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The Relationship Between Food and Sleep

Jaber Danguir

10.1002/cphy.cp040260

Source: Supplement 14: Handbook of Physiology, Environmental Physiology

Originally published: 1996

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Interaction between Feeding and Sleep
1.1 Quantitative Aspects
1.2 Qualitative Aspects
1.3 Ischymetric Modulation of Sleep
1.4 Circadian Sleep Patterns: Possible Dependence on Lipolysis and Lipogenesis
1.5 Nutritional Slates and Sleep Cycles
2 Central Control of Food‐Sleep Interaction
2.1 Serotonin as a Possible Link
2.2 Insulin and Slow‐Wave Sleep
2.3 Somatostatin and Paradoxical Sleep
3 Sleep Impairments during Advanced Age: Possible Involvement of Peripheral Hormonal Deficits
4 Water Intake and Sleep: The Case of Diabetes Insipidus
5 Conclusion
Figure 1. Figure 1.

Daily durations of slow‐wave sleep (SWS) and paradoxical sleep (PS) expressed in minutes (mean ± SEM) during the control (C) day, the first 3 days (1, 2, 3), and the tenth day (10) during a cafeteria diet presentation and during the 4 days (11, 12, 13, 14) when the cafeteria diet was withdrawn.*P < 0.01; **P < 0.001 (paired t test, experimental vs. control days).
Figure 2. Figure 2.

Slow‐wave sleep (SWS) and paradoxical sleep (PS) expressed as percentages (mean ± SEM) of the recording time and body weight (BW) expressed as percentages of the control (C) day, during the control day, the 4 days of food deprivation, and the 3 days following restitution of food. Daily food intake (FI) was compared between control and refeeding days.
Figure 3. Figure 3.

Time spent in slow‐wave sleep (SWS) and in paradoxical sleep (PS) (mean ± SEM), expressed in minutes on a 2 h period base throughout day, in rats under control saline infusion (dashed lines) and following alternating insulin‐epinephrine infusions (solid lines). Insulin was infused from 0800 to 1600 and replaced by epinephrine from 1600 to 0800. Light cycle, 0800 to 2000.
Figure 4. Figure 4.

Schematic representation of the possible mechanisms underlying the relation between feeding and sleep. These behaviors are directly influenced by metabolic rate (B) fluctuations (ischymetric control), which are dependent on the hypothalamic control of peripheral secretion of metabolic hormones (A). The latter are in turn triggered by the light‐dark cycle.
Figure 5. Figure 5.

Time spent in slow‐wave sleep (SWS) and in paradoxical sleep (PS), expressed in minutes (mean ± SEM) on a 2 h period base throughout the nychthemeron, in rats under control conditions and following continuous i.c.v. infusion of insulin. Arrow indicates beginning of infusion.
Figure 6. Figure 6.

Left: Daily durations of slow‐wave sleep (SWS) and paradoxical sleep (PS) (mean ± SEM) on the third day after the injection of streptozotocin and 15 days later, compared to control values (C) and following i.v. infusion of exogenous insulin (day 21) and its removal (day 22). Right: Specific dose‐dependent restoration of SWS following chronic i.c.v. infusion of three different doses of insulin during days 4, 5, and 6 after administration of streptozotocin, compared to values obtained on day 3 poststreptozotocin (str).*P < 0.05; **P < 0.01 (paired t test).
Figure 7. Figure 7.

Slow‐wave sleep (SWS) and paradoxical sleep (PS) expressed as percentages (mean ± SEM) of the level on the control (C) day, during the 2 days rats received chronic i.c.v. administration of somatostatin (20 μg/24 h) and during the 2 days which followed its withdrawal.*P < 0.01 (paired t test).
Figure 8. Figure 8.

