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Evidence for Roles of Brain Peptides in Thermoregulation

Wesley G. Clark, Melvin J. Fregly

10.1002/cphy.cp040108

Source: Supplement 14: Handbook of Physiology, Environmental Physiology

Originally published: 1996

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Hypothermic Peptides
1.1 Angiotensin II (All)
1.2 Neurotensin (NT)
1.3 Summary
2 Hyperthermic Peptides
2.1 Beta‐Endorphin (BE)
2.2 Luteinizing Hormone–Releasing Hormone (LH‐RH)
2.3 Somatostatin (SS)
2.4 Thyrotropin‐Releasing Hormone (TRH)
2.5 Vasoactive Intestinal Polypeptide (VIP)
2.6 Summary
3 Antipyretic Peptides
3.1 AVP
3.2 Alpha‐MSH
3.3 Corticotropin‐Releasing Factor (CRF)
3.4 Summary
4 Concluding Comments
References
 1. Ahokas, R. A., J. Seydoux, J. Llanes‐Q, T. A. Mashburn, Jr., and C. M. Blatteis. Hypothalamic opioids and the acute‐phase glycoprotein response in guinea pigs. Brain Res. Bull. 15: 603–608, 1985.
 2. Baldino, F., Jr., and B. Wolfson. Postsynaptic actions of neurotensin on preoptic‐anterior hypothalamic neurons in vitro. Brain Res. 325: 161–170, 1985.
 3. Banks, W. A., and A. J. Kastin. Peptide transport systems for opiates across the blood–brain barrier. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E1–E10, 1990.
 4. Beckman, A. L., and C. Llados‐Eckman. Antagonism of brain opioid peptide action reduces hibernation bout duration. Brain Res. 328: 201–205, 1985.
 5. Bell, R. C., and J. M. Lipton. Pulsatile release of antipyretic neuropeptide α‐MSH from septum of rabbit during fever. Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol. 21): R1152–R1157, 1987.
 6. Bell, R. E., J. Feng, and J. M. Lipton. Is the endogenous antipyretic neuropeptide α‐MSH responsible for reduced fever in aged rabbits? Peptides 8: 501–504, 1987.
 7. Bernardini, G. L., D. B. Richards, and J. M. Lipton. Antipyretic effect of centrally administered CRF. Peptides 5: 57–59, 1984.
 8. Bissette, G., C. B. Nemeroff, P. T. Loosen, A. J. Prange, Jr., and M. A. Lipton. Hypothermia and cold intolerance induced by the intracisternal administration of hypothalamic peptide neurotensin. Nature 262: 607–609, 1976.
 9. Björklund, A., and T. Hökfelt, eds. Handbook of Chemical Neuroanatomy. GABA and Neuropeptides in the CNS. Amsterdam: Elsevier, 1985, vol. 4, pt. I.
 10. Björklund, A., T. Hökfelt, and M. J. Kuhar. Handbook of Chemical Neuroanatomy. Neuropeptides in the CNS. Amsterdam: Elsevier, 1990, vol. 9, pt. II.
 11. Bläsig, J., V. Höllt, U. Bäuerle, and A. Herz. Involvement of endorphins in emotional hyperthermia of rats. Life Sci. 23: 2525–2531, 1978.
 12. Blatteis, C. M. Functional anatomy of the hypothalamus from the point of view of thermoregulation. In: Contributions to Thermal Physiology, edited by Z. Szelenyi, and M. Szekely. Oxford: Pergamon, 1981, p. 2–12.
 13. Blatteis, C. M. Hypothalamic substances in the control of body temperature: general characteristics. Federation Proc. 40: 2735–2740, 1981.
 14. Blatteis, C. M., L. Xin, and N. Quan. Neuromodulation of fever: apparent involvement of opioids. Brain Res. Bull. 26: 219–223, 1991.
 15. Bligh, J. The central neurology of mammalian thermoregulation. Neuroscience 4: 1213–1236, 1979.
 16. Bodnar, R. J., M. M. Wallace, G. Nilaver, and E. A. Zimmerman. The effects of centrally administered antisera to neurotensin and related peptides upon nociception and related behaviors. Ann. N. Y. Acad. Sci. 400: 244–257, 1982.
 17. Boulant, J. S., M. L. Carras, and J. B. Dean. Neurophysiological aspects of thermoregulation. In: Advances in Comparative and Environmental Physiology, edited by L. C. H. Wang. Berlin: Springer, 1989, p. 117–160.
 18. Brandt, N. J., L. Terenius, B. B. Jacobsen, L. Klinken, Å. Nordius, S. Brandt, K. Blebvad, and M. Yssing. Hyper‐endorphin syndrome in a child with necrotizing encephalomyelopathy. N. Engl. J. Med. 303: 914–916, 1980.
 19. Brown, M., L. R. Fisher, R. T. Mason, J. Rivier, and W. Vale. Neurobiological actions of cysteamine. Federation Proc. 44: 2556–2560, 1985.
 20. Brown, M., L. A. Fisher, P. E. Sawchenko, L. W. Swanson, and W. W. Vale. Biological effects of cysteamine: relationship to somatostatin depletion. Regul. Pept. 5: 163–179, 1983.
