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Food Additives and Contaminants

A. D. Campbell, W. Horwitz, J. A. Burke, C. F. Jelinek, J. V. Rodricks, S. I. Shibko

10.1002/cphy.cp090110

Source: Supplement 26: Handbook of Physiology, Reactions to Environmental Agents

Originally published: 1977

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Additives
1.1 Food Additives
1.2 Color Additives
1.3 Feed Additives
1.4 Pesticides
2 Contaminants
2.1 Plant Toxins
2.2 Animal Toxins
2.3 Microbial Toxins
2.4 Organic Industrial Chemicals
2.5 Toxic Elements
3 Summary
References
 1. Bakir, F., S. F. Damluji, L. Amin‐Zaki, M. Murtadha, A. Khalidi, N. Y. Al‐Rawi, S. Tikriti, H. I. Dhahir, T. W. Clarkson, J. C. Smith, and R. A. Doherty. Methylmercury poisoning in Iraq. An interuniversity report. Science 181: 230–241, 1973.
 2. Baughman, R., and M. Meselson. An analytical method for detecting TCDD (dioxin): levels of TCDD in samples from Vietnam. Environ. Health Perspect. 5: 27–35, 1973.
 3. Codex Alimentarius Commission of the Joint FAO/WHO Food Standard Program., List of additives evaluated for their safety‐in‐use in food. First Series. Rome, Italy: Food and Agriculture Organization of the United Nations, World Health Organization, CAC/FAL, 1973.
 4. Committee on Government Operations, House of Representatives, Ninety‐Second Congress, First Session., Hearings before a subcommittee March 16–18, 29, and 30, 1971. Regulation of food additives and medicated animal feeds. Washington, D.C.: U.S. Govt. Printing Office, 1971, p. 172. (GPO No. 5270–1144).
 5. Corneliussen, P. E. Pesticide residues in total diet samples (VI). Pesticide Monit. J. 5: 313–330, 1972.
 6. Detroy, R. W., E. B. Lillehoj, and A. Ciegler. Aflatoxin and related compounds. In: Microbial Toxins, vol. VI, edited by A. Ciegler, S. Kadis, and S. J. Ajl. New York: Academic, 1971.
 7. Duggan, R. E., and P. E. Corneliussen. Dietary intake of pesticide chemicals in the United States (III), June 1968‐April 1970. Pesticide Monit. J. 5: 331–341, 1972.
 8. Duggan, R. E., G. Q. Lipscomb, E. L. Cox, R. E. Heatwole, and R. C. Kling. Pesticide residue levels in foods in the United States from July 1, 1963 to June 30, 1969. Pesticide Monit. J. 5: 73–212, 1971.
 9. Environmental Protection Agency., Code of Federal Regulations. Title 40 Protection of Environment Revised as of July, 1974. Washington, D.C.: EPA, 1974, p. 222–307.
 10. Expert Group., Methyl mercury in fish. A toxicologic‐epidemiologic evaluation of risks. Stockholm.: Nordisk Hygienisk Tidskrift, Suppl. 4, 1971.
 11. Firestone, D. Etiology of chick edema disease. Environ. Health Perspect. 5: 59–66, 1973.
 12. Firestone, D., J. Ress, N. L. Brown, R. P. Barron, and J. N. Damico. Determination of the polychlorodibenzo‐p‐dioxins and related compounds in commercial chlorophenols. J. Assoc. Off. Anal. Chem. 55: 85–92, 1972.
 13. Fishbein, L., and W. G. Flamm. Potential environmental hazards. II. Feed additives and pesticides. Sci. Total Environ. 1: 31–64, 1972.
 14. Food and Drug Administration., Code of Federal Regulations. Title 21 Food and Drugs, Parts 1 to 9 revised as of April 1, 1974. Washington, D.C.: U.S. Govt. Printing Office, 1974, p. 139–204.
 15. Food and Drug Administration., Code of Federal Regulations. Title 21 Food and Drugs, Parts 10 to 129 revised as of April 1, 1974. Washington, D.C.: U.S. Govt. Printing Office, 1974, p. 287–649.
 16. Food and Drug Administration., Code of Federal Regulations, Title 21 Food and Drugs, Parts 10 to 129 and Parts 130 to 140 revised as of April 1, 1974. Washington, D.C.: U.S. Govt. Printing Office, 1974, Subpart C. Sections 121.200–121.347 and Part 135e.
