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Endocrine Control of Acid‐Base Balance

Robert J. Alpern

10.1002/cphy.cp070315

Source: Supplement 22: Handbook of Physiology, The Endocrine System, Endocrine Regulation of Water and Electrolyte Balance

Originally published: 2000

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Components of Renal Acid‐Base Regulation
1.1 Renal Acid Excretion
1.2 Glomerular Filtration
1.3 Urinary Buffers
1.4 Tubular H+/HCO3− Transport
2 Regulation by Peptide Hormones and Catecholamines
2.1 Signaling Intermediates
2.2 Angiotensin II
2.3 Adrenergic Catecholamines
2.4 Endothelin
2.5 Parathyroid Hormone
2.6 Dopamine
2.7 Atrial Natriuretic Factor
2.8 Insulin
3 Regulation by Steroid Hormones
3.1 Mineralocorticoids
3.2 Glucocorticoids
4 Regulation by Thyroid Hormone
Figure 1. Figure 1.

Renal synthesis and transport of NH3/NH4+. See text for explanation. [From Alpern and Preisig 4 with permission.]
Figure 2. Figure 2.

H+/HCO3− transport in the proximal tubule.
Figure 3. Figure 3.

H+/HCO3− transport in the thick ascending limb.
Figure 4. Figure 4.

H+/HCO3− transport in α (a) and β (b) intercalated cells.
Figure 5. Figure 5.

Correlation between proximal convoluted tubule (PCT) HCO3− absorption and luminal cAMP secretion in the rat proximal tubule. CON, control; SAR, saralasim; PTX, pertussis toxin; PT, pertussis toxin pretreatment, AII, angiotensin II; PTH, parathyroid hormone; [From Lin and Cogan 145 with permission.]
Figure 6. Figure 6.

Localization of angiotensin II receptots along the nephron. PCT, proximal convoluted tubule; PR, pars recta; MAL, medullary ascending limb; CAL, cortical ascending limb; DCT, distal convoluted tubule; CCT, cortical convoluted tubule; MCT, medullary convoluted tubule. [From Mujais et al. 162 with permission.]
Figure 7. Figure 7.

Regulation of proximal tubule Na+ absorption by angiotensin II. [From Harris and Navar 97 with permission.]
Figure 8. Figure 8.

Expression of ETB endothelin receptors leads to regulation of Na‐H exchanger 3 by endothelin‐I (ET‐1). [From Chu et al. 59 with permission.]
Figure 9. Figure 9.

Endothelin B (ETB) receptors increase cell Ca2+ [From Chu et al. 59 with permission.]
Figure 10. Figure 10.

Endothelin B (ETB) receptors increase tyrosine phosphorylation of focal adhesion proteins. [From Chu et al. 60 with permission.]
Figure 11. Figure 11.

Effect of aldosterone on the rate of H+ secretion expressed as a function of mucosal pH. [From Al‐Awgati et al. 2 with permission.]


Figure 1.

Renal synthesis and transport of NH3/NH4+. See text for explanation. [From Alpern and Preisig 4 with permission.]



Figure 2.

H+/HCO3− transport in the proximal tubule.



Figure 3.

H+/HCO3− transport in the thick ascending limb.



Figure 4.

H+/HCO3− transport in α (a) and β (b) intercalated cells.



Figure 5.

Correlation between proximal convoluted tubule (PCT) HCO3− absorption and luminal cAMP secretion in the rat proximal tubule. CON, control; SAR, saralasim; PTX, pertussis toxin; PT, pertussis toxin pretreatment, AII, angiotensin II; PTH, parathyroid hormone; [From Lin and Cogan 145 with permission.]



Figure 6.

Localization of angiotensin II receptots along the nephron. PCT, proximal convoluted tubule; PR, pars recta; MAL, medullary ascending limb; CAL, cortical ascending limb; DCT, distal convoluted tubule; CCT, cortical convoluted tubule; MCT, medullary convoluted tubule. [From Mujais et al. 162 with permission.]



Figure 7.

Regulation of proximal tubule Na+ absorption by angiotensin II. [From Harris and Navar 97 with permission.]



Figure 8.

Expression of ETB endothelin receptors leads to regulation of Na‐H exchanger 3 by endothelin‐I (ET‐1). [From Chu et al. 59 with permission.]



Figure 9.

Endothelin B (ETB) receptors increase cell Ca2+ [From Chu et al. 59 with permission.]



Figure 10.

Endothelin B (ETB) receptors increase tyrosine phosphorylation of focal adhesion proteins. [From Chu et al. 60 with permission.]



Figure 11.

Effect of aldosterone on the rate of H+ secretion expressed as a function of mucosal pH. [From Al‐Awgati et al. 2 with permission.]

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Article Title: Endocrine Control of Acid‐Base Balance
 

How to Cite

Robert J. Alpern. Endocrine Control of Acid‐Base Balance. Compr Physiol 2011, Supplement 22: Handbook of Physiology, The Endocrine System, Endocrine Regulation of Water and Electrolyte Balance: 570-603. First published in print 2000. doi: 10.1002/cphy.cp070315