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Feedback Regulation of Growth Hormone Secretion

William B. Wehrenberg, Andrea Giustina

10.1002/cphy.cp070511

Source: Supplement 24: Handbook of Physiology, The Endocrine System, Hormonal Control of Growth

Originally published: 1999

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Definitions
1.1 Ultrashort‐Loop Feedback
1.2 Short‐Loop Feedback
1.3 Long‐Loop Feedback
2 Ultrashort‐Loop Feedback (Autocrine Regulation)
2.1 Ultrashort‐Loop Feedback Regulation of Growth Hormone–Releasing Hormone by Growth Hormone–Releasing Hormone
2.2 Ultrashort‐Loop Feedback Regulation of Somatostatin by Somatostatin
2.3 Ultrashort‐Loop Feedback Regulation of Growth Hormone by Growth Hormone
3 Short‐Loop Feedback
3.1 Intrahypothalamic Short‐Loop Feedback Pathways
3.2 Pituitary–Hypothalamic Short‐Loop Feedback Pathways
4 Long‐Loop Feedback
4.1 Adrenal Hormones: Glucocorticoids
4.2 Adrenal Hormones: Mineralocorticoids
4.3 Gonadal Hormones
4.4 Thyroid Hormones
4.5 Growth Factors
4.6 Other Hormones
4.7 Metabolic Factors
5 Summary
Figure 1. Figure 1.

Schematic illustration of the ultrashort‐loop feedback mechanisms regulating growth hormone (GH) secretion. GHRH, growth hormone–releasing hormone.
Figure 2. Figure 2.

Schematic illustration of the short‐loop feedback mechanisms regulating growth hormone (GH) secretion. GHRH, growth hormone–releasing hormone.
Figure 3. Figure 3.

Schematic illustration of the long‐loop feedback mechanisms regulating growth hormone (GH) secretion. GHRH, growth hormone–releasing hormone; IGF, insulin‐like growth factor.


Figure 1.

Schematic illustration of the ultrashort‐loop feedback mechanisms regulating growth hormone (GH) secretion. GHRH, growth hormone–releasing hormone.



Figure 2.

Schematic illustration of the short‐loop feedback mechanisms regulating growth hormone (GH) secretion. GHRH, growth hormone–releasing hormone.



Figure 3.

Schematic illustration of the long‐loop feedback mechanisms regulating growth hormone (GH) secretion. GHRH, growth hormone–releasing hormone; IGF, insulin‐like growth factor.

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Article Title: Feedback Regulation of Growth Hormone Secretion
 

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William B. Wehrenberg, Andrea Giustina. Feedback Regulation of Growth Hormone Secretion. Compr Physiol 2011, Supplement 24: Handbook of Physiology, The Endocrine System, Hormonal Control of Growth: 299-327. First published in print 1999. doi: 10.1002/cphy.cp070511