Abstract
The sections in this article are:
- 1 Molecules Involved in Immunoglobulin a Transport
- 2 Anatomic and Cellular Basis of Immunoglobulin a Response
- 3 Immunoglobulin a Transport into Secretions
Immunoglobulin a Secretion
Stephen Holland, John H. Eldridge, Jerry R. McGhee, Charles D. Alley
10.1002/cphy.cp060421
Source: Supplement 19: Handbook of Physiology, The Gastrointestinal System, Intestinal Absorption and Secretion
Originally published: 1991
Published online: January 2011
Full Article on Wiley Online Library
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Figure 1. Diagram of the Peyer's patch, showing the specialized epithelium overlying the lymphoid nodules. M, microfold epithelial cells enveloping lymphocytes; F, follicle (corona); GC, germinal center; TDA, thymus‐dependent area; HEV, high endothelial venule. |
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Figure 2. Electron micrograph of a portion of mouse Peyer's patch epithelium. The M cells have short microvilli (M), envelop lymphoid cells (L), and appear to be the site at which lymphoid cells traverse basement membrane. MN, M‐cell nucleus. |
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Figure 3. Diagram of two M cells characterized by having short microvilli (MV) that are somewhat irregular, highly attenuated cytoplasma, pinocytotic vesicles (PV) in the apical cytoplasm, enveloped lymphoid cells (L), and highly complex lateral borders. MN, M‐cell nucleus; BM, basement membrane; E, enterocyte. |
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Figure 4. Schematic representation of secretory component (SC)–mediated transport of polymeric Ig. 1, Synthesis of SC within rough endoplasmic reticulum after transport and processing in the Golgi (2); 3, incorporation of SC into epithelial cell plasma membrane; polymeric Ig released by plasma cells in lamina propria (LP) combines with membrane‐bound SC and the complex is pinocytosed (4); pinocytotic vesicle is transported through the cytoplasm (5, 6) where sorting and membrane recirculation occur (7); the SC‐Ig complex becomes released from vesicle membrane and is released into lumen (L) by exocytosis (8). |
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