References |
1. |
Alberti, K. G.,
N. J. Christiansen,
S. E. Christiansen,
A. P. Hansen,
J. Iversen,
K. Lundbaek,
K. Seyer‐Hansen, and
H. Orskov.
Inhibition of insulin secretion by somatostatin.
Lancet
2:
1299–1301,
1973.
|
2. |
Anderson, E., and
J. A. Long.
Hormonal influences on the secretion of insulin.
Recent Prog. Horm. Res.
2:
209–223,
1946.
|
3. |
Ashcroft, F. M., and
S. J. H. Ashcrott.
Mechanism of insulin secretion. In:
Insulin: Molecular Biology to Pathology,
edited by F. M. Ashcroft and
S. J. H. Ashcroft.
Oxford:
Oxford University Press,
1992,
p. 97–150.
|
4. |
Ashcroft, S. J. H..
Glucoreceptor mechanisms and the control of insulin release and biosynthesis.
Diabetologia
18:
5–15,
1980.
|
5. |
Ashcroft, S. J. H., and
P. J. Randle.
Enzymes of glucose metabolism in normal mouse pancreatic islets.
Biochem. J.
119:
5–15,
1970.
|
6. |
Ashmore, J.,
A. B. Hastings,
F. B. Nesbett, and
A. E. Renold.
Studies on carbohydrate metabolism in rat liver slices; hormonal factors influencing glucose 6‐phosphatase.
J. Biol. Chem.
218:
77–88,
1956.
|
7. |
Ashmore, J., and
G. Weber.
The role of hepatic glucose 6‐phosphatase in the regulation of carbohydrate metabolism.
Vitam. Horm.
17:
91–132,
1959.
|
8. |
Ashour, B., and
R. G. Hansford.
Effect of fatty acids and ketones on the activity of pyruvate dehydrogenase in skeletal‐muscle mithcondria.
J. Biol Chem.
214:
725–736,
1983.
|
9. |
Banting, F. G. and
C. H. Best.
The internal secretion of the pancreas.
J. Lab. Clin. Med.
7:
251–266,
1922.
|
10. |
Banting, F. G.,
C. H. Best,
J. B. Collip,
W. R. Campbell,
A. A. Fletcher,
J. J. R. MacLeod, and
E. C. Noble.
The effect produced on diabetes by extracts of pancreas.
Trans. Assoc. Am. Physicians
1–11,
1922.
|
11. |
Barrera, C. R.,
G. Namihira,
L. Hamilton,
P. Munk,
M. H. Eley,
T. C. Linn, and
L. J. Reed.
Alpha‐keto‐acid dehydrogenase complexes XVI. Studies on the subunit structure of the pyruvate dehydrogenase complexes from bovine kidney and heart.
Arch. Biochem. Biophys.
148:
343–358,
1972.
|
12. |
Baxter, M. A., and
H. G. Coore.
The mode of regulation of pyruvate dehydrogenase of lactating gland.
Biochem. J.
174:
553–561,
1978.
|
13. |
Berry, M. N.,
J. W. Phillips,
D. C. Henly, and
D. G. Clark.
Effects of fatty acid oxidation on glucose utilization by isolated hepatocytes.
FEBS Lett.
319:
26–30,
1993.
|
14. |
Best, C. H..
Nineteen hundred twenty one in Toronto.
Diabetes
21:
385–395,
1972.
|
15. |
Bliss, M..
The Discovery of Insulin.
Chicago:
University of Chicago Press,
1982.
|
16. |
Boden, G.,
X. Chen,
J. Rosner, and
M. Barton.
Effects of a 48h fat infusion on insulin secretion and glucose utilisation.
Diabetes
44:
1239–1242,
1995.
|
17. |
Boden, G.,
X. Chen,
J. Ruiz,
J. V. White, and
L. Rossetti.
Mechanism of fatty acid‐induced inhibition of glucose uptake.
J. Clin. Invest.
53:
2438–2456,
1994.
|
18. |
Boden, G.,
F. Jadell,
J. White,
Y. Liang,
M. Mozzoli,
X. Chen,
E. Coleman, and
C. Smith.
Effect of fat on insulin‐stimulated carbohydrate metabolism in normal man.
J. Clin. Invest.
88:
960–966,
1991.
|
19. |
Bromer, W.,
L. G. Sinn, and
O. K. Behrens.
The amino acid sequence of glucagon. V. Location of amide groups, acid degradation studies and summary of sequential evidence.
J. Am. Chem. Soc.
79:
2807–2810,
1957.
|
20. |
Cahill, G. F., Jr., and
O. E. Owen.
Some observations on carbohydrate metabolism in man. In:
Carbohydrate Metabolism and Its Disorders,
edited by F. Dickens,
P. J. Randle, and
W. J. Whelan.
New York:
Academic Press,
1968,
vol. I,
p. 497–522.
|
21. |
Cate, R. L., and
T. E. Roche.
A unifying mechanism for stimulation of mammalian pyruvate dehydrogenase kinase by reduced nicotinamide adenine dinucleotide, dihydrolipoamide, acetyl coenzyne A, or pyruvate.
J. Biol. Chem.
253:
496–503,
1978.
|
22. |
Cate, R. L., and
T. E. Roche.
Function and regulation of mammalian pyruvate dehydrogenase complex. Acetylation, interlipoyl acetyl transfer, and migration of the pyruvate dehydrogenase component.
Biol. Chem.
254:
1659–1665,
1979.
|
23. |
Caterson, I. D.,
S. J. Fuller, and
P. J. Randle.
Effect of the fatty acid oxidation inhibitor 2‐tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and diabetic rats.
Biochem. J.
208:
53–60,
1982.
|
24. |
Chen, G.,
L. Wang,
S. Liu,
C. Chuang, and
T. E. Roche.
Activated function of the pyruvate dehydrogenase phosphatase through Ca2+‐facilitated binding to the inner lipoyl domain of the dihydrolipoyl acetyltransferase.
J. Biol. Chem.
271:
28064–28070,
1996.
|
25. |
Chen, S.,
A. Ogawa,
M. Ohneda,
R. H. Unger,
D. W. Foster, and
J. D. McGarry.
More direct evidence for a malonyl CoA carnitine palmitoyl transferase I interaction as a key event in pancreatic beta cell signaling.
Diabetes
43:
878–883,
1994.
|
26. |
Civelek, V. N.,
J. T. Deeney,
N. J. Shalosky,
K. Tornheim,
R. G. Hansford,
M. Prentkl, and
B. E. Corkey.
Regulation of pancreatic beta‐cell mitochondrial metabolism: influence of Ca2+, substrate and ADP.
Biochem. J.
318:
615–621,
1996.
|
27. |
Cohen, P..
The structure and regulation of protein phosphatases.
Annu. Rev. Biochem.
58:
453–508,
1989.
|
28. |
Collett, M. S., and
R. L. Erikson.
Protein kinase activity associated with the avian sarcoma virus src gene product.
Proc. Natl. Acad. Sci. USA.
