| References |
| 1. |
Ackermann, E., and
A. Rane.
The monooxygenase system in the human fetal liver: subcellular distribution and studies on the in vitro metabolism of aniline.
Chem.‐Biol. Interact.
3:
233–234,
1971.
|
| 2. |
Alvares, A. P.,
A. Kappas,
W. Levin, and
A. H. Conney.
Inducibility of benzo[α]pyrene hydroxylase in human skin by polycyclic hydrocarbons.
Clin. Pharmacol. Therap.
14:
30–40,
1973.
|
| 3. |
Alvares, A. P.,
S. Leigh,
A. Kappas,
W. Levin, and
A. H. Conney.
Induction of aryl hydrocarbon hydroxylase in human skin.
Drug Metab. Disposition
1:
386–390,
1973.
|
| 4. |
Alvares, A. P.,
G. Schilling,
W. Levin, and
R. Kuntzman.
Studies on the induction of CO‐binding pigments in liver microsomes by phenobarbital and 3‐methylcholanthrene.
Biochem. Biophys. Res. Commun.
29:
521–526,
1967.
|
| 5. |
Alvares, A. P.,
G. Schilling,
W. Levin,
R. Kuntzman,
L. Brand, and
L. C. Mark.
Cytochromes P‐450 and b5 in human liver microsomes.
Clin. Pharmacol. Therap.
10:
655–659,
1969.
|
| 6. |
Autor, A. P.,
R. M. Kaschnitz,
J. K. Heidema, and
M. J. Coon.
Sedimentation and other properties of the reconstituted liver microsomal mixed‐function oxidase system containing cytochrome P‐450, reduced triphosphopyridine nucleotide‐cytochrome P‐450 reductase, and phosphatidylcholine.
Mol. Pharmacol.
9:
93–104,
1972.
|
| 7. |
Autor, A. P.,
R. M. Kaschnitz,
J. K. Heidema,
T. A. van der Hoeven,
W. Duppel, and
M. J. Coon.
Role of phospholipid in the reconstituted liver microsomal mixed‐function oxidase system containing cytochrome P‐450 and NADPH‐cytochrome P‐450 reductase.
Drug Metab. Disposition
1:
156–163,
1973.
|
| 8. |
Baron, J.,
W. E. Taylor, and
B. S. S. Masters.
Immunochemical studies on electron transport chains involving cytochrome P‐450. The role of the iron‐sulfur protein, adrenodoxin, in mixed‐function oxidation reactions.
Arch. Biochem. Biophys.
150:
105–115,
1972.
|
| 9. |
Basu, T. K.,
J. W. T. Dickerson, and
D. V. W. Parke.
Effect of development on the activity of microsomal drugmetabolizing enzymes in rat liver.
Biochem. J.
124:
19–24,
1971.
|
| 10. |
Bend, J. R.,
G. E. R. Hook,
R. E. Easterling,
T. E. Gram, and
J. R. Fouts.
A comparative study of the hepatic and pulmonary microsomal mixed‐function oxidase systems in the rabbit.
J. Pharmacol. Exptl. Therap.
183:
206–217,
1972.
|
| 11. |
Bend, J. R.,
G. E. R. Hook, and
T. E. Gram.
Characterization of lung microsomes as related to drug metabolism.
Drug Metab. Disposition
1:
358–367,
1973.
|
| 12. |
Bergheim, P.,
G. H. Rathgen, and
K. J. Netter.
Interaction of drugs and steroids with human placental microsomes.
Biochem. Pharmacol.
22:
1633–1645,
1973.
|
| 13. |
Bhattacharaya, M., and
C. Carruthers.
Problems involved in the isolation of subcellular components from human epidermis.
J. Soc. Cosmetic Chemists
22:
95–107,
1971.
|
| 14. |
Bickel, M.
The pharmacology and biochemistry of N‐oxides.
Pharmacol. Rev.
21:
325–355,
1969.
|
| 15. |
Billing, B. H., and
M. Black.
The action of drugs on bilirubin metabolism in man.
Ann. NY Acad. Sci.
179:
403–410,
1971.
|
| 16. |
Brodie, B. B.,
J. Axelrod,
J. R. Cooper,
L. Gaudette,
B. N. La Du,
C. Mitoma, and
S. Udenfriend.
Detoxication of drugs and other foreign compounds by liver microsomes.
Science
121:
603–604,
1955.
|
| 17. |
Brodie, B. B.,
J. R. Gillette, and
B. N. La Du.
Enzymatic metabolism of drugs and other foreign compounds.
Ann. Rev. Biochem.
27:
427–454,
1958.
|
| 18. |
Brodie, B. B.,
W. D. Reid,
A. K. Cho,
G. Sipes,
G. Krishna, and
J. R. Gillette.
Possible mechanism of liver necrosis caused by aromatic organic compounds.
Proc. Natl. Acad. Sci. US
68:
160–164,
1971.
|
| 19. |
Brown, R. R.,
J. A. Miller, and
E. C. Miller.
The metabolism of methylated aminoazo dyes. IV. Dietary factors enhancing demethylation in vitro.
J. Biol. Chem.
209:
211–222,
1954.
|
| 20. |
Bryson, M. J., and
I. H. Kaiser.
Cleavage of cholesterol side chain by adrenal mitochondrial components containing cytochrome P‐450 and nonheme iron protein (Abstract).
Federation Proc.
25:
494,
1966.
|
| 21. |
Bryson, M. J., and
M. L. Sweat.
Cleavage of cholesterol side‐chain associated with cytochrome P‐450, flavoprotein, and nonheme iron‐protein derived from the bovine adrenal cortex.
J. Biol. Chem.
243:
2799–2804,
1968.
|
| 22. |
Bürki, K.,
A. G. Liebelt, and
E. Bresnick.
Induction of aryl hydrocarbon hydroxylase in mouse tissues from a high and low cancer strain and their F1 hybrids.
J. Natl. Cancer Inst.
50:
369–380,
1973.
|
| 23. |
Burstein, S., and
B. R. Bhavnani.
Effect of phenobarbital administration on the in vitro hydroxylation of cortisol and an over‐all substrate and product metabolism in the guinea pig and rat.
Endocrinology
80:
351–356,
1967.
|
| 24. |
Cammer, W., and
R. W. Estabrook.
Respiratory activity of adrenal cortex mitochondria during steroid hydroxylation.
Arch. Biochem. Biophys.
122:
721–734,
1967.
|
| 25. |
Castro, J. A., and
J. R. Gillette.
Species and sex differences in the kinetic constants for the N‐demethylation of ethylmorphine by liver microsomes.
Biochem. Biophys. Res. Commun.
28:
426–430,
1967.
|
| 26. |
Castro, J. A.,
F. E. Greene,
P. L. Gigon,
H. Sasame, and
J. R. Gillette.
Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixedfunction oxygenase system of male rats which catalyzes ethylmorphine metabolism.
Biochem. Pharmacol.
19:
2461–2468,
1970.
|
| 27. |
Chen, W.,
P. A. Vrindten,
P. G. Dayton, and
J. J. Burns.
Accelerated aminopyrine metabolism in human subjects pretreated with phenylbutazone.
Life Sci.
2:
35–42,
1962.
|
| 28. |
Chhabra, R. S., and
J. R. Fouts.
Sex differences in the metabolism of xenobiotics by extrahepatic tissues in rats.
Drug Metab. Disposition
2:
375–379,
1974.
|
| 29. |
Chhabra, R. S.,
R. J. Pohl, and
J. R. Fouts.
A comparative study of xenobiotic‐metabolizing enzymes in liver and gut of various animal species.
Drug Metab. Disposition
2:
443–447,
1974.
|
| 30. |
Cohen, B. S., and
R. W. Estabrook.
Microsomal electron transport reactions. II. The use of reduced triphosphopyridine nucleotide and/or reduced diphosphopyridine nucleotide for the oxidative N‐demethylation of aminopyrine and other drug substrates.
Arch. Biochem. Biophys.
143:
46–53,
1971.
|
| 31. |
Conney, A. H.