 21. Brown, M., J. Rivier, and W. Vale. Bombesin: potent effects on thermoregulation in the rat. Science 196: 998–1000, 1977
 22. Brown, M., J. Rivier, and W. Vale. Brain peptides affecting thermoregulation. Clin. Res. 25: 147A, 1977.
 23. Bruce, D. S., G. W. Cope, T. R. Elam, K. A. Ruit, P. R. Oeltgen, and T.‐P. Su. Opioids and hibernation. I. Effects of naloxone on bear HIT's depression of guinea pig ileum contractility and on induction of summer hibernation in the ground squirrel. Life Sci. 41: 2107–2113, 1987.
 24. Burks, T. F. Opioids and opioid receptors in thermoregulation. In: Int. Encyclopedia Pharmacol. Ther. Thermoregulation: Pathology, Pharmacology, and Therapy, edited by E. Schönbaum, and P. Lomax. New York: Pergamon, 1991, sect. 132, p. 489–508.
 25. Carr, D. B., R. Bergland, A. Hamilton, H. Blume, N. Kasting, M. Arnold, J. B. Martin, and M. Rosenblatt. Endotoxin‐stimulated opioid peptide secretion: two secretory pools and feedback control in vivo. Science 217: 845–848, 1982.
 26. Carraway, R., and S. E. Leeman. The amino acid sequence of a hypothalamic peptide, neurotensin. J. Biol. Chem. 250: 1907–1911, 1975
 27. Chandra, A., H. C. Chou, C. Chang, and M. T. Lin. Effects of intraventricular administration of neurotensin and somatostatin on thermoregulation in the rat. Neuropharmacology 20: 715–718, 1981.
 28. Chern, Y.‐f., and M.‐t. Lin. Effects of intraventricular administration of sympathomimetic agents on metabolic, vasomotor and temperature responses in Taiwan monkeys. Jpn. J. Physiol. 31: 599–603, 1981.
 29. Clark, W. G. Changes in body temperature after administration of amino acids, peptides, dopamine, neuroleptics and related agents. Neurosci. Biobehav. Rev. 3: 179–231, 1979.
 30. Clark, W. G. Changes in body temperature after administration of antipyretics, LSD, Δ9‐THC and related agents: I. Neurosci. Biobehav. Rev. 11: 35–96, 1987.
 31. Clark, W. G., and Y. L. Clark. Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents. Neurosci. Biobehav. Rev. 4: 175–240, 1980.
 32. Clark, W. G., and J. M. Lipton. Brain and pituitary peptides in thermoregulation. In: Int. Encyclopedia Pharmacol. Ther. Thermoregulation: Pathology, Pharmacology, and Therapy, edited by E. Schönbaum, and P. Lomax. New York: Pergamon, 1991, sect. 132, p. 509–560.
 33. Clark, W. G., and J. M. Lipton. Changes in body temperature after administration of amino acids, peptides, dopamine, neuroleptics and related agents: II. Neurosci. Biobehav. Rev. 9: 299–371, 1985.
 34. Clark, W. G., and J. M. Lipton. Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents: II. Neurosci. Biobehav. Rev. 9: 479–552, 1985.
 35. Clark, W. G., J. M. Lipton, and S. I. Said. Hyperthermic responses to vasoactive intestinal polypeptide (VIP) injected into the third cerebral ventricle of cats. Neuropharmacology 17: 883–885, 1978.
 36. Clark, W. G., I.‐H. Pang, and G. L. Bernardini. Evidence against involvement of β‐endorphin in thermoregulation in the cat. Pharmacol. Biochem. Behav. 18: 741–745, 1983.
 37. Cooper, K. E., S. Blähser, T. J. Malkinson, G. Merker, J. Roth, and E. Zeisberger. Changes in body temperature and vasopressin content of brain neurons, in pregnant and non‐pregnant guinea pigs, during fevers produced by Poly I: Poly C. Pflügers Arch. 412: 292–296, 1988.
 38. Cooper, K. E., N. W. Kasting, K. Lederis, and W. L. Veale. Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep. J. Physiol. 295: 33–45, 1979.
 39. Cooper, K. E., A. M. Naylor, and W. L. Veale. Evidence supporting a role for endogenous vasopressin in fever suppression in the rat. J. Physiol. 387: 163–172, 1987.
 40. Coquerel, A., I. Dubuc, J.‐F. Menard, P. Kitabgi, and J. Costentin. Naloxone‐insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan. Brain Res. 398: 386–389, 1986.
 41. De Meirleir, K., T. Arentz, W. Hollmann, and L. Vanhaelst. The role of endogenous opiates in thermal regulation of the body during exercise. Br. Med. J. 290: 739–740, 1985.
 42. Dinarello, C. A. Endogenous pyrogens. The role of cytokines in the pathogenesis of fever. In: Fever: Basic Mechanisms and Management, edited by P. A. Mackowiak. New York: Raven, 1991, p. 23–47.
 43. Doris, P. A. Vasopressin and the regulation of evaporative water loss and body temperature in the cat. Brain Res. 251: 127–136, 1982.
 44. Drago, F., and S. Amir. Effects of hyperprolactinaemia on core temperature of the rat. Brain Res. Bull. 12: 355–358, 1984.
 45. Dua, A. K., C. Pinsky, and F. S. LaBella. Stereoepimer specific inhibition in vivo of enkephalin degrading brain aminopeptidase. Proc. West. Pharmacol. Soc. 27: 549–552, 1984.
 46. Ekblad, E., L. Edvinsson, C. Wahlestedt, R. Uddman, R. Hakanson, and F. Sundler. Neuropeptide Y coexists and cooperates with noradrenaline in perivascular nerve fibers. Regul. Pept. 8: 225–235, 1984.