 17. Food and Drug Administration., FDA Pesticide Analytical Manual (2nd ed., revised), edited by B. McMahon and L. Sawyer (vol. I) and by J. Markus and B. Puma (vol. II). Washington, D. C.: U. S. Food and Drug Administration, 1973.
 18. Food Protection Committee., Chemicals used in food processing. Washington, D.C.: National Academy of Sciences‐National Research Council, 1965. (Publication No. 1274).
 19. Food Protection Committee., Principles and procedures for evaluating the safety of food additives. Washington, D.C.: National Academy of Sciences‐National Research Council, 1959. (Publication No. 750).
 20. Friberg, L., M. Piscator, and G. Norberg. Cadmium in the environment. Cleveland: CRC Press, 1971, p. 1–166.
 21. Furia, T. E. (editor)., Handbook of food additives. (2nd ed.) Cleveland: CRC Press, 1972, p. 1–998.
 22. Ganther, H. E., C. Goudie, M. L. Sunde, M. J. Kopecky, P. Wagner, S.‐H. Oh, and W. G. Hoekstra. Selenium: relation to decreased toxicity of methylmercury added to diets containing tuna. Science 175: 1122–1124, 1972.
 23. Halstead, B. W. Poisonous and venomous marine animals of the world. 3 vols., Washington, D.C.: U.S. Govt. Printing Office, 1965.
 24. Horwitz, W. (editor)., Food Additives. In: Official Methods of Analysis of the Association of Official Analytical Chemists (12th ed.). Washington, D.C.: Association of Official Analytical Chemists, 1975, p. 348–385.
 25. Horwitz, W. (editor)., Metals and Other Elements as Residues in Foods. In: Official Methods of Analysis of the Association of Official Analytical Chemists (12th ed.). Washington, D.C.: Association of Official Analytical Chemists, 1975, p. 428–429.
 26. Horwitz, W. (editor)., Natural Poisons. In: Official Methods of Analysis of the Association of Official Analytical Chemists (12th ed.). Washington, D.C.: Association of Official Analytical Chemists, 1975, p. 462–481.
 27. Horwitz, W. (editor)., Pesticide Residues. In: Official Methods of Analysis of the Association of Official Analytical Chemists (12th ed.). Washington, D.C.: Association of Official Analytical Chemists, 1975, p. 518–551.
 28. Interdepartmental Task Force on PCBs., Polychlorinated biphenyls and the environment. Washington, D.C.: National Technical Information Service, U.S. Department of Commerce, Springfield, Va., 1972, p. 1–181. (COM 72–10419).
 29. Jaeger, R. J., and R. J. Rubin. Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissues. New Engl. J. Med. 287: 1114–1118, 1972.
 30. Joint FAO/WHO Expert Committee on Food Additives., FAO Nutrition Meetings Report Series. Geneva: World Health Organization, 1956. (WHO Technical Reference Series, 1956.).
 31. Kingsbury, J. M. Poisonous plants of the United States and Canada. Englewood Cliffs, N.J.: Prentice‐Hall, 1964.
 32. Liener, I. E. (editor)., Toxic Constituents of Plant Food. New York: Academic, 1969.
 33. Lisk, D. J. Recent developments in the analysis of toxic elements. Science 184: 1137–1141, 1974.
 34. Manske, D., and P. E. Corneliussen. Pesticide residues in total diet samples (VII). Pesticide Monit. J. 8: 110–124, 1974.
 35. Martin, H. (editor)., Pesticide Manual (2nd ed.). Worchester, England: British Crop Protection Council, 1971.
 36. Melnikov, N. N. Chemistry of Pesticides, English translation edited by F. A. Gunther and J. P. Gunther, New York, Heidelberg, Berlin: Springer‐Verlag, 1971.
 37. Mussman, H. C. Drug and chemical residues in domestic animals. In: Symposium on implications of environmental pharmacology and toxicology: food sources of incidental exposure, April 8, 1974. Federation Proc. 34(2): 197–201, 1975.
 38. National Institute of Environmental Health Sciences., Perspective on PAEs [phthalic acid esters]. Environ. Health Perspect. 3: 1–182, 1973.
 39. NRC/NAS Committee on Biologic Effects of Atmospheric Pollutants. Asbestos. Washington, D.C.: Natl. Res. Council‐Natl. Acad. Sci., 1971.