Pharmacological implications of microsomal enzyme induction.
Pharmacol. Rev.
19:
317–366,
1967.
|
| 32. |
Conney, A. H.,
R. R. Brown,
J. A. Miller, and
E. C. Miller.
The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system.
Cancer Res.
17:
628–633,
1957.
|
| 33. |
Conney, A. H.,
R. Welch,
R. Kuntzman,
R. Chang,
M. Jacobson,
A. D. Munro‐Faure,
A. W. Peck,
A. Bye,
A. Poland,
P. J. Poppers,
M. Finster, and
J. A. Wolff.
Effects of environmental chemicals on the metabolism of drugs, carcinogens, and normal body constituents in man.
Ann. NY Acad. Sci.
179:
155–172,
1971.
|
| 34. |
Constantopoulos, G., and
T. T. Tchen.
Cleavage of cholesterol side chain by adrenal cortex. I. Cofactor requirement and product of cleavage.
J. Biol. Chem.
236:
65–67,
1961.
|
| 35. |
Cooper, D. Y.
Discovery of the function of the heme protein P‐450: a systematic approach to scientific research.
Life Sci.
13:
1151–1161,
1973.
|
| 36. |
Cooper, D. Y.,
R. W. Estabrook, and
O. Rosenthal.
The stoichiometry of C21 hydroxylation of steroids by adrenocortical microsomes.
J. Biol. Chem.
238:
1320–1323,
1963.
|
| 37. |
Cooper, D. Y.,
S. Levin,
S. Narasimhulu,
O. Rosenthal, and
R. W. Estabrook.
Photochemical action spectrum of the terminal oxidase of mixed function oxidase systems.
Science
147:
400–402,
1965.
|
| 38. |
Correia, M. A., and
G. J. Mannering.
DPNH synergism of TPNH‐dependent mixed function oxidase reactions.
Drug Metab. Disposition
1:
139–149,
1973.
|
| 39. |
Creaven, P. J., and
R. T. Williams.
Post‐mortem survival of aromatic hydroxylating activity in liver.
Biochem. J.
87:
19p,
1963.
|
| 40. |
Dao, T. L., and
R. M. Varela.
On the mechanism of inducing protection of the adrenal cortex against injury from 7,12‐dimethylbenz[α]anthracene. 1. Effects of inducers on benzpyrene hydroxylase activity.
Cancer Res.
26:
1015–1021,
1966.
|
| 41. |
Dao, T. L., and
H. Yogo.
Effects of polynuclear hydrocarbons on benzpyrene hydroxylase activity in rats.
Proc. Soc. Exptl. Biol. Med.
116:
1048–1050,
1964.
|
| 42. |
Davies, D. S.,
P. L. Gigon, and
J. R. Gillette.
Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation.
Life Sci., Part 2
8:
85–91,
1969.
|
| 43. |
Davies, D. S.,
S. S. Thorgeirsson,
A. Breckenridge, and
M. Orme.
Interindividual differences in rates of drug oxidation in man.
Drug Metab. Disposition
1:
411–417,
1973.
|
| 44. |
Davison, A. N.
The conversion of Schradan (OMPA) and Parathion into inhibitors of cholinesterase by mammalian liver.
Biochem. J.
61:
203–209,
1955.
|
| 45. |
Denk, H.,
J. B. Schenkman,
P. G. Bacchin,
F. Hutterer,
F. Schaffner, and
H. Popper.
Mechanism of cholestasis. III. Interaction of synthetic detergents with the microsomal cytochrome P‐450 dependent biotransformation system in vitro.
Exptl. Mol. Pathol.
14:
263–276,
1971.
|
| 46. |
Devereux, T. R., and
J. R. Fouts.
N‐Oxidation and demethylation of N,N‐dimethylaniline by rabbit liver and lung microsomes. Effects of age and metals.
Chem.‐Biol. Interact.
8:
91–105,
1974.
|
| 47. |
Diel, H.,
J. Schadelin, and
V. Ullrich.
Studies on the kinetics of cytochrome P‐450 reduction in rat liver microsomes.
Hoppe‐Seylers Z. Physiol. Chem.
351:
1359–1371,
1970.
|
| 48. |
Douglas, J. F.,
B. J. Ludwig, and
N. Smith.
Studies on the metabolism of meprobamate.
Proc. Soc. Exptl. Biol. Med.
112:
436–438,
1963.
|
| 49. |
Dowell, A. R.,
K. H. Kilburn, and
P. C. Pratt.
Shortterm exposure to nitrogen dioxide.
Arch. Intern. Med. Symposia
9:
214–220,
1971.
|
| 50. |
Ellin, Å.,
S. V. Jakobsson,
J. B. Schenkman, and
S. Orrenius.
Cytochrome P‐450k of rat kidney cortex microsomes: its involvement in fatty acid ω‐ and (ω − 1)‐hydroxylation.
Arch. Biochem. Biophys.
150:
64–71,
1972.
|
| 51. |
Estabrook, R. W.,
D. Y. Cooper, and
O. Rosenthal.
The light reversible carbon monoxide inhibition of the steroid C21‐hydroxylase system of the adrenal cortex.
Biochem. Z.
338:
741–755,
1963.
|
| 52. |
Estabrook, R. W.,
J. R. Gillette, and
K. C. Leibman (editors).
Microsomes and Drug Oxidations.
Baltimore:
Williams & Wilkins,
1973.
|
| 53. |
Estabrook, R. W.,
J. I. Mason,
J. Baron,
D. Lambeth, and
M. Waterman.
Drugs, alcohol and sex hormones: A molecular perspective of the receptivity of cytochrome P‐450.
Ann. NY Acad. Sci.
212:
27–49,
1973.
|
| 54. |
Estabrook, R. W.,
T. Matsubara,
J. I. Mason,
J. Werringloer, and
J. Baron.
Studies on the molecular function of cytochrome P‐450 during drug metabolism.
Drug Metab. Disposition
1:
98–110,
1973.
|
| 55. |
Feuer, G.,
J. C. Sosa‐Lucero,
G. Lumb, and
G. Moddel.
Failure of various drugs to induce drug‐metabolizing enzymes in extrahepatic tissues of the rat.
Toxicol. Appl. Pharmacol.
19:
579–589,
1971.
|
| 56. |
Fouts, J. R.
Some in vitro conditions that affect detection and quantitation of phenobarbital‐induced increases in hepatic microsomal drug‐metabolizing enzyme activity.
Toxicol. Appl. Pharmacol.
16:
48–65,
1970.
|
| 57. |
Fouts, J. R.
Liver smooth endoplasmic reticulum “microsomal” drug‐metabolizing enzyme system. In:
Methods in Pharmacology,
edited by A. Schwartz.
New York:
Appleton‐Century‐Crofts,
1971,
vol. 1,
p. 287–325.
|
| 58. |
Fouts, J. R., and
R. H. Adamson.
Drug metabolism in the newborn rabbit.
Science
129:
897–898,
1959.
|
| 59. |
Fours, J. R., and
T. R. Devereux.
Developmental aspects of hepatic and extrahepatic drug‐metabolizing enzyme systems: microsomal enzymes and components in rabbit liver and lung during the first month of life.
J. Pharmacol. Exptl. Therap.
183:
458–468,
1972.
|
| 60. |
Fouts, J. R., and
L. G. Hart.
Hepatic drug metabolism during the perinatal period.
Ann. NY Acad. Sci.
123:
245–251,
1965.
|
| 61. |
Fouts, J. R., and
R. J. Pohl.
Further studies on the effects of metal ions on rat liver microsomal reduced nicotinamide adenine dinucleotide phosphate‐cytochrome P‐450 reductase.
J. Pharmacol. Exptl. Therap.
179:
91–100,
1971.
|
| 62. |
Fouts, J. R., and
L. A. Rogers.
Morphological changes in the liver accompanying stimulation of microsomal drugmetabolizing enzyme activity by phenobarbital, chlordane, benzpyrene or methylcholanthrene in rats.