 47. Feldberg, W., and R. D. Myers. Effects on temperature of amines injected into the cerebral ventricles. A new concept of temperature regulation. J. Physiol. (Lond.) 173: 226–236, 1979.
 48. Feng, J. D., T. Dao, and J. M. Lipton. Effects of preoptic microinjections of α‐MSH on fever and normal temperature control in rabbits. Brain Res. Bull. 18: 473–477, 1987.
 49. Fyda, D. M., W. B. Mathieson, K. E. Cooper, and W. L. Veale. The effectiveness of arginine vasopressin and sodium salicylate as antipyretics in the Brattleboro rat. Brain Res. 512: 243–247, 1990.
 50. Girardot, M.‐N., and F. A. Holloway. Naltrexone antagonizes the biobehavioral adaptation to cold water stress in rats. Pharmacol. Biochem. Behav. 22: 769–779, 1985.
 51. Glyn, J. R., and J. M. Lipton. Hypothermic and antipyretic effects of centrally administered ACTH and α‐melanotropin. Peptides 2: 177–187, 1981.
 52. Glyn‐Ballinger, J. R., G. L. Bernardini, and J. M. Lipton. α‐MSH injected into the septal region reduces fever in rabbits. Peptides 4: 199–203, 1983.
 53. Griffiths, E. C., P. Slater, and P. S. Widdowson. The hypothermic action of carbachol in the rat brain periaqueductal grey area may involve neurotensin. Br. J. Pharmacol. 88: 653–658, 1986.
 54. Hayes, A. G., M. Skingle, and M. B. Tyers. Effect of β‐funaltrexamine on opioid side‐effects produced by morphine and U‐50,488H. J. Pharm. Pharmacol. 37: 841–843, 1985.
 55. Heath, M. E. Vascular receptors involved in effect of neuropeptide Y (NPY) on peripheral blood flow in the rat foot and tail. In: Thermal Balance in Health and Disease, Recent Basic Research and Clinical Progress, edited by E. Zeisberger, E. Schönbaum, and P. Lomax. Basel: Birkhauser, 1994, p. 215–220.
 56. Heath, M. E., and J. R. Thomas. Neuropeptide‐Y (NPY) reduces cutaneous microcirculatory blood flow and increases total blood flow in the rat tail. In: Temperature Regulation, Recent Physiological and Pharmacological Advances, edited by A. S. Milton. Basel: Birkhauser, 1994, p. 171–175.
 57. Hellon, R. F., Y. Townsend, and W. I. Cranston. Naloxone does not influence a pyrogen fever in rabbits. Pflügers Arch. 404: 290–291, 1985.
 58. Hermes, M. L. H. J., R. M. Buijs, M. Masson‐Pévet, T. P. Van Der Woude, P. Pévet, R. Brenklé, and R. Kirsch. Central vasopressin infusion prevents hibernation in the European hamster (Cricetus cricetus). Proc. Natl. Acad. Sci. USA 86: 6408–6411, 1989.
 59. Holdeman, M., O. Khorram, W. K. Samson, and J. M. Lipton. Fever‐specific changes in central MSH and CRF concentrations. Am. J. Physiol. 248 (Regulatory Integrative Comp. Physiol. 17): R125–R129, 1985.
 60. Hori, T. An update on thermosensitive neurons in the brain: from cellular biology to thermal and non‐thermal homeostatic functions. Jpn. J. Physiol. 41: 1–22, 1991.
 61. Hori, T., M. Yamasaki, T. Asami, H. Koga, and T. Kiyohara. Responses of anterior hypothalamic‐preoptic thermosensitive neurons to thyrotropin releasing hormone and cyclo(His‐Pro). Neuropharmacology 27: 895–901, 1988.
 62. Hori, T., M. Yamasaki, T. Kiyohara, and M. Shibata. Responses of preoptic thermosensitive neurons to poikilothermia‐inducing peptides—bombesin and neurotensin. Pflügers Arch. 407: 558–560, 1986.
 63. Huang, B.‐S., M. J. Kluger, and R. L. Malvin. Thermal responses to central angiotensin II, SQ 20881, and dopamine infusions in sheep. Am. J. Physiol. 248 (Regulatory Integrative Comp. Physiol. 17): R371–R377, 1985.
 64. Itoh, S., and R. Hirota. Effect of intraventricular administration of vasoactive intestinal polypeptide on body temperature in the rat. Jpn. J. Physiol. 32: 677–681, 1982.
 65. Iversen, L. L., S. D. Iversen, and S. H. Snyder, eds. Neuropeptides. Handbook of Psychopharmacology. New York: Plenum, 1983, vol. 16.
 66. Janský, L. Neuropeptides and the central regulation of body temperature during fever and hibernation. J. Thermal Biol. 15: 329–347, 1990.
 67. Kandasamy, S. B., W. A. Hunt, and A. H. Harris. Role of neurotensin in radiation‐induced hypothermia in rats. Radiat. Res. 126: 218–222, 1991.
 68. Kandasamy, S. B., and B. A. Williams. Absence of endotoxinfever but not hyperthermia in Brattleboro rats. Experientia 39: 1343–1344, 1983.
 69. Kandasamy, S. B., and B. A. Williams. Hyperthermic responses to central injections of some peptide and non‐peptide opioids in the guinea‐pig. Neuropharmacology 22: 621–628, 1983.