75:
2021–2024,
1978.
|
29. |
Cook, W. H.,
D. Lipkin, and
R. Markham.
The formation of a cyclic dianhydrodiadenylic acid by the alkaline degradation of adenosine 5′‐triphosphoric
J. Am. Chem. Soc.
79:
3607,
1957.
|
30. |
Cooper, G. J. S.,
B. Leighton,
G. D. Dimiatridis,
S. M. Parry‐Billings,
J. M. Kowalchuk,
K. Howland,
J. B. Rothbard,
A. C. Willis, and
K. B. M. Reid.
Amylin found in amyloid deposits in human type 2 diabetes may be a hormone that regulates glycogen metabolism in skeletal muscle.
Proc. Natl. Acad. Sci. U.S.A.
85:
7763–7766,
1988.
|
31. |
Cooper, G. J. S.,
A. C. Willis,
A. Clark,
R. C. Turner,
R. B. Sim, and
K. B. M. Reid.
Purification and characterization of a peptide from amyloid‐rich pancreases of type 2 diabetic patients.
Proc. Natl. Acad. Sci. U.S.A.
84:
8628–8632,
1987.
|
32. |
Cooper, R. H.,
P. J. Randle, and
R. M. Denton.
Regulation of heart muscle pyruvate dehydrogenase kinase.
Biochem. J.
143:
625–641,
1974.
|
33. |
Cooper, R. H.,
P. J. Randle, and
R. M. Denton.
Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction.
Nature
257:
808–809,
1975.
|
34. |
Coore, H. G.,
R. M. Denton,
B. R. Martin, and
P. J. Randle.
Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones.
Biochem. J.
125:
115–127,
1971.
|
35. |
Coore, H. G., and
P. J. Randle.
Inhibition of glucose phosphorylation by mannoheptulose.
Biochem. J.
91:
56–59,
1964.
|
36. |
Coore, H. G., and
P. J. Randle.
Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro.
Biochem. J.
93:
66–78,
1964.
|
37. |
Coore, H. G., and
P. J. Randle.
Secretion of insulin by rabbit pancreas in vitro.
Biochem. J.
84:
78P,
1962.
|
38. |
Coore, H. G.,
P. J. Randle,
E. Simon,
E. P. Kraicer, and
M. C. Shelesnyak.
Block of insulin secretion from the pancreas by D‐mannoheptulose.
Nature
197:
1264–1266,
1963.
|
39. |
Cori, C. F..
Influence of hormones on enzymatic reactions. In:
Report of First Int. Congr. Biochem.,
edited by Biochemical Society.
Cambridge:
Cambridge University Press,
1950,
p. 9–18.
|
40. |
Cori, G. T.,
S. P. Colowick, and
C. F. Cori.
The activity of the phosphorylating enzyme in muscle extracts.
J. Biol. Chem.
127:
771–782,
1939.
|
41. |
Cori, C. F., and
G. T. Cori.
Polysaccharide phosphorylase. In:
Les Prix Nobel en 1947.
Stockholm:
Stockholm Imprimiere Royale,
1949,
p. 216–223.
|
42. |
Cori, G. T., and
C. F. Cori.
The enzymatic conversion of phosphorylase a to b.
J. Biol. Chem.
158:
321–352,
1945.
|
43. |
Cori, G. T., and
A. A. Green.
Crystalline muscle phosphorylase. II Prosthetic group.
J. Biol. Chem.
151:
31–38,
1943.
|
44. |
Cori, G. T. C. F.,
A. A. Green, and
G. T. Cori.
Crystalline muscle phosphorylase.
J. Biol. Chem.
142,
447–448,
1942.
|
45. |
Crofford, O. B., and
A. E. Renold.
Glucose uptake by incubated rat epididymal adipose tissue. Rate limiting steps and site of insulin action.
J. Biol. Chem.
240:
14–21,
1965.
|
46. |
Cruickshank, E. W. H., and
C. W. Startup.
Action of insulin on respiratory quotient, oxygen utilisation, carbon dioxide production and sugar utilisation in mammalian diabetic heart.
J. Physiol.
81:
153–161,
1934.
|
47. |
Cuendet, G. S.,
E. G. Loten and
A. E. Renold.
Evidence that the glucose fatty acid cycle is operative in isolated skeletal (soleus) muscle.
Diabetologia
12:
336E,
1975.
|
48. |
Czech, M. P..
The nature and regulation of the insulin receptor: structure and function.
Annu. Rev. Physiol.
47:
357–381,
1985.
|
49. |
Davoren, P. R., and
E. W. Sutherland.
The effect of epinephrine and other agents on the synthesis and release of adenosine 3′5′ monophosphate by whole pigeon erythrocytes.
J. Biol. Chem.
238:
3009–3015,
1963.
|
50. |
Davoren, P. R., and
E. W. Sutherland.
The cellular location of adenyl cyclase in the pigeon erythrocyte.
J. Biol. Chem.
238:
3016–3023,
1963.
|
51. |
DeFronzo, R. A.,
E. Ferrannini,
R. Hendler,
P. Felig, and
J. Wahren.
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycaemia in man.
Diabetes
32:
35–45,
1983.
|
52. |
DeFronzo, R. A.,
R. Gunnarsson,
O. Björkman,
M. Olsson, and
J. Wahren.
Effects of insulin on peripheral and splanchnic glucose metabolism in non‐insulin‐dependent (type II) diabetes mellitus.
J. Clin. Invest.
76:
149–155,
1985.
|
53. |
De Marcucci, O., and
J. G. Lindsay.
Component X: and immunologically distinct polypeptide associated with mammalian pyruvate dehydrogenase multi‐enzyme complex.
Eur. J. Biochem.
149:
641–648,
1985.
|
54. |
Dennis, S. C.,
M., DeBuysere,
R. Scholz, and
M. S. Olson.
Studies on the relationship between ketogenesis and pyruvate oxidation in isolated rat liver mitochondria
J. Biol. Chem.
253:
2229–2237,
1978.
|
55. |
Denton, R. M.,
H. G. Coore,
B. R. Martin, and
P. J. Randle.
Insulin activates pyruvate dehydrogenase in rat epididymal adipose tissue.
Nature (New Biol.)
231:
115–117,
1971.
|
56. |
Denton, R. M.,
N. H. Edgell,
B. J. Bridges, and
G. P. Poole.
Acute regulation of pyruvate kinase activity in rat epididymal adipose tissue by insulin.
Biochem. J.
180:
523–531,
1979.
|
57. |
Denton, R. M.,
P. J. Randle, and
B. R. Martin.
Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.
Biochem. J.
128:
161–163,
1972.
|
58. |
Denton, R. M., and
J. M. Tavaré.
Does mitogen‐activated‐protein kinase have a role in insulin action. These case for and against.
Eur. J. Biochem.
227:
597–611,
1995.
|
59. |
Denyer, G. S.,
A. L. Kerbey, and
P. J. Randle.
Kinase activator protein mediates longer‐term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria.
Biochem. J.
239:
347–354,
1986.
|
60. |
Dole, V. P..
Relation between non‐esterifled fatty acids in plasma and metabolism of glucose.
J. Clin. Invest.
35:
150–159,
1956.
|
61. |
Drury, D. R., and
A. N. Wick.
Can other fuels substitute for glucose in tissues subjected to intense insulin activity.