J. Pharmacol. Exptl. Therap.
147:
112–119,
1965.
|
| 63. |
Garfinkel, D.
Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions.
Arch. Biochem. Biophys.
77:
493–509,
1958.
|
| 64. |
Gelboin, H. V.
Studies on the mechanism of microsomal hydroxylase induction and its role in carcinogen action.
Rev. Can. Biol.
31:
39–60,
1972.
|
| 65. |
Gelboin, H. V., and
N. R. Blackburn.
The stimulating effect of 3‐methylcholanthrene on microsomal amino acid incorporation and benzpyrene hydroxylase activity and its inhibition by actinomycin D.
Biochim. Biophys. Acta
72:
657–660,
1963.
|
| 66. |
Gelboin, H. V., and
N. R. Blackburn.
The stimulatory effect of 3‐methylcholanthrene on benzpyrene hydroxylase activity in several rat tissues: inhibition by actinomycin D and puromycin.
Cancer Res.
24:
356–360,
1964.
|
| 67. |
Gelboin, H. V.,
F. Wiebel, and
L. Diamond.
Dimethyl‐benzanthracene tumorigenesis and aryl hydrocarbon hydroxylase in mouse skin: Inhibition by 7,8‐benzoflavone.
Science
170:
169–171,
1970.
|
| 68. |
Gentil, A., and
P. Sims.
The metabolism of 7,12‐dimethylbenz[a]anthracene by homogenates of the stomach and small intestine.
Z. Krebsforsch.
76:
223–230,
1971.
|
| 69. |
Gigon, P. L.,
T. E. Gram, and
J. R. Gillette.
Effect of drug substrates on the reduction of hepatic microsomal cytochrome P‐450 by NADPH.
Biochem. Biophys. Res. Commun.
31:
558–562,
1968.
|
| 70. |
Gigon, P. L.,
T. E. Gram, and
J. R. Gillette.
Studies on the rate of reduction of hepatic microsomal cytochrome P‐450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Mol. Pharmacol.
5:
109–122,
1969.
|
| 71. |
Gillette, J. R.
Metabolism of drugs and other foreign compounds by enzymatic mechanisms.
Progr. Drug Res.
6:
13–73,
1963.
|
| 72. |
Gillette, J. R.
Biochemistry of drug oxidation and reduction by enzymes in hepatic endoplasmic reticulum.
Advan. Pharmacol.
4:
219–261,
1966.
|
| 73. |
Gillette, J. R.
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Metabolism
20:
215–227,
1971.
|
| 74. |
Gillette, J. R.,
B. B. Brodie, and
B. N. La Du.
The oxidation of drugs by liver microsomes: On the role of TPNH and oxygen.
J. Pharmacol. Exptl. Therap.
119:
532–540,
1957.
|
| 75. |
Gillette, J. R.,
A. H. Conney,
G. J. Cosmides,
R. W. Estabrook,
J. R. Fouts, and
G. J. Mannering (editors).
Microsomes and Drug Oxidations: Proceedings.
New York:
Academic Press,
1969.
(Symp. Microsomes and Drug Oxidations.)
|
| 76. |
Gillette, J. R.,
D. C. Davis, and
H. A. Sasame.
Cytochrome P‐450 and its role in drug metabolism.
Ann. Rev. Pharmacol.
12:
57–84,
1972.
|
| 77. |
Gillette, J. R., and
T. E. Gram.
Cytochrome P‐450 reduction in liver microsomes and its relationship to drug metabolism. In:
Microsomes and Drug Oxidations: Proceedings,
edited by J. R. Gillette,
A. H. Conney,
G. J. Cosmides,
R. W. Estabrook,
J. R. Fouts, and
G. J. Mannering.
New York:
Academic Press,
1969,
p. 133–149.
(Symp. Microsomes and Drug Oxidations.)
|
| 78. |
Gilman, A. G., and
A. H. Conney.
The induction of aminoazo‐dye N‐demethylase in extra‐hepatic tissues by 3‐methylcholanthrene.
Biochem. Pharmacol.
12:
591–593,
1963.
|
| 79. |
Glazer, R. I.,
J. B. Schenkman, and
A. G. Sartorelli.
Immunochemical studies on the role of reduced nicotinamide adenine dinucleotide phosphate‐cytochrome c (P‐450) reductase in drug oxidation.
Mol. Pharmacol.
7:
683–688,
1971.
|
| 80. |
Grasso, P.,
M. Williams,
R. Hodgson,
M. G. Wright, and
S. D. Gandolli.
The histochemical distribution of aniline hydroxylase in rat tissues.
Histochem. J.
3:
117–126,
1971.
|
| 81. |
Greengard, P.,
S. Psychoyos,
H. H. Tallan,
D. Y. Cooper,
O. Rosenthal, and
R. W. Estabrook.
Aldosterone synthesis by adrenal mitochondria. III. Participation of cytochrome P‐450.
Arch. Biochem. Biophys.
121:
298–303,
1967.
|
| 82. |
Grundin, R.,
S. Jakobsson, and
D. L. Cinti.
Induction of microsomal arylhydrocarbon (3,4‐benzo[α]pyrene) hydroxylase and cytochrome P‐450k in rat kidney cortex. 1. Characteristics of the hydroxylase system.
Arch. Biochem. Biophys.
158:
544–555,
1973.
|
| 83. |
Halkerston, I. D. K.,
J. Eichorn, and
O. Hechter.
TPNH requirement for cholesterol side chain cleavage in adrenal cortex.
Arch. Biochem. Biophys.
85:
287–289,
1959.
|
| 84. |
Hansten, P. D.
Drug Interactions
(2nd ed.).
Philadelphia:
Lea and Febiger,
1973.
|
| 85. |
Harding, B. W.,
L. D. Wilson,
S. H. Wong, and
D. H. Nelson.
Electron carriers of the rat adrenal and the 11‐beta‐hydroxylating system.
Steroids Suppl.
2:
51–77,
1965.
|
| 86. |
Harding, B. W.,
S. H. Wong, and
D. H. Nelson.
Carbon monoxide‐combining substances in rat adrenal.
Biochim. Biophys. Acta
92:
415–417,
1964.
|
| 87. |
Hart, L. G.,
R. H. Adamson,
R. L. Dixon, and
J. R. Fouts.
Stimulation of hepatic microsomal drug metabolism in the newborn and fetal rabbit.
J. Pharmacol. Exptl. Therap.
137:
103–106,
1963.
|
| 88. |
Hartiala, K.
Metabolism of hormones, drugs and other substances by the gut.
Physiol. Rev.
53:
496–534,
1973.
|
| 89. |
Hayaishi, O.
Enzymic hydroxylation.
Ann. Rev. Biochem.
38:
21–44,
1969.
|
| 90. |
Heinonen, J.,
S. Takki, and
L. Jarho.
Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes.
Acta Anaesthesiol. Scand.
14:
89–95,
1970.
|
| 91. |
Hlavica, P., and
M. Kiese.
N‐oxidation of N‐alkyl and N,N‐dialkyl anilines by rabbit liver microsomes.
Biochem. Pharmacol.
18:
1501–1509,
1969.
|
| 92. |
Holtzman, J. L.,
T. E. Gram,
P. L. Gigon, and
J. R. Gillette.
The distribution of the components of mixedfunction oxidase between the rough and the smooth endoplasmic reticulum of liver cells.
Biochem. J.
110:
407–412,
1968.
|
| 93. |
Hook, G. E. R.,
J. R. Bend, and
J. R. Fouts.
Mixedfunction oxidases and the alveolar macrophage.
Biochem. Pharmacol.
21:
3267–3277,
1972.
|
| 94. |
Hook, G. E. R.,
J. R. Bend, and
J. R. Fouts.
The effect of some biphenyl solubilizing and suspending agents on the activity of biphenyl 4‐hydroxylase of rabbit liver microsomes.
Chem.‐Biol. Interact.
