. Upper, spirogram where volume in lung (in percent VC) is plotted against time. Lower. maximum expiratory flow‐volume curve, in which maximum flow (ordinate) is plotted against the lung volume at which it occurs.
Figure 9. Figure 9.

Closing volume tracing. Left: [133Xe] resulting from inhalation of 133Xe boluses at onset of slow VC inspiration; regional concentrations were measured at TLC. Right: expired [133Xe] during subsequent slow VC expiration. Ordinates, [133Xe] with same scale; left abscissa, distance (D) from apex (0 cm) to base of erect lung; right abscissa, lung volume during expiration. FA, fractional concentration in dry alveolar gas; , fractional concentration in dry expired gas; mCi, millicuries.

Adapted from Millette et al. 252


Figure 1.

Lung volumes as defined by spirometer tracing on right. TLC, total lung capacity; VC, vital capacity; RV, residual volume; IC, inspiratory capacity; FRC, functional residual capacity; IRV, inspiratory reserve volume; TV, tidal volume; ERV, expiratory reserve volume.

From Comroe et al. 60, The Lung: Clinical Physiology and Pulmonary Function Tests (2nd ed.). Copyright 1962 by Year Book Medical Publishers, Inc., Chicago, IL


Figure 2.

Elastic recoil of lung, chest wall, and lung plus chest wall (algebraic sum of pressure pertaining to lung and chest wall curves at equal volumes). Ordinate, volume in percent TLC; abscissa, pressure difference across each structure, pressure on outside being subtracted from pressure on inside.

Adapted from Rahn et al. 295


Figure 3.

Determinants of RV. Four spirometer tracings shown, 2 (A, B) from young subject and 2 (C, D) from old subject. Expired volume (ordinates) plotted against time (abscissas) as in each tracing the subject approaches RV. In A and C, maximum expirations are unaided; in B and D, positive external pressure is applied to chest wall (squeeze).

Adapted from Leith and Mead 199


Figure 4.

Effect of volume of esophageal balloon on measured esophageal pressure. Ordinate, esophageal pressure in cmH2O; abscissa, balloon volume in ml. Data collected at lung volumes ranging from 0% to 100% VC. Solid lines, esophageal pressure‐volume relationship at each lung volume; dashed line, pressure‐volume characteristic of isolated esophageal balloon; dotted line, esophageal pressure‐volume relationship for system with volume‐displacement coefficient of 0.05 ml/cmH2O and balloon volume of 2 ml at atmospheric pressure. Pes, esophageal pressure; Ves, esophageal balloon volume.

From Milic‐Emili et al. 250


Figure 5.

Effect of age on pressure‐volume curve of the lung. Ordinate, volume in percent TLC; abscissa, transpulmonary pressure. Each curve from a group of normal nonsmoking men averaging 29 yr, 49 yr, and 70 yr.

Adapted from Knudson et al. 184


Figure 6.

Pulmonary pressure‐flow curves. Ordinate, flow in liters/s; abscissa, transpulmonary pressure. Positive flow is inspiratory, negative flow is expiratory. Ovoid figure, flow and transpulmonary pressure during slight hyperventilation; heavy solid line, pressure‐flow relationship of several larger breaths after volume‐related pressure has been subtracted.

Adapted from Mead and Whittenberger 241


Figure 7.

Isovolume expiratory pressure‐flow curves. Ordinate, flow (); abscissa, transpulmonary pressure. Data gathered at 4 lung volumes are shown.

Adapted from Hyatt et al. 162


Figure 8.

Recordings of forced expiration. Upper, spirogram where volume in lung (in percent VC) is plotted against time. Lower. maximum expiratory flow‐volume curve, in which maximum flow (ordinate) is plotted against the lung volume at which it occurs.



Figure 9.

Closing volume tracing. Left: [133Xe] resulting from inhalation of 133Xe boluses at onset of slow VC inspiration; regional concentrations were measured at TLC. Right: expired [133Xe] during subsequent slow VC expiration. Ordinates, [133Xe] with same scale; left abscissa, distance (D) from apex (0 cm) to base of erect lung; right abscissa, lung volume during expiration. FA, fractional concentration in dry alveolar gas; , fractional concentration in dry expired gas; mCi, millicuries.