Ciba Found. Symp.
8:
211–217,
1953.
|
62. |
Ebina, Y.,
L. Ellis,
K. Jarnagin,
M. Edery,
L. Graf,
E. Clauser,
L. H. Ou,
F. Masiarz,
Y. W. Kan,
I. D. Goldfine,
R. A. Roth, and
W. J. Rutter.
The human insulin receptor cDNA: the structural basis for hormone‐activated transmembrane signalling.
Cell
40:
747–758,
1985.
|
63. |
Erikson, E.,
M. S. Collett, and
R.L. Erikson.
In vitro synthesis of a functional avian sarcoma virus transforming‐gene product.
Nature
274:
919–921,
1988.
|
64. |
Erikson, R. L.,
M. S. Collett,
E. Erikson, and
A. P. Purchio.
Evidence that the avian sarcoma virus transforming gene product is a cAMP‐independent protein kinase.
Proc. Natl. Acad. Sci. U.S.A.
78:
6260–6264,
1979.
|
65. |
Fatania, H. R.,
T. C. Vary, and
P. J. Randle.
Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n‐octanoate.
Biochem. J.
234:
233–236,
1986.
|
66. |
Felber, J. P.,
A. Golay,
C. Felley, and
E. Jequier.
Regulation of glucose storage in obesity and diabetes. Metabolic aspects.
Diabetes Metab. Rev.
4:
691–700,
1988.
|
67. |
Felig, P., and
V. Koivisto.
Recent advances in body fuel metabolism.
Contemp. Metab.
1:
359–384,
1979.
|
68. |
Ferrannini, E.,
E. J. A. Bevilacqua, and
R. A. DeFronzo.
Effect of fatty acids on glucose production and utilisation in man.
J. Clin. Invest.
72:
1737–1747,
1983.
|
69. |
Fischer, E. H., and
E. G. Krebs.
Conversion of phosphorylase b to phosphorylase a in muscle extracts.
J. Biol. Chem.
216:
121–132,
1955.
|
70. |
Fulcher, G. R.,
M. Walker,
C. Catalano,
M. Farrer, and
K. G. M. M. Alberti.
Acute metabolic and hormonal responses to the inhibition of lipolysis in non‐obese patients with non insulin‐dependent (type‐2) diabetes mellitus—effects of acipimox.
Clin. Sci. (Colch.)
82:
565–571,
1992.
|
71. |
Fuller, S. J., and
P. J. Randle.
Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal‐muscle mitochondria.
Biochem. J.
219:
635–646,
1984.
|
72. |
Gameltoft, S..
Insulin receptors: binding kinetics and structure‐function relationship of insulin.
Physiol. Rev.
64:
1322–1378,
1984.
|
73. |
Garland, P. B., and
P. J. Randle.
Control of pyruvate dehydrogenase in the perfused rat heart by the intracellular concentration of acetyl coenzyme A.
Biochem. J.
91:
6c–7c,
1964.
|
74. |
Garland, P. B.,
P. J. Randle and
E. A. Newsholme.
Citrate as an intermediary in the inhibition of phosphofructokinase in rat heart muscle by fatty acids, ketone bodies, pyruvate, diabetes and starvation.
Nature
195:
381–383,
1963.
|
75. |
Gemmill, C. L., and
L. Hamman.
The effect of insulin on glycogen deposition and on glucose utilization by isolated muscles.
Bull. Johns Hopkins Hosp.
68:
50–57,
1941.
|
76. |
Grodsky, G. M.,
A. A. Batts,
L. L. Bennett,
C. Vcella,
N. B. McWilliams, and
D. F. Smith.
Effects of carbohydrates on secretion of insulin from isolated rat pancreas.
Am. J. Physiol.
205:
638–644,
1963.
|
77. |
Groop, L. C.,
R. C. Bonadonna,
S. Delprato,
K. Ratheiser, and
R. A. De‐Fronzo.
Effect of prolonged overnight fasting on energy metabolism in non‐insulin‐dependent diabetic and non‐diabetic subjects.
Acta Endocrinol. (Copenh.)
123:
30–36,
1990.
|
78. |
Groop, L. C.,
R. C. Bonadonna,
S. Delprato,
K. Ratheiser,
K. Zyck,
E. Ferrannini, and
R. A. DeFronzo.
Glucose and free fatty acid metabolism in non‐insulin‐dependent diabetes mellitus—evidence for multiple sites of insulin resistance.
J. Clin. Invest.
84:
205–213,
1989.
|
79. |
Hales, C. N., and
D. J. P. Barker.
Type 2 (non‐insulin‐dependent) diabetes mellitus: the thrifty phenotype hypothesis.
Diabetologia
35:
595–601,
1993.
|
80. |
Hales, C. N.,
M. Desai, and
S. E. Ozanne.
The thrifty phenotype hypothesis: how does it look after 5 years?
Diabet. Med.
14:
189–195,
1987.
|
81. |
Halestrap, A. P., and
R. M. Denton.
Insulin and the regulation of adipose tissue acetyl coenzyme A carboxylase.
Biochem. J.
132:
509–517,
1973.
|
82. |
Hansford, R. G..
Studies on the effects of coenzyme A‐SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.
J. Biol. Chem.
251:
5483–5489,
1976.
|
83. |
Hers, H.‐G.,
L. Hue and
E. van Schaftingen.
The fructose 6‐phosphate/fructose 1,6‐bisphosphate cycle.
Curr, Top. Cell. Regul
18:
199–209,
1981.
|
84. |
Hers, H. G., and
E. van Schaftingen.
Fructose 2,6‐bisphosphate two years after its discovery.
Biochem. J.
206:
1–12,
1982.
|
85. |
Hubinger, A.,
G. Weiker,
H. P. O. Wolf, and
F. A. Gries.
The effect of Etomoxir on insulin sensitivity in type‐2 diabetic patients.
Horm. Metab. Res.
24:
115–118,
1992.
|
86. |
Hue, L.,
L. Maisin, and
M. H. Rider.
Palmitate inhibits liver glycolysis: involvement of fructose 2,6‐bisphosphate in the glucose fatty acid cycle.
Biochem. J.
251:
541–545,
1988.
|
87. |
Hunter, T.,
R. A. Lindberg, and
D. S. Middlemas.
Novel receptor tyrosine kinases. In:
The Biology and Medicine of Signal Transduction,
edited by Y. Nishizuka et al.
New York:
Raven
1990,
p. 260–266.
|
88. |
Hunter, T.,
R. A. Lindberg,
D. S. Middlemas,
S. Tracy, and
P. van der Greer.
Receptor tyrosine kinases and phosphatases.
Cold Spring Harh Symp. Quant. Biol.
57:
25–40,
1992.
|
89. |
Hunter, T., and
B. M. Sefton.
The Rous sarcoma virus src gene product is a protein kinase that phosphorylates tyrosine. In:
Protein Phosphorylation and Bio‐regulation. FMI‐EMBO Workshop, Basel, 1979.