 70. Kandasamy, S. B., and B. A. Williams. Hypothermic and antipyretic effects of ACTH and α‐melanotropin in guinea‐pigs. Neuropharmacology 23: 49–53, 1984.
 71. Kapás, L., G. Benedek, and B. Penke. Cholecystokinin interferes with the thermoregulatory effect of exogenous and endogenous opioids. Neuropeptides 14: 85–92, 1989.
 72. Kasting, N. W. Criteria for establishing a physiological role for brain peptides. A case in point: the role of vasopressin in thermoregulation during fever and antipyresis. Brain Res. Rev. 14: 143–153, 1989.
 73. Kasting, N. W., W. L. Veale, and K. E. Cooper. Convulsive and hypothermic effects of vasopressin in the brain of the rat. Can. J. Physiol. Pharmacol. 58: 316–319, 1980.
 74. Kasting, N. W., and M. F. Wilkinson. An antagonist to the antipyretic effects of intracerebroventricularly administered vasopressin in the rat. In: Homeostasis and Thermal Stress, edited by K. Cooper, P. Lomax, E. Schönbaum, and W. L. Veale. Basel: Karger, 1986, p. 137–139.
 75. Kasting, N. W., and M. F. Wilkinson. Vasopressin functions as an endogenous antipyretic in the newborn. Biol. Neonate 51: 249–254, 1987.
 76. Katovich, M. J., J. W. Simpkins, and J. O'Meara. Effects of acute central LH‐RH administration on the skin temperature response in morphine dependent rats. Brain Res. 494: 85–94, 1989.
 77. Kavaliers, M., and M. Hirst. The presence of an opioid system mediating behavioral thermoregulation in the terrestrial snail, Cepaea nemoralis. Neuropharmacology 23: 1285–1289, 1984.
 78. Kiyohara, T., T. Hori, M. Shibata, and T. Nakashima. Effects of angiotensin II on preoptic thermosensitive neurones in the rat. In: Thermal Physiology, edited by J. R. S. Hales. New York: Raven, 1984, p. 141–144.
 79. Kluger, M. J. Fever: role of pyrogens and cryogens. Physiol. Rev. 71: 93–127, 1991.
 80. Kong, J. Y., A. K. Thureson‐Klein, and R. L. Klein. Are NPY and enkephalins co‐stored in the same noradrenergic neurons and vesicles? Peptides 11: 565–575, 1990.
 81. Kramarova, L. I., S. H. Kolaeva, R. Yu. Yukhananov, and V. V. Rozhanets. Content of DSIP, enkephalins and ACTH in some tissues of active and hibernating ground squirrels (Citellus suslicus). Comp. Biochem. Physiol. 74C: 31–33 1983.
 82. Kromer, W. Naltrexone influence on hibernation. Experientia 36: 581–582, 1980.
 83. Laemle, L. K., and J. R. Cotter. VIP‐like immunoreactivity in the anterior hypothalamic area of a hibernating bat varies with physiological state. Brain Res. 441: 398–402, 1988.
 84. Lahti, H., M. Koskinen, A. Pyörnilä, and R. Hissa. Hyperthermia after intrahypothalamic injections of thyrotropin releasing hormone (TRH) in the pigeon. Experientia 39: 1338–1340, 1983.
 85. Landgraf, R., T. J. Malkinson, W. L. Veale, K. Lederis, and Q. J. Pittman. Vasopressin and oxytocin in rat brain in response to prostaglandin fever. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R1056–R1062, 1990.
 86. Laorden, M. L., F. S. Miralles, and M. M. Puig. High doses of l‐naloxone but neither d‐naloxone nor β‐funaltrexamine prevent hyperthermia‐induced seizures in rat pups. J. Pharm. Pharmacol. 40: 223–224, 1988.
 87. Leconte, J.‐M., J. Costentin, A. Vlaiculescu, P. Chaillet, H. Marcais‐Collado, C. Llorens‐Cortes, M. Leboyer, and J.‐C. Schwartz. Pharmacological properties of acetorphan, a parenterally active “enkephalinase” inhibitor. J. Pharmacol. Exp. Ther. 237: 937–944, 1986.
 88. Lee, T. F., F. Nurnberger, M. L. Jourdan, and L. C. H. Wang. Possible involvement of septum in seasonal changes in thermoregulatory responses to met‐enkephalinamide in ground squirrels. In: Thermoregulation: Research and Clinical Applications, edited by P. Lomax, and E. Schönbaum. Basel: Karger, 1989, p. 200–203.
 89. LeFeuvre, R. A., L. Aisenthal, and N. J. Rothwell. Involvement of corticotropin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5‐HT) and related compounds. Brain Res. 555: 245–250, 1991.
 90. LeFeuvre, R. A., N. J. Rothwell, and M. J. Stock. Activation of brown fat thermogenesis in response to central injection of corticotropin releasing hormone in the rat. Neuropharmacology 26: 1217–1221, 1987.
 91. Leshin, L. S., and P. V. Malven. Bacteremia‐induced changes in pituitary hormone release and effect of naloxone. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E585–E591, 1984.
 92. Lin, M. T. Effects of angiotensin II on metabolic, respiratory and vasomotor activities as well as body temperatures in the rabbit. J. Neural Transm. 49: 197–204, 1980.
 93. Lin, M. T. Metabolic, respiratory, vasomotor, and body temperature responses to TRH, angiotensin II, substance P, neurotensin, somatostatin, LH‐RH, beta‐endorphin, oxytocin, or vasopressin in the rat. Adv. Biosci. 38: 229–251, 1982.
