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Villous motility

William A. Womack, Peter R. Kvietys, D. Neil Granger

10.1002/cphy.cp060125

Source: Supplement 16: Handbook of Physiology, The Gastrointestinal System, Motility and Circulation

Originally published: 1989

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Anatomical Considerations And Contractile Patterns
2 Regulation Of Villous Motility
2.1 Nervous Control
2.2 Postprandial Regulation
3 Physiological Implications Of Villous Motility
4 Conclusions
Figure 1. Figure 1.

Frequency distribution of villous contraction rate in dog duodenum, jejunum, and ileum. Mean frequency was highest in duodenum (7.3 ± 0.1), intermediate in jejunum (4.0 ± 0.1), and lowest in ileum (2.0 ± 0.1).

From Womack et al. 64
Figure 2. Figure 2.

Percent change in frequency of villous contraction in dog jejunum induced by nutrient solutions. Amino acid solutions (15 and 30 mM) and a micellar oleic acid solution caused significant (P < 0.05) increases in contraction frequency. The mixed micellar (MM) solution consisted of 15 mM taurocholic acid, 5 mM monoolein, and 10 mM oleic acid. Taurocholic acid (TC) (15 mM), alone or in combination with monoolein (5 mM), did not increase villous motility.

From Womack et al. 64
Figure 3. Figure 3.

Effect of venous pressure elevation on villous contraction frequency and lymph flow. A venous pressure elevation of 20 cmH2O caused significant (P < 0.05) increases in both parameters. Villous contraction frequency rose 55% ± 14%, whereas lymph flow increased 54% ± 2%.

From Womack et al. 65
Figure 4. Figure 4.

Representative plasma‐dilution experiment. Intravenous saline infusion (2.5 ml·min−1 · kg−1 body wt) resulted in parallel changes in villous motility and lymph flow.

From Womack et al. 65
Figure 5. Figure 5.

Relationship between lymph flow (% of control) and villous motility (% of control). Regression analysis yielded statistically significant correlation (P < 0.001) with correlation coefficient of 0.83.

From Womack et al. 65
Figure 6. Figure 6.

Proposed mechanism for role of villous motility in lymph propulsion.

From Womack et al. 65
Figure 7. Figure 7.

Response of intestinal villous motility (A), blood flow (B), and oxygen uptake (C) to graded reductions in arterial pressure. Values obtained at 100 mmHg were taken as control, and all other values were expressed as percent of control. Blood flow demonstrated a linear decline as arterial pressure was reduced, and villous motility and oxygen uptake remained at control levels until pressure was reduced to <60 mmHg. *, Significant difference from control (P < 0.05).

From Womack et al. 65


Figure 1.

Frequency distribution of villous contraction rate in dog duodenum, jejunum, and ileum. Mean frequency was highest in duodenum (7.3 ± 0.1), intermediate in jejunum (4.0 ± 0.1), and lowest in ileum (2.0 ± 0.1).

From Womack et al. 64


Figure 2.

Percent change in frequency of villous contraction in dog jejunum induced by nutrient solutions. Amino acid solutions (15 and 30 mM) and a micellar oleic acid solution caused significant (P < 0.05) increases in contraction frequency. The mixed micellar (MM) solution consisted of 15 mM taurocholic acid, 5 mM monoolein, and 10 mM oleic acid. Taurocholic acid (TC) (15 mM), alone or in combination with monoolein (5 mM), did not increase villous motility.

From Womack et al. 64


Figure 3.

Effect of venous pressure elevation on villous contraction frequency and lymph flow. A venous pressure elevation of 20 cmH2O caused significant (P < 0.05) increases in both parameters. Villous contraction frequency rose 55% ± 14%, whereas lymph flow increased 54% ± 2%.

From Womack et al. 65


Figure 4.

Representative plasma‐dilution experiment. Intravenous saline infusion (2.5 ml·min−1 · kg−1 body wt) resulted in parallel changes in villous motility and lymph flow.

From Womack et al. 65


Figure 5.

Relationship between lymph flow (% of control) and villous motility (% of control). Regression analysis yielded statistically significant correlation (P < 0.001) with correlation coefficient of 0.83.

From Womack et al. 65


Figure 6.

Proposed mechanism for role of villous motility in lymph propulsion.

From Womack et al. 65


Figure 7.

Response of intestinal villous motility (A), blood flow (B), and oxygen uptake (C) to graded reductions in arterial pressure. Values obtained at 100 mmHg were taken as control, and all other values were expressed as percent of control. Blood flow demonstrated a linear decline as arterial pressure was reduced, and villous motility and oxygen uptake remained at control levels until pressure was reduced to <60 mmHg. *, Significant difference from control (P < 0.05).

From Womack et al. 65
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Article Title: Villous motility
 

How to Cite

William A. Womack, Peter R. Kvietys, D. Neil Granger. Villous motility. Compr Physiol 2011, Supplement 16: Handbook of Physiology, The Gastrointestinal System, Motility and Circulation: 975-986. First published in print 1989. doi: 10.1002/cphy.cp060125