Adapted from Millette et al. 252
References
 1. Agostoni, E. Volume‐pressure relationships of the thorax and lung in the newborn. J. Appl. Physiol. 14: 909–913, 1959.
 2. Agostoni, E., and W. O. Fenn. Velocity of muscle shortening as a limiting factor in respiratory air flow. J. Appl. Physiol. 15: 349–353, 1960.
 3. Agostoni, E., G. Gurtner, G. Torri, and H. Rahn. Respiratory mechanics during submersion and negative‐pressure breathing. J. Appl. Physiol. 21: 251–258, 1966.
 4. Agostoni, E., and J. Mead. Statics of the Respiratory System. In: Handbook of Physiology. Respiration, edited by W. O. Fenn and H. Rahn., Washington, DC: Am. Physiol. Soc., 1964, sect. 3, vol. I, chapt. 13, p. 387–409.
 5. Agostoni, E., and H. Rahn. Abdominal and thoracic pressures at different lung volumes. J. Appl. Physiol. 15: 1087–1092, 1960.
 6. Agostoni, E., and G. Torri. Diaphragm contraction as a limiting factor to maximum expiration. J. Appl. Physiol. 17: 427–428, 1962.
 7. Altman, P. L., and D. S. Dittmer (editors). Biological Handbooks. Respiration and Circulation. Bethesda, MD: Fed. Am. Soc. Exp. Biol., 1971, p. 36–40.
 8. American Thoracic Society. Snowbird workshop on standardization of spirometry. Am. Rev. Respir. Dis. 119: 831–838, 1979.
 9. Anthonisen, N. R., J. Danson, P. C. Robertson, and W. R. D. Ross. Airway closure as a function of age. Respir. Physiol 8: 58–65, 1969.
 10. Anthonisen, N. R., L. J. Peress, D. I. M. Siegler, and S. Dhingra. Lung volume history and the distribution of inspired boluses. Respir. Physiol. 33: 279–288, 1978.
 11. Anthonisen, N. R., P. C. Robertson, and W. R. D. Ross. Gravity‐dependent sequential emptying of lung regions. J. Appl. Physiol. 28: 589–595, 1970.
 12. Astin, T. W., and R. W. B. Penman. Airway obstruction due to hypoxemia in patients with chronic lung disease. Am. Rev. Respir. Dis. 95: 567–575, 1967.
 13. Bachofen, H. Lung tissue resistance and pulmonary hysteresis. J. Appl. Physiol. 24: 296–301, 1968.
 14. Baier, H., A. Wanner, S. Zarzecki, and M. A. Sackner. Relationships among glottis opening, respiratory flow, and upper airway resistance in humans. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 43: 603–611, 1977.
 15. Barnett, T. B. Effects of helium and oxygen mixtures on pulmonary mechanics during airway constriction. J. Appl. Physiol 22: 707–713, 1967.
 16. Barnhard, H. J., J. A. Pierce, J. W. Joyce, and J. H. Bates. Roentgenographic determination of total lung capacity. Am. J. Med. 28: 51–60, 1960.
 17. Barrett, W. A., P. D. Clayton, and C. R. Lambson. Computerized roentgenographic determination of total lung capacity. Am. Rev. Respir. Dis. 113: 239–243, 1976.
 18. Bartlett, D., Jr. Effects of hypercapnia and hypoxia on laryngeal resistance to airflow. Respir. Physiol. 37: 293–302, 1979.
 19. Bartlett, D., Jr. Effects of vagal afferents on laryngeal responses to hypercapnia and hypoxia. Respir. Physiol. 42: 189–198, 1980.
 20. Bartlett, R. G., Jr., H. F. Brubach, R. C. Trimble, and H. Specht. Airway resistance measurement during any breathing pattern in man. J. Appl. Physiol. 14: 89–96, 1959.
 21. Beardsmore, C. S., P. Helms, J. Stocks, D. J. Hatch, and M. Silverman. Improved esophageal balloon technique for use in infants. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 735–742, 1980.
 22. Becklake, M. R., M. Leclerc, H. Strobach, and J. Swift. The N2 closing volume test in population studies: sources of variation and reproducibility. Am. Rev. Respir. Dis. 111: 141–147, 1975.
 23. Bedell, G. N., R. Marshall, A. B. DuBois, and J. H. Comroe, Jr. Plethysmographic determination of the gas trapped in the lungs. J. Clin. Invest. 35: 664–670, 1956.
 24. Begin, R., A. D. Renzetti, Jr., A. H. Bigler, and S. Watanabe. Flow and age dependence of airway closure and dynamic compliance. J. Appl. Physiol. 38: 199–207, 1975.
 25. Benson, M. K., L. A. Newberg, and J. G. Jones. Nitrogen and bolus closing volumes: differences after histamine‐induced bronchoconstriction. J. Appl. Physiol. 38: 1088–1091, 1975.
 26. Berglund, E., G. Birath, J. Bjure, G. Grimby, I. Kjellmer, L. Sandquist, and B. Soderholm. Spirometric studies in normal subjects. Acta. Med. Scand. 173: 185–192, 1963.
 27. Black, L. F., K. Offord, and R. E. Hyatt. Variability in the maximal flow‐volume curve in asymptomatic smokers and non‐smokers. Am. Rev. Respir. Dis. 110: 282–292, 1974.
 28. Blair, E., and J. B. Hickham. The effect of change in body position on lung volume and intrapulmonary gas mixing in normal subjects. J. Clin. Invest. 34: 383–389, 1955.
 29. Blide, R. W., H. D. Kerr, and W. S. Spicer, Jr. Measurement of upper and lower airway resistance and conductance in man. J. Appl. Physiol. 19: 1059–1069, 1964.
 30. Bode, F. R., J. Dosman, R. R. Martin, H. Ghezzo, and P. T. Macklem. Age and sex differences in lung elasticity, and in closing capacity in nonsmokers. J. Appl. Physiol. 41: 129–135, 1976.
 31. Bondurant, S., J. Mead, and C. D. Cook. A re‐evaluation of effects of acute central congestion on pulmonary compliance in normal subjects. J. Appl. Physiol. 15: 875–877, 1960.
 32. Bouhuys, A., V. R. Hunt, B. M. Kim, and A. Zapletal. Maximum expiratory flow rates in induced bronchoconstriction in man. J. Clin. Invest. 48: 1159–1168, 1969.
 33. Bouhuys, A., and B. Jonson. Alveolar pressure, airflow rate, and lung inflation in man. J. Appl. Physiol. 22: 1086–1100, 1967.
 34. Bradley, C. A., and N. R. Anthonisen. Rib cage and abdominal restrictions have different effects on lung mechanics. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 946–952, 1980.
 35. Briscoe, W. A. Lung volumes. In: Handbook of Physiology. Respiration, edited by W. O. Fenn and H. Rahn Washington, DC: Am. Physiol. Soc, 1965, sect. 3, vol. II, chapt. 53, p. 1345–1379.
 36. Briscoe, W. A., and A. B. DuBois. The relationship between airway resistance, airway conductance, and lung volume in subjects of different age and body size. J. Clin. Invest. 37: 1279–1285, 1958.
 37. Brown, R., F. G. Hoppin, Jr., R. H. Ingram, Jr., N. A. Saunders, and E. R. McFadden, Jr. Influence of abdominal gas on the Boyle's law determination of thoracic gas volume. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 44: 469–473, 1978.
 38. Brown, R., R. H. Ingram, Jr., and E. R. McFadden, Jr. Problems in the plethysmographic assessment of changes in total lung capacity in asthma. Am. Rev. Respir. Dis. 118: 685–692, 1978.
 39. Brown, R., S. Scharf, and R. H. Ingram, Jr. Nonhomogeneous alveolar pressure swings in the presence of airway closure. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 398–402, 1980.
 40. Brown, R., S. M. Scharf, and R. Ingram, Jr. Nonhomogeneous alveolar pressure swings: effect of different respiratory muscles. J. Appl. Physiol.: Respirat. Environ. Physiol. 52: 638–641, 1982.
 41. Bruce, E. N., and A. C. Jackson. Smoothing of MEFV curves by digital filtering of flow as a function of volume. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 202–206, 1980.
 42. Bubis, M. J., M. Sigurdson, D. S. McCarthy, and N. R. Anthonisen. Differences between slow and fast vital capacities in patients with obstructive disease. Chest 77: 626–631, 1980.
 43. Buhain, W. J., J. S. Brody, and A. B. Fisher. Effect of artificial airway obstruction on elastic properties of the lung. J. Appl. Physiol. 33: 589–594, 1972.
 44. Buist, A. S., and B. B. Ross. Predicted values for closing volumes using a modified single breath nitrogen test. Am. Rev. Respir. Dis. 107: 744–752, 1973.
 45. Buist, A. S., and B. B. Ross. Quantitative analysis of the alveolar plateau in the diagnosis of early airway obstruction. Am. Rev. Respir. Dis. 108: 1078–1087, 1973.
 46. Burger, E. J., Jr., and P. Macklem. Airway closure: demonstration by breathing 100% O2 at low lung volumes and by N2 washout. J. Appl. Physiol 25: 139–148, 1968.
 47. Butler, J., C. G. Caro, R. Acala, and A. B. DuBois. Physiological factors affecting airway resistance in normal subjects and in patients with obstructive respiratory disease. J. Clin. Invest. 39: 584–591, 1960.
 48. Butler, J., and B. H. Smith. Pressure‐volume relationships of the chest in the completely relaxed anesthetized patient. Clin. Sci. 16: 125–146, 1957.
 49. Campbell, E. J. M., and J. H. Green. The variations in intra‐abdominal pressure and the activity of the abdominal muscles during breathing: a study in man. J. Physiol. London 122: 282–290, 1953.
 50. Caro, C. G., J. Butler, and A. B. DuBois. Some effects of restriction of chest cage expansion on pulmonary function in man: an experimental study. J. Clin. Invest. 39: 573–583, 1960.
 51. Castile, R. G., R. E. Hyatt, and J. R. Rodarte. Determinants of maximal expiratory flow and density dependence in normal humans. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 897–904, 1980.