7:
205–222,
1973.
|
| 95. |
Hook, G. E. R.,
J. R. Bend,
D. Hoel,
J. R. Fouts, and
T. E. Gram.
Preparation of lung microsomes and a comparison of the distribution of enzymes between subcellular fractions of rabbit lung and liver.
J. Pharmacol. Exptl. Therap.
182:
474–490,
1972.
|
| 96. |
Ichihara, K.,
E. Kusunose, and
M. Kusunose.
Some properties and distribution of the ω‐hydroxylation system of medium‐chain fatty acids.
Biochim. Biophys. Acta
176:
704–712,
1969.
|
| 97. |
Ichihara, K.,
E. Kusunose, and
M. Kusunose.
A fatty acid ω‐hydroxylation system solubilized from porcine kidney cortex microsomes.
Biochim. Biophys. Acta
239:
178–189,
1971.
|
| 98. |
Ichikawa, Y.,
T. Uemura, and
T. Yamano.
The role of the hydrophobic bonding in hemoprotein P‐450 and the effect of organic compounds on the conversion of hemoprotein P‐450 to hemoprotein P‐420. In:
Structure and Function of Cytochromes,
edited by K. Okunuki,
M. D. Kamen, and
I. Sekuzu.
Baltimore:
Univ. Park,
1968,
p. 634–644.
|
| 99. |
Imai, Y., and
R. Sato.
Substrate interaction with hydroxylase system in liver microsomes.
Biochem. Biophys. Res. Commun.
22:
620–626,
1966.
|
| 100. |
Imai, Y., and
R. Sato.
Conversion of P‐450 to P‐420 by neutral salts and other reagents.
European J. Biochem.
1:
419–426,
1967.
|
| 101. |
Inano, H., and
B. Tamaoki.
Steroid 7α‐hydroxylase of rat testes.
Biochemistry
10:
1503–1509,
1971.
|
| 102. |
Jakobsson, S. V., and
D. L. Cinti.
Studies on the cytochrome P‐450‐containing mono‐oxygenase system in human kidney cortex microsomes.
J. Pharmacol. Exptl. Therap.
185:
226–234,
1973.
|
| 103. |
Jakobsson, S.,
R. Grundin,
H. Thor, and
D. L. Cinti.
Induction of microsomal aryl hydrocarbon (3,4‐benzo[α]pyrene) hydroxylase and cytochrome P‐450k in rat kidney cortex. II. Interactions with the induced hemoprotein.
Arch. Biochem. Biophys.
158:
556–565,
1973.
|
| 104. |
Jakobsson, S.,
H. Thor, and
S. Orrenius.
Fatty acid inducible cytochrome P‐450 of rat kidney cortex microsomes.
Biochem. Biophys. Res. Commun.
39:
1073–1080,
1970.
|
| 105. |
Jefcoate, C. R.,
R. Hume, and
G. S. Boyd.
Separation of two forms of cytochrome P‐450 from adrenal cortex mitochondria.
FEBS Letters
9:
41–44,
1970.
|
| 106. |
Jondorf, W. R.,
R. P. Maickel, and
B. B. Brodie.
Inability of newborn mice and guinea pigs to metabolize drugs.
Biochem. Pharmacol.
1:
352–354,
1959.
|
| 107. |
Juchau, M. R.
Human placental hydroxylation of 3,4‐benzpyrene during early gestation and at term.
Toxicol. Appl. Pharmacol.
18:
665–675,
1971.
|
| 108. |
Juchau, M. R.
Mechanisms of drug biotransformation reactions in the placenta.
Federation Proc.
31:
48–51,
1972.
|
| 109. |
Juchau, M. R., and
D. C. Dyer.
Pharmacology of the placenta.
Pediatric Clin. N. Am.
19:
65–79,
1972.
|
| 110. |
Juchau, M. R.,
Q. H. Lee, and
P. H. Blake.
Inverse correlation between aryl hydrocarbon hydroxylase activity and conversion of cholesterol to pregnenolone in human placentas at term.
Life Sci., Part 2
11:
949–956,
1972.
|
| 111. |
Juchau, M. R.,
K. R. Niswander, and
S. J. Yaffe.
Drug metabolizing systems in homogenates of human immature placentas.
Am. J. Obstet. Gynecol.
100:
348–356,
1968.
|
| 112. |
Juchau, M. R., and
M. G. Pedersen.
Drug biotransformation reactions in the human fetal adrenal gland.
Life Sci.
12:
193–204,
1973.
|
| 113. |
Juchau, M. R.,
M. G. Pedersen, and
K. G. Symms.
Hydroxylation of 3,4‐benzpyrene in human fetal tissue homogenates.
Biochem. Pharmacol.
21:
2269–2272,
1972.
|
| 114. |
Juchau, M. R., and
K. G. Symms.
Aniline hydroxylation in the human placenta‐Mechanistic aspects.
Biochem. Pharmacol.
21:
2053–2064,
1972.
|
| 115. |
Juchau, M. R., and
S. J. Yaffe.
Biotransformation of drug substrates in placental homogenates. In:
The Foetal‐Placental Unit,
edited by A. Pecile and
C. Finzi.
Amsterdam:
Excerpta Medica Foundation,
1969,
p. 260–270.
|
| 116. |
Kato, R.
Possible role of P‐450 in the oxidation of drugs in liver microsomes.
J. Biochem. Tokyo
59:
574–583,
1966.
|
| 117. |
Kato, R.,
E. Chiesara, and
G. Frontino.
Influence of sex difference on the pharmacological action and metabolism of some drugs.
Biochem. Pharmacol.
11:
221–227,
1962.
|
| 118. |
Kato, R., and
J. R. Gillette.
Effect of starvation on NADPH‐dependent enzymes in liver microsomes of male and female rats.
J. Pharmacol. Exptl. Therap.
150:
279–284,
1965.
|
| 119. |
Kato, R.,
A. Takanaka, and
M. Takayanagi.
Studies on the mechanism of sex difference in drug‐oxidizing activity of liver microsomes.
Japan. J. Pharmacol.
18:
482–489,
1968.
|
| 120. |
Kato, R.,
P. Vassanelli,
G. Frontino, and
E. Chiesara.
Variation in the activity of liver microsomal drug metabolizing enzymes in rats in relation to the age.
Biochem. Pharmacol.
13:
1037–1051,
1964.
|
| 121. |
Kaufman, S.
The enzymatic conversion of phenylalanine to tyrosine.
J. Biol. Chem.
226:
511–524,
1957.
|
| 122. |
Kimura, T., and
K. Suzuki.
Enzymatic reduction of nonheme iron protein (adrenodoxin) by reduced nicotinamide adenine dinucleotide phosphate.
Biochem. Biophys. Res. Commun.
20:
373–379,
1965.
|
| 123. |
Kinoshita, N., and
H. V. Gelboin.
The role of aryl hydrocarbon hydroxylase in 7,12‐dimethylbenz[α]anthracene skin tumorigenesis: On the mechanism of 7,8‐benzoflavone inhibition of tumorigenesis.
Cancer Res.
32:
1329–1339,
1972.
|
| 124. |
Kinoshita, T., and
S. Horie.
Studies on P‐450. III. On the absorption spectrum of P‐450 in rabbit liver microsomes.
J. Biochem. Tokyo
61:
26–34,
1967.
|
| 125. |
Klingenberg, M.
Pigments of rat liver microsomes.
Arch. Biochem. Biophys.
75:
376–386,
1958.
|
| 126. |
Koch‐Weser, J., and
E. M. Sellers.
Drug interactions with coumarin anticoagulants.
New Engl. J. Med.
285:
487–498,
547–558,
1971.
|
| 127. |
Kristensen, M., and
J. M. Jansen.
Potentiation of the tolbutamide effect by dicoumarol.
Diabetes
16:
211–214,
1967.
|
| 128. |
Kuntzman, R.,
L. C. Mark,
L. Brand,
M. Jacobson,
W. Levin, and
A. H. Conney.
Metabolism of drugs and carcinogens by human liver enzymes.