 94. Lin, M. T., A. Chandra, Y. F. Chern, and B. L. Tsay. Effects of thyrotrophic‐releasing hormone (TRH) on thermoregulation in the rat. Experientia 36: 1077–1078, 1980
 95. Lin, M. T., A. Chandra, and J. J. Jou. Angiotensin II inhibits both heat production and heat loss mechanisms in the rat. Can. J. Physiol. Pharmacol. 58: 909–914, 1980.
 96. Lin, M. T., Y. F. Chern, F. F. Chen, and C. Y. Su. Serotoninergic mechanisms of beta‐endorphin‐induced hypothermia in rats. Pflügers Arch. 382: 87–90, 1979.
 97. Lin, M. T., P. C. Chu, and S. Y. Leu. Effects of TSH, TRH, LH and LHRH on thermoregulation and food and water intake in the rat. Neuroendocrinology 37: 206–211, 1983.
 98. Lin, M. T., W. N. Uang, and H. K. Chan. Hypothalamic neuronal responses to iontophoretic application of morphine in rats. Neuropharmacology 23: 591–594, 1984.
 99. Lin, M.T., W.‐N. Uang, and L.‐T. Ho. Hypothalamic somatostatin may mediate endotoxin‐induced fever in the rat. Naunyn Schmiedebergs Arch. Pharmacol. 339: 608–612, 1989.
 100. Lin, M. T., W. N. Uang, L. T. Ho, J. Chuang, and L. J. Fan. Somatostatin: a hypothalamic transmitter for thermoregulation in rats. Pflügers Arch. 413: 528–532, 1989.
 101. Lin, M. T., P. S. Wang, J. Chuang, L. J. Fan, and S. J. Won. Cold stress or a pyrogenic substance elevates thyrotropin releasing hormone levels in the rat hypothalamus and induces thermogenic reactions. Neuroendocrinology 50: 177–181, 1989.
 102. Lin, M. T., and C. P. Yang. Effects of thyrotropin‐releasing hormone on thermoregulatory responses and hypothalamic neuronal activity in rats. Ann. N. Y. Acad. Sci. 553: 579–581, 1989.
 103. Lipton, J. M. MSH in CNS control of fever and its influence on inflammation/immune responses. In: The Melanotropic Peptides. Biological Roles, edited by M. E. Hadley. Boca Raton, FL: CRC 1989, vol. 2, p. 97–113.
 104. Lipton, J. M. Modulation of host defense by the neuropeptide α‐MSH. Yale J. Biol. Med. 63: 173–182, 1990.
 105. Lipton, J. M., and W. G. Clark. Neurotransmitters in temperature control. Annu. Rev. Physiol. 48: 613–623, 1986.
 106. Loosen, P. T., C. B. Nemeroff, G. Bissette, G. D. Burnett, A. J. Prang, Jr., and M. A. Lipton. Neurotensin‐induced hypothermia in the rat: structure‐activity studies. Neuropharmacology 17: 109–113, 1978.
 107. Lundberg, J. M., and T. Hokfelt. Co‐existence of peptides and classical neurotransmitters. Trends Neurosci. 6: 325–333, 1983.
 108. Lundberg, J. M., J. Pernow, S. Locroix, A. Franco‐Cerededa, A. Rudehill, and T. Hokfelt. Neuropeptide tyrosine (NPY) and sympathetic cardiovascular control. In: Neuropeptide Y, edited by V. Mutt, K. Fuxe, T. Hökfelt, and J. M. Lundberg, New York: Raven, 1989, p. 191–200.
 109. Malkinson, T. J., T. E. Bridges, K. Lederis, and W. L. Veale. Perfusion of the septum of the rabbit with vasopressin antiserum enhances endotoxin fever. Peptides 8: 385–389, 1987.
 110. Margules, D. L., B. Goldman, and A. Finck. Hibernation: an opioid‐dependent state? Brain Res. Bull. 4: 721–724, 1979.
 111. Marks‐Kaufman, R., and T. Balmagiya. Acute effects of naltrexone on energy balance and thermoregulation in rats. Nutr. Reports Int. 32: 337–347, 1985.
 112. Martin, L. W., A. Catania, M. E. Hiltz, and J. M. Lipton. Neuropeptide α‐MSH antagonizes IL‐6‐ and TNF‐induced fever. Peptides 12: 297–299, 1991.
 113. Martin, S. M., T. J. Malkinson, W. L. Veale, and Q. J. Pittman. Prostaglandin fever in rats is altered by kainic acid lesions of the ventral septal area. Brain Res. 455: 196–200, 1988.
 114. Martin, S. M., T. J. Malkinson, W. L. Veale, and Q. J. Pittman. Depletion of brain α‐MSH alters prostaglandin and interleukin fever in rats. Brain Res. 526: 351–354, 1990.
 115. Merker, G., S. Blähser, and E. Zeisberger. Reactivity pattern of vasopressin‐containing neurons and its relation to the antipyretic reaction in the pregnant guinea pig. Cell Tissue Res. 212: 47–61, 1980.
 116. Merker, G., J. Roth, and E. Zeisberger. Thermoadaptive influence on reactivity pattern of vasopressinergic neurons in the guinea pig. Experientia 45: 722–726, 1989.
 117. Metcalf, G., P. W. Dettmar, and T. Watson. The role of neuropeptides in thermoregulation. In: Thermoregulatory Mechanisms and Their Therapeutic Implications, edited by B. Cox, P. Lomax, A. S. Milton, and E. Schönbaum. Basel: Karger, 1980, p. 175–179.