Basel:
Karger,
1980,
p. 193–208.
|
90. |
Hunter, T., and
B. M. Sefton.
The transforming gene product of Rous sarcoma virus phosphorylates tyrosine.
Proc. Natl. Acad. Sci. U.S.A.
77:
1311–1315,
1980.
|
91. |
Hutson, N. J., and
P. J. Randle.
Enhanced activity of pyruvate dehydrogenase kinase in rat heart mitochondria in alloxan‐diabetes or starvation.
FEBS Lett.,
92:
73–76,
1978.
|
92. |
Jacot, E.,
R. A. DeFronzo,
E. Jéquier,
E. Maeder, and
J. P. Felber.
The effect of hyperglycemia, hyperinsulinaemia and route of glucose administration on glucose oxidation and glucose storage.
Metabolism
31:
922–930,
1982.
|
93. |
Johnson, A. B.,
M. Argyraki,
J. C. Thow,
B. G. Cooper,
G. Fulcher, and
R. Taylor.
Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen sythase activity in normal man.
Clin. Sci. (Colch.)
82:
219–226,
1992.
|
94. |
Jones, B. S., and
S. J. Yeaman.
Long‐term regulation of pyruvate dehydrogenase complex. Evidence that kinase‐activator protein (KAP) is free pyruvate dehydrogenase kinase.
Biochem. J.
275:
781–784,
1991.
|
95. |
Jungas, R. L..
Hormonal regulation of pyruvate dehydrogenase.
Metabolism
20:
43–53,
1971.
|
96. |
Kasuga, M.,
F. A. Karlsson, and
C. R. Kahn.
Insulin stimulates the phosphorylation of the 95000–dalton subunit of its own receptor.
Science
215:
185–186,
1982.
|
97. |
Kerbey, A. L.,
A. Kearns, and
P. J. Randle.
Dephosphorylation of pig heart pyruvate dehydrogenase phosphate complexes by pig heart pyruvate dehydrogenase phosphatase.
Biochem. J.
195:
51–59,
1981.
|
98. |
Kerbey, A. L.,
P. M. Radcliffe, and
P. J. Randle.
Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of ATP/ADP, NADH/NAD+ and acetyl CoA/CoA.
Biochem. J.
164:
509–519,
1977.
|
99. |
Kerbey, A. L.,
P. M. Radcliffe,
P. H. Sugden, and
P. J. Randle.
Regulation of kinase reactions in pig heart pyruvate dehydrogenase complex.
Biochem. J.
181:
427–433,
1979.
|
100. |
Kerbey, A. L., and
P. J. Randle.
Pyruvate dehydrogenase kinase/activator in rat heart mitochondria: assay, effect of starvation, and effect of protein synthesis inhibitors on starvation.
Biochem. J.
206:
103–111,
1982.
|
101. |
Kerbey, A. L., and
P. J. Randle.
Pyruvate dehydrogenase kinase activity of pig heart pyruvate dehydrogenase (El component of pyruvate dehydrogenase complex).
Biochem. J.
231:
523–529,
1985.
|
102. |
Kerbey, A. L.,
P. J. Randle,
R. H. Cooper,
S. Whitehouse,
H. T. Pask, and
R. M. Denton.
Regulation of pyruvate dehydrogenase in rat heart.
Biochem. J.
154:
327–348,
1976.
|
103. |
Krahl, M. E..
Effect of insulin and protein hormones on glucose uptake in muscle.
Ann. N.Y. Acad. Sci.
54:
649–670,
1952.
|
104. |
Krahl, M. E..
Functions of insulin and other regulatory factors in peptide formation.
Recent Prog. Horm. Res.
12:
199–219,
1956.
|
105. |
Krebs, E. G., and
E. H. Fischer.
The phosphorylase b to a converting enzyme of rabbit skeletal muscle.
Biochim. Biopyhs. Acta
20:
150–157,
1956.
|
106. |
Krebs, E. G.,
C. Gonsalez,
J. B. Posner,
D. S. Love,
G. E. Bravold, and
E. H. Fischer.
Interconversion of muscle phosphorylases b and a. In:
Ciba Foundation Symposium on Control of Glycogen Metabolism.
London:
Churchill,
1964,
p. 200–210.
|
107. |
Krebs, E. G.,
D. J. Graves, and
E. H. Fischer.
Factors affecting the activity of phosphorylase b kinase.
J. Biol. Chem.
234:
2867–2873,
1959.
|
108. |
Krebs, H. A..
Metabolism of amino acids. III. Deamination of amino acids.
Biochem. J.
29:
1620–1644,
1935.
|
109. |
Lane, M. A..
The cytological characteristics of the areas of Langerhans.
Am. J. Anat.
7:
409–422,
1907.
|
110. |
Larner, J.,
C. Villar‐Palasi, and
Richman D J..
Insulin stimulated glycogen formation in rat diaphragm. Levels of tissue intermediates in short term experiments.
Ann. N.Y. Acad. Sci.
82:
345–353,
1959.
|
111. |
Larsson, L. I.,
F. Sundler, and
R. Hakanson.
Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells.
Cell Tissue Res.
156:
167–171,
1975.
|
112. |
Lee, K. H.,
T. Thrall, and
K. H. Kim.
Hormonal regulation of acetylCoA carboxylase—effect of insulin and epinephrine.
Biochem. Biophys. Res. Commun.
54:
1135–1140,
1973.
|
113. |
Lefebvre, P. J..
From plant physiology to human metabolic investigations.
Diahetologia
28:
255–263,
1985.
|
114. |
Leloir, L. F., and
C. E. Cardini.
Biosynthesis of glycogen from uridine diphosphate glucose.
J. Am. Chem. Soc.
79:
6340–6341,
1957.
|
115. |
Levene, P. A., and
D. W. Hill.
On a dipeptide phosphoric acid isolated from casein.
J. Biol. Chem.
101:
711–718,
1933.
|
116. |
Levine, R., and
M. S. Goldstein.
On the mechanism of action of insulin.
Recent Prog. Horm. Res.
11:
343–375,
1955.
|
117. |
Linn, T. C.,
F. H. Pettit,
F. Hucho, and
L. J. Reed.
Alpha‐ketoacid dehydrogenase complexes, XI. Comparative studies of regulatory properties of the pyruvate dehydrogenase complexes from kidney, heart, and liver mitochondria.
Biochemistry
64:
227–234,
1969.
|
118. |
Linn, T. C.,
F. H. Pettit, and
L. J. Reed.
Regulation of the activity of pyruvate dehydrogenase complex by phosphorylation and dephosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
62:
234–241,
1989.
|
119. |
Lipmann, F..
Über die Bindung der phosphorsäure in phosphoproteinen. I Isolierung einer phosphorhaltigen aminosaüre (serine‐phosphorsaüre) aus casein.
Biochem. Z.
262:
3–8,
1933.
|
120. |
Luft, R.,
S. Efendic,
T. Hokfelt,
O. Johansson, and
A. Arimur.
Immunohistochemical evidence for the localization of somatostatin‐like immunoreactivity in a cell population of the pancreatic islets.
Med. Biol. Eng.
52:
428–430,
1974.
|
121. |
Lundsgaard, E..
