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Insulin‐Like Growth Factor Binding Proteins

David R. Clemmons

10.1002/cphy.cp070519

Source: Supplement 24: Handbook of Physiology, The Endocrine System, Hormonal Control of Growth

Originally published: 1999

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Gene Structures
1.1 Insulin‐Like Growth Factor Binding Protein 1
1.2 Insulin‐Like Growth Factor Binding Protein 2
1.3 Insulin‐Like Growth Factor Binding Protein 3
1.4 Insulin‐Like Growth Factor Binding Protein 4
1.5 Insulin‐Like Growth Factor Binding Protein 5
1.6 Insulin‐Like Growth Factor Binding Protein 6
1.7 Acid Labile Subunit
2 Protein Structures
2.1 Insulin‐Like Growth Factor Binding Protein 1
2.2 Insulin‐Like Growth Factor Binding Protein 2
2.3 Insulin‐Like Growth Factor Binding Protein 3
2.4 Insulin‐Like Growth Factor Binding Protein 4
2.5 Insulin‐Like Growth Factor Binding Protein 5
2.6 Insulin‐Like Growth Factor Binding Protein 6
2.7 Insulin‐Like Growth Factor Binding Protein‐Related Proteins
3 Control of Gene Expression, Synthesis, and Secretion of Insulin‐Like Growth Factor Binding Proteins by Cells and Tissues
3.1 Tissue Expression
3.2 Secretion by Cells In Vitro
4 Variables that Regulate Pericellular Abundanbce of Insulin‐Like Growth Factor Binding Proteins
4.1 Proteolysis
4.2 Phosphorylation of Insulin‐Like Growth Factor Binding Proteins
4.3 Binding to Cell Surfaces and to Extracellular Matrix
5 Regulation of Insulin‐Like Growth Factor Actions in vitro and in vivo
5.1 Regulation of Half‐Life
5.2 Modulation of Insulin‐Like Growth Factor Actions
5.3 Specific Functions of Each Form of Binding Protein
5.4 A Unified Theory of the Mechanism of Action of Insulin‐Like Growth Factor Binding Proteins in Connective Tissue Cells
5.5 Use of Insulin‐Like Growth Factor Analogs
5.6 Related Proteins
6 Control of Insulin‐Like Growth Factor Binding Protein Concentrations in Physiologic Fluids
6.1 Methodologic Considerations
6.2 Detection of Insulin‐Like Growth Factor Binding Proteins in Physiologic Fluids Other than Blood
6.3 Regulation of Insulin‐Like Growth Factor Binding Proteins in Serum
6.4 Regulation of Insulin‐Like Growth Factor Binding Proteins by Hormones
7 Summary
Figure 1. Figure 1.

Amino acid sequences of the human IGFBPs. Asterisks indicate the conserved cysteines.
Figure 2. Figure 2.

Amino acid sequence of IGF‐I. The B‐domain that contains the amino acid residues (3,4,15, and 16) important for the binding of IGF‐I to IGFBPs is indicated at the top of the figure.


Figure 1.

Amino acid sequences of the human IGFBPs. Asterisks indicate the conserved cysteines.



Figure 2.

Amino acid sequence of IGF‐I. The B‐domain that contains the amino acid residues (3,4,15, and 16) important for the binding of IGF‐I to IGFBPs is indicated at the top of the figure.

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Article Title: Insulin‐Like Growth Factor Binding Proteins
 

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David R. Clemmons. Insulin‐Like Growth Factor Binding Proteins. Compr Physiol 2011, Supplement 24: Handbook of Physiology, The Endocrine System, Hormonal Control of Growth: 573-631. First published in print 1999. doi: 10.1002/cphy.cp070519