 52. Cherniack, R. M., and E. Brown. A simple method for measuring total respiratory compliance: normal values for males. J. Appl. Physiol. 20: 87–91, 1965.
 53. Cherniack, R. M., L. E. Farhi, B. W. Armstrong, and D. F. Proctor. A comparison of esophageal and intrapleural pressure in man. J. Appl. Physiol. 8: 203–211, 1955.
 54. Cherniack, R. M., and M. B. Raber. Normal standards for ventilatory function using an automated wedge spirometer. Am. Rev. Respir. Dis. 106: 38–46, 1972.
 55. Christie, R. V. The lung volume and its subdivisions. I. Methods for measurement. J. Clin. Invest. 11: 1099–1118, 1932.
 56. Clarke, S. W., J. G. Jones, and D. H. Glaister. Changes in pulmonary ventilation in different postures. Clin. Sci. 37: 357–369, 1969.
 57. Clément, J., and K. P. van de Woestijne. Variability of maximum expiratory flow‐volume curves and effort independency. J. Appl. Physiol. 31: 55–62, 1971.
 58. Clements, J. A., J. T. Sharp, R. P. Johnson, and J. O. Elam. Estimation of pulmonary resistance by repetitive interruption of airflow. J. Clin. Invest. 38: 1262–1270, 1959.
 59. Colebatch, H. J. H., I. A. Greaves, and C. K. Y. Ng. Exponential analysis of elastic recoil and aging in healthy males and females. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 683–691, 1979.
 60. Colebatch, H. J. H., C. K. Y. Ng, and N. Nikov. Use of an exponential function for elastic recoil. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 387–393, 1979.
 61. Comroe, J. H., Jr., R. E. Forster, A. B. DuBois, W. A. Briscoe, and E. Carlsen. Lung volumes. In: The Lung.: Clinical Physiology and Pulmonary Function Tests (2nd ed.). Chicago, IL: Year Book, 1962, chapt. 2, p. 8.
 62. Cook, C. D., P. J. Helliesen, and S. Agathon. Relation between mechanics of respiration, lung size and body size from birth to young adulthood. J. Appl. Physiol. 13: 349–352, 1958.
 63. Cortese, D. A., J. R. Rodarte, K. Rehder, and R. E. Hyatt. Effect of posture on the single‐breath oxygen test in normal subjects. J. Appl. Physiol. 41: 474–479, 1976.
 64. Cournand, A., E. D. Baldwin, R. C. Darling, and D. W. Richards, Jr. Studies on the intrapulmonary mixture of gases. IV. The significance of the pulmonary emptying rate and a simplified open circuit measurement of residual air. J. Clin. Invest. 20: 681–689, 1941.
 65. Cournand, A., D. W. Richards, and R. C. Darling. Graphic tracings of respiration in study of pulmonary disease. Am. Rev. Tuberc. 44: 123–172, 1939.
 66. Cournand, A., I. G. Yarmush, and R. L. Riley. Influence of body size on gaseous nitrogen elimination during high oxygen breathing. Proc. Soc. Exp. Biol. Med. 48: 280–284, 1941.
 67. Craig, D. B., D. S. McCarthy, I. J. Gilmour, L. D. H. Wood, and R. M. Cherniack. Measurement of “closing volume” initiated from functional residual capacity. Respir. Physiol. 28: 325–331, 1976.
 68. Crapo, R. O., A. H. Morris, and R. M. Gardner. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am. Rev. Respir. Dis. 123: 659–664, 1981.
 69. Daly, W. J., and S. Bondurant. Direct measurement of respiratory pleural pressure changes in normal man. J. Appl. Physiol 18: 513–518, 1963.
 70. Darling, R. C., A. Cournand, and D. W. Richards, Jr. Studies on the intrapulmonary mixing of gases. II. An open circuit method for measuring residual air. J. Clin. Invest. 19: 609–618, 1940.
 71. Davis, C., E. J. M. Campbell, P. Openshaw, N. B. Pride, and G. Woodruff. Importance of airway closure in limiting maximal expiration in normal man. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 695–701, 1980.
 72. Davy, H. Researches, Chemical and Philosophical, Chiefly Concerning Nitrous Oxide or Dephlogisticated Nitrous Air, and Its Respiration. London: Johnson, 1800.
 73. Dawson, S. V., and E. A. Elliott. Wave‐speed limitation on expiratory flow—a unifying concept. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 43: 498–515, 1977.
 74. Dayman, H. The expiratory spirogram. Am. Rev. Tuberc. 83: 842–855, 1961.
 75. Dejours, P., and H. Rahn. Residual volume measurements by the gas expansion method and nitrogen dilution method. J. Appl. Physiol. 5: 445–448, 1953.
 76. Delavault, E., G. Saumon, and R. Georges. Characterization and validation of forced input method for respiratory impedance measurement. Respir. Physiol. 40: 119–136, 1980.
 77. Demedts, M., J. Clément, D. C. Stânescu, and K. P. van de Woestijne. Inflection point on transpulmonary pressure‐volume curves and closing volume. J. Appl. Physiol. 38: 228–235, 1975.
 78. Dennis, M. W., J. S. Douglas, J. U. Casby, J. A. J. Stolwijk, and A. Bouhuys. On‐line analog computer for dynamic lung compliance and pulmonary resistance. J. Appl. Physiol. 26: 248–252, 1969.
 79. Despas, P. J., M. Leroux, and P. T. Macklem. Site of airway obstruction in asthma as determined by measuring maximal expiratory flow breathing air and a helium‐oxygen mixture. J. Clin. Invest. 51: 3235–3242, 1972.
 80. De Troyer, A., and J. Bastenier‐Geens. Effects of neuromuscular blockade on respiratory mechanics in conscious man. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 1162–1168, 1979.
 81. De Troyer, A., and S. Borenstein. Acute changes in respiratory mechanics after phyridostigmine injection in patients with myasthenia gravis. Am. Rev. Respir. Dis. 121: 629–638, 1980.
 82. De Troyer, A., J.‐C. Yernault, M. Englert, D. Baran, and M. Paiva. Evolution of intrathoracic airway mechanics during lung growth. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 44: 521–527, 1978.
 83. De Troyer, A., J.‐C. Yernault, and D. Rodenstein. Influence of beta‐2 agonist aerosols on pressure‐volume characteristics of the lungs. Am. Rev. Respir. Dis. 118: 987–995, 1978.
 84. De Troyer, A., J.‐C. Yernault, and D. Rodenstein. Effects of vagal blockade on lung mechanics in normal man. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 217–226, 1979.
 85. Dinwiddie, R., and G. Russell. Relationship of intraesophageal pressure to intrapleural pressure in the newborn. J. Appl. Physiol. 33: 415–417, 1972.
 86. Dollfuss, R. E., J. Milic‐Emili, and D. V. Bates. Regional ventilation of the lung, studied with boluses of 133xenon. Respir. Physiol. 2: 234–246, 1967.
 87. Dosman, J., F. Bode, J. Urbanetti, R. Antic, R. Martin, and P. T. Macklem. Role of inertia in the measurement of dynamic compliance. J. Appl. Physiol. 38: 64–69, 1975.
 88. Dosman, J. A., F. Bode, J. Urbanetti, R. Martin, and P.T. Macklem. The use of a helium‐oxygen mixture during maximum expiratory flow to demonstrate obstruction in small airways in smokers. J. Clin. Invest. 55: 1090–1099, 1975.
 89. Douglas, N. J., G. B. Drummond, and M. F. Sudlow. Breathing at low lung volumes and chest strapping: a comparison of lung mechanics. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50: 650–657, 1981.
 90. Douglas, N. J., P. K. Wraith, H. M. Brash, J. Millar, M. F. Sudlow, and D. C. Flenley. Computer measurement of dynamic compliance: technique and reproducibility in man. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 903–910, 1980.
 91. Drazen, J. M., S. H. Loring, and R. H. Ingram, Jr. Distribution of pulmonary resistance: effects of gas density, viscosity, and flow rate. J. Appl. Physiol. 41: 388–395, 1976.
 92. Drazen, J. M., S. H. Loring, and R. H. Ingram, Jr. Localization of airway constriction using gases of varying density and viscosity. J. Appl. Physiol. 41: 396–399, 1976.
 93. Drazen, J. M., S. H. Loring, and R. Regan. Validation of an automated determination of pulmonary resistance by electrical subtraction. J. Appl. Physiol. 40: 110–113, 1976.
 94. DuBois, A. B., S. Y. Botelho, G. N. Bedell, R. Marshall, and J. H. Comroe, Jr. A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen dilution method for measuring functional residual capacity in normal subjects. J. Clin. Invest. 35: 322–326, 1956.
 95. DuBois, A. B., S. Y. Botelho, and J. H. Comroe, Jr. A method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J. Clin. Invest. 35: 327–335, 1956.
 96. DuBois, A. B., A. W. Brody, D. H. Lewis, and B. F. Burgess, Jr. Oscillation mechanics of lungs and chest in man. J. Appl. Physiol. 8: 587–594, 1956.
 97. Emmanuel, G., W. A. Briscoe, and A. Cournand. A method for the determination of the volume of air in the lungs: measurement in chronic pulmonary emphysema. J. Clin. Invest. 20: 329–337, 1961.
 98. Engel, L. A., A. Grassino, and N. R. Anthonisen. Demonstration of airway closure in man. J. Appl. Physiol. 38: 1117–1125, 1975.
 99. Ferris, B. G. Epidemiology standardization project. Am. Rev. Respir. Dis. 118: 55–88, 1978.
 100. Ferris, B. G., Jr., J. Mead, and N. R. Frank. Effect of body position on esophageal pressure and measurement of pulmonary compliance. J. Appl. Physiol. 14: 521–524, 1959.
 101. Ferris, B. G., Jr., J. Mead, and L. H. Opie. Partitioning of respiratory flow resistance in man. J. Appl. Physiol. 19: 653–658, 1964.