J. Pharmacol. Exptl. Therap.
152:
151–156,
1966.
|
| 129. |
Kupfer, D.,
L. L. Bruggeman, and
T. Munsell.
Studies on the occurrence of N‐demethylase activity in adrenal and hepatic preparations from guinea pigs and rats. The effect of various substances on the magnitude of this activity.
Arch. Biochem. Biophys.
129:
185–189,
1969.
|
| 130. |
La Du, B. N.,
H. G. Mandel, and
E. L. Way.
Fundamentals of Drug Metabolism and Disposition.
Baltimore:
Williams & Wilkins,
1971.
|
| 131. |
Lehrmann, Ch.,
V. Ullrich, and
W. Rummel.
Phenobarbital inducible drug monooxygenase activity in the small intestine of mice.
Naunyn‐Schmeidebergs Arch. Pharmakol.
276:
89–98,
1973.
|
| 132. |
Lu, A. Y. H., and
M. J. Coon.
Role of hemoprotein P‐450 in fatty acid ω‐hydroxylation in a soluble enzyme system from liver microsomes.
J. Biol. Chem.
243:
1331–1332,
1968.
|
| 133. |
Lu, A. Y. H.,
M. Jacobson,
W. Levin,
S. B. West, and
R. Kuntzman.
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IV. Hydroxylation of aniline.
Arch. Biochem. Biophys.
153:
294–297,
1972.
|
| 134. |
Lu, A. Y. H.,
R. Kuntzman,
S. West, and
A. H. Conney.
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. I. Determination of substrate specificity by the cytochrome P‐450 and P‐448 fractions.
Biochem. Biophys. Res. Commun.
42:
1200–1206,
1971.
|
| 135. |
Lu, A. Y. H.,
R. Kuntzman,
S. West,
M. Jacobson, and
A. H. Conney.
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P‐450 and P‐448 fractions in drug and steroid hydroxylations.
J. Biol. Chem.
247:
1727–1734,
1972.
|
| 136. |
Lu, A. Y. H.,
W. Levin,
S. B. West,
M. Jacobson,
D. Ryan,
R. Kuntzman, and
A. H. Conney.
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P‐450 fraction from control and phenobarbital‐treated rats.
J. Biol. Chem.
248:
456–460,
1973.
|
| 137. |
Lu, A. Y. H.,
H. W. Strobel, and
M. J. Coon.
Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P‐450 from liver microsomes: Lipid requirement for drug demethylation.
Biochem. Biophys. Res. Commun.
36:
545–551,
1969.
|
| 138. |
Lu, A. Y. H., and
S. West.
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. III. Properties of the reconstituted 3,4‐benzpyrene hydroxylase system.
Mol. Pharmacol.
8:
490–500,
1972.
|
| 139. |
Lucier, G. W.,
O. S. McDaniel,
G. E. R. Hook,
B. Fowler,
B. R. Sonawane, and
E. Faeder.
TCDD‐induced changes in rat liver microsomal enzymes.
Environ. Health Perspectives
5:
199–209,
1973.
|
| 140. |
Lynch, W. T., and
M. J. Coon.
Effect of tri‐o‐tolylphosphate pretreatment on the toxicity of parathion in mice (Abstract).
Federation Proc.
25:
687,
1966.
|
| 141. |
Machino, A.,
H. Inano, and
B. Tamaoki.
Studies on enzyme reactions related to steroid biosynthesis. I. Presence of cytochrome P450 in testicular tissue and its role in the biogenesis of androgens.
J. Steroid Biochem.
1:
9–16,
1969.
|
| 142. |
Mackler, B.,
B. Haynes,
D. S. Tattoni,
D. F. Tippit, and
V. C. Kelley.
Studies of adrenal steroid hydroxylation. I. Purification of the microsomal 21‐hydroxylase system.
Arch. Biochem. Biophys.
145:
194–198,
1971.
|
| 143. |
Maines, M. D., and
B. S. Westfall.
Sex difference in the metabolism of hexobarbital in the Mongolian gerbil (Meriones unguiculatus).
Proc. Soc. Exptl. Biol. Med.
138:
820–822,
1971.
|
| 144. |
Mannering, G. J.
Microsomal enzyme systems which catalyze drug metabolism. In:
Fundamentals of Drug Metabolism and Drug Disposition,
edited by B. N. La Du,
H. G. Mandel, and
E. L. Way.
Baltimore:
Williams & Wilkins,
1971,
p. 206–252.
|
| 145. |
Mannering, G. J.
Properties of cytochrome P‐450 as affected by environmental factors: Qualitative changes due to administration of polycyclic hydrocarbons.
Metabolism
20:
228–245,
1971.
|
| 146. |
Mason, H. S.
Mechanisms of oxygen metabolism.
Science
125:
1185–1188,
1957.
|
| 147. |
Mason, H. S.
Oxidases.
Ann. Rev. Biochem.
34:
595–634,
1965.
|
| 148. |
Mason, J. I.,
R. W. Estabrook, and
J. L. Purvis.
Testicular cytochrome P‐450 and iron‐sulfur protein as related to steroid metabolism.
Ann. NY Acad. Sci.
212:
406–419,
1973.
|
| 149. |
Masters, B. S. S.,
J. Baron,
W. E. Taylor,
E. L. Isaacson, and
J. Lospalluto.
Immunochemical studies on electron transport chains involving cytochrome P‐450. I. Effects of antibodies to pig liver microsomal reduced triphosphopyridine nucleotide‐cytochromec reductase and the non‐heme iron protein from bovine adrenocortical mitochondria.
J. Biol. Chem.
246:
4143–4150,
1971.
|
| 150. |
Masters, B. S. S.,
H. Kamin,
Q. H. Gibson, and
C. H. Williams.
Studies on the mechanism of microsomal triphosphopyridine nucleotide‐cytochromec reductase.
J. Biol. Chem.
240:
921–931,
1965.
|
| 151. |
Masters, B. S. S.,
E. B. Nelson,
B. A. Schacter,
J. Baron, and
E. L. Isaacson.
NADPH‐cytochromec reductase and its role in microsomal cytochrome P‐450‐dependent reactions.
Drug Metab. Disposition
1:
121–128,
1973.
|
| 152. |
Matsubara, T., and
Y. Tochino.
Electron transport systems of lung microsomes and their physiological functions. I. Intracellular distribution of oxidative enzymes in lung cells.
J. Biochem. Tokyo
70:
981–991,
1971.
|
| 153. |
McIntosh, E. N.,
F. Mitani,
V. I. Užgris,
C. Alonso, and
H. A. Salhanick.
Comparative studies on mitochondrial and partially purified bovine corpus luteum cytochrome P‐450.
Ann NY Acad. Sci.
212:
392–405,
1973.
|
| 154. |
McLeod, S. M.,
K. W. Renton, and
N. R. Eade.
Development of hepatic microsomal drug‐oxidizing enzymes in immature male and female rats.
J. Pharmacol. Exptl. Therap.
183:
489–498,
1972.
|
| 155. |
Meigs, R. A., and
K. J. Ryan.
Mixed function oxidation reactions in biological oxidations: Human placenta.
Science
158:
532,
1967.
|
| 156. |
Meigs, R. A., and
K. J. Ryan.
Cytochrome P‐450 and steroid biosynthesis in the human placenta.
Biochim. Biophys. Acta
165:
476–482,
1968.
|
| 157. |
Miyake, Y.,
J. L. Gaylor, and
H. S. Mason.
Properties of a submicrosomal particle containing P‐450 and a flavoprotein.
J. Biol. Chem.
243:
5788–5797,
1968.
|
| 158. |
Mueller, G. C., and
J. A. Miller.
The metabolism of methylated aminoazo dyes. II. Oxidative demethylation by rat liver homogenates.
J. Biol. Chem.
202:
579–587,
1953.
|
| 159. |
Murphy, S. D., and
K. P. Dubois.
The influence of various factors on the enzymatic conversion of organic thiophosphates to anticholinesterase agents.