Insulin and muscle. In:
Proc. IIe Cong. Int. Thérapeutique.
Brussels:
Editions Arsica,
1950,
p. 119–129.
|
122. |
Lundsgaard, E..
On the mode of action of insulin.
Lakaraeforen. Forh.
45:
143–152,
1939.
|
123. |
Maizels, E. Z.,
N. B. Ruderman,
M. N. Goodman, and
D. Lau.
Effeet of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat.
Biochem. J.
162:
234–241,
1977.
|
124. |
Marchington, D. R.,
A. L. Kerbey,
M. G. Giardina,
E. A. Jones, and
P. J. Randle.
Longer term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes.
Biochem. J.
257:
487–491,
1989.
|
125. |
Marchington, D. R.,
A. L. Kerbey, and
P. J. Randle.
Longer term regulation of pyruvate dehydrogenase in cultured rat cardiac myocytes.
Biochem. J.
267:
245–247,
1990.
|
126. |
Matschinsky, F. M..
Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta cells and hepatocytes.
Diabetes
39:
647–652,
1990.
|
127. |
Matschinsky, F. M., and
J. E. Ellerman.
Metabolism of glucose in the islets of Langerhans.
J. Biol. Chem.
243:
2730–2736,
1968.
|
128. |
Mattevi, A.,
A. de Kok, and
R. N. Perham.
The pyruvate dehydrogenase complex.
Curr. Opin. Struct. Biol.
2:
277–287,
1992.
|
129. |
McAllister, A.,
S. P. Allison, and
P. J. Randle.
Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3‐hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo.
Biochem. J.
134:
1067–1081,
1973.
|
130. |
McCormaek, J. G..
Studies on the activation of rat liver pyruvate dehydrogenase and 2‐oxoglutarate dehydrogenase complexes by adrenaline and glucagon. Role of increases in mitochondrial calcium.
Biochem. J.
231:
597–608,
1985.
|
131. |
McCormaek, J. G., and
R. M. Denton.
Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated heart mitochondria that adrenaline activates the pyruvate and 2‐oxoglutarate dehydrogenase complexes by increasing the mitochondrial concentration of Ca2+.
Biochem. J.
218:
235–247,
1984.
|
132. |
McCormaek, J. G.,
A. P. Halestrap, and
R. M. Denton.
Role of calcium ions in regulation of mammalian intramitochondrial metabolism.
Physiol. Rev.
70:
391–425,
1990.
|
133. |
McCormaek, J. G.,
E. A. Longo, and
B. Corkey.
Glucose‐induced activation of pyruvate dehydrogenase in islets.
Biochem. J.
267:
527–530,
1990.
|
134. |
Meyer, H. U.,
B. Curchod,
P. Pahud,
E. Jequier, and
J. P. Felber.
Modifications of glucose storage and oxidation in nonobese diabetics, measured by continuous indirect calorimetry.
Diabetes
29:
752–756,
1980.
|
135. |
Mistry, S. C.,
D. A., Priestman,
A. L. Kerbey, and
P. J. Randle.
Evidence that rat liver pyruvate dehydrogenase kinase activator protein is a pyruvate dehydrogenase kinase.
Biochem. J.
275:
775–779,
1991.
|
136. |
Murlin, J. R.,
H. G. Clough,
C. B. Gibbs, and
A. M. Stokes.
Aqueous extract of pancreas. I Influence on the carbohydrate metabolism of depancreatised animals.
J. Biol Chem.
56:
253–256,
1923.
|
137. |
Nuutila, P.,
V. A. Koivisto,
J. Knuuti,
U. Ruotsalainen,
M. Teras,
M. Haaparanta,
J. Bergman,
O., Solin,
L. M. Voipiopulkki,
U. Wegelius and
H. Yki‐Jarvinen.
Glucose free fatty acid cycle operates in human heart and skeletal muscle in vivo.
J. Clin. Invest.
89:
1767–1774,
1992.
|
138. |
Opie, E. L..
On the relation of the chronic interstitial pancreatitis to the islands of Langerhans and to diabetes mellitus.
J. Exp. Med.
5:
419–425,
1900–1901.
|
139. |
Paolisso, G.,
A. Gambardella,
L. Amato,
R. Tortoriello,
A. D'Amore,
M. Varricchio, and
F. D'Onofrio.
Opposite effects of short‐and long‐term fatty acid infusion on insulin secretion in healthy subjects.
Diabetologia
38:
1295–1299,
1995.
|
140. |
Park, C. R.,
H. E. Morgan,
M. J. Henderson,
D. M. Regen,
E. Cadenas, and
R. L. Post.
The regulation of glucose uptake in muscle as studied in the perfused rat heart.
Recent Prog. Horm. Res.
17:
493–529,
1961.
|
141. |
Park, C. R.,
R. L Post,
C. F. Kalman,
J. F. Wright, Jr.,
L. H. Johnson, and
H. E. Morgan.
The transport of glucose and other sugars across cell membranes and the effect of insulin.
Ciba Found. Symp.
9:
240–260,
1956.
|
142. |
Passonneau, J. V., and
O. H. Lowry.
Phosphofructokinase and the Pasteur effect.
Biochim. Biophys. Res. Commun.
12:
268–273,
1952.
|
143. |
Paulesco, N. C..
Action de l'extrait pancréatique
C. R. Soc. Biol.
27:
555–559,
1921.
|
144. |
Paulesco, N. C..
Recherche sur le rôle du pancréas dans l'assimilation nutritive.
Arch. Int. Physiol.
17:
85–103,
1921.
|
145. |
Perham, R. N..
Interaction of protein domains in the assembly and mechanism of 2‐oxo acid dehydrogenase multienzyme complexes. In:
Alpha‐Ketoacid Dehydrogenase Complexes,
edited by M. S. Patel,
T. E. Roche, and
R. A. Harris.
Boston:
Birkhäuser,
1996,
p. 1–16.
|
146. |
Pettit, F. H.,
J. W. Pelley, and
L. J. Reed.
Regulation of pyruvate dehydrogenase kinase and phosphatase by acetylCoA/CoA and NADH/NAD+ ratios.
Biochim. Biophys. Res. Commun.
65:
575–583,
1975.
|
147. |
Pettit, F. H., and
L. J. Reed.
Pyruvate dehydrogenase complex from bovine kidney and heart.
Methods Enzymol.
89:
377–386,
1982.
|
148. |
Pettit, F. H., and
L. J. Reed.
Pyruvate dehydrogenase kinase from bovine kidney.
Methods Enzymol.
90:
195–200,
1982.
|
149. |
Piatti, P. M.,
L. D. Monti,
M. Pacchioni,
A. E. Pontiroli, and
G. Pozza.
Forearm insulin‐mediated and non‐insulin‐mediated glucose uptake and muscle metabolism in man. Role of free fatty acids and blood glucose levels.
Metab. Clin. Exp.
40:
926–933,
1999
|
150. |
Pilkis, S. J.,
M. R. El‐Maghrabi,
M. McGrane,
J. Pilkis,
E. Fox, and
T. H. Claus.
Fructose 2,6‐bisphosphate as a mediator of hormone action at the fructose 6‐phosphate/fructose 1,6‐bisphosphate substrate cycle.