 102. Ferris, B. G., Jr., and D. S. Pollard. Effect of deep and quiet breathing on pulmonary compliance in man. J. Clin. Invest. 39: 143–149, 1960.
 103. Finucane, K. E., B. A. Egan, and S. V. Dawson. Linearity and frequency response of pneumotachographs. J. Appl. Physiol. 32: 121–126, 1972.
 104. Fisher, A. B., A. B. DuBois, and R. W. Hyde. Evaluation of the forced oscillation technique for the determination of resistance to breathing. J. Clin. Invest. 47: 2045–2057, 1968.
 105. Fletcher, G., and J. W. Bellville. On‐line computation of pulmonary compliance and work of breathing. J. Appl. Physiol. 21: 1321–1327, 1966.
 106. Forkert, L., S. Dhingra, and N. R. Anthonisen. Airway closure and closing volume. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 24–30, 1979.
 107. Frank, N. R. Influence of acute pulmonary vascular congestion on recoiling force of excised cats' lungs. J. Appl. Physiol. 14: 905–908, 1959.
 108. Frank, N. R., M. O. Amdur, J. Worcester, and J. L. Whittenberger. Effects of acute controlled exposure to SO2 on respiratory mechanics in healthy male adults. J. Appl. Physiol. 17: 252–258, 1962.
 109. Frank, N. R., J. Mead, and B. G. Ferris, Jr. The mechanical behavior of the lungs in healthy elderly persons. J. Clin. Invest. 36: 1680–1687, 1957.
 110. Frank, N. R., J. Mead, and J. L. Whittenberger. Comparative sensitivity of four methods for measuring changes in respiratory flow resistance in man. J. Appl. Physiol. 31: 934–938, 1971.
 111. Fry, D. L., and R. E. Hyatt. Pulmonary mechanics: a unified analysis between pressure, volume, and gas flow in the lungs of normal and diseased subjects. Am. J. Med. 29: 672–689, 1960.
 112. Fry, D. L., R. E. Hyatt, C. B. McCall, and A. J. Mallos. Evaluation of three types of respiratory flowmeters. J. Appl. Physiol. 10: 210–214, 1957.
 113. Fry, D. L., W. W. Stead, R. V. Ebert, R. I. Lubin, and H. S. Wells. The measurement of intraesophagic pressure and its relationship to intrathoracic pressure. J. Lab. Clin. Med. 40: 664–673, 1972.
 114. Gaensler, E. A. Analysis of the ventilatory defect by timed vital capacity measurements. Am. Rev. Tuberc. 64: 256–278, 1951.
 115. Gamsu, G., D. H. Shames, J. McMahon, and R. H. Greenspan. Radiographically determined lung volumes at full inspiration and during dynamic forced expiration in normal subjects. Invest. Radiol. 10: 100–108, 1975.
 116. Gardiner, A. J., L. Wood, P. Gayrard, H. Menkes, and P. Macklem. Influence of constriction in central or peripheral airways on maximal expiratory flow rates in dogs. J. Appl. Physiol. 36: 554–560, 1974.
 117. Garfinkel, F., and R. S. Fitzgerald. The effect of hyperoxia, hypoxia, and hypercapnia on FRC and occlusion pressure in human subjects. Respir. Physiol. 33: 241–250, 1978.
 118. Gautier, H., R. Peslin, A. Grassino, J. Milic‐Emili, B. Hannhart, E. Powell, G. Miserocchi, M. Bonora, and J. T. Fischer. Mechanical properties of the lungs during acclimatization to altitude. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52: 1407–1415, 1982.
 119. Gibson, G. J., and N. B. Pride. Pulmonary mechanics in fibrosing alveolitis. Am. Rev. Respir. Dis. 116: 637–647, 1977.
 120. Gibson, G. J., N. B. Pride, J. Davis, and R. C. Schroter. Exponential description of the static pressure‐volume curve of normal and diseased lungs. Am. Rev. Respir. Dis. 120: 799–811, 1979.
 121. Gibson, G. J., N. B. Pride, C. O'Cain, and R. Quagliato. Sex and age differences in pulmonary mechanics in normal nonsmoking subjects. J. Appl. Physiol. 41: 20–25, 1976.
 122. Gillespie, D. J., Y.‐L. Lai, and R. E. Hyatt. Comparison of esophageal and pleural pressures in the anesthetized dog. J. Appl. Physiol. 35: 709–713, 1973.
 123. Gilson, J. C., and P. Hugh‐Jones. The measurement of the total lung volume and breathing capacity. Clin. Sci. 7: 185–216, 1949.
 124. Goldberg, H. S., W. Mitzner, K. Adams, H. Menkes, S. Lichtenstein, and S. Permutt. Effect of intrathoracic pressure on pressure‐volume characteristics of the lung in man. J. Appl. Physiol. 38: 411–417, 1975.
 125. Goldman, H. I., and M. R. Becklake. Respiratory function tests: normal values of median altitudes and the prediction of normal results. Am. Rev. Tuberc. 79: 457–467, 1959.
 126. Goldman, M., R. J. Knudson, J. Mead, N. Peterson, J. R. Schwaber, and M. E. Wohl. A simplified measurement of respiratory resistance by forced oscillation. J. Appl. Physiol. 28: 113–116, 1970.
 127. Goldsmith, J. R. A simple test of maximal expiratory flow for detecting ventilatory obstruction. Am. Rev. Tuberc. 78: 180–190, 1958.
 128. Goldstein, D., and J. Mead. Use of magnetometers to volume‐reference flow‐volume curves. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 731–736, 1980.
 129. Goldstein, D., and J. Mead. Total respiratory impedance immediately after panting. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 1024–1028, 1980.
 130. Greaves, I. A., and H. J. H. Colebatch. Elastic behavior and structure of normal and emphysematous lungs post mortem. Am. Rev. Respir. Dis. 121: 127–136, 1980.
 131. Green, M., J. Mead, F. Hoppin, and M. E. Wohl. Analysis of the forced expiratory maneuver. Chest 63: 335–365, 1973.
 132. Green, M., J. Mead, and J. M. Turner. Variability of maximum expiratory flow‐volume curves. J. Appl. Physiol. 37: 67–74, 1974.
 133. Griffin, P. M., and N. Zamel. Volume‐displacement body plethysmograph using a large flowmeter without pressure compensation. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 1127–1130, 1979.
 134. Grimby, G., T. Takashima, W. Graham, P. T. Macklem, and J. Mead. Frequency dependence of flow resistance in patients with obstructive lung disease. J. Clin. Invest. 47: 1455–1465, 1968.
 135. Guyatt, A. R., and J. H. Alpers. Factors affecting airway conductance: a study of 752 working men. J. Appl. Physiol. 24: 310–316, 1968.
 136. Guyatt, A. R., J. A. Siddorn, H. M. Brash, and D. C. Flenley. Reproducibility of dynamic compliance and flow‐volume curves in normal man. J. Appl. Physiol. 39: 341–348, 1975.
 137. Habib, M. P., and L. A. Engel. Influence of the panting technique on the plethysmographic measurement of thoracic gas volume. Am. Rev. Respir. Dis. 117: 265–271, 1978.
 138. Hahn, H. L., P. D. Graf, and J. A. Nadel. Effect of vagal tone on airway diameters and on lung volume in anesthetized dogs. J. Appl. Physiol. 41: 581–589, 1976.
 139. Hamilton, W. F., and A. B. Morgan. Mechanism of the postural reduction in vital capacity in relation to orthopnea and storage of blood in the lungs. Am. J. Physiol 99: 526–533, 1931.
 140. Harris, A. S. Inspiratory tonus in anoxia. Am. J. Physiol. 143: 140–147, 1945.
 141. Harris, T. R., P. C. Pratt, and K. H. Kilburn. Total lung capacity measured by roentgenograms. Am. J. Med. 50: 756–763, 1971.
 142. Heaf, P. J. D., and F. J. Prime. The compliance of the thorax in normal human subjects. Clin. Sci. 15: 319–327, 1956.
 143. Helliesen, P. J., C. D. Cook, L. Friedlander, and S. Agathon. Studies of respiratory physiology in children. Pediatrics 22: 80–93, 1958.
 144. Herrald, F. J., and J. McMichael. Determination of lung volume, a constant volume modification of Christie's method. Proc. R. Soc. London Ser. B 126: 491–501, 1939.
 145. Hida, W., T. Sasaki, H. Inoue, and T. Takishima. Inflection points of lung pressure‐volume curves using a three‐balloon‐catheter system. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 931–937, 1979.
 146. Higenbottam, T. Narrowing of glottis opening in humans associated with experimentally induced bronchoconstriction. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol 49: 403–407, 1980.
 147. Higenbottam, T., and T. J. H. Clark. A method for standardizing airway resistance measurements for variations in lung volume. Clin. Sci. 57: 397–400, 1979.
 148. Higenbottam, T., and T. J. H. Clark. Influence of breath holding at total lung capacity on maximal expiratory flow measurements. Clin. Sci. 60: 11–15, 1981.
 149. Hildebrandt, J. Dynamic properties of air‐filled excised cat lung determined by liquid plethysmograph. J. Appl. Physiol. 27: 246–250, 1969.
 150. Hogg, J. C., P. T. Macklem, and W. T. Thurlbeck. Site and nature of airway obstruction in chronic obstructive lung disease. N. Engl. J. Med. 278: 1355–1360, 1968.
 151. Holtz, B., R. Sixt, and B. Bake. Effects of preinspiratory volume on the nitrogen closing volume test. Respir. Physiol. 40: 241–251, 1980.
 152. Holub, D., and R. Frank. A system for rapid measurement of lung function in small animals. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 394–398, 1979.
 153. Hoppin, F. G., Jr., M. Green, and M. S. Morgan. Relationship of central and peripheral airway resistance to lung volume in dogs. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 44: 728–737, 1978.