J. Pharmacol. Exptl. Therap.
124:
194–202,
1958.
|
| 160. |
Nakamura, Y.,
H. Otsuka, and
B. I. Tamaoki.
Activation of rat adrenal mitochondrial steroid 11‐beta‐ and 18‐hydroxylases by a new protein factor.
Biochim. Biophys. Acta
96:
339–341,
1965.
|
| 161. |
Narasimhulu, S.,
D. Y. Cooper, and
O. Rosenthal.
Spectrophotometric properties of a triton‐clarified steroid 21‐hydroxylase system of adrenocortical microsomes.
Life Sci.
4:
2102–2107,
1965.
|
| 162. |
Neal, R. A.
A comparison of the in vitro metabolism of parathion in the lung and liver of the rabbit.
Toxicol. Appl. Pharmacol.
23:
123–130,
1972.
|
| 163. |
Nebert, D. W.,
J. E. Gielen, and
F. M. Goujon.
Genetic expression of aryl hydrocarbon hydroxylase induction. III. Changes in the binding of n‐octylamine to cytochrome P‐450.
Mol. Pharmacol.
8:
651–666,
1972.
|
| 164. |
Nebert, D. W.,
J. Winker, and
H. V. Gelboin.
Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women.
Cancer Res.
29:
1763–1769,
1969.
|
| 165. |
Nelson, E. B.,
P. P. Raj,
K. J. Belfi, and
B. S. S. Masters.
Oxidative drug metabolism in human liver microsomes.
J. Pharmacol. Exptl. Therap.
178:
580–588,
1971.
|
| 166. |
Nishibayashi, H., and
R. Sato.
Preparation of hepatic microsomal particles containing P‐450 as sole heme constituent and absolute spectra of P‐450.
J. Biochem. Tokyo
63:
766–779,
1968.
|
| 167. |
Noordhoek, J.
The effect of castration and testosterone on some components of the microsomal drug metabolizing system in mice.
FEBS Letters
24:
255–259,
1972.
|
| 168. |
Omura, T.,
E. Sanders,
R. W. Estabrook,
D. Y. Cooper, and
O. Rosenthal.
Isolation from adrenal cortex of a non‐heme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide‐cytochrome P‐450 reductase.
Arch. Biochem. Biophys.
117:
660–673,
1966.
|
| 169. |
Omura, T., and
R. Sato.
Fractional solubilization of haemoproteins and partial purification of carbon monoxide‐binding cytochrome from liver microsomes.
Biochim. Biophys. Acta
71:
224–226,
1963.
|
| 170. |
Omura, T., and
R. Sato.
The carbon monoxide‐binding pigment of liver microsomes. I. Evidence for its hemoprotein nature.
J. Biol. Chem.
239:
2370–2378,
1964.
|
| 171. |
Omura, T.,
R. Sato,
D. Y. Cooper,
O. Rosenthal, and
R. W. Estabrook.
Function of cytochrome P‐450 of microsomes.
Federation Proc.
24:
1181–1189,
1965.
|
| 172. |
Oppelt, W. W.,
M. Zange,
W. E. Ross, and
H. Remmer.
Comparison of microsomal drug hydroxylation in lung and liver of various species.
Res. Commun. Chem. Pathol. Pharmacol.
1:
43–56,
1970.
|
| 173. |
Orrenius, S.,
A. Berg, and
L. Ernster.
Effects of trypsin on the electron transport systems of liver microsomes.
European J. Biochem.
11:
193–200,
1969.
|
| 174. |
Orrenius, S.,
Å. Ellin,
S. V. Jakobsson,
H. Thor,
D. L. Cinti,
J. B. Schenkman, and
R. W. Estabrook.
The cytochrome P‐450‐containing mono‐oxygenase system of rat kidney cortex microsomes.
Drug Metab. Disposition
1:
350–357,
1973.
|
| 175. |
Orrenius, S., and
H. Thor.
Fatty acid interaction with the hydroxylating enzyme system of rat liver microsomes.
European J. Biochem.
9:
415–418,
1969.
|
| 176. |
Parke, D. V.
The Biochemistry of Foreign Compounds.
New York:
Pergamon Press,
1968.
(Intern. Ser. Monographs Pure Appl. Biol., Biochem. Div., vol 5.)
|
| 177. |
Pelkonen, O.
Drug metabolism and drug‐induced spectral interactions in human fetal microsomes.
Biochem. Pharmacol.
22:
2357–2364,
1973.
|
| 178. |
Pelkonen, O.,
P. Arvela, and
N. T. Kärki.
3,4‐Benzpyrene and N‐methylaniline metabolizing enzymes in the immature human foetus and placenta.
Acta Pharmacol. Toxicol.
30:
385–395,
1971.
|
| 179. |
Pelkonen, O.,
E. H. Kaltiala,
T. K. I. Larmi, and
N. T. Kärki.
Comparison of activities of drug‐metabolizing enzymes in human fetal and adult livers.
Clin. Pharmacol. Therap.
14:
840–846,
1973.
|
| 180. |
Pelkonen, O.,
M. Vorne,
P. Jouppila, and
N. T. Kärki.
Metabolism of chlorpromazine and p‐nitrobenzoic acid in the liver, intestine and kidney of the human foetus.
Acta Pharmacol. Toxicol.
29:
284–294,
1971.
|
| 181. |
Philpot, R. M., and
J. R. Fouts.
Cytochrome P‐450 isolated from rabbit liver and lung (Abstract).
Pharmacologist
15:
169,
1973.
|
| 182. |
Plager, J. E., and
L. T. Samuels.
The conversion of progesterone to 17‐hydroxy‐11‐deoxycorticosterone by fractionated beef homogenates.
J. Biol. Chem.
211:
21–29,
1954.
|
| 183. |
Poore, R. E., and
R. A. Neal.
Evidence for extrahepatic metabolism of parathion.
Toxicol. Appl. Pharmacol.
23:
759–768,
1972.
|
| 184. |
Posner, H. S.,
C. Mitoma,
S. Rothberg, and
S. Udenfriend.
Enzymatic hydroxylation of aromatic compounds. III. Studies on the mechanism of microsomal hydroxylation.
Arch. Biochem. Biophys.
94:
280–290,
1961.
|
| 185. |
Quinn, G. P.,
J. Axelrod, and
B. B. Brodie.
Species, strain and sex differences in metabolism of hexobarbitone, amidopyrine, antipyrine and aniline.
Biochem. Pharmacol.
1:
152–159,
1958.
|
| 186. |
Raisfield, I. H.
Drug interactions in the therapy of cardiovascular disorders.
Am. Heart J.
81:
709–715,
1971.
|
| 187. |
Raisfield, I. H.
Clinical pharmacology of drug interactions.
Ann. Rev. Med.
24:
385–418,
1973.
|
| 188. |
Rane, A., and
E. Ackermann.
Metabolism of ethylmorphine and aniline in human fetal liver.
Clin. Pharmacol. Therap.
13:
663–670,
1972.
|
| 189. |
Rane, A.,
M. Berggren,
S. Yaffe, and
J. L. E. Ericsson.
Oxidative drug metabolism in the perinatal rabbit liver and placenta. A biochemical and morphologic study.
Xenobiotica
3:
37–48,
1973.
|
| 190. |
Rane, A., and
J.‐Å. Gustafsson.
Formation of a 16, 17‐trans‐glycolic metabolite from a 16‐dihydro‐androgen in human fetal liver microsomes.
Clin. Pharmacol. Therap.
14:
833–839,
1973.
|
| 191. |
Reid, W. D.,
J. M. Glick, and
G. Krishna.
Metabolism of foreign compounds by alveolar macrophages of rabbits.
Biochem. Biophys. Res. Commun.
49:
626–634,
1972.
|
| 192. |
Reid, W. D.,
K. F. Ilett,
J. M. Glick, and
G. Krishna.
Metabolism and binding of aromatic hydrocarbons in the lung: Relationship to experimental bronchiolar necrosis.
Am. Rev. Respirat. Diseases
107:
539–551,
1973.
|
| 193. |
Reid, W. D., and
G. Krishna.
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
Exptl. Mol. Pathol.