 118. Millan, M. J., M. H. Millan, and A. Herz. The role of the ventral noradrenergic bundle in relation to endorphins in the control of core temperature, open‐field and ingestive behaviour in the rat. Brain Res. 263: 283–294, 1983.
 119. Millan, M. J., R. Przewlocki, M. Jerlicz, Ch. Gramsch, V. Höllt, and A. Herz. Stress‐induced release of brain and pituitary β‐endorphin: major role of endorphins in generation of hyperthermia, not analgesia. Brain Res. 208: 325–338, 1981.
 120. Moolchandani, J., and T. Krupin. Central effects of vasoactive intestinal polypeptide on intraocular pressure and body temperature in rabbits. Curr. Eye Res. 6: 935–941, 1987.
 121. Mooradian, A. D., G. K. Morley, R. McGeachie, S. Lundgren, and J. E. Morley. Spontaneous periodic hypothermia. Neurology 34: 79–82, 1984.
 122. Muraki, K., Y. Nishi, H. Okahata, M. Arai, H. Yamada, S. Fijita, Y. Miyachi, K. Ueda, S. Yamawaki, and H. Yajima. Neurotensin‐like immunoreactivity (NTLI) concentration in the cerebrospinal fluid of children and its alteration in a febrile aseptic meningitis. Life Sci. 40: 1365–1370, 1987.
 123. Murphy, M. T., and J. M. Lipton. Peripheral administration of α‐MSH reduces fever in older and younger rabbits. Peptides 3: 775–779, 1982.
 124. Murphy, M. T., D. B. Richards, and J. M. Lipton. Antipyretic potency of centrally administered α‐melanocyte stimulating hormone. Science 221: 192–193, 1983.
 125. Myers, R. D., and T. F. Lee. Neurochemical aspects of thermoregulation. In: Advances in Comparative and Environmental Physiology, edited by L. C. H. Wang, Berlin: Springer, 1989, p. 161–203.
 126. Naylor, A. M., G. J. Gubitz, C. A. Dinarello, and W. L. Veale. Central effects of vasopressin and 1‐desamino‐8‐d‐arginine vasopressin (DDAVP) on interleukin‐1 fever in the rat. Brain Res. 401: 173–177, 1987.
 127. Naylor, A. M., Q. J. Pittman, and W. L. Veale. Stimulation of vasopressin release in the ventral septum of the rat brain suppresses prostaglandin E1 fever. J. Physiol. (Lond.) 399: 177–189, 1988.
 128. Naylor, A. M., W. D. Ruwe, A. F. Kohut, and W. L. Veale. Perfusion of vasopressin within the ventral septum of the rabbit suppresses endotoxin fever. Brain Res. Bull. 15: 209–213, 1985.
 129. Naylor, A. M., W. D. Ruwe, and W. L. Veale. Antipyretic action of centrally administered arginine vasopressin but not oxytocin in the cat. Brain Res. 385: 156–160, 1986.
 130. Naylor, A. M., W. D. Ruwe, and W. L. Veale. Thermoregulatory actions of centrally‐administered vasopressin in the rat. Neuropharmacology 25: 787–794, 1986.
 131. Nemeroff, C. B., G. Bissette, A. J. Prang, Jr., P. T. Loosen, T. S. Barlow, and M. A. Lipton. Neurotensin: central nervous system effects of a hypothalamic peptide. Brain Res. 128: 485–496, 1977.
 132. Nurnberger, F., T. F. Lee, M. L. Jourdan, and L. C. H. Wang. Seasonal changes in methionine‐enkephalin immunoreactivity in the brain of a hibernator, Spermophilus columbianus. Brain Res. 547: 115–121, 1991.
 133. Ohgo, S., K. Nakatsuru, Y. Oki, E. Ishikawa, and S. Matsukura. Stimulation by interleukin‐1 (IL‐1) of the release of rat corti‐cotropin‐releasing factor (CRF), which is independent of the cholinergic mechanism, from superfused rat hypothalamo‐neurohypophysial complexes. Brain Res. 550: 213–219, 1991.
 134. Okuda, C., T. Mizobe, and M. Miyazaki. Effects of hypothermia on thyrotropin‐releasing hormone content in the rat brain. Pharmacol. Biochem. Behav. 30: 941–944, 1988.
 135. Opp, M., F. Obál, Jr., and J. M. Krueger. Corticotropin‐releasing factor attenuates interleukin 1‐induced sleep and fever in rabbits. Am. J. Physiol. 257 (Regulatory Integrative Comp. Physiol. 26): R528–R535, 1989.
 136. Pae, Y.‐S., H. Lai, and A. Horita. Hyperthermia in the rat from handling stress blocked by naltrexone injected into the preoptic‐anterior hypothalamus. Pharmacol. Biochem. Behav. 22: 337–339, 1985.
 137. Pittman, Q. J., T. J. Malkinson, N. W. Kasting, and W. L. Veale. Enhanced fever following castration: possible involvement of brain arginine vasopressin. Am. J. Physiol. 254 (Regulatory Integrative Comp. Physiol. 23): R513–R517, 1988.
 138. Prange, A. J., Jr., C. B. Nemeroff, G. Bissette, P. J. Manberg, A. J. Osbahr, III, G. B. Burnett, P. T. Loosen, and G. W. Kraemer. Neurotensin: distribution of hypothermic response in mammalian and submammalian vertebrates. Pharmacol. Biochem. Behav. 11: 473–477, 1979.