Mol. Cell. Endocrinol.
25:
245–266,
1991
|
151. |
Pollak, L., and
G. Fehér.
Der mechanisms der Insulinwirkung.
Klin. Wochenschr.
15:
1282–1283,
1936.
|
152. |
Popov, K. M.,
N. Y. Kedishvili,
Y. Zhao,
R. Gudi, and
R. A. Harris.
Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase.
J. Biol. Chem.
269:
29720–29724,
1994.
|
153. |
Posternak, S..
Sur le noyau phosphoré de la caséine.
C. R. Seances Acad. Sci.
184:
217–220,
1927.
|
154. |
Pratt, M. L., and
T. E. Roche.
Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenase kinase and synergistic inhibition by pyruvate and ADP.
J. Biol. Chem.
254:
7191–7195,
1979.
|
155. |
Prentki, M.,
S. Vischer,
M. C. Glennon,
R. Regazzi,
J. T. Deeney, and
B. E. Corkey.
Malonyl‐CoA and long chain acyl‐CoA esters as metabolic coupling factors in nutrient‐induced insulin secretion.
J. Biol. Chem.
267:
5802–5810,
1992.
|
156. |
Priestman, D. A.,
S. C. Mistry,
A. Halsall, and
P. J. Randle.
Role of protein synthesis and of fatty acid metabolism in the longer term regulation of pyruvate dehydrogenase kinase.
Biochem. J.
300:
659–664,
1994.
|
157. |
Priestman, D. A.,
S. C. Mistry,
A. L. Kerbey, and
P. J. Randle.
Purification and partial characterization of rat liver pyruvate dehydrogenase kinase activator protein (free pyruvate dehydrogenase kinase).
FEBS Lett.
308:
83–86,
1992.
|
158. |
Rahmatullah, M., and
T. E. Roche.
Modification of bovine kidney pyruvate dehydrogenase kinase activity by CoA esters and their mechanism of action.
J. Biol. Chem.
260:
10146–10152,
1985.
|
159. |
Rall, T. W.,
E. W. Sutherland, and
J. Berthet.
The relationship of glucagon and epinephrine to liver phosphorylase.
J. Biol. Chem.
224:
463–475,
1957.
|
160. |
Rall, T. W.,
E. W. Sutherland, and
W. D. Wosilait.
The relationship of epinephrine and glucagon to liver phosphorylase. III Reactivation of liver phosphorylase in slices and in extracts.
J. Biol. Chem.
218:
483–495,
1956.
|
161. |
Randle, P. J..
Carbohydrate metabolism and lipid storage and breakdown in diabetes.
Diabetologia
2:
237–247,
1996.
|
162. |
Randle, P. J..
Endocrine control of metabolism.
Ann. U Rev. Physiol.
25:
291–324,
1964.
|
163. |
Randle, P. J..
Fuel selection in animals. Nineteenth Ciba Medal Lecture.
Biochem. Soc. Trans.
14:
799–806,
1986.
|
164. |
Randle, P. J..
Glucokinase and candidate genes for type 2 (non‐insulin‐dependent) diabetes mellitus.
Diabetologia
36:
268–275,
1993.
|
165. |
Randle, P. J..
Insulin. In
The Hormones,
edited by E. B. Astwood,
G. Pincus, and
K. V. Thiman.
London:
Academic,
1964,
vol. IV,
p. 481–530.
|
166. |
Randle, P. J..
Phosphorylation‐dephosphorylation cycles and the regulation of fuel selection in mammals.
Curr. Top. Cell. Regul.
18:
107–128,
1981.
|
167. |
Randle, P. J..
The growth hormone of the pituitary gland and metabolic processes.
Symp. Soc. Exp. Biol.
11:
183–203,
1957.
|
168. |
Randle, P. J.,
P. J. England, and
R. M. Denton.
Control of the tri‐carboxylate cycle and its interactions with glycolysis during acetate utilisation in rat heart.
Biochem. J.
117:
677–695,
1970.
|
169. |
Randle, P. J.,
P. B. Garland,
C. N. Hales, and
E. A. Newsholme.
The glucose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
Lancet
1:
785–789,
1963.
|
170. |
Randle, P. J.,
P. B. Garland,
C. N. Hales,
E. A. Newsholme,
R. M. Denton, and
C. I. Pogson.
Interactions of metabolism and the physiological role of insulin.
Recent Prog. Horm. Res.
22:
1–14,
1966.
|
171. |
Randle, P. J., and
H. E. Morgan.
Regulation of glucose uptake by muscle.
Vitam. Horm.
20:
199–249,
1964.
|
172. |
Randle, P. J.,
D. A. Priestman,
S. C. Mistry, and
A. Halsall.
Mechanisms modifying glucose oxidation in diabetes mellitus.
Diabetologia
37
(Suppl. 2):
S155–S161,
1994.
|
173. |
Randle, P. J.,
P. H. Sugden,
A. L. Kerbey,
P. M. Radcliffe, and
N. J. Hutson.
Regulation of pyruvate oxidation and the conservation of glucose.
Biochem. Soc. Symp.
43:
47–67,
1978.
|
174. |
Recant, L..
Pituitary respiratory quotient depressing factor.
J. Clin. Invest.
31:
656–657,
1952.
|
175. |
Reed, L. J..
Regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation–dephosphorylation cycle.
Curr. Top. Cell. Regul.
18:
95–106,
1981.
|
176. |
Reed, L. J., and
M. L. Hackert.
Structure function relationships in dihydrolipoamide dehydrogenases.
J. Biol. Chem.
265:
18971–18974,
1990.
|
177. |
Reed, L. J.,
J. E. Lawson,
X. D. Niu, and
J. Yan.
Pyruvate dehydrogenase phosphatase. In:
Alpha‐Ketoacid Dehydrogenase Complexes,
edited by M. S. Patel,
T. E. Roche, and
R. A. Harris.
Boston:
Birkhäuser,
1996,
p. 131–138.
|
178. |
Rennie, M. J., and
J. O. Holloszy.
Inhibition of glucose uptake and glycogenolysis by availability of oleate in well oxygenated perfused skeletal muscle.
Biochem. J.
168:
161–170,
1977.
|
179. |
Rimington, C..
The phosphorus of caseinogen. I. Isolation of a phosphorus containing peptone from tryptic digests of caseinogen. II. Constitution of phosphopeptone
Biochem. J.
21:
1179–1193,
1927.
|
180. |
Roche, T. E., and
R. L. Cate.
Evidence for lipoic acid mediated NADH and acetlyCoA stimulation of liver and kidney and kidney pyruvate dehydrogenase kinase.
Biochem. Biophys. Res. Commun.
72:
1375–1383,
1976.
|
181. |
Roche, T. E.,
S. Liu,
J. C. Ravindran,
J. C. Baker, and
L. Wang.
Role of E2 core in the dominant mechanisms of regulatory control of mammalian pyruvate dehydrogenase. In:
Alpha‐ketoacid Dehydrogenase complexes,
edited by M. S. Patel,
T. E. Roche, and
R. A. Harris.
Boston:
Birkhäuser,
1996,
p. 17–32.
|
182. |
Rousselle, J.,
A. Buckert,
P. Pahud,
E. Jequier, and
J. P. Felber.
Relationship between glucose oxidation and glucose tolerance in man.