18:
80–99,
1973.
|
| 194. |
Remmer, H., and
H. J. Merker.
Effect of drugs on the formation of smooth endoplasmic reticulum and drug‐metabolizing enzymes.
Ann. NY Acad. Sci.
123:
79–97,
1965.
|
| 195. |
Remmer, H.,
J. Schenkman,
R. W. Estabrook,
H. Sasame,
J. Gillette,
S. Narasimhulu,
D. Y. Cooper, and
O. Rosenthal.
Drug interaction with hepatic microsomal cytochrome.
Mol. Pharmacol.
2:
187–190,
1966.
|
| 196. |
Remmer, H.,
B. Schoene, and
R. A. Fleischmann.
Induction of the unspecific hydroxylase in the human liver.
Drug Metab. Disposition
1:
224–230,
1973.
|
| 197. |
Ryan, K. J., and
L. L. Engel.
Hydroxylation of steroids at carbon 21.
J. Biol. Chem.
225:
103–114,
1957.
|
| 198. |
Sasame, H. A.,
J. R. Mitchell,
S. Thorgeirsson, and
J. R. Gillette.
Relationship between NADH‐ and NADPH‐oxidation during drug metabolism.
Drug Metab. Disposition
1:
150–155,
1973.
|
| 199. |
Sato, R.,
T. Omura, and
H. Nishibayashi.
Carbon monoxide‐binding hemoprotein and NADPH‐specific flavoprotein in liver microsomes and their roles in microsomal electron transport. In:
Oxidases and Related Redox Systems: Proceedings,
edited by T. E. King,
H. S. Mason, and
M. Morrison.
New York:
Wiley,
1965,
vol. 2,
p. 861–878.
(Intern. Symp., 2nd, Amherst, Mass., July 1964.)
|
| 200. |
Scharf, R., and
V. Ullrich.
In vitro induction of drug monooxygenase activity by phenobarbital in the isolated mouse jejunum.
Naunyn‐Schmiedebergs Arch. Pharmakol.
278:
329–332,
1973.
|
| 201. |
Schenkman, J. B.
Hepatic microsomal mixed function oxidase.
Science
168:
612–613,
1970.
|
| 202. |
Schenkman, J. B.
Studies on the nature of the type I and type II spectral changes in liver microsomes.
Biochemistry
9:
2081–2091,
1970.
|
| 203. |
Schenkman, J. B., and
D. L. Cinti.
The rate‐limiting step in aminopyrine demethylase of rat liver microsomes.
Biochem. Pharmacol.
19:
2396–2399,
1970.
|
| 204. |
Schenkman, J. B.,
D. L. Cinti,
P. W. Moldeus, and
S. Orrenius.
Newer aspects of substrate binding to cytochrome P‐450.
Drug Metab. Disposition
1:
111–120,
1973.
|
| 205. |
Schenkman, J. B.,
D. L. Cinti,
S. Orrenius,
P. Moldeus, and
R. Kraschnitz.
The nature of the reverse type I (modified type II) spectral change in liver microsomes.
Biochemistry
11:
4243–4251,
1972.
|
| 206. |
Schenkman, J. B.,
I. Frey,
H. Remmer, and
R. W. Estabrook.
Sex differences in drug metabolism by rat liver microsomes.
Mol. Pharmacol.
3:
516–525,
1967.
|
| 207. |
Schenkman, J. B.,
H. Greim,
M. Zange, and
H. Remmer.
On the problem of possible other forms of cytochrome P450 in liver microsomes.
Biochim. Biophys. Acta
171:
23–31,
1969.
|
| 208. |
Schenkman, J. B.,
H. Remmer, and
R. W. Estabrook.
Spectral studies of drug interaction with hepatic microsomal cytochrome.
Mol. Pharmacol.
3:
113–123,
1967.
|
| 209. |
Schenkman, J. B., and
R. Sato.
The relationship between the pH‐induced spectral change in ferriprotoheme and the substrate‐induced spectral change of the hepatic microsomal mixed‐function oxidase.
Mol. Pharmacol.
4:
613–620,
1968.
|
| 210. |
Schlede, E., and
H. J. Merker.
Effect of benzo(α)pyrene treatment on the benzo(α)pyrene hydroxylase activity in maternal liver, placenta, and fetus of the rat during day 13 to day 19 of gestation.
Naunyn‐Schmiedebergs Arch. Pharmakol.
272:
89–100,
1972.
|
| 211. |
Sher, S. P.
Drug enzyme induction and drug interactions: literature tabulation.
Toxicol. Appl. Pharmacol.
18:
780–834,
1971.
|
| 212. |
Shimizu, K.,
M. Hayano,
M. Gut, and
R. I. Dorfman.
The transformation of 20α‐hydroxycholesterol to isocaproic acid and C21 steroids.
J. Biol. Chem.
236:
695–699,
1961.
|
| 213. |
Short, C. R., and
L. E. Davis.
Perinatal development of drug‐metabolizing enzyme activity in swine.
J. Pharmacol. Exptl. Therap.
174:
185–196,
1970.
|
| 214. |
Short, C. R.,
M. D. Maines, and
B. A. Westfall.
Postnatal development of drug‐metabolizing enzyme activity in liver and extrahepatic tissues of swine.
Biol. Neonatorum
21:
54–68,
1972.
|
| 215. |
Simpson, E. R., and
G. S. Boyd.
The cholesterol side‐chain cleavage system of the adrenal cortex: a mixed‐function oxidase.
Biochem. Biophys. Res. Commun.
24:
10–17,
1966.
|
| 216. |
Sladek, N. E., and
G. J. Mannering.
Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N‐demethylating systems.
Mol. Pharmacol.
5:
174–185,
1969.
|
| 217. |
Solomon, H. M.
Clinical disorders of drug interaction.
Advan. Internal Med.
16:
285–301,
1970.
|
| 218. |
Solomon, H. M., and
J. J. Schrogie.
Effect of phenyramidol and bishydroxycoumarin on the metabolism of tolbutamide in human subjects.
Metabolism
16:
1029–1033,
1967.
|
| 219. |
Solomon, S.,
P. Levitan, and
S. Liebermann.
Possible intermediates between cholesterol and pregnenolone in corticosteroidogenesis.
Rev. Can. Biol.
15:
282,
1956.
|
| 220. |
Sorokin, S. P.
The cells of the lungs. In:
Morphology of Experimental Respiratory Carcinogenesis,
edited by P. Nettesheim,
M. G. Hanna, Jr., and
J. W. Deatherage, Jr.
Oak Ridge, Tenn:
U.S. Atomic Energy Comm.,
1970,
p. 3–43.
(AEC Symp. Ser., No. 21.)
|
| 221. |
Stripp, B.,
F. E. Greene, and
J. R. Gillette.
Extinction coefficients for cytochrome P‐450 in hepatic microsomes from male and female rats.
Pharmacology
6:
56–64,
1971.
|
| 222. |
Strobel, H. W.,
A. Y. H. Lu,
J. Heidema, and
M. J. Coon.
Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P‐450 and in fatty acid, hydrocarbon, and drug hydroxylation.
J. Biol. Chem.
245:
4851–4854,
1970.
|
| 223. |
Sweat, M. L.
Enzymatic synthesis of 17‐hydroxycorticosterone.
J. Am. Chem. Soc.
73:
4056,
1951.
|
| 224. |
Swidler, G.
Handbook of Drug Interactions.
New York:
Wiley,
1971.
|
| 225. |
Symms, K. G., and
M. R. Juchau.
Stabilization, solubilization, partial purification and some properties of cytochrome P‐450 present in CaCl2‐precipitated human placental microsomes.
Life Sci.
13:
1221–1230,
1973.
|
| 226. |
Takesue, Y., and
R. Sato.
Enzyme distribution in subcellular fractions of intestinal mucosal cells.
J. Biochem. Tokyo
64:
873–883,
1968.
|
| 227. |
Tamulski, T. S.,
C. E. Morreal, and
T. L. Dao.
Comparative metabolism of 7,12‐dimethylbenz(α)anthracene in liver and mammary tissue.