Paradoxical sleep (PS) and slow‐wave sleep (SWS) (mean ± SEM) in rats which received i.p. injections of three different doses of the somatostatin analogue (SMS), compared to values observed under control (C, no infusion) or vehicle (V) administration. *P < 0.05; **P < 0.01; ***P 0.001 (paired t test).
Figure 9. Figure 9.

Hypothetical schema of the respective effects of carbohydrates and proteins upon slow‐wave sleep (SWS) and paradoxical sleep (PS).


Figure 1.

Daily durations of slow‐wave sleep (SWS) and paradoxical sleep (PS) expressed in minutes (mean ± SEM) during the control (C) day, the first 3 days (1, 2, 3), and the tenth day (10) during a cafeteria diet presentation and during the 4 days (11, 12, 13, 14) when the cafeteria diet was withdrawn.*P < 0.01; **P < 0.001 (paired t test, experimental vs. control days).



Figure 2.

Slow‐wave sleep (SWS) and paradoxical sleep (PS) expressed as percentages (mean ± SEM) of the recording time and body weight (BW) expressed as percentages of the control (C) day, during the control day, the 4 days of food deprivation, and the 3 days following restitution of food. Daily food intake (FI) was compared between control and refeeding days.



Figure 3.

Time spent in slow‐wave sleep (SWS) and in paradoxical sleep (PS) (mean ± SEM), expressed in minutes on a 2 h period base throughout day, in rats under control saline infusion (dashed lines) and following alternating insulin‐epinephrine infusions (solid lines). Insulin was infused from 0800 to 1600 and replaced by epinephrine from 1600 to 0800. Light cycle, 0800 to 2000.



Figure 4.

Schematic representation of the possible mechanisms underlying the relation between feeding and sleep. These behaviors are directly influenced by metabolic rate (B) fluctuations (ischymetric control), which are dependent on the hypothalamic control of peripheral secretion of metabolic hormones (A). The latter are in turn triggered by the light‐dark cycle.



Figure 5.

Time spent in slow‐wave sleep (SWS) and in paradoxical sleep (PS), expressed in minutes (mean ± SEM) on a 2 h period base throughout the nychthemeron, in rats under control conditions and following continuous i.c.v. infusion of insulin. Arrow indicates beginning of infusion.



Figure 6.

Left: Daily durations of slow‐wave sleep (SWS) and paradoxical sleep (PS) (mean ± SEM) on the third day after the injection of streptozotocin and 15 days later, compared to control values (C) and following i.v. infusion of exogenous insulin (day 21) and its removal (day 22). Right: Specific dose‐dependent restoration of SWS following chronic i.c.v. infusion of three different doses of insulin during days 4, 5, and 6 after administration of streptozotocin, compared to values obtained on day 3 poststreptozotocin (str).*P < 0.05; **P < 0.01 (paired t test).



Figure 7.

Slow‐wave sleep (SWS) and paradoxical sleep (PS) expressed as percentages (mean ± SEM) of the level on the control (C) day, during the 2 days rats received chronic i.c.v. administration of somatostatin (20 μg/24 h) and during the 2 days which followed its withdrawal.*P < 0.01 (paired t test).



Figure 8.

Paradoxical sleep (PS) and slow‐wave sleep (SWS) (mean ± SEM) in rats which received i.p. injections of three different doses of the somatostatin analogue (SMS), compared to values observed under control (C, no infusion) or vehicle (V) administration. *P < 0.05; **P < 0.01; ***P 0.001 (paired t test).



Figure 9.

Hypothetical schema of the respective effects of carbohydrates and proteins upon slow‐wave sleep (SWS) and paradoxical sleep (PS).