 154. Horie, T., and J. Hildebrandt. Volume history, static equilibrium, and dynamic compliance of excised cat lung. J. Appl. Physiol. 33: 105–112, 1972.
 155. Howell, J. B. L., and B. W. Peckett. Studies of the elastic properties of the thorax of supine anesthetized paralyzed human subjects. J. Physiol. London 136: 1–19, 1957.
 156. Hurtado, A., and W. W. Fray. Studies of total pulmonary capacity and its subdivisions. III. Changes with body posture. J. Clin. Invest. 12: 825–831, 1933.
 157. Hutchinson, J. Lecture on vital statistics, embracing an account of a new instrument for detecting the presence of disease in the system. Lancet 1: 567–570, 1844.
 158. Hutchinson, J. Lecture on vital statistics, concluded. Lancet 1: 597, 1844.
 159. Hyatt, R. E. The interrelationships of pressure, flow and volume during various respiratory maneuvers in normal and emphysematous subjects. Am. Rev. Respir. Dis. 83: 676–683, 1961.
 160. Hyatt, R. E., and R. E. Flath. Relationship of air flow to pressure during maximal respiratory effort in man. J. Appl. Physiol. 21, 477–482, 1966.
 161. Hyatt, R. E., G. C. Okeson, and J. R. Rodarte. Influence of expiratory flow limitation on the pattern of lung emptying in normal man. J. Appl. Physiol. 35: 411–419, 1973.
 162. Hyatt, R. E., D. P. Schilder, and D. L. Fry. Relationship between maximum expiratory flow and degree of lung inflation. J. Appl. Physiol. 13: 331–336, 1958.
 163. Hyatt, R. E., and R. E. Wilcox. Extrathoracic airway resistance in man. J. Appl. Physiol. 16: 326–330, 1961.
 164. Hyatt, R. E., and R. E. Wilcox. The pressure‐flow relationships of the intrathoracic airway in man. J. Clin. Invest. 42: 29–39, 1963.
 165. Hyatt, R. E., I. R. Zimmerman, G. M. Peters, and W. J. Sullivan. Direct writeout of total respiratory resistance. J. Appl. Physiol. 28: 675–678, 1970.
 166. Ingram, R. H., Jr. Effects of airway versus arterial CO2 changes on lung mechanics in dogs. J. Appl. Physiol. 38: 603–607, 1975.
 167. Ingram, R. H., Jr., and E. R. McFadden, Jr. Localization and mechanisms of airway responses. N. Engl. J. Med. 197: 596–600, 1977.
 168. Ingram, R. H., Jr., and C. F. O'Cain. Frequency dependence of compliance in apparently healthy smokers versus non‐smokers. Bull. Physio‐Pathol. Respir. 7: 195–212, 1971.
 169. Ingram, R. H., Jr., C. F. O'Cain, and W. W. Fridy, Jr. Simultaneous quasi‐static lung pressure‐volume curves and “closing volume” measurements. J. Appl. Physiol. 36: 135–141, 1974.
 170. Ingram, R. H., Jr., and D. P. Schilder. Effect of gas compression on pulmonary pressure, flow, and volume relationship. J. Appl. Physiol. 21: 1821–1826, 1966.
 171. Ingram, R. H., Jr., and D. P. Schilder. Association of a decrease in dynamic compliance with a change in gas distribution. J. Appl. Physiol. 23: 911–916, 1967.
 172. Ingram, R. H., Jr., J. J. Wellman, E. R. McFadden, Jr., and J. Mead. Relative contributions of large and small airways to flow limitation in normal subjects before and after atropine and isoproterenol. J. Clin. Invest. 59: 696–703, 1977.
 173. Jackson, A. C., P. J. Gulesian, Jr., and J. Mead. Glottal aperture during panting with voluntary limitation of tidal volume. J. Appl. Physiol. 39: 834–836, 1975.
 174. Jackson, A. C., H. T. Milhorn, Jr., and J. R. Norman. A reevaluation of the interrupter technique for airway resistance measurement. J. Appl. Physiol. 36: 264–268, 1974.
 175. Jackson, A. C., and A. Vinegar. A technique for measuring frequency response of pressure, volume, and flow transducers. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 462–467, 1979.
 176. Jaeger, M. J., and A. B. Otis. Measurement of airway resistance with a volume displacement body plethysmograph. J. Appl. Physiol. 19: 813–820, 1964.
 177. Johnson, L. F., Jr., and J. Mead. Volume‐pressure relationships during pressure breathing and voluntary relaxation. J. Appl. Physiol. 18: 505–508, 1963.
 178. Jones, J. G., and S. W. Clark. The effect of expiratory flow rate on regional lung emptying. Clin. Sci. 37: 343–356, 1969.
 179. Jones, J. G., R. B. Fraser, and J. A. Nadel. Prediction of maximum expiratory flow rate from area‐transmural pressure curve of compressed airway. J. Appl. Physiol. 38: 1002–1011, 1975.
 180. Kaneko, K., J. Mohler, and O. Balchum. Effect of preinspiratory lung volume on closing volume determination by nitrogen method. J. Appl. Physiol. 38: 10–15, 1975.
 181. King, T. K. C. Mechanical properties of the lungs in the rat. J. Appl. Physiol. 21: 259–264, 1966.
 182. Knowles, J. H., S. K. Hong, and H. Rahn. Possible errors using esophageal balloon in determination of pressure‐volume characteristics of the lung and thoracic cage. J. Appl. Physiol. 14: 525–530, 1959.
 183. Knudson, R. J., B. Burrows, and M. D. Lebowitz. The maximal expiratory flow‐volume curve: its use in the detection of ventilatory abnormalities in a population study. Am. Rev. Respir. Dis. 114: 971–979, 1976.
 184. Knudson, R. J., D. F. Clark, T. C. Kennedy, and D. E. knudson. Effect of aging alone on mechanical properties of the normal adult human lung. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 43: 1054–1062, 1977.
 185. Knudson, R. J., and W. T. Kaltenborn. Evaluation of lung elastic recoil by exponential curve analysis. Respir. Physiol. 46: 29–42, 1981.
 186. Knudson, R. J., and M. D. Lebowitz. Maximal mid‐expiratory flow (FEF 25–75%): normal limits and assessment of sensitivity (Letter). Am. Rev. Respir. Dis. 117: 609–610, 1978.
 187. Knudson, R. J., M. D. Lebowitz, A. P. Burton, and D. E. Knudson. The closing volume test: evaluation of nitrogen and bolus methods in a random population. Am. Rev. Respir. Dis. 115: 423–434, 1977.
 188. Knudson, R. J., M. D. Lebowitz, and R. C. Slatin. The timing of the forced vital capacity. Am. Rev. Respir. Dis. 119: 315–318, 1979.
 189. Knudson, R. J., J. Mead, and D. E. Knudson. Contribution of airway collapse to supramaximal expiratory flows. J. Appl. Physiol. 36: 653–667, 1974.
 190. Knudson, R. J., R. C. Slatin, M. D. Lebowitz, and B. Burrows. The maximum expiratory flow‐volume curve. Am. Rev. Respir. Dis. 113: 587–600, 1976.
 191. Koo, K. W., D. E. Leith, C. B. Sherter, and G. L. Snider. Respiratory mechanics in normal hamsters. J. Appl. Physiol. 40: 936–942, 1976.
 192. Kryger, M., R. R. Martin, P. T. Macklem, and N. R. Anthonisen. Effect of gas density and expiratory flow on “closing volume.” J. Appl. Physiol. 37: 831–834, 1974.
 193. Lai, Y.‐L. Lung volume and pleural pressure in the anesthetized hamster. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 927–931, 1979.
 194. Landau, L. I., L. M. Taussig, P. T. Macklem, and P. H. Beaudry. Contribution of inhomogeneity of lung units to the maximal expiratory flow‐volume curve in children with asthma and cystic fibrosis. Am. Rev. Respir. Dis. 111: 725–731, 1973.
 195. Lándsér, F. J., J. Nagels, J. Clément, and K. P. van de Woestijne. Errors in the measurement of total respiratory resistance and reactance by forced oscillations. Respir. Physiol. 28: 289–301, 1976.
 196. Lándsér, F. J., J. Nagels, M. Demedts, L. Billiet, and K. P. van de Woestijne. A new method to determine frequency characteristics of the respiratory system. J. Appl. Physiol. 41: 101–106, 1976.
 197. LeBlanc, P., F. Ruff, and J. Milic‐Emili. Effects of age and body position on “airway closure” in man. J. Appl. Physiol. 28: 448–451, 1970.
 198. Leith, D. E., and M. Bradley. Ventilatory muscle strength and endurance training. J. Appl. Physiol. 41: 508–516, 1976.
 199. Leith, D. E., and J. Mead. Mechanisms determining residual volume of the lungs in normal subjects. J. Appl. Physiol. 23: 221–227, 1967.
 200. Leith, D. E., and J. Mead. Principles of Body Plethysmography. Bethesda, MD: Natl. Heart, Lung, Blood Inst., Div. Lung Dis., 1974.
 201. Leuallen, E. C., and W. S. fowler. Maximum mid‐expiratory flow. Am. Rev. Tuberc. 72: 783–800, 1955.
 202. Lewis, B. M. Use of two inert gases to measure functional residual capacity. J. Appl. Physiol. 31: 629–631, 1971.
 203. Libby, D. M., W. B. Briscoe, and T. K. C. King. Relief of hypoxia‐related bronchoconstriction by breathing 30 percent oxygen. Am. Rev. Respir. Dis. 123: 171–175, 1981.
 204. Linn, W. S., and J. D. Hackney. Nitrogen and helium “closing volumes”: simultaneous measurement and reproducibility. J. Appl. Physiol. 34: 396–399, 1973.
 205. Lisboa, C., J. Jardim, E. Angus, and P. T. Macklem. Is extrathoracic airway obstruction important in asthma? Am. Rev. Respir. Dis. 122: 115–121, 1980.
 206. Lisboa, C., W. R. D. Ross, J. Jardim, and P. T. Macklem. Pulmonary pressure‐flow curves measured by a data‐averaging circuit. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 621–627, 1979.
 207. Lisboa, C., L. D. H. Wood, J. Jardim, and P. T. Macklem. Relation between flow, curvilinearity, and density dependence of pulmonary pressure‐flow curves. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 878–885, 1980.