Cancer Res.
33:
3117–3122,
1973.
|
| 228. |
Thomas, F. B.,
B. Nobuhisa,
N. J. Greenberger, and
D. Salsburey.
Effect of phenobarbital on small intestine structure and function in the rat.
J. Lab. Clin. Med.
80:
548–558,
1972.
|
| 229. |
Toren, D.,
K. M. J. Menon,
E. Forchielli, and
R. I. Dorfman.
In vitro cleavage of the cholesterol side chain in rat testis preparations.
Steroids
3:
381–390,
1964.
|
| 230. |
Uehleke, H.
Extrahepatic microsomal drug metabolism.
Proc. European Soc. Study Drug Toxicity, 10th Meeting, Oxford, April 1968.
Amsterdam:
Excerpta Medica Foundation,
1968,
p. 94–100.
(Excerpta Medica Intern. Congr. Ser. No. 181.)
|
| 231. |
Uehleke, H., and
H. Greim.
Stimulierung der Oxydation von Fremdstoffen in nurenmikrosomen durch phenobarbital.
Naunyn‐Schmiedebergs Arch. Pharmakol.
261:
152–161,
1968.
|
| 232. |
Vainio, H., and
O. Hanninen.
Effects of surfactants on drug metabolism in hepatic microsomes.
Suomen Kemistilehti B
45:
56–61,
1972.
|
| 233. |
Van Petten, G. R.,
G. H. Hirsch, and
A. D. Cherrington.
Drug‐metabolizing activity of the human placenta.
Can. J. Biochem.
46:
1057–1061,
1968.
|
| 234. |
Vesell, E. S.
Genetic and environmental factors affecting hexobarbital metabolism in mice.
Ann. NY Acad. Sci.
151:
900–912,
1968.
|
| 235. |
Voigt, W.,
E. P. Fernandez, and
S. L. Hsia.
Transformation of testosterone into 17 β‐hydroxy‐5α‐androstan‐3‐one by microsomal preparations of human skin.
J. Biol. Chem.
245:
5594–5599,
1970.
|
| 236. |
Wada, F.,
H. Shibata,
M. Goto, and
Y. Sakamoto.
Participation of the microsomal electron transport system involving cytochrome P‐450 in ω‐oxidation of fatty acids.
Biochim. Biophys. Acta
162:
518–524,
1968.
|
| 237. |
Wattenberg, L.
The role of the portal of entry in inhibition of tumorigenesis.
Progr. Exptl. Tumor Res.
14:
89–101,
1970.
|
| 238. |
Wattenberg, L. W.
Studies on polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Effect of diet on benzpyrene hydroxylase activity.
Cancer
20:
99–102,
1971.
|
| 239. |
Wattenberg, L. W.
Dietary modification of intestinal and pulmonary aryl hydrocarbon hydroxylase activity.
Toxicol. Appl. Pharmacol.
23:
741–748,
1972.
|
| 240. |
Wattenberg, L. W.
Enzymatic reactions and carcinogenesis. In:
Environment and Cancer,
[by] Anderson Tumor Institute, Houston, Texas.
Baltimore:
Williams & Wilkins,
1972,
p. 241–255.
(Symp. Fundamental Cancer Res., Houston, Tex., 1972.)
|
| 241. |
Wattenberg, L. W., and
J. L. Leong.
Histochemical demonstration of reduced pyridine nucleotide dependent polycyclic hydrocarbon metabolizing systems.
J. Histochem. Cytochem.
10:
412–420,
1962.
|
| 242. |
Wattenberg, L. W., and
J. L. Leong.
Effects of phenothiazines on protective systems against polycyclic hydrocarbons.
Cancer Res.
25:
365–370,
1965.
|
| 243. |
Wattenberg, L. W., and
J. L. Leong.
Induction of increased benzpyrene hydroxylase activity in the lung in vivo and in vitro (Abstract).
Proc. Am. Assoc. Cancer Res.
7:
74,
1966.
|
| 244. |
Wattenberg, L. W.,
J. L. Leong, and
A. R. Galbraith.
Induction of increased benzpyrene hydroxylase activity in pulmonary tissue in vitro.
Proc. Soc. Exptl. Biol. Med.
127:
467–469,
1967.
|
| 245. |
Wattenberg, L. W.,
J. L. Leong, and
P. J. Strand.
Benzpyrene hydroxylase activity in the gastrointestinal tract.
Cancer Res.
22:
1120–1125,
1962.
|
| 246. |
Wattenberg, L. W.,
M. A. Page, and
J. L. Leong.
Induction of increased benzpyrene hydroxylase activity by 2‐phenylthiazoles and related compounds.
Cancer Res.
28:
2539–2544,
1968.
|
| 247. |
Welch, R. M.,
Y. E. Harrison,
A. H. Conney,
P. J. Poppers, and
M. Finster.
Cigarette smoking: stimulatory effect on metabolism of 3,4‐benzpyrene by enzymes in human placenta.
Science
160:
541–542,
1968.
|
| 248. |
Welch, R. M.,
Y. E. Harrison,
B. W. Gommi,
P. J. Poppers,
M. Finster, and
A. H. Conney.
Stimulatory effect of cigarette smoking on the hydroxylation of 3,4‐benzpyrene and the N‐demethylation of 3‐methyl‐4‐monomethylaminoazobenzene by enzymes in human placenta.
Clin. Pharmacol. Therap.
10:
100–109,
1969.
|
| 249. |
Welch, R. M.,
A. Loh, and
A. H. Conney.
Cigarette smoke: stimulatory effect on metabolism of 3,4‐benzpyrene by enzymes in rat lung.
Life Sci., Part 1
10:
215–221,
1971.
|
| 250. |
West, S. B., and
A. Y. H. Lu.
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P‐450 and P‐448 for reductase in 3,4‐benzpyrene hydroxylation.
Arch. Biochem. Biophys.
153:
298–303,
1972.
|
| 251. |
Whysner, J. A.,
J. Kamseyer, and
B. W. Harding.
Substrate‐induced changes in visible absorption and electron spin resonance properties of adrenal cortex mitochondrial P‐450.
J. Biol. Chem.
245:
5441–5449,
1969.
|
| 252. |
Williams, R. T.
Detoxication Mechanisms, the Metabolism of Drugs, Toxic Substances and Other Organic Compounds.
New York:
Wiley,
1959.
|
| 253. |
Witschi, H. P., and
B. Saint‐François.
Enhanced activity of benzpyrene hydroxylase in rat liver and lung after acute cannabis administration.
Toxicol. Appl. Pharmacol.
23:
165–168,
1972.
|
| 254. |
Yaffe, S. J.,
A. Rane,
F. Sjöqvist,
L.‐O. Boréus, and
S. Orrenius.
The presence of a monooxygenase system in human fetal liver microsomes.
Life Sci., Part 2
9:
1189–1200,
1970.
|
| 255. |
Yago, N.,
R. I. Dorfman, and
E. Forchielli.
Extramitochondrial NADPH and cholesterol side‐chain cleaving enzyme system in the heavy mitochondria of bovine corpora lutea.
J. Biochem. Tokyo
62:
345–352,
1967.
|
| 256. |
Zampaglione, N. G., and
G. J. Mannering.
Properties of benzpyrene hydroxylase in the liver, intestinal mucosa and adrenal of untreated and 3‐methylcholanthrene treated rats.
J. Pharmacol. Exptl. Therap.
185:
676–685,
1973.
|
| 257. |
Ziegler, D. M.,
C. H. Mitchell, and
D. Jollow.
The properties of a purified hepatic microsomal mixed function amine oxidase. In:
Microsomes and Drug Oxidations: Proceedings,
edited by J. R. Gillette,
A. H. Conney,
G. J. Cosmides,
R. W. Estabrook,
J. R. Fouts, and
G. J. Mannering.
New York:
Academic Press,
1969,
p. 173–188.
(Symp. Microsomes and Drug Oxidations.)
|