References
 1. Adam, K., and I. Oswald. Sleep is for tissue restoration. C. R. Coll. Physicians (Lond.) 11: 376–388, 1977.
 2. Amatruda, T. A., D. A. Black, T. A. McKenna, R. W. McCarley, and J. A. Hobson. Sleep cycle control and cholinergic mechanisms: differential effects of carbachol injections at pontine brainstem sites. Brain Res. 98: 501–515, 1975.
 3. Arnold, M. A., M. J. Perlow, S. M. Reppert, O. P. Rorstad, and J. B. Martin. Daily pattern of somatostatin in the cerebrospinal fluid of the rhesus monkey: effect of environmental lighting. Ann. Neurol. 8: 104, 1980.
 4. Bird, J. L., E. E. Wright, and M. Feldman. Pancreatic islets: a tissue rich in serotonin. Diabetes 4: 304–308, 1980.
 5. Blundell, J. E. Is there a role of serotonin (5 hydroxytryptamine) in feeding? Int. J. Obes. 1: 15–42, 1977.
 6. Borbely, A. A. Sleep in the rat during food deprivation and subsequent restitution of food. Brain Res. 124: 457–471, 1977.
 7. Brobeck, J. R., J. Tepperman, and C. N. H. Long. Experimental hypothalamic hyperphagia in the albino rat. Yale J. Biol. Med. 15: 831–853, 1943.
 8. Chihora, K. Stimulation by rat growth hormone of somatostatin release into hypophyseal portal blood [Abstract]. In: 61st Annual Meeting of the Endocrine Society, Anaheim, 1979, p. 290.
 9. Crisp, A. H. Sleep, activity and mood. Br. J. Psychiatry 137: 1–7, 1980.
 10. Danguir, J. Sleep deficits in rats with hereditary diabetes insipidus. Nature 304: 163–164, 1983.
 11. Danguir, J. Sleep deficits in diabetic rats: restoration following chronic intravenous or intracerebroventricular infusions of insulin. Brain Res. Bull. 12: 641–645, 1984.
 12. Danguir, J. Intracerebroventricular infusion of somatostatin selectively increases paradoxical sleep in rats. Brain Res. 367: 26–30, 1986.
 13. Danguir, J. Cafeteria‐diet promotes sleep in rats. Appetite 8: 49–53, 1987.
 14. Danguir, J. The somatostatin analogue SMS 201‐995 promotes paradoxical sleep in aged rats. Neurobiol. Aging 10: 367–369, 1989.
 15. Danguir, J., and S. De Saint‐Hilaire‐Kafi. Scopolamine‐induced suppression of paradoxical sleep is reversed by the somatostatin analogue SMS 201‐995 in rats. Pharmacol. Biochem. Behav. 30: 295–297, 1988.
 16. Danguir, J., and S. De Saint‐Hilaire‐Kafi. Somatostatin antiserum blocks carbachol‐induced increase of paradoxical sleep in the rat. Brain Res. 20: 9–12, 1988.
 17. Danguir, J., H. Gerard, and S. Nicolaidis. Relations between sleep and feeding patterns in the rat. J. Comp. Physiol. Psychol. 93: 820–830, 1979.
 18. Danguir, J., and S. Nicolaidis. Sleep and feeding patterns in the ventromedial hypothalamic lesioned rat. Physiol. Behav. 21: 769–777, 1978.
 19. Danguir, J., and S. Nicolaidis. Dependence of sleep on nutrients' availability. Physiol. Behav. 22: 735–740, 1979.
 20. Danguir, J., and S. Nicolaidis. Circadian sleep and feeding patterns in the rat: possible dependence on lipogenesis and lipolysis. Am. J. Physiol. 238 (Endocrinol. Metab. 1): E223–E230, 1980.
 21. Danguir, J., and S. Nicolaidis. Cortical activity and sleep in the rat lateral hypothalamic syndrome. Brain Res. 185: 305–321, 1980.