 208. Lloyd, H. M., S. T. String, and A. B. DuBois. Radiographic and plethysmographic determination of total lung capacity. Radiology 86: 7–14, 1966.
 209. Lorino, H., A. Harf, G. Atlan, Y. Brault, A. M. Lorino, and D. Laurent. Computer determination of thoracic gas volume using plethysmographic “thoracic flow.” J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 911–916, 1980.
 210. Macklem, P. T. Airway obstruction and collateral ventilation. Physiol. Rev. 51: 368–436, 1971.
 211. Macklem, P. T., R. G. Fraser, and D. V. Bates. Bronchial pressures and dimensions in health and obstructive airway disease. J. Appl. Physiol. 18: 699–706, 1963.
 212. Macklem, P. T., and J. Mead. Resistance of central and peripheral airways measured by a retrograde catheter. J. Appl. Physiol. 22: 395–401, 1967.
 213. Macklem, P. T., A. J. Woolcock, J. C. Hogg, J. A. Nadel, and N. J. Wilson. Partitioning of pulmonary resistance in the dog. J. Appl. Physiol. 26: 798–805, 1969.
 214. Manco, J. C., and R. E. Hyatt. Relationship of air trapping to increased lung recoil pressure induced by chest cage restriction. Am. Rev. Respir. Dis. 111: 21–26, 1975.
 215. Mansell, A., C. Bryan, and H. Levison. Airway closure in children. J. Appl. Physiol. 33: 711–714, 1972.
 216. Mansell, A. L., A. C. Bryan, and H. Levison. Relationship of lung recoil to lung volume and maximum expiratory flow in normal children. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 42: 817–823, 1977.
 217. Mansell, A., C. Dubrawsky, H. Levison, A. C. Bryan, and D. N. Crozier. Lung elastic recoil in cystic fibrosis. Am. Rev. Respir. Dis. 109: 190–197, 1974.
 218. Mansell, A., A. Powles, and J. Sutton. Changes in pulmonary PV characteristics of human subjects at an altitude of 5,366 m. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 79–83, 1980.
 219. Marshall, R. The physical properties of the lungs in relation to the subdivisions of lung volume. Clin. Sci. 16: 507–515, 1957.
 220. Marshall, R. Objective tests of respiratory mechanics. In: Handbook of Physiology. Respiration, edited by W. O. Fenn and H. Rahn Washington, DC: Am. Physiol. Soc, 1965, sect. 3, vol. II, chapt. 55, p. 1399–1412.
 221. Marshall, R., and A. B. DuBois. The measurement of the viscous resistance of the lung tissues in normal man. Clin. Sci. 15: 161–170, 1956.
 222. Martin, C. J., S. Das, and A. C. Young. Terminal nitrogen rise. J. Appl. Physiol. 41: 517–522, 1976.
 223. Martin, J., E. Powell, S. Shore, J. Emrich, and L. A. Engel. The role of respiratory muscles in the hyperinflation of bronchial asthma. Am. Rev. Respir. Dis. 121: 441–447, 1980.
 224. Martin, R. R., C. Lemelin, M. Zutter, and N. R. Anthonisen. Measurement of “closing volume”: applications and limitations. Bull. Physio‐Pathol. Respir. 9: 979–996, 1973.
 225. Martin, R., and P. T. Macklem. Suggested Standardized Procedures for Closing Volume Determinations (Nitrogen Method). Bethesda, MD: Natl. Heart, Lung, Blood Inst. Div. Lung Dis., 1973.
 226. Martin, R. R., J. E. Wilson, W. R. D. Ross, and N. R. Anthonisen. The effect of added external resistance on regional pulmonary filling and emptying sequences. Can. J. Physiol. Pharmacol. 49: 406–411, 1971.
 227. McCall, C. B., R. E. Hyatt, F. W. Noble, and D. L. Fry. Harmonic content of certain respiratory flow phenomena of normal individuals. J. Appl. Physiol. 10: 215–218, 1957.
 228. McCarthy, D. S., R. Spencer, R. Greene, and J. Milic‐Emili. Measurement of “closing volume” as a simple and sensitive test for early detection of small airway disease. Am. J. Med. 52: 747–753, 1972.
 229. McFadden, E. R., Jr., J. Newton‐Howes, and N. B. Pride. Acute effects of inhaled isoproterenol on the mechanical characteristics of the lungs in normal man. J. Clin. Invest. 49: 779–790, 1970.
 230. Mead, J. Control of respiratory frequency. J. Appl. Physiol 15: 325–336, 1960.
 231. Mead, J. Volume displacement body plethysmograph for respiratory measurements in human subjects. J. Appl. Physiol. 15: 736–740, 1960.
 232. Mead, J. Mechanical properties of lungs. Physiol. Rev. 41: 281–330, 1961.
 233. Mead, J. Contribution of compliance of airways to frequency‐dependent behavior of lungs. J. Appl. Physiol. 26: 670–673, 1969.
 234. Mead, J. Analysis of the configuration of maximum expiratory flow‐volume curves. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 44: 156–165, 1978.
 235. Mead, J. Dysanapsis in normal lungs assessed by the relationship between maximum flow, static recoil, and vital capacity. Am. Rev. Respir. Dis. 121: 339–342, 1980.
 236. Mead, J., and C. Collier. Relation of volume history of lungs to respiratory mechanics in anesthetized dogs. J. Appl. Physiol. 14: 669–678, 1959.
 237. Mead, J., and E. A. Gaensler. Esophageal and pleural pressures in man, upright and supine. J. Appl. Physiol. 14: 81–83, 1959.
 238. Mead, J., I. Lindgren, and E. A. Gaensler. The mechanical properties of the lung in emphysema. J. Clin. Invest. 34: 1005–1016, 1955.
 239. Mead, J., M. B. McIlroy, N. J. Selverstone, and B. C. Kriete. Measurement of intraesophageal pressure. J. Appl. Physiol. 7: 491–495, 1955.
 240. Mead, J., J. Milic‐Emili, and J. M. Turner. Factors limiting depth of a maximal inspiration in human subjects. J. Appl. Physiol. 18: 295–296, 1963.
 241. Mead, J., J. M. Turner, P. T. Macklem, and J. B. Little. Significance of the relationship between lung recoil and maximum expiratory flow. J. Appl. Physiol. 22: 95–108, 1967.
 242. Mead, J., and J. L. Whittenberger. Physical properties of human lungs measured during spontaneous respiration. J. Appl. Physiol. 5: 779–796, 1953.
 243. Mead, J., and J. L. Whittenberger. Evaluation of airway interruption techniques as a method for measuring pulmonary air‐flow resistance. J. Appl. Physiol 6: 408–416, 1954.
 244. Melissinos, C. G., and J. Mead. Maximum expiratory flow changes induced by longitudinal tension on trachea in normal subjects. J. Appl. Physiol. 43: 537–544, 1977.
 245. Melissinos, C. G., P. Webster, Y. K. Tien, and J. Mead. Time dependence of maximum flow as an index of nonuniform emptying. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 1043–1050, 1979.
 246. Michaelson, E., E. Grassman, and W. Peters. Pulmonary mechanics by spectral analysis of forced random voice. J. Clin. Invest. 56: 1210–1230, 1975.
 247. Milic‐Emili, G., and J. M. Petit. Relationship between endoesophageal and intrathoracic pressure variations in dog. J. Appl. Physiol. 14: 535–537, 1959.
 248. Milic‐Emili, G., and J. M. Petit. Effets de la teneur en oxygène de l'air inspiré sur les propriétés mécaniques des poumons chez l'homme normal. J. Physiol. Paris 52: 175–177, 1960.
 249. Milic‐Emili, J., J. A. M. Henderson, M. B. Dolovich, D. Trop, and K. Kaneko. Regional distribution of inspired gas in the lung. J. Appl. Physiol. 21: 749–759, 1966.
 250. Milic‐Emili, J., J. Mead, and J. M. Turner. Topography of esophageal pressure as a function of posture in man. J. Appl. Physiol. 19: 212–216, 1964.
 251. Milic‐Emili, J., J. Mead, J. M. Turner, and E. M. Glauser. Improved technique for estimating pleural pressure from esophageal balloons. J. Appl. Physiol. 19: 207–211, 1964.
 252. Miller, E. D., and R. E. Hyatt. Evaluation of obstructing lesions of the trachea and larynx by flow‐volume loops. Am. Rev. Respir. Dis. 108: 475–481, 1973.
 253. Millette, B., P. C. Robertson, W. R. D. Ross, and N. R. Anthonisen. Effect of expiratory flow rate on emptying of lung regions. J. Appl. Physiol. 27: 587–591, 1969.
 254. Mills, J. N. Variability of the vital capacity of the normal human subject. J. Physiol. London 110: 76–82, 1949.
 255. Mills, R. J., G. Cumming, and P. Harris. Frequency‐dependent compliance at different levels of inspiration in normal adults. J. Appl. Physiol. 18: 1061–1064, 1963.
 256. Mink, S. N., and L. D. H. Wood. How does HeO2 increase maximum expiratory flow in human lungs? J. Clin. Invest. 66: 720–729, 1980.
 257. Miranda, J. M., and R. V. Lourenço. Influence of diaphragm activity on the measurement of total chest compliance. J. Appl. Physiol. 24: 741–746, 1968.
 258. Mittman, C., N. H. Edelman, A. H. Norris, and N. W. shock. Relationship between chest wall and pulmonary compliance and age. J. Appl. Physiol. 20: 1211–1216, 1965.
 259. Morris, J. F., A. Koski, and L. C. Johnson. Spirometric standards for healthy non‐smoking adults. Am. Rev. Respir. Dis. 103: 57–67, 1971.
 260. Muller, N., A. C. Bryan, and N. Zamel. Tonic inspiratory muscle activity as a cause of hyperinflation in histamine‐induced asthma. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 869–874, 1980.
 261. Muller, N., A. C. Bryan, and N. Zamel. Tonic inspiratory muscle activity as a cause of hyperinflation in asthma. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50: 279–282, 1981.