 40. NRC/NAS Committee on Biologic Effects of Atmospheric Pollutants., Fluorides. Washington, D. C.: Natl. Res. Council‐Natl. Acad. Sci., 1971.
 41. NRC/NAS Committee on Biologic Effects of Atmospheric Pollutants., Lead: Airborne Lead in Perspective. Washington, D.C.: Natl. Res. Council‐Natl. Acad. Sci., 1972.
 42. NRC/NAS Committee on Biologic Effects of Atmospheric Pollutants., Particulate polycyclic organic matter. Washington, D.C.: Natl. Res. Council‐Natl. Acad. Sci., 1972.
 43. NRC/NAS Committee on Biologic Effects of Atmospheric Pollutants., Chromium. Washington, D.C.: Natl. Res. Council‐Natl. Acad. Sci., 1974.
 44. NRC/NAS Committee on Biologic Effects of Atmospheric Pollutants., Manganese. Washington, D.C.: Natl. Res. Council‐Natl. Acad. Sci., 1974.
 45. NRC/NAS Committee on Biologic Effects of Atmospheric Pollutants., Vanadium. Washington, D.C.: Natl. Res. Council‐Natl. Acad. Sci., 1974.
 46. NRC/NAS Committee on Biologic Effects of Atmospheric Pollutants., Nickel. Washington, D.C.: Natl. Res. Council‐Natl. Acad. Sci., 1975.
 47. Peers, F. G., and C. A. Linsell. Dietary aflatoxins and liver cancer‐population based study in Kenya. Brit. J. Cancer 27: 473, 1973.
 48. Pierce, P. E., J. F. Thompson, W. H. Likosky, L. N. Nickey, W. F. Barthel, and A. R. Hinman. Alkyl mercury poisoning in humans. Report of an outbreak. J. Am. Med. Assoc. 220: 1439–1442, 1972.
 49. Rothschild, L. (editor)., USDA testing cattle in 9 states for [polybrominated biphenyl] residues because of feed mixup. Food Chemical News 16: 20–21, 1974.
 50. Oser, B. L. Modern technology as related to the safety of food additives. Federation Proc. 20: 7, 224–230, 1961.
 51. Schantz, E. J., Seafood toxicants. In: Toxicants occurring naturally in foods. Washington, D.C.: National Academy of Sciences, 1973, p. 424–447.
 52. Scott, P. M., B. B. Coldwell, and G. S. Wiberg. Grayanotoxins. Occurrence and analysis in honey and a comparison of toxicities in mice. Food Cosmet. Toxicol. 9: 179–184, 1971.
 53. Shank, R. C., G. N. Wogan, J. B. Gibson, A. Nondasuta, J. E. Gordon, B. Subhamani, N. Bhamarapravati, and P. Siddhichai. Series of reports on aflatoxins and liver cancer in Southeast Asia. Food Cosmet. Toxicol. 10: 51–84, 171–191, 1972.
 54. Shapley, D. Herbicides: AAAS study finds dioxin in Vietnamese fish. Science 180: 285–286, 1973.
 55. Smith, M. I. The influence of diet on the chronic toxicity of selenium. U.S. Public Health Repts 54: 1441–1453, 1939.
 56. Underwood, E. J. Trace Elements in Human and Animal Nutrition (3rd ed.). New York: Academic, 1971.
 57. Whitney, A., and E. Muschik. Flexible vinyls and human safety: an objective analysis. Greenwich, Conn.: Society of Plastic Engineers, March 1973, p. 1–115.
 58. Wilson, B. J., and A. W. Haynes. Microbial Toxins. In: Toxicants Occurring Naturally in Foods. Washington, D.C.: National Academy of Sciences, 1973, p. 372–423.
 59. Wilson, B. J., D. T. C. Yang, and M. R. Boyd. Toxicity of mold‐damaged sweet potatoes. Nature 227: 521, 1970.
 60. World Health Organization., 1972 Evaluation of some pesticide residues in foods. The monographs. Geneva: World Health Organization, 1973.
 61. World Health Organization., WHO Food Additive Series, 1972, No. 4. Evaluation of mercury, lead, cadmium and the food additives amaranth, diethylpyrocarbonate, and octyl gallate. Geneva: World Health Organization, 1972.

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Article Title: Food Additives and Contaminants
 

How to Cite

A. D. Campbell, W. Horwitz, J. A. Burke, C. F. Jelinek, J. V. Rodricks, S. I. Shibko. Food Additives and Contaminants. Compr Physiol 2011, Supplement 26: Handbook of Physiology, Reactions to Environmental Agents: 167-179. First published in print 1977. doi: 10.1002/cphy.cp090110