 22. Danguir, J., and S. Nicolaidis. Intravenous infusion of nutrients and sleep in the rat: an ischymetric sleep regulation hypothesis. Am. J. Physiol. 238 (Endocrinol. Metab. 1): E307–E312, 1980.
 23. Danguir, J., and S. Nicolaidis. Chronic intracerebroventricular infusion of insulin causes selective increase of slow wave sleep in rats. Brain Res. 306: 97–103, 1984.
 24. Danguir, J., and S. Nicolaidis. Feeding, metabolism and sleep: peripheral and central mechanisms of their interaction. In: Brain Mechanisms of Sleep, edited by D. J. McGinty, R. Drucker‐Colin, A. Morrison and P. L. Parmeggiani. New York: Raven, 1985, p 321–340.
 25. Davenne, D., A. L. Francart, and A. Renaud. The effects of two types of diet on subsequent sleep. Proc. 10th Congr. Eur. Sleep Res. Soc. Gustan Fischer Verlag: Stuttgart, 1990, p. 106.
 26. Drucker‐Colin, R. R., C. W. Spanis, J. F. Sassin, and J. F. McGaugh. Growth hormone effects on sleep and wakefulness in the rat. Neuroendocrinology 18: 1–8, 1975.
 27. Evans, J. I., A. W. McLean, A. A. A. Ismail, and D. Love. Concentrations of plasma testosterone in normal men during sleep. Nature 229: 261–262, 1971.
 28. Evarts, E. V. Activity of neurons in visual cortex of the cat during sleep with low voltage fast EEG activity. J. Neurophysiol. 25: 812–816, 1962.
 29. Fernstrom, J. D., and R. J. Wurtman. Elevation of plasma tryptophan by insulin in rat. Metabolism 21: 337–342, 1972.
 30. Fernstrom, J. D., and R. J. Wurtman. Control of brain serotonin levels by the diet. In: Advances in Psychopharmacology, II, edited by B. Costa and S. Sandler. Raven Press: New York: 1974, p. 133–142.
 31. Gagliardino, J. J., and R. R. Hernandez. Circadian variation of the serum glucose and immunoreactive insulin levels. Endocrinology 88: 1529–1531, 1971.
 32. Gaito, J., and K. Bonnett. Quantitative versus qualitative RNA and protein changes in the brain during behavior. Psychol. Bull. 75: 109–127, 1971.
 33. Gnadt, J. W., and G. V. Pegram. Cholinergic brainstem mechanisms of REM sleep in the rat. Brain Res. 384: 29–41, 1986.
 34. Haider, I., and I. Oswald. Late brain recovery processes after drug overdosage. Br. Med. J. 2: 318–322, 1970.
 35. Havrankova, J., J. Roth, and M. Browstein. Insulin receptors are widely distributed in the central nervous system. Nature 272: 827–829, 1978.
 36. Heiss, W. D., G. Pawlik, K. Herholz, R. Wagner, and K. Wienhard. Regional cerebral glucose metabolisme in man during wakefulness, sleep and dreaming. Brain Res. 327: 362–366, 1985.
 37. Jacobs, B. L., and B. E. Jones. The role of central monoamine and acetylcholine systems in sleep‐wakefulness states: mediation or modulation? In: Cholinergic‐Monoaminergic Interactions in the Brain, edited by L. L. Butcher. New York: Academic, 1978, p. 271–290.
 38. Jacobs, B. L., and D. J. McGinty. Effects of food deprivation on sleep and wakefulness. Exp. Neurol. 30: 212–222, 1971.
 39. Jolin, T., and A. Montes. Daily rhythm of plasma glucose and insulin level in rats. Horm. Res. 4: 153–156, 1973.
 40. Jouvet‐Mounier, D., L. Astic, and D. Lacote. Ontogenesis of the states of sleep in rat, cat and guinea pig during the first postnatal month. Dev. Psychol. 2: 216–239, 1970.
 41. Jouvet, M. Biogenic amines and the states of sleep. Science 163: 32–41, 1969.