Metabolism
31:
866–870,
1982.
|
183. |
Sako, Y., and
V. Grill.
A 48h lipid infusion in the rat time‐dependently inhibits glucose‐induced insulin secretion and B‐cell oxidation through a process likely coupled to fatty acid oxidation.
Endocrinology
127:
1580–1589,
1990.
|
184. |
Salas, J.,
M. Salas,
E. Vinuela, and
A. Sols.
Glucokinase of rabbit liver. Purification and properties.
J. Biol. Chem.
240:
1014–1018,
1963.
|
185. |
Sale, G. J., and
P. J. Randle.
Incorporation of [32P]phosophate into the pyruvate dehydrogenase complex in rat heart mitochondria.
Biochem. J.
188:
409–421,
1980.
|
186. |
Sale, G. J., and
P. J. Randle.
Analysis of site occupancies in [32P]phosphorylated pyruvate dehydrogenase complexes by aspartyl‐prolyl cleavage.
Eur. J. Biochem.
120:
535–540,
1981.
|
187. |
Sale, G. J., and
P. J. Randle.
Occupancy of sites of phosphorylation in inactive rat heart pynvate dehydrogenase phosphate in vivo.
Biochem. J.
193:
935–946,
1981.
|
188. |
Sale, G. J., and
P. J. Randle.
Occupancy of phosphorylation sites in pyruvate dehydrogenase phosphate complex in rat heart in vivo.
Biochem. J.
206:
221–229,
1982.
|
189. |
Sale, G. J., and
P. J. Randle.
Role of individual phosphorylation sites in inactivation of pyruvate dehydrogenase complex in rat heart mitochondria.
Biochem. J.
203:
99–108,
1982.
|
190. |
Sanger, F..
The chemical structure of insulin.
Ciba Found. Symp.
9:
110–119,
1956.
|
191. |
Schalch, D. S., and
D. M. Kipnis.
Abnormalities in carbohydrate tolerance associated with elevated plasma non‐esterified fatty acids.
J. Clin. Invest.
44:
2010–2020,
1964.
|
192. |
Schmidt, G..
Über den phosphorsäure haltigen baustein des casein‐moleküls.
Z. Physiol. Chem.
223:
86–88,
1934.
|
193. |
Schulze, W..
Insulin and glucagon.
Ciba Found.
9:
147–163,
1956.
|
194. |
Siess, E. A., and
O. H. Wieland.
Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated liver cells.
Biochem. J.
156:
91–102,
1976.
|
195. |
Soskin, S., and
R. Levine.
Carbohydrate Metabolism.
Chicago:
University of Chicago Press,
1946.
|
196. |
Stace, P. B.,
H. R. Fatania,
A. Jackson,
A. L. Kerbey, and
P. J. Randle.
Cyclic AMP and free fatty acids in the longer‐term regulation of pyruvate dehydrogenase kinase in rat soleus muscle.
Biochim. Biophys. Acta.
1135:
201–206,
1992.
|
197. |
Stadie, W. C..
Current concepts of the mechanism of action of insulin.
Physiol. Rev.
34:
52–100,
1952.
|
198. |
Stanley, C. J.,
L. C. Packman,
M. J. Danson,
C. E. Henderson, and
R. N. Perham.
Intramolecular coupling of active sites in the pyruvate dehydrogenase multienzyme complexes from bacterial and mammalian sources.
Biochem. J.
195:
715–721,
1981.
|
199. |
Stanley, C. J., and
R. N. Perham.
Purification of 2‐oxo acid dehydrogenase multienzyme complexes from heart by a new method.
Biochem. J.
191:
147–154,
1980.
|
200. |
Staub, A.,
L. Sinn, and
O. K. Behrens.
Purification and crystallization of hyperglycaemic glycogenolytic factor (HGF).
Science
117:
628,
1953.
|
201. |
Stein, D. T.,
V., Esser,
B. E. Stevenson,
K. E. Lane,
J. H. Whiteside,
M. B. Daniels,
S. Chen and
J. D. McGarry.
Essentiality of circulating fatty acids for glucose stimulated insulin secretion in the fasted rat.
J. Clin. Invest.
97:
2728–2735,
1996.
|
202. |
Stepp, L. R.,
F. H. Pettit,
S. J. Yeaman, and
L. H. Reed.
Purification and properties of pyruvate dehydrogenase kinase from bovine kidney.
J. Biol. Chem.
258:
9454–9458,
1983.
|
203. |
Sugden, M. C. and
M. J. Holness.
Hormonal and nutritional modulation of PDHC status. In:
Alpha‐Ketoacid Dehydrogenase Complexes,
edited by M. S. Patel,
T. E. Roche, and
R. A. Harris.
Boston:
Birkhäuser,
1996,
p. 1–16.
|
204. |
Sugden, P. H.,
N. J. Hutson,
A. L. Kerbey, and
P. J. Randle.
Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re‐activation by pyruvate dehydrogenase phosphate phosphatase.
Biochem. J.
169:
433–435,
1978.
|
205. |
Sugden, P. H., and
P.J. Randle.
Regulation of pig heart pyruvate dehydrogenase by phosphorylation. Studies on the subunit and phosphorylation stoichiometries.
Biochem. J.
173:
659–668,
1978.
|
206. |
Sutherland, E. W., and
C. F. Cori.
Effect of hyperglycaemic‐glycogenolytic factor and epinephrine on liver phosphorylase.
J. Biol. Chem.
188:
531–543,
1951.
|
207. |
Sutherland, E. W., and
T. W. Rall.
The properties of an adenine ribonucleotide produced with cellular particles, ATP, Mg++ and epinephrine or glucagon.
J. Am. Chem. Soc.
79:
3608,
1957.
|
208. |
Sutherland, E. W., and
T. W. Rall.
Formation of a cyclic adenine ribonucleotide by tissue particles.
J. Biol. Chem.
232:
1065–1076,
1958.
|
209. |
Sutherland, E. W., and
T. W. Rall.
Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles.
J. Biol. Chem.
232:
1077–1091,
1958.
|
210. |
Teague, W. M.,
F. H., Pettit,
T.‐L. Wu,
S. R. Silberman, and
L. J. Reed.
Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney.
Biochemistry
21:
5585–5592,
1982.
|
211. |
Thiébaud, D.,
R. A., DeFronzo,
E. Jacot,
A. Golay,
K. Acheson,
E. Maeder,
E. Jéquier, and
J.‐P. Felber.
Effect of long chain triglyceride infusion on glucose metabolism in man.
Metabolism
31,
1128–1136.
|
212. |
Thiébaud, D. E.,
Jacot, R. A.,
DeFronzo, E.,
Maeder, E. Jéquier, and
J. P. Felber.
The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man.
Diabetes
31:
957–963,
1982.
|
213. |
Tonks, N. K.,
C. D. Diltz, and
E. H. Fischer.
Purification of the major protein‐tyrosine‐phosphatases of human placenta.
