References |
1. |
Barker, E. L.,
R. S. Westphal,
D. Schmidt, and
E. Sanders‐Bush.
Constitutively active 5‐hydroxytryptamine 2c receptors reveal novel inverse agonist activity of receptor ligands.
J. Biol. Chem.
260:
11607–11690,
1994.
|
2. |
Cheng, Y. and
W. H. Prusoff.
Relationship between the inhibition constant (Ki) and the concentration of an inhibitor that causes a 50% inhibition (I50) of an enzymatic reaction.
Biochem. Pharmacol.
22:
3099–3108,
1973.
|
3. |
Cohen, J. B.,
M. Weber,
J ‐P. Changeaux.
Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata.
Mol. Pharmacol.
10:
904–932,
1974.
|
4. |
DeLean, A.,
A. A. Hancock, and
R. J. Lefkowitz.
Validation and statistical analysis of the computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological subtypes.
Mol. Pharmacol.
21:
5–16,
1982.
|
5. |
Garcia, M. L.,
V. F. King,
P. K. S. Siegl,
J. P. Reuben, and
G. J. Kaczorowski.
Binding of Ca++ entry blockers to cardiac sarcolemmal membrane vesicles: Characterization of diltiazem‐binding sites and their interaction with dihydropyridine and aralkylamine receptors.
J. Biol. Chem.
261:
8146–8157,
1986.
|
6. |
Horstman, D. A.,
S. Brandon,
A. L. Wilson,
C. A. Guyer,
E. J. Cragoe, Jr., and
L. E. Limbird.
An aspartate conserved among G protein‐–coupled receptors confers allosteric regulation of α2‐adrenergic receptors by sodium.
J. Biol. Chem.
365
(35):
21590–21595,
1990.
|
7. |
Kenakin, R. P.,
R. A. Bond, and
T. I. Bonner.
Definition of pharmacological receptors.
Pharm. Rev.
44:
351–362,
1992.
|
8. |
Klotz, I. M. and
D. L. Hunston.
Mathematical models for ligand‐receptor binding: Real sites, ghost sites.
J. Biol. Chem.
259:
10060–10062,
1984.
|
9. |
Lefkowitz, R. J.,
S. Cotecchia,
P. Samama, and
T. Costa.
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.
Trends Pharmacol. Sci.
14:
303–307,
1993.
|
10. |
Limbird, L. E.
Cell Surface Receptors: A Short Course on Theory and Methods,
Second Edition.
Boston:
Kluwer Academic Publishers,
1996.
|
11. |
Monaghan, D. T.,
H. J. Olverman,
L. Nguyen, and
J. C. Watkins.
Two classes of N‐methyl‐d‐aspartate recognition sites and differential distribution and differential regulation by glycine.
Proc. Natl. Acad. Sci. USA
85:
9836–9840,
1988.
|
12. |
Prezeau, L.,
J. Gomez,
S. Ahern,
S. Mary,
T. Galvez,
J. Bockaert, and
J ‐P. Pin.
Changes in the carboxyl‐terminal domain of metabotropic glutamate receptor 1 by alternative splicing generates receptors with differing agonist‐independent activity.
Mol. Pharmacol.
49:
422–429,
1996.
|
13. |
Rodbard, D.
A graphic method for the determination and presentation of binding parameters in complex systems.
Anal. Biochem.
20:
525–532,
1973.
|
14. |
Rosenthal, H. E.
A graphic method for the determination and presentation of binding parameters in complex systems.
Anal. Biochem.
20:
525–532,
1967.
|
15. |
Samama, P.,
S. Cotecchia,
T. Costa, and
R. J. Lefkowitz.
A mutation‐induced activated state of the β2‐adrenergic receptor: extending the ternary complex model.
J. Biol. Chem.
268:
4625–4636,
1993.
|
16. |
Scatchard, G.
The attractions of proteins for small molecules and ions.
Ann. N.Y. Acad. Sci.
51:
660–672,
1949.
|
17. |
Schild, H. O.
pA, a new scale for the measurement of drug antagonism.
Brit. J. Pharm.
2:
189–206,
1947.
|
18. |
Simons, S. S., Jr. and
W. B. Pratt.
Glucocorticoid receptor thiols and steroid‐binding activity.
Methods Enzymol.
257:
406–422,
1995.
|
19. |
Sklar, L.
Signal transduction and ligand‐receptor dynamics in the human neutrophil. Transient response and occupancy‐response relations at the formyl peptide receptor.
J. Biol. Chem.
260:
1461–1467,
1985.
|
20. |
Stephenson, R. P.
A modification of receptor theory.
Br. J. Pharm.
11:
379–393,
1956.
|
21. |
Swillens, S.
Interpretation of binding curves obtained with high receptor concentrations; practical aid for computer analysis.
Mol. Pharmacol.
47:
1197–1203,
1985.
|