 42. Jouvet, M. Hypnogenic indolamine‐dependent factors and paradoxical sleep rebound. In: Sleep, edited by W. P. Koella. Basel: Karger, 1983, p. 2–18.
 43. Karadzic, B., and B. Mrsulja. Deprivation of paradoxical sleep and brain glycogen. J. Neurochem. 16: 29–34, 1969.
 44. Kizer, J. S., C. B. Nemeroff, and N. W. Youngblood. Neurotoxic amino acids and structurally related analogs. Endocrinology 29: 301–318, 1978.
 45. Kleine, N. Periodische schlafsucht. Psychiatr. Neurol. 57: 285–320, 1925.
 46. Kleitman, N. Sleep and Wakefulness (2nd ed.), Chicago: University of Chicago Press, 1963.
 47. Levin, M. Periodic somnolence and morbid hunger: a new syndrome. Brain 59: 494–504, 1936.
 48. Lucero, M. A. Lengthening of REM sleep duration consecutive to learning in the rat. Brain Res. 20: 319–322, 1970.
 49. McFayden, U. M., I. Oswald, and V. A. Lewis. Starvation and human slow‐wave sleep. J. Appl. Physiol. 35: 391–394, 1973.
 50. Mendelson, W. B., S. Slater, P. Gold, and J. C. Gillin. The effect of growth hormone administration on sleep: a dose‐response study. Biol. Psychiatry 15: 613–618, 1980.
 51. Moruzzi, G. The functional significance of sleep with particular regard to the brain mechanisms underlying consciousness. In: Brain and Conscious Experience, edited by J. Eccles. New York: Springer, 1966, p. 345–388.
 52. Mouret, J. R., and P. Bobillier. Diurnal rhythms of sleep in the rat: augmentation of paradoxical sleep following alternation of the feeding schedule. Int. J. Neurosci. 2: 265–270, 1971.
 53. Nicolaidis, S. Early systemic responses to orogastric stimulation in the regulation of food and water balance. Functional and electrophysiological data. Ann. N. Y. Acad. Sci. 167: 1176–1203, 1969.
 54. Nicolaidis, S. Rôle des reflexes anticipateurs oro‐végétatifs dans la régulation hydrominérale et énergétique. J. Physiol. (Paris) 74: 1–19, 1978.
 55. Nicolaidis, S., and N. Rowland. Metering of intravenous versus oral nutrients and regulation and energy balance. Am. J. Physiol. 231: 661–668, 1976.
 56. Olivo, M., K. Kitahama, J. L. Valatx, and M. Jouvet. Neonatal monosodium glutamate dosing alters the sleep‐wake cycle of the mature rat. Neurosci. Lett. 67: 186–190, 1986.
 57. Oswald, I. Human brain protein, drugs and dreams. Nature 223: 893–897, 1969.
 58. Panksepp, J., J. E. Jalowiec, A. Z. Zolovick, W. C. Stern, and P. J. Morgane. Inhibition of glycolytic metabolism and sleep‐waking states in cats. Pharmacol. Biochem. Behav. 1: 117–119, 1973.
 59. Parmeggiani, P. L., L. F. Agnati, G. Zamboni, and T. Cianci. Hypothalamic temperature during the sleep cycle at different ambient temperatures. Electroencephalogr. Clin. Neurophysiol. 38: 589–596, 1975.
 60. Petitjean, F., S. Seguin, M. H. Des Rosiers, D. Salvert, C. Buda, M. Janin, G. Debilly, M. Jouvet, and P. Bobillier. Consommation cérébrale locale du glucose au cours de l'éveil et du sommeil lent chez le chat. C. R. Acad. Sci. III 292: 1211–1214, 1981.
 61. Reich, P., J. K. Driver, and M. L. Karnovsky. Sleep: effects on incorporation of inorganic phosphate into brain fractions. Science 157: 336–338, 1967.
 62. Reivich, M., G. Isaacs, E. Evarts, and S. Kety. The effect of slow‐wave sleep and REM sleep on regional cerebral blood flow in cats. J. Neurochem. 15: 301–306, 1968.