J. Biol. Chem.
263:
6722–6730,
1988.
|
214. |
Tutwiler, G. F..
Glucose fatty acid cycle. Possible therapeutic implications. In:
Diabetes,
edited by R. Larkins,
P. Zimmet, and
D. Chisholm.
Amsterdam:
Elsevier,
1988,
p. 175–179.
|
215. |
Ullrich, A.,
J. R. Bell,
E. Y. Chen,
R. Herrera,
L. M. Petruzelli,
T. J. Dull,
A. Gray,
L. Coussens,
Y. C. Liao,
M. Tsubokawa,
A. Mason,
P. H. Seeburg,
C. Grunfeld,
O. M. Rosen, and
J. Ramachandran.
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
Nature
313:
756–761,
1985.
|
216. |
Vaag, A.,
P. Skott,
P. Damsbo,
M. A. Gall,
A. Richter, and
H. Beck‐Nielsen.
Effect of the antilipolytic nicotinic acid analogue a cipimox on whole‐body and skeletal muscle glucose.
J. Clin. Invest.
88
1282–1290,
1991.
|
217. |
Vale, W.,
P. Brazeau,
G. Grant,
A. Nussey,
R. Burgus,
J. Rivier,
N. Ling, and
R. Guillemin.
Preliminary observations on the mechanism of action of somatostatin, a hypothalamic factor inhibiting the secretion of growth hormone.
C. R. Acad. Sci.
275:
2913–2916,
1972.
|
218. |
Villar‐Palasi, C., and
J. A. Larner.
Uridine coenzyme linked pathway of glycogen synthesis in muscle.
Biochim. Biophys. Acta
30:
449,
1958.
|
219. |
Villar‐Palasi, C., and
J. Larner.
Insulin treatment and increased uridine diphosphate glucose glycogen transglucosylase activity in muscle.
Arch. Biochem. Biophys.
94:
436–442,
1961.
|
220. |
von Mering, J., and
O. Minkowski.
Diabetes mellitus after extirpation of the pancreas.
Arch. Exp. Pathol. Pharmakol.
26:
375,
378,
1889–1890.
|
221. |
Wahren, J.,
P. Felig, and
L. Hagenfeld.
Physical exercise and fuel homeostasis in diabetes mellitus.
Diabetologia
14:
213–222,
1978.
|
222. |
Walker, M.,
G. R. Fulcher,
C. Catalano,
G. Petranyi,
H. Orskov, and
K. G. M. M. Alberti.
Physiological levels of plasma nonesterified fatty acids impair forearm glucose uptake in normal man.
Clin. Sci. (Colch.)
79:
167–174,
1990.
|
223. |
Walker, M.,
G. R. C. F. Sum,
H. Orskov, and
K. G. M. M. Alberti.
Effect of glycemia and non‐esterified fatty acids on forearm glucose uptake in normal humans.
Metabolism
31:
866–870,
1991.
|
224. |
Walsh, D. A.,
R. H. Cooper,
R. M. Denton,
B. J. Bridges, and
P. J. Randle.
The elementary reactions of the pig heart pyruvate dehydrogenase complex. A study of the inhibition by phosphorylation.
Biochem. J.
157:
41–67,
1976.
|
225. |
Walsh, D. A.,
J. P. Perkins, and
E. G. Krebs.
An adenosine 3′, 5′‐monophosphate‐dependant protein kinase from rabbit skeletal muscle.
J. Biol. Chem.
243:
3763–3765,
1968.
|
226. |
Warnotte, C.,
P. Gilon,
M. Nenquin, and
J. C. Henquin.
Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse β‐cells.
Diabetes
43:
703–711,
1994.
|
227. |
Waters, E. T.,
J. P. Fletcher, and
I. A. Mirsky.
Relation between carbohydrate and 3‐hydroxy butyrate utilisation by heart lung preparations.
Am. J. Physiol.
122:
542–546,
1938.
|
228. |
Wells, P. G.,
G. W. Moore,
D. Rabin,
G. R. Wilkinson,
J. A. Oates, and
P. W. Stacpoole.
Metabolic and pharmacokinetics of intravenously administered dichloroacetate in humans.
Diabetologia
19:
109–113,
1980.
|
229. |
Westermark, P.,
C. Wernstedt,
E. Wilander,
D. W. Hayden,
T. D. O'Brien and
K. H. Johnson.
Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide‐like protein also present in normal islet cells.
Proc. Natl. Acad. Sci. U.S.A.
84:
3881–3885,
1988.
|
230. |
Whitehouse, S. and
R. H. Cooper and
P. J. Randle.
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.
Biochem. J.
141:
761–777,
1974.
|
231. |
Whitehouse, S. and
P. J. Randle.
Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate.
Biochem. J.
134:
651–653,
1973.
|
232. |
Wieland, O. H..
The mammalian pyruvate dehydrogenase complex: structure and regulation.
Rev. Physiol. Biochem. Pharmacol.
96:
123–170,
1983.
|
233. |
Wieland, O. H.,
E. A. Siess,
L. Weiss,
G. Loffler,
C. Patzelt,
R. Portenhauser,
U. Hartmann, and
A. Schirmann.
Regulation of the mammalian pyruvate dehydrogenase complex by covalent modification.
Symp. Soc. Exp. Biol.
27:
371–400,
1973.
|
234. |
Wolfe, B. M.,
S. Klein,
E. J. Peter,
B. F. Schmidt, and
R. R. Wolfe.
Effect of elevated free fatty acids on glucose oxidation in normal humans.
Metabolism
37:
323–329,
1988.
|
235. |
Wosilait, W. D., and
E. W. Sutherland.
The relationship of epinephrine and glucagon to liver phosphorylase. II Enzymatic inactivation of liver phosphorylase.
J. Biol. Chem.
218:
469–481,
1956.
|
236. |
Yki‐Jarvinen, H.,
I. Puhakainen, and
V. A. Koivisto.
Effect of free fatty acids on glucose uptake and non oxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation.
J. Clin. Endocrinol. Metab.
72:
1268–1277,
1991.
|
237. |
Zhou, Y. P., and
V. Grill.
Long term exposure of rat pancreatic islets to fatty acids inhibits glucose induced insulin secretion and biosynthesis through a glucose fatty acid cycle.
J. Clin. Invest.
93:
8870–8876,
1994.
|
238. |
Zhou, Y. P., and
V. Grill.
Long term exposure to fatty acids and ketones inhibits B‐cell functions in human pancreatic islets of Langerhans.
J. Clin. Endocrinol. Metab.
80:
1584–1590,
1995.
|
239. |
Zhou, Y. P., and
V. Grill.
Palmitate‐induced B‐cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets.
Diabetes
44:
394–399,
1995.
|
240. |
Zhou, Y. P.,
D. A. Priestman,
P. J. Randle, and
V. E. Grill.
Fasting and decreased B cell sensitivity: important role for fatty acid‐induced inhibition of PDH activity.
Am. J. Physiol.
270:
(Endocrinol. Metab. 33):
E988–E994,
1996.
|