 139. Prasad, C., J. J. Jacobs, and J. F. Wilber. Immunological blockade of endogenous thyrotropin‐releasing hormone produces hypothermia in rats. Brain Res. 193: 580–583, 1980.
 140. Prasad, C., T. Matsui, J. Williams, and A. Peterkofsky. Thermoregulation in rats: opposing effects of thyrotropin releasing hormone and its metabolite histidyl‐proline diketopiperazine. Biochem. Biophys. Res. Commun. 85: 1582–1587, 1978.
 141. Rezvani, A. H., and J. E. Heath. Reduced thermal sensitivity in the rabbit by β‐endorphin injection into the preoptic/anterior hypothalamus. Brain Res. 292: 297–302, 1984.
 142. Richards, D. B., and J. M. Lipton. Effect of α‐MSH 11–13 (lysine–proline–valine) on fever in the rabbit. Peptides 5: 815–817, 1984.
 143. Riedel, W., and S. L. Burke. Selective autonomic nervous control of thyroid hormone and calcitonin secretion during metabolic and cardiorespiratory activation by intracisternal thyrotropin‐releasing hormone (TRH). J. Auton. Nerv. Syst. 24: 157–173, 1988.
 144. Robertson, B. A., L. C. Gahring, and R. A. Daynes. Neuropeptide regulation of interleukin‐1 activities. Capacity of α‐mela‐nocyte stimulating hormone to inhibit interleukin‐1‐inducible responses in vivo and in vitro exhibits target cell selectivity. Inflammation 10: 371–385, 1986.
 145. Rothwell, N. J. CRF is involved in the pyrogenic and thermogenic effects of interleukin‐1β in the rat. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E111–E115, 1989.
 146. Rothwell, N. J., A. Hardwick, R. A. LeFeuvre, S. R. Crosby, and A. White. Central actions of CRF on thermogenesis are mediated by pro‐opiomelanocortin products. Brain Res. 541: 89–92, 1991.
 147. Rowland, N. E., B. H. Li, A. K. Rozelle, M. J. Fregly, N. Garcia, and G. C. Smith. Localization of changes in immediate early gene in brain in relation to hydromineral balance: intravenous angiotensin II. Brain Res. Bull. 33: 427–436, 1994.
 148. Samson, W. K., J. M. Lipton, J. A. Zimmer, and J. R. Glyn. The effect of fever on central α‐MSH concentrations in the rabbit. Peptides 2: 419–423, 1981.
 149. Schwellnus, M. P., and N. F. Gordon. The role of endogenous opioids in thermoregulation during sub‐maximal exercise. Med. Sci. Sports Exerc. 19: 575–578, 1987.
 150. Schwellnus, M. P., and N. F. Gordon. Effect of opioid antagonism on esophageal temperature during exercise. Med. Sci. Sports Exerc. 20: 381–384, 1988.
 151. Sharpe, L. G., J. E. Garnett, and N. S. Olsen. Thermoregulatory changes to cholinomimetics and angiotensin II, but not to the monoamines microinjected into the brain stem of the rabbit. Neuropharmacology 18: 117–123, 1979.
 152. Sharpe, L. G., and L. W. Swanson. Drinking induced by injections of angiotensin into forebrain and midbrain sites of the monkey. J. Physiol. (Lond.) 239: 595–622, 1974.
 153. Shido, O., and T. Nagasaka. Effects of intraventricular angiotensin II on heat balance at various ambient temperatures in rats. Jpn. J. Physiol. 35: 163–167, 1985.
 154. Shido, O., Y. Yoneda, and T. Nagasaka. Changes in brown adipose tissue metabolism following intraventricular vasoactive intestinal peptide and other gastrointestinal peptides in rats. Jpn. J. Physiol. 39: 359–369, 1989.
 155. Shih, S. T., O. Khorram, J. M. Lipton, and S. M. McCann. Central administration of α‐MSH antiserum augments fever in the rabbit. Am. J. Physiol. 250 (Regulatory Integrative Comp. Physiol. 19): R803–R806, 1986.
 156. Shih, S. T., and J. M. Lipton. Intravenous α‐MSH reduces fever in the squirrel monkey. Peptides 6: 685–687, 1985.
 157. Simon, E. J. Opioid receptors and endogenous opioid peptides. Med. Res. Rev. 11: 357–374, 1991.
 158. Simpkins, J. W., M. J. Katovich, and I.‐C. Song. Similarities between morphine withdrawal in the rat and the menopausal hot flush. Life Sci. 32: 1957–1966, 1983
 159. Simpson, J. B., and A. Routtenberg. Subfornical organ: site of drinking elicitation by angiotensin. Science 181: 1172–1175, 1973.
 160. Stanton, T. L., N. F. Sartin, and A. L. Beckman. Changes in body temperature and metabolic rate following microinjection of Met‐enkephalinamide in the preoptic/anterior hypothalamus of rats. Regul. Pept. 12: 333–343, 1985.
 161. Stewart, J., and R. Eikelboom. Interaction between the effects of stress and morphine on body temperature in rats. Life Sci. 28: 1041–1045, 1981
 162. Stump, B. S., A. J. Bane, and D. D. Avery. Food deprivation does not influence body or selection temperature in rats receiving intraventricular bombesin. Pharmacol. Biochem. Behav. 48: 881–885, 1994.