 262. Muller, N., G. Volgyesi, L. Becker, M. H. Bryan, and A. C. Bryan. Diaphragmatic muscle tone. J. Appl. Physiol. 47: 279–284, 1979.
 263. Murphy, B. G., J. Dosman, F. Bode, and P. T. Macklem. A dynamic compliance computer: comparison of on‐line results with manual calculations in man. J. Appl. Physiol. 36: 629–633, 1974.
 264. Murphy, B. G., and L. A. Engel. Models of the pressure‐volume relationship of the lung. Respir. Physiol. 32: 183–194, 1978.
 265. Nadel, J. A., H. J. H. Colebatch, and C. R. Olsen. Location and mechanism of airway constriction after barium sulfate microembolism. J. Appl. Physiol. 19: 387–394, 1964.
 266. Nadel, J. A., and D. F. Tierney. Effect of a previous deep inspiration on airway resistance in man. J. Appl. Physiol. 16: 717–719, 1961.
 267. Nagels, J., F. J. Lándsér, L. Van der Linden, J. Clément, and K. P. Van de Woestijne. Mechanical properties of lungs and chest wall during spontaneous breathing. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 408–416, 1980.
 268. Naimark, A., and R. M. Cherniack. Compliance of the respiratory system and its components in health and obesity. J. Appl. Physiol. 15: 377–382, 1960.
 269. Nathar, S. P., M. D. Lebowitz, and R. J. Knudson. Spirometric testing: number of tests required and selection of data. Chest 76: 384–388, 1979.
 270. Neergaard, K. von, and K. Wirz. Über eine Methode zur Messung der Lungenelastizität am lebenden Menschen, insbesondere beim Emphysem. Z. Klin. Med. 105: 35–50, 1927.
 271. Neergaard, K. von, and K. Wirz. Die Messung der Strömungswiderstände in den Atemwegen des Menschen, insbesondere bei Asthma und Emphysem. Z. Klin. Med. 105: 51–82, 1927.
 272. Neuburger, N., H. Levison, A. C. Bryan, and K. Kruger. Transit time analysis of the forced expiratory spirogram in growth. J. Appl. Physiol. 40: 329–332, 1976.
 273. Newhouse, M. T., M. R. Becklake, P. T. Macklem, and M. McGregor. Effect of alterations in end‐tidal CO2 tension on flow resistance. J. Appl. Physiol. 19: 745–749, 1964.
 274. Nielsen, T. M., and O. F. Pedersen. The effect of oxygen on peripheral airways. Acta. Physiol. Scand. 99: 257–260, 1977.
 275. Nunneley, S. A., E. T. Flynn, Jr., and E. M. Camporesi. Two‐tracer method for rapid determination of residual volume. J. Appl. Physiol. 37: 286–289, 1974.
 276. O'Cain, C. F., M. J. Hensley, E. R. McFadden, Jr., and R. H. Ingram, Jr. Pattern and mechanism of airway response to hypocapnia in normal subjects. J. Appl. Physiol. 47: 8–12, 1979.
 277. Ogilvie, C. M., R. E. Forster, W. S. Blakemore, and J. W. Morton. A standardized breath holding technique for the clinical measurement of pulmonary diffusing capacity by the single breath method. J. Clin. Invest. 36: 1–32, 1957.
 278. Osmanliev, D. P., and P. K. Popov. Influence of expiratory flow rate on closing volume measurement. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 1011–1015, 1979.
 279. Otis, A. B., C. B. McKerrow, R. A. Bartlett, J. Mead, M. B. McIlroy, N. J. Selverstone, and E. P. Radford, Jr. Mechanical factors in distribution of pulmonary ventilation. J. Appl. Physiol. 8: 427–443, 1956.
 280. Paiva, M., J. C. Yernault, P. Van Eerdeweghe, and M. Englert. A sigmoid model of the static volume‐pressure curve of human lung. Respir. Physiol. 23: 317–323, 1975.
 281. Paleček, F. Measurement of ventilatory mechanics in the rat. J. Appl. Physiol. 27: 149–156, 1969.
 282. Pelzer, A.‐M., and M. L. Thomson. Effect of age, sex, stature, and smoking habits on human airway conductance. J. Appl. Physiol. 21: 469–476, 1966.
 283. Pengelly, L. D. Curve‐fitting analysis of pressure‐volume characteristics of the lungs. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 42: 111–116, 1977.
 284. Pennock, B. E., C. P. Cox, R. M. Rogers, W. A. Cain, and J. H. Wells. A noninvasive technique for measurement of changes in specific airway resistance. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 399–406, 1979.
 285. Permutt, S., and H. A. Menkes. Spirometry: analysis of the forced expiration within the time domain. In: Lung Biology in Health and Disease. The Lung in the Transition Between Health and Disease, edited by P. T. Macklem and S. Permutt New York: Dekker, 1979, vol. 12, p. 113–151.
 286. Petit, J. M., and G. Milic‐Emili. Measurement of endoesophageal pressure. J. Appl. Physiol. 13: 481–485, 1958.
 287. Peyser, E., A. Sass‐Kortsák, and F. Verzár. Influence of O2 content of inspired air on total lung volume. Am. J. Physiol. 163: 111–117, 1950.
 288. Picken, J. J., D. E. Niewoehner, and E. H. Chester. Prolonged effects of viral infections of the upper respiratory tract upon small airways. Am. J. Med. 52: 738–746, 1972.
 289. Pierce, J. A., and R. V. Ebert. The elastic properties of the lungs in the aged. J. Lab. Clin. Med. 51: 63–71, 1958.
 290. Pimmel, R. L., M. J. Tsai, D. C. Winter, and P. A. Bromberg. Estimating central and peripheral respiratory resistance. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45: 375–380, 1978.
 291. Prefaut, C., E. Lupi‐H, and N. R. Anthonisen. Human lung mechanics during water immersion. J. Appl. Physiol. 40: 320–323, 1976.
 292. Pride, N. B., S. Permutt, R. L. Riley, and B. Bromberger‐Barnea. Determinants of maximum expiratory flow from the lungs. J. Appl. Physiol. 23: 646–662, 1967.
 293. Proulx, P. A., A. Harf, H. Lorino, G. Atlan, and D. Laurent. Dynamic characteristics of air‐filled differential pressure transducers. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 608–614, 1979.
 294. Racineux, J. L., R. peslin and B. Hannhart. Sensitivity of forced expiration indices to induced changes in peripheral airway resistance. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50: 15–20, 1981.
 295. Rahn, H., W. O. Fenn, and A. B. Otis. Daily variations of vital capacity, residual air, and expiratory reserve including a study of the residual air method. J. Appl. Physiol. 1: 725–736, 1949.
 296. Rahn, H., A. B. Otis, L. E. Chadwick, and W. O. Fenn. The pressure‐volume diagram of the thorax and lung. Am. J. Physiol. 146: 161–178, 1946.
 297. Richards, C. C., and L. Backman. Lung and chest wall compliance of apneic paralyzed infants. J. Clin. Invest. 40: 273–278, 1961.
 298. Ries, A. L., J. L. Clausen, and P. J. Friedman. Measurement of lung volumes from supine portable chest radiographs. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 1332–1335, 1979.
 299. Robertson, P. C., N. R. Anthonisen, and D. Ross. Effect of inspiratory flow rate on regional distribution of inspired gas. J. Appl. Physiol. 26: 438–443, 1969.
 300. Rodarte, J. R., L. W. Burgher, R. E. Hyatt, and K. Rehder. Lung recoil and gas trapping during oxygen breathing at low lung volumes. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 43: 138–143, 1977.
 301. Rodarte, J. R., R. E. Hyatt, and D. A. Cortese. Influence of expiratory flow on closing capacity at low expiratory flow rates. J. Appl. Physiol. 39: 60–65, 1975.
 302. Rodarte, J. R., R. E. Hyatt, and P. R. Westbrook. Determination of lung volume by single‐ and multiple‐breath nitrogen washout. Am. Rev. Respir. Dis. 114: 131–136, 1976.
 303. Rodenstein, D. O., D. C. Stänescu, and C. Francis. Demonstration of failure of body plethysmography in airway obstruction. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52: 949–954, 1982.
 304. Rohrer, F. Der Zusammenhang der Atemkräfte und ihre Abhängigkeit vom Dehnungszustand der Atmungsorgane. Pfluegers Arch. Gesamte Physiol. Menschen Tiere 165: 419–444, 1916.
 305. Rossiter, C. E., and H. Weill. Ethnic differences in lung function: evidence for proportional differences. Int. J. Epidemiol. 3: 55–61, 1974.
 306. Roussos, C. S., M. Fixley, J. Genest, M. Cosio, S. Kelly, R. R. Martin, and L. A. Engel. Voluntary factors influencing the distribution of inspired gas. Am. Rev. Respir. Dis. 116: 457–467, 1977.
 307. Saibene, F., and J. Mead. Frequency dependence of pulmonary quasi‐static hysteresis. J. Appl. Physiol. 26: 732–737, 1969.
 308. Salazar, E., and J. H. Knowles. An analysis of pressure‐volume characteristics of the lungs. J. Appl. Physiol. 19: 97–104, 1964.
 309. Sasaki, H., W. Hida, and T. Takishima. Influence of body position on dynamic compliance in young subjects. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 42: 706–710, 1977.
 310. Sasaki, T., S. Suzuki, M. Sugiyama, and T. Takishima. Frequency dependence of dynamic compliance analyzed from one cycle of breathing. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 45–53, 1980.
 311. Saunders, N. A., M. F. Betts, L. D. Pengelly, and A. S. Rebuck. Changes in lung mechanics induced by acute isocapnic hypoxia. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 42: 413–419, 1977.