 63. Roffwarg, H. P., J. Muzio, and W. Dement. The ontogenetic development of the sleep‐dream cycle in humans. Science 152: 604–619, 1966.
 64. Rosenberg, R. S., H. Zepelin, and A. Rechtschaffen. Sleep in young and old rats. J. Gerontol. 34: 525–532, 1979.
 65. Rubin, R. T., R. E. Poland, and B. B. Tower. Prolactin‐related testosterone secretion in normal adult men. J. Clin. Endocrinol. Metab. 42: 112–116, 1976.
 66. Ruckebusch, Y., and M. Gaujoux. Sleep‐inducing effect of a high‐protein diet in sheep. Physiol. Behav. 17: 9–12, 1976.
 67. Sangiah, S., D. F. Caldwell, M. J. Villeneuse, and J. J. Clancy. Sleep: sequential reduction of paradoxical sleep (REM) and elevation of slow‐sleep (NREM) by non convulsive dose of insulin in rats. Life Sci. 31: 763–769, 1982.
 68. Sassin, J. F., A. G. Frantz, S. Kapen, and E. D. Weitzman. The nocturnal rise of human prolactin is dependent on sleep. J. Clin. Endocrinol. Metab. 37: 436–440, 1973.
 69. Schusdziarra, V. Role of somatostatin in nutrient regulation. In: Somatostatin, edited by Y. C. Patel and G. S. Tannenbaum. New York: Plenum, 1985, p. 425–445.
 70. Sheppard, M. C., S. Kronheim, and B. L. Pimstone. Stimulation by growth hormone of somatostatin release from the rat hypothalamus in vitro. Clin. Endocrinol. 9: 583–587, 1978.
 71. Stern, W. C., J. E. Jalowiec, H. Shabshelowitz, and P. J. Morgane. Effect of growth hormone on sleep waking patterns in cats. Horm. Behav. 6: 189–196, 1975.
 72. Takahashi, S., D. M. Kipnis, and W. H. Daughaday. Growth hormone secretion during sleep. J. Clin. Invest. 47: 2079–2090, 1968.
 73. Utsumi, M., Y. Hirose, K. Ishihara, H. Makimura, and S. Baba. Hyperinsulinemia and hypersomatostanemia in hypothalamic obese rats induced by monosodium glutamate. Biomed. Res. 1 (suppl.): 154–158, 1980.
 74. Van den Noort, S., and K. Brine. Effect of sleep on brain labile phosphates and metabolic rate. Am. J. Physiol. 218: 1434–1439, 1970.
 75. Van Houten, M., B. I. Posner, B. M. Kopriwa, and J. R. Brawer. Insulin‐binding sites in the rat brain: in vivo localization to the circumventricular organs by quantitative radioautography. Endocrinology 105: 666–673, 1979.
 76. Veosei, L., M. Balazs, and G. Telegdy. Action of somatostatin in the central nervous system. Front. Horm. Res. 15: 36–57, 1987.
 77. Woods, S. C., and D. Porte, Jr. Relationship between plasma and cerebrospinal fluid levels in dogs. Am. J. Physiol. 233 (Endocrinol. Metab. Gastrointest. Physiol. 2) E331–E334, 1977.
 78. Wurtman, R. J., and J. D. Fernstrom. Control of brain neurotransmitter synthesis by precursor availability and nutritional state. Biochem. Pharmacol. 25: 1691–1696, 1976.
 79. Zepelin, H., and A. Rechtschaffen. Mammalian sleep, longevity and energy metabolism. Brain Behav. Evol. 10: 425–470, 1974.

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Article Title: The Relationship Between Food and Sleep
 

How to Cite

Jaber Danguir. The Relationship Between Food and Sleep. Compr Physiol 2011, Supplement 14: Handbook of Physiology, Environmental Physiology: 1375-1387. First published in print 1996. doi: 10.1002/cphy.cp040260