 163. Tanaka, J., and M. Nomura. Involvement of neurons sensitive to angiotensin II in the median preoptic nucleus in the drinking response induced by angiotensin II activation of the subfornical organ in rats. Exp. Neurol. 119: 235–239, 1993.
 164. Tanaka, J., H. Saito, and H. Kaba. Subfornical organ and hypothalamic paraventricular nucleus connections with median preoptic nucleus neurons: an electrophysiological study in the rat. Exp. Brain Res. 68: 579–583, 1987.
 165. Tatro, J. B. Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and α‐melanocyte stimulating hormone. Brain Res. 536: 124–132, 1990.
 166. Teklu, B., A. Habte‐Michael, D. A. Warrell, N. J. White, and D. J. M. Wright. Meptazinol diminishes the Jarisch‐Herxheimer reaction of relapsing fever. Lancet 1: 835–839, 1983.
 167. Travis, K. A., and A. K. Johnson. In vitro sensitivity of median preoptic neurons to angiotensin II, osmotic pressure, and temperature. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R1200–R1205, 1993.
 168. Uhl, G. R., and S. H. Snyder. Neurotensin receptor binding, regional and subcellular distributions favor transmitter role. Eur. J. Pharmacol. 41: 89–91, 1977.
 169. Vybíral, S., J. Nacházel, and L. Janský. Hyperthermic effect of neurotensin in the rabbit. Pflügers Arch. 406: 312–314, 1986.
 170. Waeber, B., J. F. Aubert, R. Corder, P. Evequoz, J. Nussberger, R. Gaillard, and H. R. Brunner. Cardiovascular effects of neuropeptide Y. Am. L. Hypertens. 1: 193–199, 1988.
 171. Wakabayashi, I., Y. Tonegawa, and T. Shibasaki. Hyperthermic action of somatostatin‐28. Peptides 4: 325–330, 1983.
 172. Walker, P., E. Grouzmann, M. Burnier, and B. Waeber. The role of neuropeptide Y in cardiovascular regulation. Trends Pharmacol. Sci. 12: 111–115, 1991.
 173. Wang, L. C. H., T. F. Lee, and M. L. Jourdan. Seasonal difference in thermoregulatory responses to opiates in a mammalian hibernator. Pharmacol. Biochem. Behav. 26: 565–571, 1987.
 174. Wilkinson, M. F., and N. W. Kasting. Antipyresis due to centrally administered vasopressin differentially alters thermoregulatory effectors depending on the ambient temperature. Regul. Pept. 19: 45–54, 1987.
 175. Wilkinson, M. F., and N. W. Kasting. The antipyretic effects of centrally administered vasopressin at different ambient temperatures. Brain Res. 415: 275–280, 1987.
 176. Wilkinson, M. F., and N. W. Kasting. Central vasopressin V1‐receptors mediate indomethacin‐induced antipyresis in rats. Am. J. Physiol. 256 (Regulatory Integrative Comp. Physiol. 25): R1164–R1168, 1989.
 177. Wilkinson, M. F., and N. W. Kasting. Central vasopressin V1‐blockade prevents salicylate but not acetaminophen antipyresis. J. Appl. Physiol.: Respir. Environ. Exerc. Physiol. 68: 1793–1798, 1990.
 178. Wilson, K. M., and M. J. Fregly. Angiotensin II‐induced hypothermia in rats. J. Appl. Physiol.: Respir. Environ. Exerc. Physiol. 58: 534–543, 1985.
 179. Wilson, K. M., and M. J. Fregly. Factors affecting angiotensin II‐induced hypothermia in rats. Peptides 6: 695–701, 1985.
 180. Won, S.‐J., and M.‐T. Lin. The hypothalamic somatostatin (SS) may mediate the fever produced by polyriboinosinic acid: poly‐ribocytidylic acid (poly I:C) in rabbits. In: Thermal Physiology, 1989, edited by J. B. Mercer. Amsterdam: Elsevier, 1989, p. 421–425.
 181. Yachnis, A. T., J. N. Crawley, R. T. Jensen, M. M. McGrane, and T. W. Moody. The antagonism of bombesin in the CNS by substance P analogues. Life Sci. 35: 1963–1969, 1984
 182. Zeisberger, E. Antipyretic action of vasopressin in the ventral septal area of the guinea pig's brain. In: Thermoregulation: Research and Clinical Applications, edited by P. Lomax, and E. Schönbaum. Basel: Karger, 1989, p. 65–68.
 183. Zeisberger, E. Comparison of antipyretic actions of different neuropeptides in the same site of brain septum in the guinea pig. In: Thermal Physiology, 1989, edited by J. B. Mercer. Amsterdam: Elsevier, 1989, p. 117–122.
 184. Zeisberger, E. The role of septal peptides in thermoregulation and fever. In: Thermoreception and Temperature Regulation, edited by J. Bligh and K. Voigt. Berlin: Springer‐Verlag, 1990, p. 273–283.
 185. Zeisberger, E., G. Merker, and S. Blähser. Fever response in the guinea pig before and after parturition. Brain Res. 212: 379–392, 1981.

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Article Title: Evidence for Roles of Brain Peptides in Thermoregulation
 

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Wesley G. Clark, Melvin J. Fregly. Evidence for Roles of Brain Peptides in Thermoregulation. Compr Physiol 2011, Supplement 14: Handbook of Physiology, Environmental Physiology: 139-153. First published in print 1996. doi: 10.1002/cphy.cp040108