 312. Scheidt, M., R. E. Hyatt, and K. Rehder. Effects of rib cage or abdominal restriction on lung mechanics. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 51: 1115–1121, 1981.
 313. Schilder, D. P., R. E. Hyatt, and D. L. Fry. An improved balloon system for measuring intraesophageal pressure. J. Appl. Physiol. 14: 1057–1058, 1959.
 314. Schoenberg, J. B., G. J. Beck, and A. Bouhuys. Growth and decay of pulmonary function in healthy blacks and whites. Respir. Physiol. 33: 367–393, 1978.
 315. Sharp, J. T., J. P. Henry, S. K. Sweany, W. R. Meadows, and R. J. Pietras. Effects of mass loading the respiratory system in man. J. Appl. Physiol. 19: 959–966, 1964.
 316. Sinnett, E. E., A. C. Jackson, D. E. Leith, and J. P. Butler. Fast integrated flow plethysmograph for small mammals. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50: 1104–1110, 1981.
 317. Slutsky, A. S., and J. M. Drazen. Estimating central and peripheral respiratory resistance: an alternative analysis. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 1325–1331, 1979.
 318. Spann, R. W., and R. E. Hyatt. Factors affecting upper airway resistance in conscious man. J. Appl. Physiol. 31: 708–712, 1971.
 319. Stamm, A. M., J. L. Clausen, and G. M. Tisi. Effect of aerosolized isoproterenol on resting myogenic tone in normals. J. Appl. Physiol. 40: 525–532, 1976.
 320. Stânescu, D. C., R. Fesler, C. Veriter, A. Frans, and L. Brasseur. A modified measurement of respiratory resistance by forced oscillation during normal breathing. J. Appl. Physiol. 39: 305–311, 1975.
 321. Stânescu, D. C., S. Mahieu‐van der Linden, C. Veriter, L. Piret, and L. Brasseur. Even distribution of 133Xe bolus inhaled at residual volume in healthy subjects. Respir. Physiol. 35: 177–187, 1978.
 322. Stânescu, D., N. E. Moavero, C. Veriter, and L. Brasseur. Frequency dependence of respiratory resistance in healthy children. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 268–272, 1979.
 323. Stânescu, D. C., J. Pattijn, J. Clément, and K. P. van de Woestijne. Glottis opening and airway resistance. J. Appl. Physiol. 32: 460–466, 1972.
 324. Stânescu, D. C., D. Rodenstein, M. Cauberghs, and K. P. van de Woestijne. Failure of body plethysmography in bronchial asthma. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52: 939–948, 1982.
 325. Stânescu, D., C. Veriter, and L. Brasseur. Difference between the He bolus and N2 technique for measuring closing volume. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 42: 859–864, 1977.
 326. Stocks, J., and S. Godfrey. Nasal resistance during infancy. Respir. Physiol. 34: 233–245, 1978.
 327. Stocks, J., N. M. Levy, and S. Godfrey. A new apparatus for the accurate measurement of airway resistance in infancy. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 43: 155–159, 1977.
 328. Streider, D. J., R. Laguarda, L. C. Stigol, and M. E. Wohl. Increased lung recoil during hypoxia in dogs. Respir. Physiol. 21: 193–201, 1974.
 329. Strope, G. L., C. L. Cox, R. L. Pimmel, and W. A. Clyde, Jr. Dynamic respiratory mechanics in intact anesthetized hamsters. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 197–203, 1980.
 330. Stubbs, S. E., and R. E. Hyatt. Effect of increased lung recoil pressure on maximal expiratory flow in normal subjects. J. Appl. Physiol. 32: 325–331, 1972.
 331. Susskind, H., P. Richards, and H. Atkins. The measurement of “closing volume” as affected by lung volume at tracer bolus inspiration, breath holding, and expiratory flow rate. Scand. J. Respir. Dis. Suppl. 85: 218–227, 1974.
 332. Sutherland, P. W., T. Katsura, and J. Milic‐Emili. Previous volume history of the lung and regional distribution of gas. J. Appl. Physiol. 25: 566–574, 1968.
 333. Swenson, E. W., T. N. Finley, and S. V. Guzman. Unilateral hypoventilation in man during temporary occlusion of one pulmonary artery. J. Clin. Invest. 40: 383–385, 1961.
 334. Swyer, P. R., R. C. Reiman, and J. J. Wright. Ventilation and ventilatory mechanics in the newborn. Pediatrics 8: 37–57, 1960.
 335. Sybrecht, G. W., L. Garrett, and N. R. Anthonisen. Effect of chest strapping on regional lung function. J. Appl. Physiol. 39: 707–713, 1975.
 336. Taussig, L. M., T. R. Harris, and M. D. Lebowitz. Lung function in infants and children. Am. Rev. Respir. Dis. 116: 233–239, 1977.
 337. Tenney, S. M., H. Rahn, R. C. Stroud, and J. C. Mithoefer. Adaption to high altitude: changes in lung volumes during the first seven days at Mt. Evans, Colorado. J. Appl. Physiol. 5: 607–613, 1953.
 338. Tien, Y.‐K., E. A. Elliott, and J. Mead. Variability of the configuration of maximum expiratory flow‐volume curves. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 565–570, 1979.
 339. Tierney, D. F., and J. A. Nadel. Concurrent measurements of functional residual capacity by three methods. J. Appl. Physiol. 17: 871–873, 1962.
 340. Travis, D. M., M. Green, and H. Don. Simultaneous comparison of helium and nitrogen expiratory “closing volumes.” J. Appl. Physiol. 34: 304–308, 1973.
 341. Travis, D. M., M. Green, and H. F. Don. Expiratory flow rate and closing volumes. J. Appl. Physiol. 35: 626–630, 1973.
 342. Trop, D., R. Peeters, and K. P. van de Woestijne. Localization of recording site in the esophagus by means of cardiac artifacts. J. Appl. Physiol. 29: 283–287, 1970.
 343. Turner, J. M., J. Mead, and M. E. Wohl. Elasticity of human lungs in relation to age. J. Appl. Physiol. 25: 664–671, 1968.
 344. Van Lith, P., F. N. Johnson, and J. T. Sharp. Respiratory elastances in relaxed and paralyzed states in normal and abnormal men. J. Appl. Physiol. 23: 475–486, 1967.
 345. Vincent, N. J., R. Knudson, D. E. Leith, P. T. Macklem, and J. Mead. Factors influencing pulmonary resistance. J. Appl. Physiol. 29: 236–243, 1970.
 346. Vinegar, A., E. E. Sinnett, and D. E. Leith. Dynamic mechanisms determine functional residual capacity in mice, Mus musculus. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 46: 867–871, 1979.
 347. Vuilleumier, P. Über ein Methode zur Messung des intraalveolaren Druckes and der Strömungswiderstände in Atemwegen des Menschen. Z. Klin. Med. 143: 698, 1943–44.
 348. Webster, P. M., N. Zamel, A. C. Bryan, and K. Kruger. Volume dependence of instantaneous time constants derived from the maximal expiratory flow‐volume curve. Am. Rev. Respir. Dis. 115: 805–810, 1977.
 349. Wellman, J. J., R. Brown, R. H. Ingram, Jr., J. Mead, and E. R. McFadden, Jr. Effect of volume history on successive partial expiratory flow‐volume maneuvers. J. Appl. Physiol. 41: 153–158, 1976.
 350. Wells, H. S., W. W. Stead, T. D. Rossing, and J. Ognanovich. Accuracy of an improved spirometer for recording of fast breathing. J. Appl. Physiol. 14: 451–454, 1959.
 351. Williams, S. P., J. M. Fullton, M. J. Tsai, R. L. Pimmel, and A. M. Collier. Respiratory impedance and derived parameters in young children by forced random noise. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47: 169–174, 1979.
 352. Wilmon, T. L., and A. R. Behnke. Residual lung volume determinations by the methods of helium substitution and volume expansion. Am. J. Physiol. 153: 138–142, 1948.
 353. Wood, L. D. H., L. A. Engel, P. Griffin, P. Despas, and P. T. Macklem. Effect of gas physical properties and flow on lower pulmonary resistance. J. Appl. Physiol. 41: 234–244, 1976.
 354. Wood, T. E., P. McLeod, N. R. Anthonisen, and P. T. Macklem. Mechanics of breathing in mitral stenosis. Am. Rev. Respir. Dis. 104: 52–60, 1971.
 355. Woolcock, A. J., P. T. Macklem, J. C. Hogg, N. J. Wilson, J. A. Nadel, N. R. Frank, and J. Brain. Effect of vagal stimulation on central and peripheral airways in dogs. J. Appl. Physiol. 26: 806–813, 1969.
 356. Woolcock, A. J., N. J. Vincent, and P. T. Macklem. Frequency dependence of compliance as a test for obstruction in small airways. J. Clin. Invest. 4: 1097–1106, 1969.
 357. Wright, H. M., and C. B. McKerrow. Maximum forced expiratory flow rate as a measure of ventilatory capacity. Br. Med. J. 2: 1041–1047, 1959.
 358. Yamashiro, S. M., S. K. Karuza, and J. D. Hackney. Phase compensation of Fleisch pneumotachographs. J. Appl. Physiol. 36: 493–495, 1974.
 359. Zapletal, A., E. K. Motoyama, K. P. van de Woestijne, V. R. Hunt, and A. Bouhuys. Maximum expiratory flow‐volume curves and airway conductance in children and adolescents. J. Appl. Physiol. 26: 308–316, 1969.
 360. Zapletal, A., T. Paul, and M. Šamánek. Pulmonary elasticity in children and adolescents. J. Appl. Physiol. 40: 953–961, 1976.

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Article Title: Tests of Mechanical Function
 

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N. R. Anthonisen. Tests of Mechanical Function. Compr Physiol 2011, Supplement 12: Handbook of Physiology, The Respiratory System, Mechanics of Breathing: 753-784. First published in print 1986. doi: 10.1002/cphy.cp030344